LOCUS       NM_001374051            4202 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus Ras and Rab interactor 1 (Rin1), transcript variant 1,
            mRNA.
ACCESSION   NM_001374051 XM_006531709
VERSION     NM_001374051.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4202)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4202)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4202)
  AUTHORS   Thai,M., Ting,P.Y., McLaughlin,J., Cheng,D., Muschen,M., Witte,O.N.
            and Colicelli,J.
  TITLE     ABL fusion oncogene transformation and inhibitor sensitivity are
            mediated by the cellular regulator RIN1
  JOURNAL   Leukemia 25 (2), 290-300 (2011)
   PUBMED   21102429
  REMARK    GeneRIF: BCR-ABL1 kinase activity is regulated by RIN1
REFERENCE   4  (bases 1 to 4202)
  AUTHORS   Bliss,J.M., Gray,E.E., Dhaka,A., O'Dell,T.J. and Colicelli,J.
  TITLE     Fear learning and extinction are linked to neuronal plasticity
            through Rin1 signaling
  JOURNAL   J Neurosci Res 88 (4), 917-926 (2010)
   PUBMED   19830836
  REMARK    GeneRIF: This study provided evidence that Rin1 normally functions
            as a negative regulator of fear learning and memory (Rin1-/- mice
            have enhanced fear conditioning and diminished fear extinction).
REFERENCE   5  (bases 1 to 4202)
  AUTHORS   Dzudzor,B., Huynh,L., Thai,M., Bliss,J.M., Nagaoka,Y., Wang,Y.,
            Ch'ng,T.H., Jiang,M., Martin,K.C. and Colicelli,J.
  TITLE     Regulated expression of the Ras effector Rin1 in forebrain neurons
  JOURNAL   Mol Cell Neurosci 43 (1), 108-116 (2010)
   PUBMED   19837165
  REMARK    GeneRIF: These results provide insight into regulated expression of
            Rin1, define a promoter useful in telencephalic neuron studies, and
            describe a novel REST site variant directing expression to mature
            neurons.
REFERENCE   6  (bases 1 to 4202)
  AUTHORS   Deininger,K., Eder,M., Kramer,E.R., Zieglgansberger,W., Dodt,H.U.,
            Dornmair,K., Colicelli,J. and Klein,R.
  TITLE     The Rab5 guanylate exchange factor Rin1 regulates endocytosis of
            the EphA4 receptor in mature excitatory neurons
  JOURNAL   Proc Natl Acad Sci U S A 105 (34), 12539-12544 (2008)
   PUBMED   18723684
  REMARK    GeneRIF: the EphA4 receptor is required for synaptic plasticity in
            the amygdala, raising the possibility that an underlying mechanism
            of Rin1 function in amygdala is to down-regulate EphA4 signaling by
            promoting its endocytosis.
REFERENCE   7  (bases 1 to 4202)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 4202)
  AUTHORS   Hu,H., Bliss,J.M., Wang,Y. and Colicelli,J.
  TITLE     RIN1 is an ABL tyrosine kinase activator and a regulator of
            epithelial-cell adhesion and migration
  JOURNAL   Curr Biol 15 (9), 815-823 (2005)
   PUBMED   15886098
  REMARK    GeneRIF: RIN1 is an ABL tyrosine kinase activator and a regulator
            of epithelial-cell adhesion and migration.
REFERENCE   9  (bases 1 to 4202)
  AUTHORS   de Napoles,M., Mermoud,J.E., Wakao,R., Tang,Y.A., Endoh,M.,
            Appanah,R., Nesterova,T.B., Silva,J., Otte,A.P., Vidal,M.,
            Koseki,H. and Brockdorff,N.
  TITLE     Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A
            to heritable gene silencing and X inactivation
  JOURNAL   Dev Cell 7 (5), 663-676 (2004)
   PUBMED   15525528
  REMARK    GeneRIF: Rin1 links histone ubiquitylation to gene silencing and X
            inactivation.
REFERENCE   10 (bases 1 to 4202)
  AUTHORS   Dhaka,A., Costa,R.M., Hu,H., Irvin,D.K., Patel,A., Kornblum,H.I.,
            Silva,A.J., O'Dell,T.J. and Colicelli,J.
  TITLE     The RAS effector RIN1 modulates the formation of aversive memories
  JOURNAL   J Neurosci 23 (3), 748-757 (2003)
   PUBMED   12574403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124502.4.
            
            On Sep 10, 2019 this sequence version replaced XM_006531709.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC124502.4         72647-72773         c
            128-308             AC124502.4         72334-72514         c
            309-423             AC124502.4         72120-72234         c
            424-496             AC124502.4         71958-72030         c
            497-588             AC124502.4         71756-71847         c
            589-1329            AC124502.4         70872-71612         c
            1330-1635           AC124502.4         70313-70618         c
            1636-1767           AC124502.4         69858-69989         c
            1768-1919           AC124502.4         69581-69732         c
            1920-4202           AC124502.4         66517-68799         c
FEATURES             Location/Qualifiers
     source          1..4202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.23 cM"
     gene            1..4202
                     /gene="Rin1"
                     /note="Ras and Rab interactor 1"
                     /db_xref="GeneID:225870"
                     /db_xref="MGI:MGI:2385695"
     exon            1..127
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2369
                     /gene="Rin1"
                     /note="isoform 1 is encoded by transcript variant 1; ras
                     interaction/interference protein 1"
                     /codon_start=1
                     /product="ras and Rab interactor 1 isoform 1"
                     /protein_id="NP_001360980.1"
                     /db_xref="GeneID:225870"
                     /db_xref="MGI:MGI:2385695"
                     /translation="MEDPGETGAHPLGATNLNFVPGHQQKEKPSTDPLYDTPDTRGVQ
                     AGGSQQPARTVSLRERLLITRPVWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQA
                     LCVRLPEASGPSFVSSHYIEESTGGVSLEGSELMFQDLVQLICGYCRTRDILLLPLRL
                     PRAIHQAATHKELEAISHLGMEFWSSSLNTKDQQRPSEAPPIPRLKARSPQELDQGTG
                     AALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTSSSQ
                     TERLPPRQLLQRESSVGYRVPGSAASPCLPPLPSLQEVDCCSPSSSEEEGSSGSPTTS
                     PRLSRPRHRRPLLRSMSSAFCSLLAPERQVGRAATMLMQNRYTAVGQLVQDLLTQVRA
                     GPEPRELQGIRQALSRARAMLSAELGPEKLLPPERLELVLEKSLHRSVLKPLRPILAA
                     RLRRRLSADGSLGRLAEGFRLARTQGPGAFGSHLTLSSPVETEQVRQKLLQLLRAYSP
                     SAQVKWLLQACKLLYTALKSQAGENAGADEFLPLLSLVLAQCDLPDLLLEAEYMSELL
                     EPTLLTGEGGYYLTSLSASLALLSGLSQARALPLSPAQELQRSLALWEQRRLPATHSF
                     QHLLRVAYQDPSTGCTSKTLAVPPGSSIATLSQLCATKFRVTQPDAFGLFLYKDQGYH
                     RLPPEALAHRLPATGYLIYRRAERPETQGAVAEKAKTGSKGPEAGAWEEETGGLNREG
                     KPRIAVDQEGKDQARGGHIGPEEQKAEGSQALEE"
     exon            128..308
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..423
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..496
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..588
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..1329
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1635
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1767
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1919
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..4202
                     /gene="Rin1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4184..4189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rin1"
                     /note="hexamer: AATAAA"
     polyA_site      4202
                     /gene="Rin1"
                     /note="major polyA site"
ORIGIN      
        1 attgtcttcc tgagtcccag gagaagccga aggagctccc agccatggaa gaccctggtg
       61 agaccggagc acaccctctg ggagccacca acctgaactt tgtacctggg caccaacaga
      121 aagaaaagcc atctacagac ccactgtatg acacacctga taccagaggg gtacaggcag
      181 gcgggtccca acagccagca cgtactgtga gccttcggga gcggctgctg atcacccggc
      241 ctgtgtggtt acagctgcgg gccaacgctg cagccgcgct gcacgtgctg aggacagagc
      301 ctccggggac cttcctggtg cggaaatcta acactcgcca gtgccaggct ctgtgtgtgc
      361 ggctgccaga agctagtggc ccctcttttg tctccagcca ctatatcgaa gagagtactg
      421 gcggtgtctc tttggagggc tcagagctca tgttccagga cctggtgcag ctcatctgtg
      481 gatactgccg taccagggac attcttctcc tccctctccg actccccaga gccattcatc
      541 aggcagccac ccacaaagag ctggaggcca tctcccatct gggcatggag ttctggagct
      601 cctcactcaa caccaaggac caacagaggc cttcggaagc cccacccata ccccggctga
      661 aggctcgctc ccctcaagag ctggatcagg gcactggtgc tgccctctgc ttcttcaacc
      721 ccctcttccc cggggatctg ggccccacca aacgagagaa attcaagagg agtttcaaag
      781 tgcgagtgtc caccgagacc tccagccctc tgtctccacc tgctgtgccg cctcccccag
      841 tcccggtgct tccagggaca tcttccagcc aaacggaaag actgccccct cgacagctgc
      901 tgcagaggga gagctcagtg ggatatcgtg tgccaggaag tgctgccagc ccttgtcttc
      961 ctcccctacc ttcccttcag gaggtggact gctgctctcc cagcagctca gaggaggagg
     1021 gctcttcagg aagccctaca acctccccac gcctaagccg cccaaggcac cggcggcctc
     1081 tgcttcggtc catgagttct gctttctgct ctctgctggc accagagagg caggtgggcc
     1141 gggcagccac aatgctaatg caaaaccgat acacagccgt gggtcagcta gtgcaggacc
     1201 tactgaccca ggttcgggct ggtcccgagc cccgggagtt gcagggcatc cgccaggccc
     1261 taagtcgggc ccgggccatg ctgagcgcag agctgggccc tgagaagctg ctaccaccag
     1321 agcggctgga attggtcctg gagaagtccc tgcatcgctc tgttctcaag cctcttcgac
     1381 ccattctggc tgcccgcctg cggcgccggc tttccgcaga tggttccctc ggccgcctag
     1441 ctgagggctt ccgcctggcc cggacccagg ggcctggagc cttcgggtcc cacctgactc
     1501 tttcttcccc agtggagaca gaacaggtgc gccagaagct gctgcagctc cttcgtgcct
     1561 actcacctag tgcccaggtc aagtggctcc tgcaggcctg caagctgcta tacacagccc
     1621 tgaagagcca ggcaggagag aatgcaggtg ctgatgagtt cctgcctctg ctgagccttg
     1681 ttttggccca gtgcgacctt cctgacctcc tgttagaagc tgagtatatg tcagagctcc
     1741 tggaacccac cctgctcact ggagagggtg gctactacct gaccagcctc tcagccagcc
     1801 tggccttgtt gagtggccta agccaggccc gagcactgcc actcagccca gcacaggagc
     1861 tccagcgctc cctggccctc tgggaacagc gccgcctgcc ggccacccac agcttccagc
     1921 atctcctccg agtagcctac caggacccca gcacaggttg cacctccaag accctggctg
     1981 tgcccccagg gtcttcaatt gccacgttga gccaactctg tgctaccaag ttccgagtga
     2041 cccaaccaga tgcgtttggc ctcttcctct acaaggacca gggctaccat cgcctgcccc
     2101 ctgaagccct agcccacagg cttcctgcaa ctggctacct catctatcgc cgggcagagc
     2161 gccctgagac ccagggggct gtagcagaaa aggcaaagac aggcagcaag gggccagagg
     2221 caggagcatg ggaggaggag acagggggtc taaacagaga agggaaacct cggatagctg
     2281 ttgaccaaga aggcaaggat caggccagag gaggtcacat aggaccagag gaacaaaagg
     2341 cagaaggaag ccaggctttg gaagagtagc taggaagaac caaaggggtt acctgggccc
     2401 ccgggagcct ctaagtccac tcttcccagc tgccaagctt cctttaccac ccacccacag
     2461 ttctctgtgg tgtctgccac cacctctggc cgatcttcat aagtccacct gctagggaac
     2521 agggagctgg ccatatagac tagagcagcg ttaagagagc tgggagactc acagaccctc
     2581 tgtttaaggc ccctggcttc tgtctcccca tagcccacag ggataaacgt gtctggtaag
     2641 gggaaaatcc tcctgatagc cataggggcg tggtgggagg gtagtcctgg cttcttttgc
     2701 ctctcccact gcccatggag agatgctgga gcatcaagac cctgtgcaac tccagtctct
     2761 cctagttcta ggggtcaggg aaccagaatg gcagcaaagc tccccaaact aacagctctt
     2821 ctcagacata gcatctggtg tgcaaagaag ggatatgact gctgttctgc agggttccta
     2881 gagtgaccca ggacctacat ggatggttgg cggctcagct caggcaggag aaagaagaaa
     2941 gaatgagtgt tagcagctat ggcaagcctg tcccgtaggc agcctctacc aggctactac
     3001 cctcacctgt gtcttctttc ccggtcagtt cagagatggt tgtcaccctg gaggtcaggc
     3061 cgtaggagag aaagcatcta tgttccagtc ttttctcacg atcagaaatc tgttgagggg
     3121 ctggtgagat ggctcagtgg taagagcacc caactgctct tccgaaggtc cagagttcaa
     3181 atcccagcaa ccacatggtg gctcacaacc atctgtaacg agatctgact ccctcttgtg
     3241 gtgtgtcaga agacagctac agaaatctgt tgagacactg aagtatttct gggaaattgg
     3301 accctgagaa ataatgcacg ctagcaggaa gagaagtttc cagaacagag aggtgctcca
     3361 caaacattgc cgtcgtaccc cactccttgg gtccttacta aagcttgata atgaggaatg
     3421 gtgtagctgt gggccccacg gcagtacagg ttaggtaatt cccaagacgt tccagcagac
     3481 tagccctcca ggctcaggca gcagccccag agggaagccc actgcaaatc tgagcagaga
     3541 aaaataccca ccaaaagcca caagagggcg catacagccc gagaagctgc tgagggtcac
     3601 ccaccctctt cactccccta ccctgcccga gcagtgggag gggggtggct aaagagaatt
     3661 taagagcctc agaatgtgga cagtcactgg cctcacacac tcttatagca gcttgggaca
     3721 tgcagagcag agacccctta tagtcagaga ttcttagaag aggattgttt ccggacaaag
     3781 gaggaccaca gccaggctca gagctgctct cctgggcctc tgagtaccag ggcaccaact
     3841 tagatgtgat gcacatacca acaggaggta gactttcaaa tccacatcta gtcagtatag
     3901 ggttccaaac tagtcactag gccaccagtg ttccttgccc acttctatgc ccctccctcc
     3961 gcaggaggga aaagtgtgtg ataagggaca agttcatctg atatctaaca tctggtgggg
     4021 agggtggcca cggttctttt ggccttttct ccaccaccca ggaggggcca cacacaaggc
     4081 tgctggatct tcaaggctct aaacagcatg gccccctatt ccattatatg tctttccttc
     4141 ctccctaatc ctttgtacag gatggagcac tctgcaggtg ctcaataaat ggtgtctact
     4201 ga
//
