LOCUS       NP_808288                980 aa            linear   ROD 27-APR-2025
DEFINITION  ras and Rab interactor 3 isoform 1 [Mus musculus].
ACCESSION   NP_808288
VERSION     NP_808288.2
DBSOURCE    REFSEQ: accession NM_177620.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 980)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 980)
  AUTHORS   Vallet,M., Sophocleous,A., Tornqvist,A.E., Azfer,A., Hof,R.V.,
            Albagha,O.M. and Ralston,S.H.
  TITLE     Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by
            Reducing Bone Resorption and Favouring Bone Formation
  JOURNAL   Calcif Tissue Int 109 (1), 92-102 (2021)
   PUBMED   33725152
  REMARK    Erratum:[Calcif Tissue Int. 2021 Jul;109(1):103. doi:
            10.1007/s00223-021-00849-w. PMID: 33871686]
REFERENCE   3  (residues 1 to 980)
  AUTHORS   Shen,R., Zhao,X., He,L., Ding,Y., Xu,W., Lin,S., Fang,S., Yang,W.,
            Sung,K., Spencer,B., Rissman,R.A., Lei,M., Ding,J. and Wu,C.
  TITLE     Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's
            disease
  JOURNAL   Transl Neurodegener 9 (1), 26 (2020)
   PUBMED   32552912
  REMARK    GeneRIF: Upregulation of RIN3 induces endosomal dysfunction in
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 980)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139330.4, BC137907.1 and BC058432.1.
            
            On May 29, 2009 this sequence version replaced NP_808288.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032205.1, AY265356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.45 cM"
     Protein         1..980
                     /product="ras and Rab interactor 3 isoform 1"
                     /note="Ras interaction/interference protein 3"
                     /calculated_mol_wt=107090
     Region          1..40
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P59729.2)"
     Region          52..153
                     /region_name="SH2_RIN3"
                     /note="Src homology 2 (SH2) domain found in Ras and Rab
                     interactor 3 (RIN3)-like proteins; cd10395"
                     /db_xref="CDD:198258"
     Site            order(70,88,114,116)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198258"
     Site            order(115,143)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198258"
     Region          247..496
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P59729.2)"
     Region          509..560
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P59729.2)"
     Region          584..729
                     /region_name="Interaction with RAB5B.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P59729.2)"
     Region          736..839
                     /region_name="VPS9"
                     /note="Vacuolar sorting protein 9 (VPS9) domain;
                     pfam02204"
                     /db_xref="CDD:460489"
     Region          874..961
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     CDS             1..980
                     /gene="Rin3"
                     /gene_synonym="6430500K07"
                     /coded_by="NM_177620.4:213..3155"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26118.1"
                     /db_xref="GeneID:217835"
                     /db_xref="MGI:MGI:2385708"
ORIGIN      
        1 mrraeapssa hpagpipdag kgegeedeek dgtrlglstt prnciprrgi svleklvktc
       61 pvwlqlglgq aeaakilqqe magmflvcrd nnlkqlvlcv hfpslkgssa evleypikee
      121 kailylegsv lvfedifrli afycvsrdll pftlrlpqai leassflele tisnlglgfw
      181 dsslnsrgsa eplrspapgt passslrptt hyancsceie lsvgndrlwf vnpifiedci
      241 lpadppplpt gsypprptpa tpdatsptsk gsprrppppp plptvpptgp arplappvpp
      301 agplpnsplt ptshlaphap gppghsnqpp mtaceslprp avglgpfgee emkpgttpnp
      361 lhqapppplp lkkalpaapp rrriservsl esqnvgtstd rdhsgisrta slnlppqstv
      421 sslgdrpprt teqsqdteak ashadsipvp pgkakqppvp pprkkrvsrq lastllsple
      481 spiqeassek qatgaswegl spvrqagmqh lqvqssscpq sspefkgsqa slsdslgvpa
      541 saadqdsyst ssaeeelefs spnvkkkpsm ildkarhrls fvsfasvfha flssdrklyk
      601 kvvelaqdks syfgslvqdy kvyslemmar qtsstemlqe irtmmtqlks yllqstelka
      661 lveptlhsee eleaivesal ykcvlkplke ainsslleih srdgslqqlk enqlvvlatt
      721 ttdlgvttsv pevavmekil qkltsmhkay spgkkisill ktckliydsm algnpgkpyg
      781 addflpvlmy vlarsnltem llnveymmel mdpalqlgeg syyltttyga lehiknydki
      841 tvtrqlsvev qdsihrwerr rtlnkarasr ssvqdficvs ylkpeqqsrt lasradtaaq
      901 alcaqcaekf evsqpqdyrl fvlvdgrcfq ladealphri kgyllrsepk rdfhfvyrpq
      961 dsgkdassqp civvrepnfl
//
