LOCUS       NM_177620               3880 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Ras and Rab interactor 3 (Rin3), transcript variant 1,
            mRNA.
ACCESSION   NM_177620
VERSION     NM_177620.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3880)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3880)
  AUTHORS   Vallet,M., Sophocleous,A., Tornqvist,A.E., Azfer,A., Hof,R.V.,
            Albagha,O.M. and Ralston,S.H.
  TITLE     Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by
            Reducing Bone Resorption and Favouring Bone Formation
  JOURNAL   Calcif Tissue Int 109 (1), 92-102 (2021)
   PUBMED   33725152
  REMARK    Erratum:[Calcif Tissue Int. 2021 Jul;109(1):103. doi:
            10.1007/s00223-021-00849-w.. PMID: 33871686]
REFERENCE   3  (bases 1 to 3880)
  AUTHORS   Shen,R., Zhao,X., He,L., Ding,Y., Xu,W., Lin,S., Fang,S., Yang,W.,
            Sung,K., Spencer,B., Rissman,R.A., Lei,M., Ding,J. and Wu,C.
  TITLE     Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's
            disease
  JOURNAL   Transl Neurodegener 9 (1), 26 (2020)
   PUBMED   32552912
  REMARK    GeneRIF: Upregulation of RIN3 induces endosomal dysfunction in
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3880)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139330.4, BC137907.1 and BC058432.1.
            
            On May 29, 2009 this sequence version replaced NM_177620.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032205.1, AY265356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC139330.4         117327-117398
            73-412              BC137907.1         1-340
            413-413             AC139330.4         147387-147387
            414-3693            BC137907.1         342-3621
            3694-3880           BC058432.1         1337-1523
FEATURES             Location/Qualifiers
     source          1..3880
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.45 cM"
     gene            1..3880
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /note="Ras and Rab interactor 3"
                     /db_xref="GeneID:217835"
                     /db_xref="MGI:MGI:2385708"
     exon            1..253
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..3155
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /note="isoform 1 is encoded by transcript variant 1; Ras
                     interaction/interference protein 3"
                     /codon_start=1
                     /product="ras and Rab interactor 3 isoform 1"
                     /protein_id="NP_808288.2"
                     /db_xref="CCDS:CCDS26118.1"
                     /db_xref="GeneID:217835"
                     /db_xref="MGI:MGI:2385708"
                     /translation="MRRAEAPSSAHPAGPIPDAGKGEGEEDEEKDGTRLGLSTTPRNC
                     IPRRGISVLEKLVKTCPVWLQLGLGQAEAAKILQQEMAGMFLVCRDNNLKQLVLCVHF
                     PSLKGSSAEVLEYPIKEEKAILYLEGSVLVFEDIFRLIAFYCVSRDLLPFTLRLPQAI
                     LEASSFLELETISNLGLGFWDSSLNSRGSAEPLRSPAPGTPASSSLRPTTHYANCSCE
                     IELSVGNDRLWFVNPIFIEDCILPADPPPLPTGSYPPRPTPATPDATSPTSKGSPRRP
                     PPPPPLPTVPPTGPARPLAPPVPPAGPLPNSPLTPTSHLAPHAPGPPGHSNQPPMTAC
                     ESLPRPAVGLGPFGEEEMKPGTTPNPLHQAPPPPLPLKKALPAAPPRRRISERVSLES
                     QNVGTSTDRDHSGISRTASLNLPPQSTVSSLGDRPPRTTEQSQDTEAKASHADSIPVP
                     PGKAKQPPVPPPRKKRVSRQLASTLLSPLESPIQEASSEKQATGASWEGLSPVRQAGM
                     QHLQVQSSSCPQSSPEFKGSQASLSDSLGVPASAADQDSYSTSSAEEELEFSSPNVKK
                     KPSMILDKARHRLSFVSFASVFHAFLSSDRKLYKKVVELAQDKSSYFGSLVQDYKVYS
                     LEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVEPTLHSEEELEAIVESALYK
                     CVLKPLKEAINSSLLEIHSRDGSLQQLKENQLVVLATTTTDLGVTTSVPEVAVMEKIL
                     QKLTSMHKAYSPGKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLT
                     EMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKNYDKITVTRQLSVEVQDSIHR
                     WERRRTLNKARASRSSVQDFICVSYLKPEQQSRTLASRADTAAQALCAQCAEKFEVSQ
                     PQDYRLFVLVDGRCFQLADEALPHRIKGYLLRSEPKRDFHFVYRPQDSGKDASSQPCI
                     VVREPNFL"
     exon            254..461
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            462..579
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            580..652
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            653..744
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            745..2229
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2538
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2670
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2834
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3865
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3765..3770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /note="hexamer: ATTAAA"
     polyA_site      3790
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /note="major polyA site"
     regulatory      3840..3845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /note="hexamer: AATAAA"
     polyA_site      3865
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /note="major polyA site"
ORIGIN      
        1 cacggccgaa tggcttctga caaaaaaccc ttgaccacca aggccggcct cttcctgcga
       61 gccccgcgcg ctgcgatcca ggaagtggaa ggcagcggcc ccgcgcttcc ccactgggcg
      121 cgcggctggc ggcggcgccc agcccggccc tcggcgaggg acagcgccag cgccacgcgg
      181 aggtcgctgc gtccccaatc gcctgcccca cgatgcgacg cgccgaagcg ccctcgagcg
      241 cccaccctgc cggtcctatt ccagatgctg gcaaaggaga gggagaggaa gatgaggaga
      301 aagacggcac gaggcttggt ctgtcaacca ccccgaggaa ctgcatccca cgccggggca
      361 tcagtgtcct ggagaagctg gtgaagacct gccctgtgtg gctgcagcta ggtctaggcc
      421 aggcagaggc tgccaagatc ctgcagcagg agatggctgg gatgttcctg gtgtgccggg
      481 acaacaacct gaagcaattg gtgctgtgtg tccacttccc ttccctgaag ggcagctcag
      541 ctgaggtgct ggagtacccc atcaaagaag aaaaggctat actgtacctg gaaggctcag
      601 ttcttgtgtt tgaggacatc ttcagactga ttgcgttcta ctgtgtcagt agagacttac
      661 tgcccttcac tctacggctg ccccaggcca tcctcgaagc tagcagcttc cttgaacttg
      721 agaccatctc caacctgggc ctgggtttct gggactcctc gctgaactca agaggctctg
      781 cagagccact cagaagccca gcccctggga cccctgcatc ctccagcctc cggcctacaa
      841 cccattacgc aaattgttcc tgtgaaatcg agctctccgt gggaaatgac cgcctgtggt
      901 ttgtgaatcc tattttcatc gaggactgca tcctaccggc tgatccacct ccactgccta
      961 ctggcagcta ccctccacgc cctacgcctg ccaccccgga tgctacctca cccacctcca
     1021 agggatcccc acgtcgcccc ccacctccac ccccgttacc cactgttcct cctactggcc
     1081 ctgcacggcc tcttgcgcct cctgtaccgc ctgctggccc tttgcccaac tcccccctaa
     1141 cgcccacctc tcaccttgca ccccatgcac cgggcccccc tggccactca aaccaaccac
     1201 ccatgacagc ctgcgagagt ctccctcgcc cagctgtagg cctgggcccc tttggagaag
     1261 aagagatgaa acctgggaca actcccaatc ccttgcacca agcccctccc cctccattac
     1321 ccctgaagaa ggctcttcca gcagcccctc ccaggaggcg catttctgag agggtatctc
     1381 tggaaagcca gaatgtgggg acttcaacag acagggacca ctcaggcatt tctaggacag
     1441 catcactcaa ccttcctccc cagagcaccg taagtagcct tggggacagg cctccaagga
     1501 ccacggagca aagccaggac acagaggcca aagccagcca tgctgacagc ataccagtgc
     1561 ctcctgggaa ggccaaacaa cccccagtac cacccccaag gaagaagcgg gtctcccggc
     1621 agctggcctc aacccttctc agtcccttgg agagccccat acaggaggca tcctctgaga
     1681 aacaggcgac tggtgcatct tgggaaggct tgagtcctgt ccggcaagct ggcatgcagc
     1741 acctccaagt tcagtccagc agctgtcccc aaagctctcc agagttcaag ggttcccagg
     1801 cctcactctc agacagcctg ggggtgcctg cctcggccgc tgaccaggac tcctactcaa
     1861 ccagcagtgc agaggaggag ctggagttca gcagccccaa cgtgaagaag aaaccctcaa
     1921 tgatcctgga caaggcccgc caccgcctca gcttcgtcag cttcgccagc gtcttccatg
     1981 ccttcctctc cagcgaccgc aaactgtata agaaggtggt ggagctggca caggacaaga
     2041 gctcctactt cggcagcctg gtgcaggact acaaggtgta cagcctggag atgatggccc
     2101 gccagacatc cagcactgag atgctgcagg agatccgtac catgatgacc cagctcaaga
     2161 gctacctgct acagagcact gaactcaaag ccttggtgga acccaccctg cactcggagg
     2221 aggaactcga ggccatagtg gagtcagcct tgtacaagtg tgtcttgaag cccctgaagg
     2281 aggccatcaa ctccagcctg ctggagatcc acagccggga tggctcactg cagcagctca
     2341 aggagaacca gctagtggtc ctggccacca ccaccaccga cctgggtgtg accaccagcg
     2401 tgcctgaggt ggctgtcatg gagaagatcc tgcagaagct gaccagcatg cacaaagcct
     2461 actcaccagg gaagaaaatc tccatcttgc tgaagacctg caagctcatc tatgactcca
     2521 tggctcttgg caacccaggg aagccctacg gggccgacga cttcctgcct gtgctcatgt
     2581 acgtgctggc ccgcagcaac ctcactgaga tgctcctcaa cgtggagtac atgatggagc
     2641 tcatggaccc cgccctgcag ttaggagagg gttcctacta tctgaccacc acctacggag
     2701 ccctggagca cattaaaaac tatgacaaga tcacagtgac ccgacagctg agcgtggagg
     2761 tgcaggactc catccatcgc tgggaacgca ggcgcacgct caacaaagcg cgggcctccc
     2821 gctcctctgt gcaggacttc atctgtgtgt cctacctgaa gcccgagcag cagtcacgga
     2881 cactggcgtc acgggcagac acagcagccc aggcactgtg tgcacagtgc gctgagaagt
     2941 ttgaggtgtc acagccccaa gactaccggc tcttcgtgct ggtggacggg cgctgcttcc
     3001 agctggccga cgaggctctg ccgcatcgca tcaagggtta tctgcttcgg agcgagccca
     3061 aacgagactt ccacttcgtg taccggcccc aggacagcgg caaggatgct tcaagccagc
     3121 cctgtatagt agtgcgggaa cccaacttcc tataagctgt ggtggcagga tctcctgaga
     3181 ggaggctaga gggattggga ctgggctctc attggccgct ctccttaacc acacatccct
     3241 gccatctagg tgcctgtgtc agtcacactg gtgtaacgcc cactgagcat gcctaagcca
     3301 atcaggtaga gtcattgcct gaggcaccaa gttcttagtt ggatgtaagg gaaaccaagg
     3361 ctcaggtgga agaggctctt gccagctgca gcaaacaagc ccaaccctgc tcacaccagg
     3421 ttcctcaggc aattctcctg gtcctgtctc acctcctagc ccccatcttt agtctttcct
     3481 gagaagagct cactttcccc aggactggct aatgaagggg ttcctggccc cagctgctcc
     3541 ctgaccctcg gggatggagc tgagatgttc caccacaacc caagatctaa gagtattgtt
     3601 ttgaagagac agccctgcac cgcatccctg cctcagaatt tgccttcagc taccagagtg
     3661 cctagtacaa cggggctcct gagctccact ggaagcaacc aagccagctc cagggacaca
     3721 tggacaagtt caaccaatgc cataaaattg ggagtgggag ggtcattaaa ggcctgttct
     3781 gtgatggaaa caccacaggt catcagtgtt gatgagatgc actatggggg gggggggtta
     3841 ataaaaaccc ttttgcaaaa gctaaaaaaa aaaaaaaaaa
//
