LOCUS       NM_009066               2048 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus ring finger protein 1 (Ring1), mRNA.
ACCESSION   NM_009066
VERSION     NM_009066.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2048)
  AUTHORS   Wang,Y., Li,Q., Zhang,J., Liu,P., Zheng,H., Chen,L., Wang,Z.,
            Tan,C., Zhang,M., Zhang,H., Miao,W., Wang,Y., Xuan,X., Yi,G. and
            Wang,P.
  TITLE     Ring1a protects against colitis through regulating mucosal immune
            system and colonic microbial ecology
  JOURNAL   Gut Microbes 15 (2), 2251646 (2023)
   PUBMED   37655448
  REMARK    GeneRIF: Ring1a protects against colitis through regulating mucosal
            immune system and colonic microbial ecology.
REFERENCE   2  (bases 1 to 2048)
  AUTHORS   Maezawa,S., Yukawa,M., Hasegawa,K., Sugiyama,R., Iizuka,M., Hu,M.,
            Sakashita,A., Vidal,M., Koseki,H., Barski,A., DeFalco,T. and
            Namekawa,S.H.
  TITLE     PRC1 suppresses a female gene regulatory network to ensure
            testicular differentiation
  JOURNAL   Cell Death Dis 14 (8), 501 (2023)
   PUBMED   37542070
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2048)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   4  (bases 1 to 2048)
  AUTHORS   Masui,O., Corbel,C., Nagao,K., Endo,T.A., Kezuka,F.,
            Diabangouaya,P., Nakayama,M., Kumon,M., Koseki,Y., Obuse,C.,
            Koseki,H. and Heard,E.
  TITLE     Polycomb repressive complexes 1 and 2 are each essential for
            maintenance of X inactivation in extra-embryonic lineages
  JOURNAL   Nat Cell Biol 25 (1), 134-144 (2023)
   PUBMED   36635505
REFERENCE   5  (bases 1 to 2048)
  AUTHORS   Takano,J., Ito,S., Dong,Y., Sharif,J., Nakajima-Takagi,Y.,
            Umeyama,T., Han,Y.W., Isono,K., Kondo,T., Iizuka,Y., Miyai,T.,
            Koseki,Y., Ikegaya,M., Sakihara,M., Nakayama,M., Ohara,O.,
            Hasegawa,Y., Hashimoto,K., Arner,E., Klose,R.J., Iwama,A.,
            Koseki,H. and Ikawa,T.
  TITLE     PCGF1-PRC1 links chromatin repression with DNA replication during
            hematopoietic cell lineage commitment
  JOURNAL   Nat Commun 13 (1), 7159 (2022)
   PUBMED   36443290
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2048)
  AUTHORS   del Mar Lorente,M., Marcos-Gutierrez,C., Perez,C., Schoorlemmer,J.,
            Ramirez,A., Magin,T. and Vidal,M.
  TITLE     Loss- and gain-of-function mutations show a polycomb group function
            for Ring1A in mice
  JOURNAL   Development 127 (23), 5093-5100 (2000)
   PUBMED   11060235
REFERENCE   7  (bases 1 to 2048)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   8  (bases 1 to 2048)
  AUTHORS   Garcia,E., Marcos-Gutierrez,C., del Mar Lorente,M., Moreno,J.C. and
            Vidal,M.
  TITLE     RYBP, a new repressor protein that interacts with components of the
            mammalian Polycomb complex, and with the transcription factor YY1
  JOURNAL   EMBO J 18 (12), 3404-3418 (1999)
   PUBMED   10369680
REFERENCE   9  (bases 1 to 2048)
  AUTHORS   Caron,K.M., Soo,S.C., Wetsel,W.C., Stocco,D.M., Clark,B.J. and
            Parker,K.L.
  TITLE     Targeted disruption of the mouse gene encoding steroidogenic acute
            regulatory protein provides insights into congenital lipoid adrenal
            hyperplasia
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11540-11545 (1997)
   PUBMED   9326645
REFERENCE   10 (bases 1 to 2048)
  AUTHORS   Schoorlemmer,J., Marcos-Gutierrez,C., Were,F., Martinez,R.,
            Garcia,E., Satijn,D.P., Otte,A.P. and Vidal,M.
  TITLE     Ring1A is a transcriptional repressor that interacts with the
            Polycomb-M33 protein and is expressed at rhombomere boundaries in
            the mouse hindbrain
  JOURNAL   EMBO J 16 (19), 5930-5942 (1997)
   PUBMED   9312051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY210233.1, BU614216.1, CV560731.1, BU918502.1, CX219100.1,
            BU505852.1 and CR974462.5.
            
            On Apr 18, 2009 this sequence version replaced NM_009066.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154962.1, BC009070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               BY210233.1         2-338
            338-697             BU614216.1         258-617
            698-974             CV560731.1         331-607
            975-1161            BU918502.1         18-204
            1162-1742           CX219100.1         90-670
            1743-1941           BU505852.1         510-708
            1942-2006           CR974462.5         113992-114056       c
            2007-2048           BU505852.1         775-816
FEATURES             Location/Qualifiers
     source          1..2048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2048
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /note="ring finger protein 1"
                     /db_xref="GeneID:19763"
                     /db_xref="MGI:MGI:1101770"
     exon            1..171
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            172..301
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1444
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /EC_number="2.3.2.27"
                     /note="polycomb complex protein RING1; transcription
                     repressor Ring1A; RING-type E3 ubiquitin transferase
                     RING1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RING1"
                     /protein_id="NP_033092.3"
                     /db_xref="CCDS:CCDS50070.1"
                     /db_xref="GeneID:19763"
                     /db_xref="MGI:MGI:1101770"
                     /translation="MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHS
                     ELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPN
                     FDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPM
                     PGSDQTATMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGAGAGASSVGTGGG
                     AAGGACGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKG
                     EYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQETTEPGGPGGGASDTGGPDGGGG
                     ERGVAGGGEGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVS
                     RPLELCYAPTKDPK"
     exon            302..462
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            463..678
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1068
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1342
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..2034
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1715..1720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /note="hexamer: AACAAA"
     polyA_site      1742
                     /gene="Ring1"
                     /gene_synonym="Ring1A"
                     /note="major polyA site"
ORIGIN      
        1 agggagggcg gaagtgacgt cgagcctcgg cgcccaggcc atggcggcgg tggcggtggc
       61 agcaagggtt gcggcgtgag tggcagctgc ggaccgagcg gaccagggca gcggagcccc
      121 ggggttcctg gggagaggcc cgcagcaggg cagcgcgaag gccggagctg gacctctctc
      181 agcggagccc cgcttggagg gggagggtct gtgccccgtc accatgacga cgccggcgaa
      241 tgcacagaat gccagcaaaa cgtgggaact gagtctctat gagctgcacc ggaccccgca
      301 ggaagccatc atggatggta cagagattgc ggtttcgcct cggtcactgc attctgagct
      361 catgtgtccc atctgcctgg acatgctgaa gaacacaatg accaccaagg agtgcctgca
      421 taggttctgc tcggactgca tcgtcaccgc cctgcggagc gggaacaagg agtgccctac
      481 ctgccggaaa aagctggtat ccaagcggtc cctacggccg gaccccaact tcgacgccct
      541 gatctccaaa atctacccta gccgggagga atacgaggcc catcaggacc gggtgctcat
      601 ccgcctcagc cgcctgcaca accagcaggc gctgagctcc agtatcgagg aagggctccg
      661 gatgcaggcc atgcacaggg cccagcgtgt gaggcggccg atgcctggat ctgatcagac
      721 cgccacaatg agtggggggg aaggagaacc tggggaggga gaaggggatg gagaggatgt
      781 aagctctgac tccgccccag actctgctcc aggccctgct cccaagcgac cccgcggagc
      841 gggtgcaggg gccagcagtg tagggacagg gggtggggct gctggtgggg cttgcggggg
      901 tgccggttct gaagactctg gtgaccgggg cggcaccctg ggagggggaa ccctggggcc
      961 cccaagccct cctggggccc ccagccctcc agagcccggt ggagagattg agcttgtgtt
     1021 ccggccccat cccctgcttg tggagaaagg agagtactgc cagactcggt acgtgaagac
     1081 tactgggaat gccacagtgg atcatctctc caagtacctg gccctgcgca ttgccctgga
     1141 gaggaggcag cagcaggaaa ccacagagcc cggagggcct ggtgggggtg cttcggacac
     1201 aggcggacct gatgggggtg gtggggagag aggcgttgcc ggaggaggcg aaggtcctga
     1261 ggagcctgcg ctgcccagcc tggaaggtgt cagcgaaaag cagtacacca tctacatcgc
     1321 tcctgggggc ggagcgttca cgacgctgaa tggatcactg accttggagc ttgtaaacga
     1381 gaagttctgg aaggtgtcca ggcccttaga gctctgctat gcccccacga aggacccaaa
     1441 atgatgtcac aaggggacag ctggaacatg gggaccacag ggtgtctctg tgtcccagct
     1501 cagcctgcca gcttcatctc ccaaagcccc ccagccagac agcaagagga caaaggagga
     1561 caaatggctt ttatacaaag tatctatatt gaattagtct atattggaca gcacgggccc
     1621 tgtacccact actgcctttt ctatagaccc tagtttccta ccctgctggt gataggcagg
     1681 gtggacaaga ccccctcccc gccctcctcc caacaacaaa tttgcttatt tcttctttga
     1741 aacctgcagt tctctgtgtg tgtctctcag ggggaggggg ctggaaagat ggcccagcgg
     1801 ctaagagcac tggcctcttg tgcagaggat ccgtttgatt cctagcatcc acaaggtagc
     1861 ttccaaccat ctgtaactcc agtgccaggg cgttggatgc ccttttctga cctctacagt
     1921 ctccaggaac acgtggtaca ctgactggtg caggcaaaac aaccaaacac acggaattaa
     1981 aaataagcta gttgagtggg tggattaaag gtggaggcag gccgttctct gcaaaaaaaa
     2041 aaaaaaaa
//
