LOCUS       NM_177323               3344 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus RAD50 interactor 1 (Rint1), transcript variant 1,
            mRNA.
ACCESSION   NM_177323
VERSION     NM_177323.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3344)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3344)
  AUTHORS   Gomes,A.L., Matos-Rodrigues,G.E., Frappart,P.O. and Martins,R.A.P.
  TITLE     RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis
  JOURNAL   Front Cell Dev Biol 8, 711 (2020)
   PUBMED   32850831
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3344)
  AUTHORS   Kafer,G.R. and Cesare,A.J.
  TITLE     A Survey of Essential Genome Stability Genes Reveals That
            Replication Stress Mitigation Is Critical for Peri-Implantation
            Embryogenesis
  JOURNAL   Front Cell Dev Biol 8, 416 (2020)
   PUBMED   32548123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3344)
  AUTHORS   Otterpohl,K.L. and Gould,K.A.
  TITLE     Evaluation of Rint1 as a modifier of intestinal tumorigenesis and
            cancer risk
  JOURNAL   PLoS One 12 (3), e0172247 (2017)
   PUBMED   28264000
  REMARK    GeneRIF: these data are more consistent with the hypothesis that
            RINT1 functions as an oncogene rather than a tumor suppressor gene
            in the context of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3344)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3344)
  AUTHORS   Grigaravicius,P., von Deimling,A. and Frappart,P.O.
  TITLE     RINT1 functions as a multitasking protein at the crossroads between
            genomic stability, ER homeostasis, and autophagy
  JOURNAL   Autophagy 12 (8), 1413-1415 (2016)
   PUBMED   27367497
  REMARK    GeneRIF: RINT1 has a role as a multitasking protein with roles in
            genomic stability, ER homeostasis, and autophagy
REFERENCE   7  (bases 1 to 3344)
  AUTHORS   Grigaravicius,P., Kaminska,E., Hubner,C.A., McKinnon,P.J., von
            Deimling,A. and Frappart,P.O.
  TITLE     Rint1 inactivation triggers genomic instability, ER stress and
            autophagy inhibition in the brain
  JOURNAL   Cell Death Differ 23 (3), 454-468 (2016)
   PUBMED   26383973
  REMARK    GeneRIF: A crucial role of Rint1 in vivo in genomic stability
            maintenance, as well as in prevention of endoplasmic reticulum
            stress and autophagy.
REFERENCE   8  (bases 1 to 3344)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 3344)
  AUTHORS   Oikarinen,S.I., Cleveland,A.G., Cork,K.M., Bynote,K.K.,
            Rafter,J.J., Gustafsson,J.A., Mutanen,M. and Gould,K.A.
  TITLE     Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced
            intestinal tumorigenesis
  JOURNAL   Carcinogenesis 30 (9), 1591-1596 (2009)
   PUBMED   19574546
REFERENCE   10 (bases 1 to 3344)
  AUTHORS   Lin,X., Liu,C.C., Gao,Q., Zhang,X., Wu,G. and Lee,W.H.
  TITLE     RINT-1 serves as a tumor suppressor and maintains Golgi dynamics
            and centrosome integrity for cell survival
  JOURNAL   Mol Cell Biol 27 (13), 4905-4916 (2007)
   PUBMED   17470549
  REMARK    GeneRIF: These findings suggest that RINT-1 serves as a novel tumor
            suppressor essential for maintaining the dynamic integrity of the
            Golgi apparatus and the centrosome, a prerequisite to their proper
            coordination during cell division.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005284.1, AK135334.1 and BC065059.1.
            
            On Jul 14, 2015 this sequence version replaced NM_177323.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065059.1, SRR1660821.160574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK005284.1         1-13
            14-2692             AK135334.1         2-2680
            2693-3344           BC065059.1         2660-3311
FEATURES             Location/Qualifiers
     source          1..3344
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.45 cM"
     gene            1..3344
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /note="RAD50 interactor 1"
                     /db_xref="GeneID:72772"
                     /db_xref="MGI:MGI:1916233"
     exon            1..172
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2509
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RAD50-interacting protein 1"
                     /codon_start=1
                     /product="RAD50-interacting protein 1 isoform 1"
                     /protein_id="NP_796297.2"
                     /db_xref="CCDS:CCDS39025.1"
                     /db_xref="GeneID:72772"
                     /db_xref="MGI:MGI:1916233"
                     /translation="MLAADDIGEVPAAPCCPESGDETKNTDVKSDVNTAAPAGSEQLS
                     QGGSDDALLSYVSAFIEKEVGSDLKSLKTLGKLIEQMTESKVKLEEQVLTISSEIPKR
                     IQSALKDAEESKQLLDEFLEQEAPLFSSISSHLLMAQPWMDDLGAMITQMEEIERHLA
                     YLKWVSQTEELSDNIQQYLMTNSVPEAASLLVTMTELDIQLQESSCTHLLSFMRATVK
                     FWHKILKDKLTSDFEEVLAQLHWPFTSHTQSQTVGGSRPAGTPELYSSLDTLFCQLLK
                     LQASDELLTEPKQLPEKYCLPASPPVTLPIQVMLAPLQKRFRYHFRGSRQTNVMSKPE
                     WYLAQVLMWIGNHTQFLDEKIQPILDKVGSAVNARLEFSRGLVMLILEKLASDIPCLL
                     YDDSLFCHLVDEVLLFERELHTVHGYPSTFASCMHILSEETCFQRWLTVERKFALQKM
                     DSMLSSEAAWVSQYKDISDVDEMKVPDCAEVFMTLLLVITDRYKNLPTASRKLQFLEL
                     QKDLVDDFRIRLTQVMKEETRAALGFRYCAILNAVNYISAVLADWADNVFFLQLQQAA
                     LEVFAENNVLSKLQLGQLASMESSVFDDMINLLERLKLDMLTRQVDHVFREVKDSAKL
                     YKKERWLSLPSQSEQAVMSLSSSACPLLLTLRDRLLQLEQQLCFSLFRIFWQMLAEKL
                     DLYIYQEIILANHFNEGGAAQLQFDMTRNLFPLFSHYCKRPENYFKHVKEACIILNLN
                     IGSALLLKDVLQSVSEHIPATAALNEVGVYKLAQQDVEILLNLRTNWPNTGK"
     exon            173..218
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..403
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..645
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..819
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..969
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1126
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1237
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1463
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1601
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1801
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2016
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2197
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2316
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..3298
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3298
                     /gene="Rint1"
                     /gene_synonym="1500019C06Rik; 2810450M21Rik; Rint-1"
                     /note="major polyA site"
ORIGIN      
        1 aggaagtcga ggtggcgctc aaccctgcgt cccagaaggc tggtctggtc gcccagtctg
       61 tgtgttccct agccggactc tgcaggccgg gctggcggtg catggaatcc agaattcgtg
      121 cggaggcagg atgcttgcgg ctgacgatat cggcgaagtg ccggcagccc cgtgctgccc
      181 cgagagtggt gacgaaacga agaacacaga cgtgaaaagt gacgtgaaca ctgcagctcc
      241 tgctggaagc gagcagctca gccaaggtgg cagtgacgac gcgctccttt cctatgtgtc
      301 tgcattcata gagaaggaag tgggaagtga ccttaagtct ttgaagacac ttggtaaact
      361 catagaacaa atgacagaaa gcaaagtgaa gttagaagaa caggtactta caatttcatc
      421 agaaatccct aaaagaattc aaagtgcttt aaaagatgca gaggaatcca aacaacttct
      481 tgatgagttt ctggagcagg aagcgcctct cttcagctcc attagcagcc atctgctgat
      541 ggctcagccc tggatggatg accttggagc catgatcacc cagatggaag agattgagcg
      601 gcatctcgca taccttaagt gggtgtcgca gactgaggag ctgagtgata acattcagca
      661 gtacctgatg accaacagtg tgccagaggc agcctctctc ctggtgacca tgacagaact
      721 ggacatccag cttcaggagt catcctgtac tcatcttctt agtttcatga gagccacagt
      781 taaattctgg cataaaattc tcaaggacaa gcttaccagt gattttgagg aagtcttggc
      841 acagctgcat tggccattca cctcacatac ccagtcgcaa accgttggcg ggagccggcc
      901 tgccggtacc ccggagctgt acagtagcct ggacacactg ttttgtcagc tgttgaaact
      961 acaggcctca gatgagttat taactgagcc aaaacaactc ccagaaaaat actgtcttcc
     1021 tgcctcccct cccgtgaccc tgcccataca ggtcatgctg gctcccctgc agaagagatt
     1081 caggtaccac ttcagaggca gccggcagac caacgtcatg agcaagcctg aatggtactt
     1141 ggctcaggta cttatgtgga ttggaaacca tacacagttt ctggatgaga agattcagcc
     1201 aatattggac aaagtgggct ctgcagtaaa tgcaaggctt gagttttccc gtggccttgt
     1261 gatgctcatt cttgagaagc tggcttctga tatcccctgc ctgctctacg atgacagcct
     1321 cttctgtcac ctggtggatg aggtgctgct gtttgaaagg gagctgcaca ccgttcacgg
     1381 ctatcccagc acattcgcca gctgcatgca catcctgtcg gaggagacct gtttccagag
     1441 atggctgact gtggagagaa agtttgctct tcaaaaaatg gactcaatgc tttcgtcaga
     1501 ggctgcctgg gtatcccagt ataaagacat ctctgatgtg gatgaaatga aggttccaga
     1561 ctgtgcggaa gtctttatga ccctgctttt ggttataact gacaggtata aaaatctccc
     1621 cacagcctcc cggaaactgc agttcctgga gctacagaag gacctggtag atgatttcag
     1681 gatccggtta acgcaggtga tgaaggagga gacgagagcg gccctgggct ttcggtactg
     1741 tgcgattctc aatgccgtga actatatctc agcagtgctg gcagactggg ctgacaatgt
     1801 tttctttctg cagctgcaac aggcagcact ggaggtcttt gcagagaata acgtcctcag
     1861 taaactgcag ctgggacagc tggcctccat ggagagctcg gtcttcgatg acatgatcaa
     1921 cctcttagag cgtttgaagc ttgatatgtt gacccgccaa gtagaccatg ttttcagaga
     1981 agtgaaagac tctgcaaagt tgtataagaa agaaagatgg ttgtccctgc cgtctcagtc
     2041 ggaacaggca gtgatgtcgc tgtccagctc agcctgcccg ctcctgctga ccttacggga
     2101 ccgtctgctc cagctggagc agcagctgtg tttctcgcta ttcagaatct tctggcaaat
     2161 gctggcagag aagctggacc tgtacatcta ccaggaaata atccttgcta accacttcaa
     2221 cgaaggagga gcagcccagc tgcagtttga tatgacaagg aacctctttc ctttgttttc
     2281 tcactattgc aagagaccag aaaactattt taaacatgta aaagaagcct gcatcattct
     2341 gaatttgaac atcggttctg cattactgct gaaagatgtc ctgcagtcag tgtccgagca
     2401 cattcctgcc acagcagcct taaatgaagt tggggtttac aaactggctc aacaagacgt
     2461 tgaaattctg cttaatttga gaacaaattg gcctaacact ggaaaataat gcatctttga
     2521 ggaaagtgtt gtttaagaaa gacaagagtt gcctttaatc ccagcacttg ggaggcagag
     2581 gcagtcggat ttctgagttc gaggccagcc tggtctacaa agtgagttcc aggacagcca
     2641 gggccacaca gagaaaccct gtctcgaaaa acaaacacaa acaaacaaac aaacaaaaaa
     2701 acaaagtcaa gagttggatt gaagttctct gataaagttc tgaattaatg aacctggaca
     2761 aaagaaaact tggcagaata gtttcttgtc ttgagttatg ataacactaa atcggtgacc
     2821 atcctccatc ctcccgttcc taagaaagca aagaatgaaa actcagctgt gagaagcaga
     2881 gtaagtgtat tgcaaatagg aatggagaca tctgaagaca gaatgagagc agagggtagc
     2941 ccttcctgac cgccatgtcc gaatcaaggg gagctgttgt caaaagctga atgtcgcaat
     3001 agactgtaga aactcatggg tgcatgctca tagttgaggt tcctgtatcc attttgggaa
     3061 ttcagtgttt atataatagg tggaagacac ctataacccc agcaactgaa ggctgaggca
     3121 ggaggataag gatcactgag ggttcaagac tcttctgggc aacatagtga gatcttatct
     3181 gtttcaccac cacaaaaaga ccaaaacaaa acaaaaaccc aagaccaaag cacaatagtt
     3241 ttatgagatg gtggttaagc tatggttgtt cttaatattc tattcttatg tccttccaaa
     3301 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
