LOCUS       NM_183023               5247 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus regulating synaptic membrane exocytosis 4 (Rims4),
            transcript variant 1, mRNA.
ACCESSION   NM_183023
VERSION     NM_183023.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5247)
  AUTHORS   Kim,H., Melliti,N., Breithausen,E., Michel,K., Colomer,S.F.,
            Poguzhelskaya,E., Nemcova,P., Ewell,L., Blaess,S., Becker,A.,
            Pitsch,J., Dietrich,D. and Schoch,S.
  TITLE     Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells
  JOURNAL   Brain 147 (9), 3171-3188 (2024)
   PUBMED   38478593
  REMARK    GeneRIF: Paroxysmal dystonia results from the loss of RIM4 in
            Purkinje cells.
REFERENCE   2  (bases 1 to 5247)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5247)
  AUTHORS   Uriu,Y., Kiyonaka,S., Miki,T., Yagi,M., Akiyama,S., Mori,E.,
            Nakao,A., Beedle,A.M., Campbell,K.P., Wakamori,M. and Mori,Y.
  TITLE     Rab3-interacting molecule gamma isoforms lacking the Rab3-binding
            domain induce long lasting currents but block neurotransmitter
            vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels
  JOURNAL   J Biol Chem 285 (28), 21750-21767 (2010)
   PUBMED   20452978
REFERENCE   4  (bases 1 to 5247)
  AUTHORS   Wang,Y. and Sudhof,T.C.
  TITLE     Genomic definition of RIM proteins: evolutionary amplification of a
            family of synaptic regulatory proteins
  JOURNAL   Genomics 81 (2), 126-137 (2003)
   PUBMED   12620390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591542.20, AY326955.1 and AL731698.10.
            
            On Dec 5, 2019 this sequence version replaced NM_183023.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.16189.1,
                                           SRR7652917.688156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               AL591542.20        44399-44688         c
            291-1122            AY326955.1         1-832
            1123-5247           AL731698.10        44543-48667         c
FEATURES             Location/Qualifiers
     source          1..5247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.52 cM"
     gene            1..5247
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /note="regulating synaptic membrane exocytosis 4"
                     /db_xref="GeneID:241770"
                     /db_xref="MGI:MGI:2674366"
     exon            1..387
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1100
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /note="isoform 1 is encoded by transcript variant 1; RIM4
                     gamma; regulating synaptic membrane exocytosis protein 4;
                     RIM 4; rab3-interacting molecule 4"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     4 isoform 1"
                     /protein_id="NP_898844.1"
                     /db_xref="CCDS:CCDS17018.1"
                     /db_xref="GeneID:241770"
                     /db_xref="MGI:MGI:2674366"
                     /translation="MERSQSRLSLSASFEALAIYFPCMNSFDDEDAADSRRLKGAIQR
                     STETGLAVEMPSRTLRQASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGP
                     AQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLE
                     NGVCIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARV
                     LLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGERS"
     exon            388..526
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /inference="alignment:Splign:2.1.0"
     exon            527..639
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /inference="alignment:Splign:2.1.0"
     exon            640..741
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /inference="alignment:Splign:2.1.0"
     exon            742..881
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /inference="alignment:Splign:2.1.0"
     exon            882..5247
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5226..5231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /note="hexamer: ATTAAA"
     polyA_site      5247
                     /gene="Rims4"
                     /gene_synonym="6530406L02; Rim4"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgct gcgccgccgc cgccaccacc accaccaccg ccaccaccgc cgccaccgcc
       61 actgcctccg ccaccgccgc cgccaccgcc gcgagcacct cgcgtctcgg gctccacgcg
      121 ccgccagtgt ccggccctct gcgcccggcc accagccccg ccgcctgccc gcggagcccc
      181 gggccgccgc caccacgccg cgcgccgtac tccgcgtcaa gaatggggcg gccaagctgc
      241 ccaagccgcc cgccgccgcc gcggccgagg ctcctggcgc gggcgcgggc atggagcgct
      301 cgcagagccg cctcagcctg tccgcctcct tcgaggcgct cgccatctac ttcccgtgca
      361 tgaactcctt cgatgatgag gacgcagcag acagccggag gctgaagggt gccatccaga
      421 gaagcacaga gacgggactg gccgtggaga tgcccagccg gacgctccgc caagccagcc
      481 atgagtccat cgaggacagc atgaacagct atggctcaga gggcaacctt aactatggag
      541 gagtttgtct agcttcagat gcccagttca gtgacttcct ggggagtatg ggaccagcac
      601 agtttgtggg ccgccagacc ctggctacca cacccatggg ggatgtggag attggcttgc
      661 aggagcggaa tggtcagctg gaggtggaca tcatccaggc ccggggactg actgccaagc
      721 caggctcgaa gacactgcca gctgcctata tcaaggccta tctgctggag aatggtgtct
      781 gcattgccaa gaagaaaacc aaagtggccc gcaagtcact ggacccgttg tacaaccagg
      841 tgcttctgtt tcctgagagt ccccagggca aagtcctgca ggtaatcgtg tggggaaact
      901 acgggcggat ggagcggaag cagttcatgg gcgtggctcg agtcctgctg gaggaactgg
      961 acttgaccac cctggccgtg ggctggtaca agctcttccc cacctcctcc atggtggacc
     1021 cagccacagg tccgctgctt cggcaggcat cccagctgtc cctcgagagc accgtggggc
     1081 cctgtggcga gcgatcttaa tgccggggag ggggaggggc tccgcgagat ggcctggaga
     1141 ccacccagcc ctgacctggg accccaggcc caggggcaca ttggacattg gaggatgggg
     1201 ttcttccccc acagtgggga agcagaatgg ggagacctgc cccccttggg cccctcctca
     1261 ctccttcacc tcctacccct gagaccttcc ctttcccagt gggttggcta cacttttgac
     1321 ttggccggtt ttgacctggt ggatgcggct acaatcagag aaggactgag gtggcagagc
     1381 aaaccactct tctgccctac cccaccccac cccacctgtc cctcttttgc ctccttggaa
     1441 gctcgctgcc cagagccaag tccagaacca agccggccat ctccatggtg ccaattacca
     1501 gcaagtgtct ttcctgcggc actgggttcc ggcagctact ccagccccag agctgatggg
     1561 gcagtttgca aggatccgga gccagctcct gaggggggcg cccagagctc cccacttgga
     1621 ggggagtatg ggtctccttc tgcctgcccg tggaaggagc tttgccgcag cctgtctgag
     1681 tccatccatc catcccctcc tacctgtccc tctgctggaa gctctaggaa ttgggagcca
     1741 gcagagacca aagggaagga ggaggtacct gaggcttggc aggatcccca ggggtccttg
     1801 ccccatggga ttgcaacaag ctggtctgga gctcttggtg gactggaaag gacattgtca
     1861 tctgtgatat ggtggaggac tgtggggacc tgagtttcca gaaccttgca catagggaac
     1921 gactctccag tgtcgggggt agtaggagcg gagcattgaa gaaagctgga attaggtcta
     1981 agtgacacca aggtcagggg tttctaaaca ggagacccct ccttgttgga tgggatcaaa
     2041 ggtaatcttg ttatcctctg cctctgggcc agggtcttgg agaggcatta gagccgcaca
     2101 cattttagtc tttaaataaa ccatcctgta ccaagggcag aagccactgc ccagcctcat
     2161 caccttggct caaggagaga tggcgttcca ggaggaggga tgcagagctg taagtgtaag
     2221 aatttagagg ctccaatgag acctgggcag ctgccttcct gtggccctcc ctggggcctg
     2281 cgggagccct tttgcatgcg agggaggaca cagtcaggcc cctatagaag cacatttcta
     2341 tcacccctcc tgggaggcgc ccagcagccc gccagtcctc ctcactagtc cctgctgtgt
     2401 agggtgtagt ccaggttagc tgggtagtta gtgttcacgc ctgaggcctg ttagctcaga
     2461 tgtagtcttt tttttttttc ttcaagcccc gggctgtgag gagagggaga ccccagtaca
     2521 ttccagaaga ttacagactc tctctagcct gggctgggct gggctgggct gggctgcctg
     2581 gctccctgga ggccagccct tccgccttct ccctgccttc ctctctcctc ccttctaggg
     2641 ttgtagccct aactgttcat cacactcagc acgctggtgt cacaccttca gcattcccga
     2701 gggttgttgg gccttgcaga ggggcctgga ctccattaga gggtgtcatt ttccaccaag
     2761 gatgccagga ctctattgag tcccacctgg ttcctggttc atctaccaag aaattccttc
     2821 tacttggaaa ttctcccatt cccaggctgg ctaagcccgg agtgcccttt agggttctgt
     2881 ccagttctgt catctccaca tgcagctgtt gacactacac agggaagggg ctgtggacag
     2941 gcccctcttc tcccattggt cttcagagtg tcattgggac tgtggatggg caggcctcct
     3001 gaacaaggga gcagggctct cgatgggctc ctttttgagg cccacagtta gccatcaccc
     3061 cattttttca acagtgtgat atcctcactg ttaggttatt actcgctgtt tggaatattt
     3121 tgagccagga gggcaccttc cctctccagc tgtcactgct gtggttgttc agggtgggac
     3181 agagcctggc tgtcacgacc aggggggaga gactcagctc taatttgaga gagagagaga
     3241 gagagagaga gagagagaga gagagagaga gagagagcat gatagcacca aggagcactg
     3301 actccaaagc aataacaccc tgaggtggtc agtgagaccc ctcagtgact ttcttgtttg
     3361 ttctgtgaaa tctcgctcac ctcctggagg ggtagagtga ggggctggag ccccatttct
     3421 tgtaccattg taagcgtgtg ccccacttcc aaggggctgt gaccactggg tgtgggagcc
     3481 atttctgtcc tcaccaaagg actcggggca gagtgatttt catccatagc ttcggggacc
     3541 aacaagccca gcctgttccc actgctgtct gaccctctgt caactcaaac tctgccatca
     3601 ggaaaggagc agagggggtg gagttggggg ccctttctgg tgctgtgtct ctaagggtgt
     3661 ttcttttttt ttcccctctg gacaaaagtc atgtatagga ctgccatgta aaggggccat
     3721 ctccattttc ctcacccaga atgcctctgc gttctgaagg gaagggcctg tagattttta
     3781 gcccatttgc atttttaaaa agaatactaa ggccctgcgt gaggagagcc aacgtggggt
     3841 ccttggtatg tccggtggca tttccgccta ggggtcccct tcatgtctca tgctgagcca
     3901 gagtcaggga aggatgaagg ggacagccat ttctcatcct ttctgctgct tttctttgga
     3961 gcctcctggt ggctcccagt tatgtcagga caaagctgta gctcatctga gaggttagga
     4021 aactcgggcc acagcaggcc tctcagcaac atgcactggg ggacaaagct gggagaccac
     4081 tgctcaaggg caggttggcc accatcatta tttccagccg ttaggcacag gtggccctgc
     4141 cctgcttggc tctcttctgg gagaagaggg tggttacagg gaggggtgcc aggttgtctg
     4201 gggtctcctg ggcaatttct ccagggatca tgagcggaag ggttttaggc tgggttgtta
     4261 cctctccagg tccagctggg agtgggttgc caacaaacaa gctacttcct gggtttgtag
     4321 agtagggggg gggctcaggg gagtcctctc taaccttcag aggcgatagc aaccccttcc
     4381 catagcacct cccacagcgt gtcccccgtg attttactct gacccccata agaaccccaa
     4441 atagcaagca aagggatgcc tgtattgaca gccttgtttt cagaagggaa cggaggaggt
     4501 ccaatgagag aggggggggg agagagagag agagggagag aaagaaagag agagagagag
     4561 agagagagag aggtgcttgc tcaagttgtg actttgaaag tgccagctcg ttctccggtg
     4621 gttcacagca caggtgtgca agcacgttag cagaggcggt taagtggttc acatgtgatt
     4681 caccaccggg ttccttcttg agcactttgg ggttcagaaa cagcacaggg gctcccacac
     4741 tctcccaagg cagagctgtt gcaccaggca aggtcacctg catttattta ttgagcaaca
     4801 gcgagtgcta caccaggccc agagccttag acccctttcc tgtcccctgc aatggctctc
     4861 ttggccctcc aagagggcct gtgtctgcaa aacaggacct tagtggacag agagtttcta
     4921 taggcttgcc tagcaagccc aagggttttt ttcctttcag caagagagcc tgtgtgggct
     4981 gggtgggagg ctagaagtag acataggtgt tacctctgag tcctttgtgc catcctgcaa
     5041 ggtgacagga agatgggacc ccagagtcct tgggctggga gcctcccttc atctacccac
     5101 ctttccctgt gtcctcttgg ggagcaggaa cggcctggtc ctccagggag ggagggtttg
     5161 gggtgcgtct gagttggagt gggtcacatg gcattgtatt catgaccaca tagctcatgt
     5221 tggaaattaa agtttttggc ttttcta
//
