LOCUS       NM_027664               4017 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus ribosomal modification protein rimK-like family member
            B (Rimklb), mRNA.
ACCESSION   NM_027664 XM_001002951 XM_132812 XM_981743 XM_981777 XM_981812
VERSION     NM_027664.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4017)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4017)
  AUTHORS   Becker,I., Wang-Eckhardt,L. and Eckhardt,M.
  TITLE     NAAG synthetase deficiency has only low influence on pathogenesis
            in a Canavan disease mouse model
  JOURNAL   J Inherit Metab Dis 47 (2), 230-243 (2024)
   PUBMED   38011891
REFERENCE   3  (bases 1 to 4017)
  AUTHORS   Wang-Eckhardt,L., Sylvester,M., Becker,I., Allam,J.P. and
            Eckhardt,M.
  TITLE     Citrylglutamate synthase deficient male mice are subfertile with
            impaired histone and transition protein 2 removal in late
            spermatids
  JOURNAL   Biochem J 479 (9), 953-972 (2022)
   PUBMED   35419597
REFERENCE   4  (bases 1 to 4017)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4017)
  AUTHORS   Maekura,K., Tsukamoto,S., Hamada-Kanazawa,M. and Takano,M.
  TITLE     Rimklb mutation causes male infertility in mice
  JOURNAL   Sci Rep 11 (1), 4604 (2021)
   PUBMED   33633267
  REMARK    GeneRIF: Rimklb mutation causes male infertility in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4017)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 4017)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   8  (bases 1 to 4017)
  AUTHORS   Collard,F., Stroobant,V., Lamosa,P., Kapanda,C.N., Lambert,D.M.,
            Muccioli,G.G., Poupaert,J.H., Opperdoes,F. and Van Schaftingen,E.
  TITLE     Molecular identification of N-acetylaspartylglutamate synthase and
            beta-citrylglutamate synthase
  JOURNAL   J Biol Chem 285 (39), 29826-29833 (2010)
   PUBMED   20657015
  REMARK    GeneRIF: Molecular identification of N-acetylaspartylglutamate
            synthase and beta-citrylglutamate synthase.
REFERENCE   9  (bases 1 to 4017)
  AUTHORS   Becker,I., Lodder,J., Gieselmann,V. and Eckhardt,M.
  TITLE     Molecular characterization of N-acetylaspartylglutamate synthetase
  JOURNAL   J Biol Chem 285 (38), 29156-29164 (2010)
   PUBMED   20643647
REFERENCE   10 (bases 1 to 4017)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB616179.1, BC052078.1, AK173135.1 and AK039398.1.
            
            On or before Mar 30, 2007 this sequence version replaced
            XM_001002951.1, XM_132812.6, XM_981812.1, XM_981777.1, XM_981743.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173135.1, SRR1660815.167856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BB616179.1         201-228
            29-2040             BC052078.1         1-2012
            2041-2405           AK173135.1         2048-2412
            2406-2561           AK039398.1         2080-2235
            2562-4017           AK173135.1         2569-4024
FEATURES             Location/Qualifiers
     source          1..4017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.55 cM"
     gene            1..4017
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /note="ribosomal modification protein rimK-like family
                     member B"
                     /db_xref="GeneID:108653"
                     /db_xref="MGI:MGI:1918325"
     exon            1..215
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /inference="alignment:Splign:2.1.0"
     exon            216..440
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1429
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /EC_number="6.3.2.41"
                     /EC_number="6.3.1.17"
                     /note="ribosomal protein S6 modification-like protein B;
                     N-acetylaspartyl-glutamate synthetase B;
                     beta-citryl-glutamate synthase B; NAAG synthetase B;
                     N-acetyl-aspartyl-glutamate synthetase B;
                     N-acetyl-aspartylglutamate synthetase B"
                     /codon_start=1
                     /product="beta-citrylglutamate synthase B"
                     /protein_id="NP_081940.1"
                     /db_xref="CCDS:CCDS39622.1"
                     /db_xref="GeneID:108653"
                     /db_xref="MGI:MGI:1918325"
                     /translation="MCSSVTGKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAV
                     VMDEMVLTVEQGNLGLRISGELISAYPQVVVVRVPTPWVQSDSDITVLRHLEKMGCRL
                     MNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNT
                     RGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYIKESHGRDVRVIVVGGRVVGTML
                     RCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGTDVCGIDLLMKDDGSFCVC
                     EANANVGFIAFDKACNLDVAGIIADYAASLLPAGRLTRRMSLLSVVSTASETSEPELG
                     PPASAAVDNMSASSSSVDSDPESTTEREMLTKLPGGLFNMNQLLANEIKLLVE"
     exon            441..671
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /inference="alignment:Splign:2.1.0"
     exon            672..758
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /inference="alignment:Splign:2.1.0"
     exon            759..962
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /inference="alignment:Splign:2.1.0"
     exon            963..4017
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2018..2023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /note="hexamer: AATAAA"
     polyA_site      2040
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /note="major polyA site"
     regulatory      2217..2222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /note="hexamer: AATACA"
     polyA_site      2238
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /note="hexamer: TATAAA"
     polyA_site      2394
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
     regulatory      3048..3053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /note="hexamer: AATAAA"
     polyA_site      3075
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
     regulatory      3129..3134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
                     /note="hexamer: AATAAA"
     polyA_site      3151
                     /gene="Rimklb"
                     /gene_synonym="4931417E21Rik; 4933426K21Rik; Naags"
ORIGIN      
        1 ggggggaggg agggagaggc cggccgaccg cgaggccgtg agaaagtggg cgagtgggtg
       61 aggacgcgcg gcctggctgc gggagccggc ggcgaggaga aaggaggcgg ctcccggcat
      121 cccgccccct ccccctcctc agcggacttc ccgcggcccg cgcttgctcc taggcggcgg
      181 ccggccgggc aggcgaggga ggagccggcg gccagataaa agtttacatc aactaatcca
      241 gaaaaggaag aacaagcaga ccgagatgtg tagctcagtg actggtaagc tgtggttctt
      301 gacagatcgt cgcatcaggg aagactaccc acagaaagag atcttacgag cgttgaaggc
      361 caaatgttgt gaagaggaat tggactttcg ggctgtggtg atggatgaga tggtgctgac
      421 ggtcgagcaa ggaaatctgg gtcttcggat cagtggagag ctaatctctg cctacccaca
      481 ggtggtggta gtgagagttc caaccccatg ggtgcagagt gatagtgata ttactgtttt
      541 gcgccaccta gagaagatgg gatgccgatt gatgaaccga cctcaagcca tccttaactg
      601 tgttaataaa ttctggacat tccaagagtt agctggccat ggtgtgcctc ttccagatac
      661 tttttcttac ggtggccacg aaaactttgc taagatgatt gatgaagcag aagtgctgga
      721 gttcccaatg gtagtgaaga atacaagggg tcatagaggc aaagctgttt tcttggcacg
      781 agataaacac catttagcgg atctaagcca tcttattcgg catgaagctc catatttgtt
      841 ccagaaatac attaaagagt ctcatggaag ggatgtacga gtcattgttg tgggaggtcg
      901 tgtagttggc accatgctac gctgttccac agatggaagg atgcaaagca actgttccct
      961 aggcggcgtg gggatgatgt gctcactgag tgaacaagga aagcagctgg ctatccaagt
     1021 gtctaatatc ctggggacgg atgtgtgtgg cattgacctg ttgatgaaag atgacggctc
     1081 cttctgtgtc tgcgaggcca atgcaaatgt aggtttcatc gcctttgata aggcttgtaa
     1141 tctagatgta gctggtatca tagcagacta tgctgcctcc cttctgcccg ctggccggct
     1201 cacccggcgc atgtccctgc tctctgtggt gtccactgcc agtgagacta gtgagccgga
     1261 gcttggtccc cctgccagcg ctgctgtcga caacatgagc gcgagttcca gctctgttga
     1321 tagcgaccct gaaagcacca ccgagcgaga gatgctcacc aagctcccag gggggctgtt
     1381 caacatgaac cagctgctag ccaatgaaat caaactcctg gtggagtgac tccactggta
     1441 aatagttaaa caacaaaacc cttgtaaaac tgtctccctg caccccacac cttcccttta
     1501 accaacttgc aatgctgttc atggagaatg ttcagaaggt tgagttacag atacagtaag
     1561 attggttaga agaaaggaaa atagatgagg cccctggtag tgattcattt atggatttca
     1621 cagaggaata ctaggtgaca cagagagaaa tggcaggctc tcatggtaac cttttcagtt
     1681 acgtatgaaa accctgctca taggccatga gaacgtgaaa ggtttttttt tttttttttt
     1741 ctccccatgg tctcttgctt ttgtttttat gtagaatggt tttgatccaa gtacttagta
     1801 gcatgacttc agtttcaaga tttgtaaaga ggaaaacatc catttacaat acagaagtgt
     1861 tttaaataat ctgaaatgtc tgctgtttct ctcagctagc atttagcgca tagttgttta
     1921 tgaactctaa ggggctctga ctggaatttc tttattttca tgtttgtctt tgttttttcc
     1981 ccttaatttg ggtgggaggg taatgtgact ataatccaat aaagattttt aattacaaaa
     2041 ttggcatgtt tgcatgatga aagggaaatg aacagtattg caatgtctgg tatacaaagt
     2101 aacatttact caatgtagat aaagttatac tagttaaaag tttgtgcatt gacttgtatt
     2161 tgttagtgtt ttagtctttt tttgaaggat atatgctctg ttaatgttgc atttttaata
     2221 catgctggta acacccttgt tctatgactg catctttaac aatggccaaa gtaaacaata
     2281 tgctactttt ggttaacaag acaccactca aaacatacac atttaaaagt ctccctgcct
     2341 tcctcttttt ctcatttaaa ggatataaaa gacaagtcaa tttcttaatg ctaactttct
     2401 gtgtttgcat ttttcacatt ttagaaagga gtatatatgt cgcatgcaag tgtacatgtt
     2461 ttattctttg tttacaccaa acagaataga ttctagtgaa tggcatgatg ggaagcagtt
     2521 tttttactga tgaattgcct tagacctcaa tagtatagag attctcccct aaagacaaca
     2581 ggaaagtaaa tgttccttaa gcttttttgt gtgtttgtat gtatgtttgt ttttgtagac
     2641 tgcttggtgt atgatttatt caaggctaca ggcttttatt taatgttatg gctgtgcatt
     2701 ttctttatgc ttaaaagatc tggagggagg tggggtggat gtttttgggg ggagatttat
     2761 ttaagtattg agtctcatat agccccacac ctaagccttc attcagtact gaccactctg
     2821 tttctttttt gaattgatga aagccccaaa ctgcatataa tatgagcctt taagtcaagg
     2881 aataaaacaa tctagtgatg agtctggaag atgtgttaag aagtggagat gcttcagggg
     2941 tcaacataat ttttccctaa gcttttctgc ttctccagtg ctgtttttct tcagatggac
     3001 tttaacctaa tttcttggac actacttcaa ggagacttca aggcaataat aaaacatcag
     3061 cattaaccac tctaacagag gtctgatcat gcttaattgt atagttctcc catttaaaaa
     3121 aggaatgtaa taaaacttgc tttcccccat agaattaagt attaaagcgg agcgaaaggt
     3181 ttcattgaca actagaatag tacctgtaac cggtgcactc ttctcaactc acctcaagac
     3241 tcacaaggag tctatcttta gggcacttta attgcatctg cacgttctga tttgcacagg
     3301 attatttgga gtcatacgta cctctgcttc actaacagaa taaaagtact tggtactttg
     3361 ctcaatgatc atattttgca gggtgcatgg tatttggtat agacaaataa atgaacaacc
     3421 gtggaatcag atcctaagac catctggttg ccacttacat tatgatatac atgtatgtaa
     3481 gttcatgcat ttgaaaacaa atagaacatc ttcacttgtt gaaaaattca cttttttatg
     3541 gtgggataat aaagaaacag gaaaattagt ttttttaatg caagcattgc tctaagatgc
     3601 tttcccagca gtttcactcc tggtcacaca gccactgtgt tgaagtgcag ctctcatcag
     3661 ccaccctcgg gtgccacact cacacgcaga ctgtaagtag ggaaggtgct catcttaaat
     3721 tctctcaaat taaggtaaac aataagaaca gatcattctg gaagaactca aaacaagtga
     3781 gagttgactt ttattcataa cttttatata gtcttcatta ctactgtgac aaaatgtatc
     3841 aaatttgtgt aatcgtgcca aatatctgaa ttactgtaaa ttttttgtac actgttaaaa
     3901 ttgtaattgt taattgtatt ttaatgattc tgattttgtt tttatgttac ttatgatgag
     3961 agttgaactc atagatccat gcattatgaa ctatgccact taaactttct aattgag
//
