LOCUS       NM_024242               2744 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus RIO kinase 1 (Riok1), mRNA.
ACCESSION   NM_024242
VERSION     NM_024242.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2744)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2744)
  AUTHORS   Griffin,E.N., Jucius,T., Sim,S.E., Harris,B.S., Heinz,S. and
            Ackerman,S.L.
  TITLE     RREB1 regulates neuronal proteostasis and the microtubule network
  JOURNAL   Sci Adv 10 (2), eadh3929 (2024)
   PUBMED   38198538
REFERENCE   3  (bases 1 to 2744)
  AUTHORS   Hong,X., Huang,H., Qiu,X., Ding,Z., Feng,X., Zhu,Y., Zhuo,H.,
            Hou,J., Zhao,J., Cai,W., Sha,R., Hong,X., Li,Y., Song,H. and
            Zhang,Z.
  TITLE     Targeting posttranslational modifications of RIOK1 inhibits the
            progression of colorectal and gastric cancers
  JOURNAL   Elife 7, e29511 (2018)
   PUBMED   29384474
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2744)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2744)
  AUTHORS   Guderian,G., Peter,C., Wiesner,J., Sickmann,A., Schulze-Osthoff,K.,
            Fischer,U. and Grimmler,M.
  TITLE     RioK1, a new interactor of protein arginine methyltransferase 5
            (PRMT5), competes with pICln for binding and modulates PRMT5
            complex composition and substrate specificity
  JOURNAL   J Biol Chem 286 (3), 1976-1986 (2011)
   PUBMED   21081503
  REMARK    GeneRIF: Describes a function for human RIOK1 as a component of the
            protein arginine methyltransferase 5 complex, conferring
            specificity for nucleolin as a methylation substrate.
REFERENCE   6  (bases 1 to 2744)
  AUTHORS   LaRonde-LeBlanc,N. and Wlodawer,A.
  TITLE     The RIO kinases: an atypical protein kinase family required for
            ribosome biogenesis and cell cycle progression
  JOURNAL   Biochim Biophys Acta 1754 (1-2), 14-24 (2005)
   PUBMED   16182620
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT010477.16, AK152707.1 and
            AV370421.1.
            
            On Feb 9, 2011 this sequence version replaced NM_024242.2.
            
            Summary: This gene encodes a member of the RIO family of atypical
            serine protein kinases. A similar protein in humans is a component
            of the protein arginine methyltransferase 5 complex that
            specifically recruits the RNA-binding protein nucleolin as a
            methylation substrate. [provided by RefSeq, Feb 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152707.1, SRR11927934.2468947.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               CT010477.16        3051-3301           c
            252-2740            AK152707.1         1-2489
            2741-2744           AV370421.1         233-236
FEATURES             Location/Qualifiers
     source          1..2744
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 17.91 cM"
     gene            1..2744
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /note="RIO kinase 1"
                     /db_xref="GeneID:71340"
                     /db_xref="MGI:MGI:1918590"
     exon            1..543
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..2176
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase RIO1"
                     /protein_id="NP_077204.2"
                     /db_xref="CCDS:CCDS26461.1"
                     /db_xref="GeneID:71340"
                     /db_xref="MGI:MGI:1918590"
                     /translation="MDCSLDRMASVVPGQFDDADSSDSENKELQPIHAEDGGVLLKSL
                     QNAAAEVKGDAETDEEDDYDDDDDWYLDDATGKLTKGCTWNGGSNYQANRQTSNYNSA
                     KMSTPIDKSLRKFENKINLNKLNVTDSVTNKVTVKLRQKEAESYRIKDKADRATVEQV
                     LDPRTRMILFKLLHKDHISEIHGCISTGKEANVYYASTPSGESRAIKIYKTSILMFKD
                     RDKYVTGEFRFRRGYCKGNPRKMVRTWAEKEMRNLCRLKTANIPCPEPIRLRSHVLLM
                     GFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRKMYQDARLVHADLSEFNMLYHGG
                     DVYIIDVSQSVEHDHPHALEFLRKDCTNVNDFFSKHAVAVMTVRELFDFVTDPSITAD
                     NMDAYLEKAMEIASQRTKEEKTSQDHVDEEVFKQAYIPRTLNEVKNYERDVDIMMRLK
                     EEDMALNTQQDNILYQTVMGLKKDLSGVQKVPALLESEVKEETCFGSDDAGGSECSDT
                     VSEEQEDQAGCRNHIADPDIDKKERKKMVKEAQREKRKNKIPKHVKKRKEKTAKAKKG
                     K"
     exon            544..745
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            746..836
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            837..906
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            907..949
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1042
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1155
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1236
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1323
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1461
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1565
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1672
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1738
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1858
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1912
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2065
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2744
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /note="hexamer: AATAAA"
     polyA_site      2740
                     /gene="Riok1"
                     /gene_synonym="3110046C13Rik; 5430416A05Rik; Ad034"
                     /note="major polyA site"
ORIGIN      
        1 gggtccagag gaagaaggtc agaggacgca agtcttcagg agcagccgga ggaaaaaaaa
       61 aacaggctga cttcctatga ccgtaaacgc catggtggag caagaacgaa aggctgggga
      121 gcaacaagag ctacacatcc cacgctacaa acaacgcacc acgcccactt cacatcgcgg
      181 attggtcttt cccggccacc gtcacgcgca tgctccctga gggcactagg gtttggagag
      241 gccctgctgg tggcatactt ccggcgttgc acttccggcc tgttggtggc cgcgtttgcc
      301 gaaaccctgt atcctgacac cccggtggcg cctggtcgtt gccttcttgg gcctggcggt
      361 tgccgaggga tttgaggggc gggaatcgcg gagacgcgtt tggatcctct aggtgggaag
      421 caggctcttc cgatcgcggc ctcaggggcg ccgaaggctc acacccctag ccatggactg
      481 cagtctggac aggatggctt cggtggtccc cgggcaattt gacgacgcgg attcctcaga
      541 cagtgaaaac aaagaactgc agccaatcca tgcagaagat ggcggcgttc tacttaaaag
      601 cctccagaat gctgcagcag aggtgaaggg cgacgctgag accgatgagg aagacgacta
      661 tgatgatgat gatgattggt acttggacga tgcaactgga aaactcacca agggttgtac
      721 ctggaatggc ggcagtaact atcaggcaaa ccgacagact tctaactaca attcagccaa
      781 aatgtctact ccaattgaca agtccttgcg aaaatttgaa aataaaatca atctaaataa
      841 gctgaatgtt actgattctg tgacaaataa agtcaccgta aaattgagac aaaaggaagc
      901 agaatcgtat cgaattaaag ataaggccga cagagcaacc gtagaacagg ttttggatcc
      961 cagaacaagg atgattttat tcaagttgtt gcataaagac cacatatcag agatacatgg
     1021 ctgtattagc actggaaaag aagctaatgt atactatgct agcacaccca gtggagagag
     1081 cagagcaatc aaaatataca aaacttctat tttgatgttc aaagatcgtg ataagtatgt
     1141 gactggggaa ttcaggttcc ggcgtggcta ttgtaaagga aaccctagga aaatggtgag
     1201 gacgtgggca gagaaggaga tgaggaattt gtgcaggcta aaaacagcaa acataccatg
     1261 tccagaacca atcaggctaa gaagtcatgt tcttctcatg ggcttcattg gcaaggatga
     1321 catgccagcc ccacttttga aaaatgtcca gctgtcagag tccaaggcac gggagttgta
     1381 cctgcaggtc attcagtaca tgaggaaaat gtatcaggac gctagacttg tccacgcgga
     1441 tctcagtgaa ttcaacatgc tgtaccatgg tggagatgtt tacatcattg atgtttctca
     1501 gtctgtggag catgaccacc cacatgcatt ggagttcttg agaaaagact gtaccaatgt
     1561 caatgatttc ttttccaagc atgctgttgc agtgatgacc gtgcgggagc tcttcgactt
     1621 cgtcacagat ccctccatca ctgctgacaa catggatgct tacctggaaa aggctatgga
     1681 aatagcatcc cagaggacca aggaagaaaa gactagccaa gatcatgtgg atgaagaggt
     1741 gttcaaacaa gcatatattc ccagaacctt aaacgaagta aagaattatg agagagatgt
     1801 ggacatcatg atgaggttaa aggaagaaga catggctttg aacactcagc aagacaacat
     1861 tctataccag actgtcatgg gattgaaaaa agatttgtca ggagtccaga aggtccccgc
     1921 gctcctagaa agtgaagtta aggaagagac ttgttttggt tcagacgatg ctgggggctc
     1981 tgagtgctcc gacacagtct ctgaagagca ggaagatcaa gccggatgca gaaaccatat
     2041 tgctgaccct gacattgata aaaaggaaag aaaaaagatg gtcaaggaag cccagagaga
     2101 gaagagaaaa aataaaatcc ctaaacatgt gaaaaaaaga aaggaaaaaa cagccaaggc
     2161 caaaaaaggc aaatagaatg gagccattcc tcggctacat tttaaccctg aaacagaagt
     2221 agctggagga ggcttcctca ctgtctcact gtcagaggag gctggggtgt ggtcatgtga
     2281 ttgtttcaaa agcctattct ttcgggatcc agtcctggct ctgcttttaa cggacttatt
     2341 aaggtattat tttaatgaag aactttgtat attttatttt tatattttta tcttgcaaac
     2401 attttcccac aagtatcaga acatgagtgt ttatgatgaa catccacgga cgaacttggg
     2461 aacatttgtt ttctttgtct atgccaaaga catatctgaa acagcctgga gctccgctcc
     2521 gagagacatc gtctggccgt tatgtgccat tcccaggagc cctgttcctg tgtgttctgg
     2581 atacacagga agctgtccta tgatcctgct tcatcttaac tatacctttc cagtgagccc
     2641 tcccagctca ggtgccattt cacacccagc catttgttca tcagatattt cagtgttcta
     2701 ggaactggga tatagctatg aataaaacca cattacttcc tttg
//
