LOCUS       NM_183018               7726 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus regulating synaptic membrane exocytosis 1 (Rims1),
            transcript variant 2, mRNA.
ACCESSION   NM_183018 XM_484842
VERSION     NM_183018.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7726)
  AUTHORS   Emperador-Melero,J., Andersen,J.W., Metzbower,S.R., Levy,A.D.,
            Dharmasri,P.A., de Nola,G., Blanpied,T.A. and Kaeser,P.S.
  TITLE     Distinct active zone protein machineries mediate Ca2+ channel
            clustering and vesicle priming at hippocampal synapses
  JOURNAL   Nat Neurosci 27 (9), 1680-1694 (2024)
   PUBMED   39160372
REFERENCE   2  (bases 1 to 7726)
  AUTHORS   Young,T.R., Yamamoto,M., Kikuchi,S.S., Yoshida,A.C., Abe,T.,
            Inoue,K., Johansen,J.P., Benucci,A., Yoshimura,Y. and Shimogori,T.
  TITLE     Thalamocortical control of cell-type specificity drives circuits
            for processing whisker-related information in mouse barrel cortex
  JOURNAL   Nat Commun 14 (1), 6077 (2023)
   PUBMED   37770450
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7726)
  AUTHORS   Wang,X.T., Zhou,L., Dong,B.B., Xu,F.X., Wang,D.J., Shen,E.W.,
            Cai,X.Y., Wang,Y., Wang,N., Ji,S.J., Chen,W., Schonewille,M.,
            Zhu,J.J., De Zeeuw,C.I. and Shen,Y.
  TITLE     cAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates presynaptic
            long-term potentiation and motor learning
  JOURNAL   Elife 12, e80875 (2023)
   PUBMED   37159499
  REMARK    GeneRIF: cAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates
            presynaptic long-term potentiation and motor learning.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7726)
  AUTHORS   Kershberg,L., Banerjee,A. and Kaeser,P.S.
  TITLE     Protein composition of axonal dopamine release sites in the
            striatum
  JOURNAL   Elife 11, e83018 (2022)
   PUBMED   36579890
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7726)
  AUTHORS   Tan,C., de Nola,G., Qiao,C., Imig,C., Born,R.T., Brose,N. and
            Kaeser,P.S.
  TITLE     Munc13 supports fusogenicity of non-docked vesicles at synapses
            with disrupted active zones
  JOURNAL   Elife 11, e79077 (2022)
   PUBMED   36398873
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7726)
  AUTHORS   Fukuda,M.
  TITLE     Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and
            Noc2. Identification of a critical determinant of Rab3A/Rab27A
            recognition by Rim2
  JOURNAL   J Biol Chem 278 (17), 15373-15380 (2003)
   PUBMED   12578829
REFERENCE   7  (bases 1 to 7726)
  AUTHORS   Castillo,P.E., Schoch,S., Schmitz,F., Sudhof,T.C. and Malenka,R.C.
  TITLE     RIM1alpha is required for presynaptic long-term potentiation
  JOURNAL   Nature 415 (6869), 327-330 (2002)
   PUBMED   11797010
  REMARK    GeneRIF: required for presynaptic long-term potentiation.
REFERENCE   8  (bases 1 to 7726)
  AUTHORS   Schoch,S., Castillo,P.E., Jo,T., Mukherjee,K., Geppert,M., Wang,Y.,
            Schmitz,F., Malenka,R.C. and Sudhof,T.C.
  TITLE     RIM1alpha forms a protein scaffold for regulating neurotransmitter
            release at the active zone
  JOURNAL   Nature 415 (6869), 321-326 (2002)
   PUBMED   11797009
  REMARK    GeneRIF: RIM1alpha interacts with several active zone molecules,
            including Munc13-1 and alpha-liprins, to form a protein scaffold in
            the presynaptic nerve terminal.
REFERENCE   9  (bases 1 to 7726)
  AUTHORS   Wang,X., Hu,B., Zimmermann,B. and Kilimann,M.W.
  TITLE     Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants
            partially related through N-terminal alpha -helix motifs
  JOURNAL   J Biol Chem 276 (35), 32480-32488 (2001)
   PUBMED   11431472
REFERENCE   10 (bases 1 to 7726)
  AUTHORS   Ozaki,N., Shibasaki,T., Kashima,Y., Miki,T., Takahashi,K., Ueno,H.,
            Sunaga,Y., Yano,H., Matsuura,Y., Iwanaga,T., Takai,Y. and Seino,S.
  TITLE     cAMP-GEFII is a direct target of cAMP in regulated exocytosis
  JOURNAL   Nat Cell Biol 2 (11), 805-811 (2000)
   PUBMED   11056535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117188.3, AC174648.2, AEKQ02040098.1, AEKQ02040097.1, AC147129.3,
            AC125522.4 and AC130211.3.
            
            On Jul 31, 2020 this sequence version replaced NM_183018.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-598               AC117188.3         154065-154662       c
            599-679             AC117188.3         75434-75514         c
            680-748             AC174648.2         39395-39463
            749-962             AC174648.2         73291-73504
            963-974             AC174648.2         75771-75782
            975-1312            AC174648.2         131252-131589
            1313-2154           AC174648.2         135635-136476
            2155-2219           AC174648.2         183223-183287
            2220-2330           AC174648.2         185123-185233
            2331-2430           AC174648.2         186622-186721
            2431-2554           AC174648.2         190317-190440
            2555-2601           AC174648.2         194141-194187
            2602-2714           AC174648.2         197038-197150
            2715-2845           AC174648.2         201554-201684
            2846-3017           AEKQ02040098.1     6098-6269           c
            3018-3171           AEKQ02040098.1     5842-5995           c
            3172-3243           AEKQ02040098.1     4767-4838           c
            3244-3400           AEKQ02040098.1     460-616             c
            3401-3526           AEKQ02040097.1     37834-37959         c
            3527-3589           AEKQ02040097.1     36243-36305         c
            3590-3679           AC147129.3         2532-2621
            3680-3751           AC147129.3         19847-19918
            3752-3934           AC147129.3         25581-25763
            3935-4047           AC147129.3         26799-26911
            4048-4160           AC147129.3         44822-44934
            4161-4327           AC147129.3         50852-51018
            4328-4563           AC125522.4         94652-94887         c
            4564-4702           AC125522.4         45217-45355         c
            4703-4815           AC125522.4         41181-41293         c
            4816-4917           AC125522.4         39372-39473         c
            4918-5057           AC125522.4         38419-38558         c
            5058-7726           AC130211.3         179052-181720       c
FEATURES             Location/Qualifiers
     source          1..7726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 8.54 cM"
     gene            1..7726
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /note="regulating synaptic membrane exocytosis 1"
                     /db_xref="GeneID:116837"
                     /db_xref="MGI:MGI:2152971"
     exon            1..598
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..5276
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     synaptic exocytosis regulator 1; Rab3 effector; regulating
                     synaptic membrane exocytosis protein 1; rab3-interacting
                     molecule 1; Rab3 interacting protein 1; regulating
                     synaptic membrane exocytosis 1 beta"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     1 isoform 2"
                     /protein_id="NP_898839.3"
                     /db_xref="GeneID:116837"
                     /db_xref="MGI:MGI:2152971"
                     /translation="MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQK
                     EEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLNIFRCVCVPRKPSSEEGGPD
                     RNWRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRT
                     KFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQDGTLSD
                     TATGAGSEVPREKKARLQERSRSQTPLSTAAVSSQDTASHGAPLDRNKGAEPSQQALG
                     PEQKQASRSRSEPPRERKKAPGLSEQNGKGGQKSERKRVPKSVVQPGEGTADERERKE
                     RRETRRLEKGRSQDYPDRLEKREDGRVAEDEKQRKEEEYQTRYRSDPNLARYPVKAPL
                     EEQQMRMHARVSRARHERRHSDVALPHTEAAAAVSAETTAGKRAQTTARVSPPESPRA
                     RAPAAQPPAEHGPPPPRPAPGPAEPPEPRVPEPLRKQGRLDPGSAVLLRKAKREKAES
                     MLRNDSLSSDQSESVRPSPPKPHRPKRGGKRRQMSVSSSEEEGVSTPEYTSCEDVELE
                     SESVSEKGDLDYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKE
                     SGALLGLKVVGGKMTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATN
                     EEVYNIILESKSEPQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVI
                     SPTSPGALKDAPQVLPGQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMY
                     FLPDRSDKSKRRTKTVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEES
                     EFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRS
                     QRISDSDISDYEVDDGIGVVPPVGYRASARESKATTLTVPEQQRTTHHRSRSVSPHRG
                     DDQGRPRSRLPNVPLQRSLDEIHPTRRSRSPTRHHDASRSLADHRSRHAESQYSSEPD
                     SELLMLPRAKRGRSAECLHMTSELQPSLDRARSASTNCLRPDTSLHSPERERHSRKSE
                     RSSIQKQSRKGTASDADRVLPPCLSRRGYAIPRATDQPVIRGKHTTRSRSSEHSSIRT
                     LCSMHHLAPGGSAPPSPLLTRTHRQGSPTQSPPADTSFGSRRGRQLPQVPVRSGSIEQ
                     ASLVVEERTRQMKMKVHRFKQTTGSGSSQELDHEQYSKYNIHKDQYRSCDNASAKSSD
                     SDVSDVSAISRASSTSRLSSTSFMSEQSERPRGRISSFTPKMQGRRMGTSGRAIIKST
                     SVSGEIYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTES
                     GHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYSSEGNLIFPGVRVGPDSQ
                     FSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTP
                     APYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMD
                     HKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPLTRRASQSSLESSSGPPC
                     IRS"
     exon            599..679
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..748
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..962
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..974
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1312
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..2154
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2219
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2330
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2430
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2554
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2601
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2714
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2845
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3017
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3171
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3243
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3400
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3526
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3589
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3679
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3751
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3934
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4047
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4160
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4327
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4563
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4564..4702
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4703..4815
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4816..4917
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4918..5057
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..7726
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7426..7431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /note="hexamer: AATAAA"
     polyA_site      7448
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /note="major polyA site"
     regulatory      7704..7709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /note="hexamer: AATAAA"
     polyA_site      7726
                     /gene="Rims1"
                     /gene_synonym="C030033M19Rik; Rab3ip1; Rim; RIM1; RIM1a;
                     RIM1alpha; Serg1"
                     /note="major polyA site"
ORIGIN      
        1 aaactggagg cagcggagcc cgcgagcaag cagcgtcggg cggccccggc ccggccccgc
       61 ccccggcccg ccagcccagc ccgcgcccgg ccgccgtgct ccggagctca gcgccagccc
      121 tcgccctctc gccgagcctc cgcctgcccg cccccgccgg ccgaggctgg gctgcgggag
      181 gcggccaggc ggccccgagc ctcgccaggg cgacccaaac aaaggcagca tccgggctcg
      241 gcgggaggca gagcatcatg agagactggg tcctcgctgt ccccggctcc gctgctgctg
      301 ccgctgccgc cgccgctgcc gccgccggga gggcttcgct gtgagcgtgg aaagcagggg
      361 cgcagctgcg gggcgtgaat ccgaaaggtg agagccagag ccagcgagcc gagggggcgg
      421 gcaggccacg aaaaatgtcc tcggccgtgg ggccccgagg tcctcgccca cccacggtgc
      481 ctccccctat gcaagaactg cccgacctga gccacctgac cgaggaggag aggaacatta
      541 tcatggcagt gatggaccgg cagaaggaag aggaggaaaa agaagaggcc atgctcaagt
      601 gtgttgtcag ggacatggcg aagcctgctg cctgcaaaac accaagaaat gctgaaagcc
      661 agccccatca accaccactg aacattttca gatgtgtctg tgttcccaga aagccaagca
      721 gcgaagaggg aggcccagac agaaactgga gattgcatca acagtttgaa agctacaagg
      781 aacaagtgag aaaaatcgga gaggaagcca ggcgttacca gggcgagcac aaagatgatg
      841 ccccgacgtg tggaatctgt cataagacaa agtttgctga tggatgtggc catctctgct
      901 cctattgtcg caccaagttc tgtgcacgct gtggaggccg agtgtctctg cgatcgaaca
      961 atgaggacaa agtggttatg tgggtatgca atttatgtcg aaagcaacaa gagatattaa
     1021 cgaaatctgg agcgtggttc ttcggaagtg gtcctcagca gcccagtcaa gatgggactc
     1081 tgagtgacac ggctacaggt gctggatctg aggtgccaag agaaaagaaa gctcggctcc
     1141 aagagcgatc aaggtctcag acgcccttga gtacagcagc tgtctcttcc caagacactg
     1201 cttcccatgg tgcaccactg gacaggaaca aaggggcgga gccctcacag caagccttgg
     1261 gtcctgaaca gaagcaggca tcaaggtcaa gaagtgagcc accaagggaa aggaagaagg
     1321 ctccagggct ttcagagcag aatggcaagg gaggccagaa gagtgagcgc aaacgtgtcc
     1381 ccaagtctgt ggtgcaaccc ggggaaggga ccgcggatga acgggagagg aaggagaggc
     1441 gggaaacccg caggctggag aaagggcgct ctcaggacta cccggaccgg ctcgagaaac
     1501 gcgaggatgg cagggtggct gaagacgaaa agcagaggaa ggaggaggag tatcagacta
     1561 ggtaccgcag cgacccgaac ctggctcgct acccggtgaa ggcgccgctg gaggaacagc
     1621 agatgcgcat gcacgcccgg gtgtcccgag cgaggcacga gcggcgccac agcgacgtgg
     1681 cgctcccgca caccgaggct gccgccgctg tgtcagccga gaccacggcg ggcaagcgcg
     1741 cgcagaccac cgccagggtc tctcccccgg agtccccgcg cgcacgcgcg cccgctgccc
     1801 agcctcccgc ggagcacggg ccgccgccgc cgcggccagc cccgggtccg gcagagccgc
     1861 ccgaaccgcg cgtccccgag ccgctccgta agcagggccg cctggacccc ggctcggctg
     1921 tgctcctgcg caaggccaag cgcgagaaag cggaaagcat gctgcggaac gactcgctga
     1981 gctccgatca gtccgagtcg gtgcggccat ccccgcccaa gccacaccgg cccaagcggg
     2041 gaggcaagag gcgtcagatg tcggtgagca gctccgagga ggagggcgtg tccacgccgg
     2101 agtacacgag ctgcgaggac gtggagctgg agagcgagag cgtgagcgag aaaggtgact
     2161 tggactactg gttggatcct gccacgtggc atagcaggga aacgtcgcct attagttcgc
     2221 atcctgtaac gtggcagcca tctaaagagg gggaccgatt aatcggccgt gttattctta
     2281 acaaaagaac aaccatgccc aaagaatcag gtgcattatt gggtctcaag gtggttggag
     2341 gaaaaatgac ggacttaggg cgtcttggtg ctttcatcac caaagtaaag aagggtagcc
     2401 tggcagatgt tgtcggacac ctaagagcag gggatgaagt tctagagtgg aatggtaaac
     2461 ccctgccggg agcaacaaac gaagaagttt acaacattat tttagaatca aaatcagaac
     2521 ctcaagttga aattattgtt tcaaggccta ttggtgacat ccccaggatc cctgagagtt
     2581 cccaccctcc cctggagtcc agttcaagtt cctttgaatc tcagaagatg gaaaggcctt
     2641 ccatttctgt tatttctcca accagccctg gagctctgaa agatgcccca caagtcttac
     2701 cagggcaact ctcagtgaag ctgtggtatg ataaggtggg gcaccagctg attgtaaatg
     2761 ttctacaagc aacagatcta ccccctagag tagatgggcg tcccagaaat ccctatgtaa
     2821 aaatgtattt tcttccagat agaagcgaca agagtaaaag aagaaccaaa acggtaaaga
     2881 aacttctaga gccaaaatgg aatcaaacat ttgtctactc acacgtacat cgtcgagatt
     2941 ttcgagagcg aatgttagaa attactgtgt gggaccagcc aagagtacag gacgaggaga
     3001 gtgaatttct aggagagatc ctcatagaat tggaaacagc acttttagat gatgagcccc
     3061 attggtataa actgcagaca catgatgaat cttcactacc tctgcctcag ccatcaccgt
     3121 tcatgcccag gcggcatatc cacggagaaa gctccagcaa aaagctacaa agatctcagc
     3181 gaatcagtga tagtgacatc tcagattatg aggttgatga tggtattggc gtagtgcctc
     3241 cagtgggtta tagagctagt gctagagaga gtaaagccac cacgttaaca gtgccagagc
     3301 agcaaagaac cacacatcac cgctcacgtt ccgtgtctcc tcatcgcggc gatgatcagg
     3361 gaaggcctcg ttcacgttta ccaaatgtgc cattacagag gagcttagat gaaatccatc
     3421 caacacgaag gtcacgttct ccaacccgac accatgatgc ctcccgaagc ctggccgatc
     3481 acagatcacg acatgcggaa agtcagtatt catcagagcc agacagtgag cttctcatgc
     3541 tgcccagagc aaaacgagga cgaagtgcag aatgcctaca catgaccagt gaactgcagc
     3601 cctctcttga cagggctagg agtgctagta ccaactgctt gagaccagat actagtttgc
     3661 attcaccaga acgagaaagg cactccagaa agtctgaaag atctagcatc caaaaacagt
     3721 ctaggaaagg cacagcctct gatgcagaca gggttctccc accatgcctt tctagaaggg
     3781 gatacgcaat cccaagagca accgatcaac cggtcattag gggaaagcat accactcgct
     3841 cccggtcgag cgagcactct agtatcagaa ccctgtgttc tatgcaccac cttgcccccg
     3901 gagggtcagc gccgccttct ccgcttctga caagaacgca ccgacaagga agccccaccc
     3961 agtcacctcc agctgacaca tcctttggca gtcgccgcgg aagacagctc ccacaggtgc
     4021 cggtccgaag cggcagtata gaacaagcga gcttagtagt ggaggaacga acgagacaga
     4081 tgaaaatgaa ggtacaccga tttaagcaga caacagggtc tgggtctagt caagaacttg
     4141 accacgagca atactccaag tacaacatac ataaagatca gtacagaagc tgtgataacg
     4201 cgtccgccaa gtcatcagat agtgatgtca gtgatgtgtc cgccatttcc agagccagca
     4261 gcacctcacg cctcagcagc acaagcttta tgtcagagca gtctgagcgc cccaggggca
     4321 ggatcagttc atttaccccc aaaatgcaag gcagacggat ggggacttca ggaagagcca
     4381 tcatcaagag caccagtgta agtggagaga tatatacact ggagcacaat gacggcagcc
     4441 agtccgacac ggccgtgggt accgttggag ctggtggaaa gaagcggagg tccagcctga
     4501 gtgccaaagt ggtagccatt gtgtctcgaa gaagcagaag cacatcacag ctcagccaga
     4561 cagagtccgg ccacaagaag ttaaaaagca ccattcagag gagtacggaa acgggaatgg
     4621 cggctgaaat gcggaagatg gtgagacagc ccagccggga gtccacggat ggcagcatca
     4681 acagttatag ctcagaagga aacttaatat ttcctggagt tcgcgtggga cctgacagtc
     4741 agttcagtga tttccttgat ggattggggc cagcccagct tgtcggccgc caaaccctcg
     4801 ccaccccagc catgggcgat atccaaatcg ggatggagga taagaagggt cagttggagg
     4861 ttgaggttat cagagcccgg agccttacac aaaaacctgg ctccaaatct acacctgctc
     4921 cctatgtgaa agtttatctt ttggaaaatg gagcctgtat tgccaaaaag aagacaagaa
     4981 ttgcacggaa aactctcgat cccttgtatc agcagtccct ggtttttgat gaaagtccac
     5041 agggtaaagt tcttcaggtg attgtctggg gtgactatgg aagaatggac cacaaatgct
     5101 ttatgggtgt ggctcaaatc ttgttggaag aacttgatct gtccagcatg gtgattggat
     5161 ggtataaatt gttccctcca tcctccctgg tggatcccac actcactccc ctgacccgcc
     5221 gggcttccca atcatcactg gaaagttcgt ctgggcctcc ctgcatccgg tcatagtaaa
     5281 ctcctaacct tccagccaaa ctctacattt caggataatt atcagaacca gatatttcat
     5341 gatcaagagc attgttggag acagacaatc aacttgtgtt ttgcctgtag tagttgttcg
     5401 ataattgtgt cccaattgtt gtttaaaaca tggcttcgta tgacagaaca aggcagtcaa
     5461 tcacattgca gtaagaatcg acatgctagt gagagccact gacacttctt gcaaatagga
     5521 aagagagaga gagagagaga gagagaggga gagagagaga gagagagaga ggggaaggaa
     5581 acctcaagtt cacacacaca ccaaactgaa caaactggaa agtctcactc tgtgaaaagg
     5641 tgtacttcac acatttctgc acagaccaca agcagtgttg tttccctggt gtttgagatt
     5701 ctttagttct tctgagtgct ttccttgttt gagcgttgtt tgctggtttt tttccccatt
     5761 gtctctcttt ctctgtcttc actatatttg ttctttccac tagtttgttt gttttgtttt
     5821 gttttgtttt tcattttttt gtctttgtct ttctttgctt cgtcataaca gagttatggt
     5881 gttcacagag acccttcctt tcttttttcc aaaagcacca aaaaagggct gaagccgtct
     5941 ctgtagcatt ttccccaaag ttttcaaaag ctgggcaagg taaagccagg gaagggtatc
     6001 agcggcagcc agtttacagt tcttccaagt cttgtatgtg gaatttacac acacacacac
     6061 acacacacac agacagtaaa aatcatcacc caaactagta gttgcagaat cacttctcag
     6121 tgaagagcgt atctgttccc attccagata attcattgct attttccatt gtttggcaca
     6181 gaagactttg aaggacctag aactgatgct ggggatgaag gctaaccaca tagtagtgct
     6241 ttggaaaccc tttccgaaat gcctttttac ttcctgataa caaaagaaaa aaaaatgttc
     6301 atgtgtagaa accatgctct caactcccca aaatggtgac taagaatgga tttgagccta
     6361 agacactttc agctatgccc aggcttctca gccatgcccc agagtagact tgtctgccct
     6421 ggaaagagca tagtatgagc tgtttaatat tgcactggaa attccagttc ataaactctg
     6481 cactaaatta atgtttttat tggatttcag tttacatttc tttaaggtca atgcaagcac
     6541 aaagcttgat ttttttaaat gcacaatatc ttactttggg ggaagaaaaa gaatacagcc
     6601 aaataccaat ttgcatattc ttcataattt cccttgtgac ctgtgtatgt gctgcaggcg
     6661 cctgcttggt cctgcagctg catcaatatg caccccctct ccttttatga gtcgttcaac
     6721 tttttgtgat ttcacagtta gagcagcatg acctggagct gttcaaagct gcatgcattt
     6781 tgtataaaaa aatatgaaaa agaaagaaaa aaagcaaaga gacaaaaggt tatttaataa
     6841 tgtatgttag ctccatatag gctggcttgt atgttgcatg tacttgtaca gtttgcttgt
     6901 taattactat attgaaataa ccaagaaatc taagccatcc atttttgtta tagacatttt
     6961 gcaggtttta gccagactca gtatgtgggt ctggtgtgaa atgtctatag atggacttta
     7021 ttttttaccc tctggaaaac atgatgtagt atggaccaaa attccttcta ataaatattt
     7081 tggtgtcgat tcctcctgtg gggctgtgac acatgtagac actgtgtaaa cactaggttt
     7141 taatccatag acatactgcc tgcaccaagt gaatcattta ttattattta cacatgtcag
     7201 aattccctgt ccattatccc acggggcaca gattgaccac cacccaccat gctgtgcagg
     7261 aagaactgaa gcacttggtg cacttctact agattccgtt ctgtcttagt ggccaacaat
     7321 caaccgatta aaattgggta gtaatatctt tctatcttga ccacttgtct taacaacccc
     7381 ttgtgctttt aagtggactt cccactcatg tatgtaaaca tgtttaataa aacttacttt
     7441 tcatgtcagt tggtagccat ctgcgttcta tgttttgcca gctttccatt gtgggttctt
     7501 tggtgcagaa ggagaaccag gtgttgggat agggaggctt gggttcgctg tctgctgtgg
     7561 gcatctgatt gacctgtcac tgcactatat atgtcttaac agacaacctg aagggtactt
     7621 tgcattacat atgagtattc actttgtcag cctgtcttaa gtgagcacat gtctatactt
     7681 ctgaaaagtg gtttattaaa gacaataaat ctcagtaaga atcaaa
//
