LOCUS       NM_024182               3661 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RIO kinase 3 (Riok3), mRNA.
ACCESSION   NM_024182
VERSION     NM_024182.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3661)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3661)
  AUTHORS   Zong,H.X., Liu,Y.Q., Wang,X.L., Miao,J.Y., Luo,L.P., Wang,J.X.,
            Chu,Y.R., Tong,W.Q., Zhao,X. and Xu,S.Q.
  TITLE     RIOK3 potentially regulates osteogenesis-related pathways in
            ankylosing spondylitis and the differentiation of bone marrow
            mesenchymal stem cells
  JOURNAL   Genomics 115 (6), 110730 (2023)
   PUBMED   37866658
  REMARK    GeneRIF: RIOK3 potentially regulates osteogenesis-related pathways
            in ankylosing spondylitis and the differentiation of bone marrow
            mesenchymal stem cells.
REFERENCE   3  (bases 1 to 3661)
  AUTHORS   Shen,Y., Tang,K., Chen,D., Hong,M., Sun,F., Wang,S., Ke,Y., Wu,T.,
            Sun,R., Qian,J. and Du,Y.
  TITLE     Riok3 inhibits the antiviral immune response by facilitating
            TRIM40-mediated RIG-I and MDA5 degradation
  JOURNAL   Cell Rep 35 (12), 109272 (2021)
   PUBMED   34161773
  REMARK    GeneRIF: Riok3 inhibits the antiviral immune response by
            facilitating TRIM40-mediated RIG-I and MDA5 degradation.
REFERENCE   4  (bases 1 to 3661)
  AUTHORS   Zhang,L., Flygare,J., Wong,P., Lim,B. and Lodish,H.F.
  TITLE     miR-191 regulates mouse erythroblast enucleation by down-regulating
            Riok3 and Mxi1
  JOURNAL   Genes Dev 25 (2), 119-124 (2011)
   PUBMED   21196494
  REMARK    GeneRIF: down-regulation of miR-191 is essential for erythroid
            chromatin condensation and enucleation by allowing up-regulation of
            Riok3 and Mxi1
REFERENCE   5  (bases 1 to 3661)
  AUTHORS   Darakhshan,F., Badie,C., Moody,J., Coster,M., Finnon,R., Finnon,P.,
            Edwards,A.A., Szluinska,M., Skidmore,C.J., Yoshida,K., Ullrich,R.,
            Cox,R. and Bouffler,S.D.
  TITLE     Evidence for complex multigenic inheritance of radiation AML
            susceptibility in mice revealed using a surrogate phenotypic assay
  JOURNAL   Carcinogenesis 27 (2), 311-318 (2006)
   PUBMED   16093251
REFERENCE   6  (bases 1 to 3661)
  AUTHORS   LaRonde-LeBlanc,N. and Wlodawer,A.
  TITLE     The RIO kinases: an atypical protein kinase family required for
            ribosome biogenesis and cell cycle progression
  JOURNAL   Biochim Biophys Acta 1754 (1-2), 14-24 (2005)
   PUBMED   16182620
  REMARK    Review article
REFERENCE   7  (bases 1 to 3661)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK147074.1.
            
            On Apr 6, 2007 this sequence version replaced NM_024182.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147074.1, AK004748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3661              AK147074.1         2-3662
FEATURES             Location/Qualifiers
     source          1..3661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 6.15 cM"
     gene            1..3661
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /note="RIO kinase 3"
                     /db_xref="GeneID:66878"
                     /db_xref="MGI:MGI:1914128"
     exon            1..124
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1621
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /EC_number="2.7.11.1"
                     /note="sudD, suppressor of bimD6 homolog"
                     /codon_start=1
                     /product="serine/threonine-protein kinase RIO3"
                     /protein_id="NP_077144.2"
                     /db_xref="CCDS:CCDS29062.1"
                     /db_xref="GeneID:66878"
                     /db_xref="MGI:MGI:1914128"
                     /translation="MDLVGVSSPEPGPAAAWGPSKCPWATPQNTVSCSLTEVMSEELA
                     KELQLEEEAAAFPEVVVAEGPFISGENIDTSSDLMLAQMLQMEFDREYDAQLRREEKK
                     FNGDSKVSISFENYRKVHPFEDSDSSEDEVDWQDTRDDPYRPAKPIPTPKKGFIGKGK
                     DITTKHDEVVCGRKNTARMENFAPGFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSA
                     RLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSLEDE
                     KEDGKAIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMH
                     NLTRMQKAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLSNEEMKDAYYQTLHL
                     MQQLYNECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFF
                     QKGGVTEALNERELFNAVSGLNISADNEADFLAEIEALEKMNEDHIQKNGRKAASFLK
                     DDGSPPVLSAD"
     exon            125..240
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            241..386
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            387..494
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            495..604
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            605..748
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            749..876
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1074
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1234
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1315
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1405
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1513
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..3661
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1767..1772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /note="hexamer: AATAAA"
     polyA_site      1793
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /note="major polyA site"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /note="hexamer: ATTAAA"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /note="hexamer: AATGAA"
     polyA_site      2992
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /note="major polyA site"
     polyA_site      2999
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
                     /note="hexamer: AGTAAA"
     polyA_site      3417
                     /gene="Riok3"
                     /gene_synonym="1200013N13Rik; D18Ertd331e; E130306C24Rik;
                     Sudd"
ORIGIN      
        1 ggagcccttt cttcctcttg tcacctctcg actctgttct cgtctctgcc ttcttcccgg
       61 aatggatctg gtcggagtgt cttcgcctga gccagggccc gcagcagctt ggggacccag
      121 taagtgccca tgggctaccc ctcaaaacac agtatcctgt tcactgaccg aggtgatgag
      181 tgaggagctg gctaaagagc tgcagttgga agaagaagcg gctgctttcc ctgaagttgt
      241 tgttgctgaa ggaccattca tttctggaga aaacattgac acttccagtg acctaatgct
      301 ggctcagatg ctacagatgg aatttgacag agaatatgat gcacagctta ggcgtgagga
      361 aaagaagttc aatggtgata gcaaagtttc catttcgttt gaaaactatc gcaaagttca
      421 tccttttgaa gacagtgaca gctctgaaga cgaggttgac tggcaggaca ctcgagacga
      481 tccctacaga ccagcaaagc caattcctac tcccaaaaag ggttttattg gaaaaggaaa
      541 agacatcacc accaagcatg atgaagtagt atgtggaagg aagaacacag caagaatgga
      601 aaattttgcc cctggctttc aggtagggga tggaattgga atggatttga aactatccaa
      661 ccacgttttt aatgccttaa aacaacacgc ctactcagaa gagcgtcgga gtgcccgtct
      721 acacgagaag aaggaacatt ctaccgctga aaaagcagtt gatcctaaga cacgcttact
      781 tatgtataaa atggtcaact ctggaatgtt ggagacaatc actggctgta ttagtacagg
      841 aaaggaatct gttgtctttc atgcatatgg agggagcctg gaggatgaaa aggaagatgg
      901 taaagctata ccaacagaat gtgccatcaa ggtatttaaa acaaccctta atgagtttaa
      961 gaatcgtgac aagtacatta aagatgattt caggtttaaa gatcgcttca gtaaactaaa
     1021 tccacgtaag atcatccgca tgtgggcaga gaaagaaatg cacaatctta caagaatgca
     1081 gaaggctgga attccttgtc caacagttgt actgcttaag aagcacattt tagttatgtc
     1141 tttcattggc catgatcaag ttccagcccc taaattaaaa gaagtaaagc ttagtaatga
     1201 agaaatgaaa gatgcctact atcagactct tcatttgatg cagcaattat ataacgaatg
     1261 tacccttgtg catgctgacc tcagcgagta taacatgttg tggcatgctg ggaaggtctg
     1321 gttgattgac gtcagtcagt cggtagagcc aacccatcct catggcctgg agttcttatt
     1381 ccgtgactgt aggaatgttt cacagttctt ccagaaagga ggagtaacgg aagccctcaa
     1441 tgaacgggag ctgttcaatg ctgtttctgg cctgaacatc tcggcagaca atgaagctga
     1501 tttcttagct gagatagaag ctttggagaa gatgaatgaa gatcacattc agaagaacgg
     1561 gaggaaagca gcctcgtttc tgaaagatga tggaagccca cctgtgctgt ctgccgacta
     1621 gtacagcggt gacggacggc agctgccata gccagcgagt ggaggtgacc tgacatacca
     1681 aagcaggagt ggacagtgct gcttctgggc ttctcacttg tgacccacgt gccagatgtg
     1741 tgcaattttt aactcggcat tgaaagaata aaatgtcact acctctcatc ttacaaaaag
     1801 gataatataa ttctttaaca ggtatagatg tgtagccaca ggagtctgga ttttatacaa
     1861 ctcatgatct gaagtgtcta gatgaggatt ttcacatagg cagtgtttcc aaatgtggga
     1921 ggtggggact gaggtgtttg caggggaggc tcgatggctg cgctctgctc cattccgctc
     1981 gcctcctgct ttcccttgcg tctttgggtg gatgttgctg ttttaaatta gcccttccta
     2041 gctgtttgac cgtgagcgtg gagaccccag tgggtactag aaatgggcac ttggcctcag
     2101 tggatggtgg aaatggacat aagcatttta ttggtacacc gtagatgtgt ggaattctac
     2161 atttccgtct catagccagg agaggtgaca ggtttctgaa agataaatat aaaaggattt
     2221 cttaactaca ttttaaaact taactttcag gttttcttca ttaggttaaa tggttggtta
     2281 tttacattta taatgagaat acaaagtatc tggaagggca gaaggtaaga atgggatctg
     2341 ctacatttta agaaggcagt gaaacatttc cgtttacgtt tccccaaatt gttcacatat
     2401 tgattgctaa tcatttggag agaactagaa caaagtaagt ggagctgttc agtaagtgga
     2461 agacacagcc tgaacagctc aagtactgaa ttgaccggct aactcggctg tgggcctctg
     2521 ccagcgtcac actggctgga ctcggcctga gaaggtgagc cttgttctga agaccagtgc
     2581 ttgcttgctc tcacctcatt accccagttc cgggagttac attggatcca ctaaccagct
     2641 tcactttctg tctggttata aagagtaaat gtaatttata gttgaaaaat tttaacatta
     2701 ttttaaattg ccaaatatgt tctttctcga ctatttattt ttgtttctgt tctactgctt
     2761 taattgcatt tcagaggagt gaatttaggt ggctcatccc acttatgttt gctgctccac
     2821 acaaagattt aaatgatgag aaattattgg ctggacacaa attgcagaaa agtcattaga
     2881 aacaatcatt taaaactttg tttgctttct tcacatattc tttctcaaac cattgcttgg
     2941 agtgtgctat gaacttgcct ttcaagaaat taaaaatgaa gagatcattt tagaattggt
     3001 tcattgtgtg gttaattctt tgtccttatt ttaatgtcct ggcaccaaga caccctttct
     3061 atagcaaagt aagcagtgca gttttggttt gtttgttttg tttgtttgtt tgtttgtttg
     3121 tttgtttttc aaggcagggt ttctctgtgt agccctggct gccctggaac tcactttgta
     3181 gaccaggctg gcctcgaact cagaaatccg cctgcctctg cctcccgagt gctgggatta
     3241 aaggcgtgtg ccactacgcc cagcagcagt gcagttttaa acacacacac acacaacttt
     3301 tgttttgagt tttacaggta tcccccccga aacccctttg tgaagtcagg acatttttca
     3361 catagctgga gatactagtt tgataaataa tccagtaaag tatgtatata ataggaatac
     3421 tttgtcttat tttattattg actgtaaaga tgtatgtatg tatgtatgta tgtatgtatg
     3481 ttaccgagct ggagagatga cagcagttaa gagcactgac tgctcttcca gaggtcctga
     3541 gtccaattcc cagcaactac atggtggctc acaagcatct gtaataggct ctgatgccct
     3601 cttctggtgt gtctgcagac agctacagtg tactcacata aaataagtaa ataaatcctt
     3661 t
//
