LOCUS       NM_001406508            4640 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Ras and Rab interactor 2 (Rin2), transcript variant 2,
            mRNA.
ACCESSION   NM_001406508 XM_006500270
VERSION     NM_001406508.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4640)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4640)
  AUTHORS   Qiao,L., Dong,C., Jia,W. and Ma,B.
  TITLE     NAA20 recruits Rin2 and promotes triple-negative breast cancer
            progression by regulating Rab5A-mediated activation of EGFR
            signaling
  JOURNAL   Cell Signal 112, 110922 (2023)
   PUBMED   37827343
  REMARK    GeneRIF: NAA20 recruits Rin2 and promotes triple-negative breast
            cancer progression by regulating Rab5A-mediated activation of EGFR
            signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672100.7.
            
            On May 16, 2022 this sequence version replaced XM_006500270.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.18611.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AL672100.7         26727-26928
            203-295             AL672100.7         28314-28406
            296-396             AL672100.7         64257-64357
            397-589             AL672100.7         86703-86895
            590-701             AL672100.7         90757-90868
            702-774             AL672100.7         93171-93243
            775-866             AL672100.7         100433-100524
            867-2027            AL672100.7         102006-103166
            2028-2333           AL672100.7         118383-118688
            2334-2465           AL672100.7         120836-120967
            2466-2629           AL672100.7         125314-125477
            2630-4640           AL672100.7         127595-129605
FEATURES             Location/Qualifiers
     source          1..4640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.25 cM"
     gene            1..4640
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /note="Ras and Rab interactor 2"
                     /db_xref="GeneID:74030"
                     /db_xref="MGI:MGI:1921280"
     exon            1..202
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            203..295
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2950
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /note="isoform 2 is encoded by transcript variant 2; ras
                     interaction/interference protein 2"
                     /codon_start=1
                     /product="ras and Rab interactor 2 isoform 2"
                     /protein_id="NP_001393437.1"
                     /db_xref="GeneID:74030"
                     /db_xref="MGI:MGI:1921280"
                     /translation="MSAWTMGAQGLDKRGSFFKLIDTIASEIGELKREMVQTDISREN
                     GLEPSETHSMVRHKDGGYSEDKDGKTCPRDSGYDSLSNRLSILDRLLHTHPIWLQLSL
                     SEEEAAEVLQAQPPGIFLVRKSSKMQKKVLSLRLPCEFGAPLKEFTIKESTYTFSLEG
                     SGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKTESQLEELAQLGLNFWSSSADN
                     KPLNSPPPHRPLPSAGICPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLF
                     LKVHSQDLSTGPKRPSTRTPNANGTERPRSPPPRPPPPAINSLHTSPGLSRTEPQTSM
                     PETVNHSKHGNVALLGTKPTPIPPPRLKKQASFLEAESSAKTLTARRPSRRSEPEPEL
                     ELELEMGTAGHAGGAPPRDAPGDCTRAPPPGSESQPPPCHGARQRLSDMSLSTSSSDS
                     LEFDRSMPLYGYEADTTSSLEDYEGESDQETMAPPIKSKKKRNSSFVLPKLVKSQLRK
                     MSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLKENKECHVSSTDMLQTI
                     RQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFH
                     TADGSWKQLKENLQLVRQRNPQELGVFAPTPDLMELEKIKLKFMTMQKMYSPEKKVML
                     LLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLH
                     GEGGYYLTSAYGALSLIKNFQEEQAARLLSSEARDTLRQWHKRRTTNRTIPSVDDFQN
                     YLRVAFQEVNSGCTGKTLLVRPYITTEDVCQLCAEKFKVEDPEEYSLFLFVDETWQQL
                     AEDTYPQKIKAELHSRPQPHIFHFVYKRIKSDPYGVIFQNGEDLTPS"
     exon            296..396
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            397..589
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..701
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            702..774
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            775..866
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            867..2027
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2333
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2465
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2629
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..4640
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4610..4615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /note="hexamer: AATAAT"
     polyA_site      4640
                     /gene="Rin2"
                     /gene_synonym="2010003K16Rik; 4632403N06Rik; RASSF4"
                     /note="major polyA site"
ORIGIN      
        1 ggacttccac tccgatgctg agccgggagc gtgaacctct ggagtcagca ggattgccgt
       61 gaagcttgcc atctctccag gagggttttg gatcactgtc cttcatccca gcaggatcac
      121 aaatggaaca ggatgccaga gagaaagtga ccaagacatg gagcaacaag tcaactagag
      181 gaggttttga aaggaaggct aggagtcccc ggcatgttgt agagcctcgc tgggggaaat
      241 gtcagcgtgg accatgggcg cccaaggtct ggacaagcga ggaagtttct ttaagctcat
      301 tgacacgatc gcctcggaga tcggagaact gaaacgggag atggtgcaga cagatatcag
      361 ccgggaaaat ggcctggaac cttctgaaac ccacagcatg gtgagacaca aggatggtgg
      421 ctactctgaa gacaaggatg ggaagacatg tccccgagac tctggctatg acagcctctc
      481 caacaggctc agcattctgg accggctcct gcatacccat cccatatggc tgcagctgag
      541 tctgagtgag gaggaggcag cagaggtcct gcaggcccag cctccaggga tctttttggt
      601 tcggaaatcc tccaaaatgc agaagaaagt cctctccctt cgcctgccct gtgaatttgg
      661 agcacctctc aaagagttta ctataaagga aagcacctac accttttccc tggaaggctc
      721 aggaatcagc tttgcagatt tattccggct tattgccttc tactgcatca gcagggacgt
      781 tttgccattc accttgaagc tgccttatgc catttcaaca gccaagacgg agtctcagct
      841 tgaagaacta gcccaactgg gactaaattt ttggagctcc tcggcagaca acaaacccct
      901 gaactcccca cctccccata ggcctcttcc ctcagccggc atctgccctg cctccttgcg
      961 tcagctctgc cttataaatg gagtgcattc tataaaaacc aggacgcctt cggagctgga
     1021 gtgcagccag accaacggag ccttgtgttt tattaatcct cttttcttga aagtgcacag
     1081 ccaggacctc agcacaggcc caaagcggcc gagcacaagg actcccaacg cgaatggcac
     1141 cgagagacct cggtcccccc cacccaggcc cccgccaccc gctattaata gtctgcacac
     1201 aagccctggg ctatccagga ctgaacccca gacgagcatg ccagaaacag tcaaccatag
     1261 caaacatggg aacgtagctc tgcttggaac aaaaccaact cccatccctc caccccggct
     1321 gaagaagcag gcttcttttt tggaagcaga aagcagcgcc aagaccttga ctgcccgccg
     1381 gcccagccgg aggtcggagc cggagcccga gctagagctg gagttagaga tgggcacagc
     1441 tgggcacgca ggtggagccc cgcctaggga cgcccccggg gattgcacaa gggcgccgcc
     1501 gcccggctct gaatcacagc caccaccgtg ccatggagcc aggcagaggc tgagcgacat
     1561 gagcctttcc acttcctcct ccgactcgct ggagttcgac cggagcatgc ctctgtatgg
     1621 gtacgaggct gacaccacca gcagcctgga ggactacgaa ggggagagtg accaagagac
     1681 catggcacct cccatcaagt ccaaaaagaa gaggaacagc tcttttgtgc tgcccaagct
     1741 tgtcaagtcc cagttgcgaa agatgagcgg ggtgttcagc tccttcatga cccctgagaa
     1801 gcggatggtc cgcaggatcg ccgagctgtc ccgggacaaa tgcacctatt ttgggtgctt
     1861 ggtgcaggac tacgtgagct tcctgaagga gaacaaggag tgccatgtgt ccagcaccga
     1921 tatgctgcag accatccggc agtttatgac ccaggtcaag aactatttgt ctcagagctc
     1981 tgaactggac ccccctattg agtcactgat cccagaagac caaattgatg tggtgttgga
     2041 gaaggccatg cacaaatgta tcttgaagcc cctcaagggc catgtggagg ccatgctgaa
     2101 ggacttccac acggctgacg gctcgtggaa acaactcaag gaaaacctac aactcgtgcg
     2161 gcagaggaac ccacaggagc tgggggtctt tgccccaacc cctgacttga tggagctgga
     2221 gaaaatcaag cttaaattca tgaccatgca gaagatgtat tcgccagaaa agaaagtcat
     2281 gcttttgcta cgggtctgta agctcatcta cactgtcatg gagaacaact cagggaggat
     2341 gtacggtgca gacgacttct tgccagtcct gacctatgtc atagctcagt gtgacatgct
     2401 tgaactggac acggaaatcg agtacatgat ggaactcctg gacccatcac tgctgcacgg
     2461 agaaggaggc tattacttga ccagtgccta tggggcgcta tctctgataa agaatttcca
     2521 agaagaacag gctgcgagac tgctcagctc cgaagccagg gacacgctga ggcagtggca
     2581 caagcggaga accaccaacc gaactatccc ctccgttgac gactttcaga attacctccg
     2641 agttgccttc caagaggtca acagcggatg cactgggaag accctccttg tgagaccgta
     2701 catcaccaca gaggatgtgt gtcagctctg tgctgagaaa tttaaggtgg aggaccctga
     2761 agagtacagc ctgtttctct ttgttgatga gacatggcaa caactggcag aggacactta
     2821 tcctcagaag atcaaggccg aactgcacag ccggcctcag ccccacatct tccactttgt
     2881 ctacaaacga atcaagagtg atccttacgg ggtgattttc cagaatggag aagacctcac
     2941 tccctcatag gggacacttg ggacttccca ttgatacatc caaaaaggga gctgagagtc
     3001 tagctttctg gctgccttgg gtttgagctt agaagacagc cacctcctca agcatccctc
     3061 agttcagtga ctaagccatc cataggctga tttggccaag ggcatccttt agatacattg
     3121 cccagatgag gtagctgaga tttgggaaat agtaagactc tcatccagaa atggtaaatt
     3181 gcatttaatg gttcaggtgt cctgagatca ctggttagtt aactagttaa ccttagccag
     3241 cttcagggtt ggcttacaca tctgtatatg tgctgaggaa acacttaagg tacaaactct
     3301 tctcttggat tcgatagcag ctgttgacaa gactgtccga tgcagttcgt caggtccctc
     3361 tcagctttgt ggatggctcc atccttccct cttgcccttc ttttgtccat ccttcatcct
     3421 atactttttt ttttttacaa agagcctttg tgtttttata tatttcatag aaaattttat
     3481 agcagttgca ggtaaactgt caggattggt ttttaaaata tttttgtaac ttttaaaata
     3541 ttctataagt atgcatgtga tttaacattt aatatttgaa gataaatctc ttgctggatt
     3601 tgagagtact gcattttaga cgcctcatag ataatctctc ttctataact ggatattttc
     3661 ggcaaatttg tggggagaga cttctggttg tcttaaagaa atccctgacg ctggccacag
     3721 gctgcctttg aaaaatcggg tgtactgttg ttacattgtt gttacattgt tcacttttag
     3781 cggtgtattg ttacattgtt cacttttagt gctggtgtct gtttatgttt ttaagcaatc
     3841 gaggctgaga attagaagag aaatgaatgt agagagaggt agagagagaa acacagactc
     3901 taaggggggg actgaggaat gtagtctgca ggttcaggct cttcgcaaga cgttggaaaa
     3961 ggagtcagta ctgtaaaata tgtgctgcgg tgagctttga caaagatctg ttccatatgc
     4021 tatctgcttt ggggaaaagt aaatcaagga taacgatccc tctgacccat tttgtaagcc
     4081 gacactaagg acatccattt atttggaggc agaaaccaag tcatgtataa tacgagttta
     4141 gttgagttca atgagatgtt gatggggaga gaatgcacta aaaccaaaac caaaccaaaa
     4201 acaaaacaaa acaaaaaaca aaccttctgt atttggttgg ggcatggtag agctaacatt
     4261 cacacactag catgctgggt tccatcctca gtgtgacaaa taatgagcaa aacaagcaga
     4321 aaacatggat gtatggtgaa gttagactta tgttgtataa gatgagttta tggacacacg
     4381 tattccagaa gggtcataca tcagtgtaat acagatcatt gcaaaacaaa agcagaaagc
     4441 catgttacta tcctgtgtaa ggatgttcag gcatctgatc tggaggacct cgtaccctgt
     4501 acaaggcttt tgttgtccca gaaccctccc ttggcacatg ctgggttgtg cttccttttg
     4561 taaatgattt tcaatggaat tttgcacata atacattgta atactgtaca ataatcctat
     4621 gtaaaataat ttttgcaata
//
