LOCUS       NM_177158               2888 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Ras and Rab interactor-like (Rinl), transcript variant
            1, mRNA.
ACCESSION   NM_177158 XM_992813
VERSION     NM_177158.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Sandner,L., Alteneder,M., Rica,R., Woller,B., Sala,E., Frey,T.,
            Tosevska,A., Zhu,C., Madern,M., Khan,M., Hoffmann,P., Schebesta,A.,
            Taniuchi,I., Bonelli,M., Schmetterer,K., Iannacone,M., Kuka,M.,
            Ellmeier,W., Sakaguchi,S., Herbst,R. and Boucheron,N.
  TITLE     The guanine nucleotide exchange factor Rin-like controls Tfh cell
            differentiation via CD28 signaling
  JOURNAL   J Exp Med 220 (11) (2023)
   PUBMED   37703004
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Woller,B., Luiskandl,S., Popovic,M., Prieler,B.E., Ikonge,G.,
            Mutzl,M., Rehmann,H. and Herbst,R.
  TITLE     Rin-like, a novel regulator of endocytosis, acts as guanine
            nucleotide exchange factor for Rab5a and Rab22
  JOURNAL   Biochim Biophys Acta 1813 (6), 1198-1210 (2011)
   PUBMED   21419809
  REMARK    GeneRIF: Data show that Rinl is closely associated with the
            cytoskeleton and thus contributes to the spatial control of Rab5a
            and Rab22 signaling at actin-positive compartments.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171210.1, AK030993.1, AK162469.1 and BF147913.1.
            
            On May 1, 2009 this sequence version replaced NM_177158.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030993.1, SRR13422600.1520687.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC171210.1         101577-101584       c
            9-1673              AK030993.1         2-1666
            1674-2868           AK162469.1         579-1773
            2869-2888           BF147913.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.93 cM"
     gene            1..2888
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /note="Ras and Rab interactor-like"
                     /db_xref="GeneID:320435"
                     /db_xref="MGI:MGI:2444024"
     exon            1..37
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            38..123
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1762
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /codon_start=1
                     /product="ras and Rab interactor-like protein"
                     /protein_id="NP_796132.2"
                     /db_xref="CCDS:CCDS21056.1"
                     /db_xref="GeneID:320435"
                     /db_xref="MGI:MGI:2444024"
                     /translation="MRLAQPDMVSAAPTEVDRLVWPLADGADKSPLGVLSTTEPLLRL
                     QRTQRVWEVPELDAQYAKAFLELWPLGSFLVIGHEPGQVLMLKAGPSSGDINTYQIQR
                     FPGGVSLESSNLCMPDCPHLLAFLSASRDVLPRTLLLPTPTVGAGDNHSDPHRLGCIQ
                     VDTSGRVLSVVNQLYLETHGGWGTETPQQTEPETGQKYSLAPRKPTPHRVSWVEDPLR
                     PEAHHTGQEVHHPGADAHSLGSEVHFSCPALEEEEVNNDCYKDEDEEGCEDMLTAHIR
                     ALARTRSSYVARQYRCLRARLISDSGNPYSPGDPATELLQDVRQLLTDLQNYLAKDPD
                     VRAVFGNRGPSILREEDLGPAVEVALCRAVLEPLKPALWTKLRTLRAQELRRLRRRQI
                     ALRVGAGPEGQSPALRNRNRIHARLAHLHAACAPRRKVALLLAVCSDVYAGLGGGENK
                     EPLGADAFLPALTEELIWSPHIGETQLDVEFLMELLDPGELRGEAGYYLTTWFGALYH
                     IAHYQPDTGRAPQGLSSEARASLRQWHRRRTLHQQAQPTAQANQPFEEPWAIGDP"
     exon            124..283
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            284..386
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            387..459
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            460..524
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            525..671
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            672..1127
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1421
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1553
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1717
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..2873
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2818
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /note="major polyA site"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2873
                     /gene="Rinl"
                     /gene_synonym="5830482F20Rik; 9930116N10Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctttcacttc ctgctgctct ggctcccctc ggaacagagg ccagagcatg gctcactggt
       61 gcctggcagc atgaggctag cccagccgga catggtgtct gcagccccta ctgaagtgga
      121 caggctggtt tggccactag cggatggagc agacaagagc ccactagggg tcctcagcac
      181 cacagagcca cttcttcgac tgcagaggac acagagagtg tgggaggtcc ccgagctgga
      241 tgctcagtat gccaaggcct ttctagagct gtggccactg gggagcttcc tggtcatcgg
      301 acatgagcct ggccaggtcc tgatgttgaa ggcaggacct tcttcaggag atatcaacac
      361 ctatcaaatt cagaggtttc ctggaggtgt gtccctggaa tcctccaacc tctgcatgcc
      421 cgactgtccc catctcctgg cctttctgtc agccagcagg gacgttttgc caaggaccct
      481 gctcttgccc acgcctactg tgggggctgg agataatcac tcagatcccc atcggcttgg
      541 ctgcatccag gtggacacct cagggagggt gctgtctgta gtgaaccagc tctacctgga
      601 gacacatgga ggctggggaa cagagactcc acagcaaaca gagccagaga ctggacagaa
      661 atacagtcta gcccccagga agcccacccc acaccgggtc tcctgggtgg aagacccttt
      721 gagaccggaa gctcaccata ctggacagga agtgcatcat cctggagcag acgctcactc
      781 ccttgggtcg gaagtgcact tttcctgtcc tgctctagaa gaggaggaag tgaacaacga
      841 ctgctacaaa gatgaagacg aggaaggttg cgaggatatg ctcactgccc acatccgtgc
      901 tctggccagg acccggagca gctatgtagc caggcagtac cgatgccttc gggcacgcct
      961 catctcagat tctggaaatc cctacagccc aggggacccg gccacagagc tgcttcagga
     1021 tgtgcgccag ctcctcactg acctccagaa ttacctggca aaagaccccg acgtcagagc
     1081 tgtctttggg aacaggggac ctagcatcct tcgggaagaa gatcttggcc ccgctgtgga
     1141 ggtggccctg tgtcgagcgg ttctagagcc cctgaagccc gccctgtgga ccaaactccg
     1201 aactctcaga gcccaggaac tacgacgact gcgcaggcgc caaatagcct tgagggtagg
     1261 agcggggcct gagggacaga gcccggcctt gcggaaccgg aaccgtatcc acgcacgcct
     1321 tgctcacttg catgcggcgt gcgccccgcg ccgcaaggtg gcgctgttgc tggcggtgtg
     1381 cagcgacgtc tacgcgggcc taggcggtgg cgagaataaa gagcccctgg gggctgacgc
     1441 ctttttacct gccctgaccg aggagctgat ctggagtcca catattgggg aaacacagct
     1501 ggatgtggag tttcttatgg agctcttgga tccaggggag ttgcgaggag aagctgggta
     1561 ttatctgacc acgtggtttg gggctctcta ccacattgct cactaccagc cagacactgg
     1621 ccgtgcaccc caggggctca gctccgaggc ccgggcctcc ctgcgccagt ggcatcgaag
     1681 acggacactg caccagcaag cccagcccac agcccaggcc aaccagcctt ttgaggagcc
     1741 atgggcaata ggggacccat gaaaactgga gttctcaaac cccagtcact tccgaacctt
     1801 ttgacccact cctctgctaa gcaagattct ggaggcatct gggtcagcat ggagggcagg
     1861 gcaggaaagg agacgtgcct cctgcaatgt cttacttcct cctcctcaat tcacctcctt
     1921 cgggtctgtc cagatgttac ctcaacgagg cgctccccag caaacaaaac ccacacccag
     1981 acagtactac aactacaacc ctctcgcctg aatctctttg gggcaggtag aataaaggca
     2041 ccgtccccaa aggtgtcttc atcctgatcc tatctgtgac tgtgacactt aacttggtca
     2101 agtgatcgtt acaaaaatga cagcatgtct ggacctgaga tgggagctta ttctggattc
     2161 ttctgcagct catgtagtta ggagggtggc agaggtacag ggaccatcat gagcttacgc
     2221 ctccagctat acagcagaat gaggtggaaa aagtacttga ggccaagacc atgaggacac
     2281 tgtggcactg aaacatagta ggtgtttagg aacacctatg tgccttgaaa acatatcact
     2341 gccctaatct ctgtgaccgt atttggcaaa agtgtttgtg cagctattat tattattttt
     2401 gttgttttgg tttttcaaga cagggctcct cggtgtagcc ctggctgtcc tggaacttgc
     2461 tgtgtagacc tggctggcct cgaactcaga catcagggat taaaggtgtg tgcccccacc
     2521 acccagctcg ttcagccatc attgaagatg ataaaatgag ggacagtgcc ccggggactg
     2581 tgtctgtgac tccaggagca cccacgccat gcgggagaca aggagaacga acggatggga
     2641 acaagagaga cgggagatgc tgggctactc caggaaagct tctccccact gccacccccc
     2701 ctctgagagc tgcagaagtc atggggccct gctgtcaacc tggtttctgt gagattagtg
     2761 atgtcagaac tctgacctcc agaattgtga gcaaataaat tcctgccgtc ttaagacacc
     2821 aaggtggtaa taataataat aatcaataaa atttaaaatg tactgacgag caaaaaaaaa
     2881 aaaaaaaa
//
