LOCUS       NM_177572               4093 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ribosomal modification protein rimK-like family member
            A (Rimkla), mRNA.
ACCESSION   NM_177572
VERSION     NM_177572.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4093)
  AUTHORS   Yan,H., Liu,W., Xiang,R., Li,X., Hou,S., Xu,L., Wang,L., Zhao,D.,
            Liu,X., Wang,G., Chi,Y. and Yang,J.
  TITLE     Ribosomal modification protein rimK-like family member A activates
            betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic
            steatosis
  JOURNAL   Signal Transduct Target Ther 9 (1), 214 (2024)
   PUBMED   39117631
  REMARK    GeneRIF: Ribosomal modification protein rimK-like family member A
            activates betaine-homocysteine S-methyltransferase 1 to ameliorate
            hepatic steatosis.
            Erratum:[Signal Transduct Target Ther. 2024 Dec 11;9(1):360. doi:
            10.1038/s41392-024-02054-1.. PMID: 39663370]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4093)
  AUTHORS   Becker,I., Wang-Eckhardt,L. and Eckhardt,M.
  TITLE     NAAG synthetase deficiency has only low influence on pathogenesis
            in a Canavan disease mouse model
  JOURNAL   J Inherit Metab Dis 47 (2), 230-243 (2024)
   PUBMED   38011891
REFERENCE   3  (bases 1 to 4093)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4093)
  AUTHORS   Becker,I., Wang-Eckhardt,L., Lodder-Gadaczek,J., Wang,Y.,
            Grunewald,A. and Eckhardt,M.
  TITLE     Mice deficient in the NAAG synthetase II gene Rimkla are impaired
            in a novel object recognition task
  JOURNAL   J Neurochem 157 (6), 2008-2023 (2021)
   PUBMED   33638175
REFERENCE   5  (bases 1 to 4093)
  AUTHORS   Lodder-Gadaczek,J., Becker,I., Gieselmann,V., Wang-Eckhardt,L. and
            Eckhardt,M.
  TITLE     N-acetylaspartylglutamate synthetase II synthesizes
            N-acetylaspartylglutamylglutamate
  JOURNAL   J Biol Chem 286 (19), 16693-16706 (2011)
   PUBMED   21454531
  REMARK    GeneRIF: ribosomal modification protein rimK-like family member A
            (Rimkla) gene is a NAAG synthetase (NAAGS-II), which synthesizes
            the N-acetylated tripeptide N-acetylaspartylglutamylglutamate
            (NAAG(2))
REFERENCE   6  (bases 1 to 4093)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   7  (bases 1 to 4093)
  AUTHORS   Collard,F., Stroobant,V., Lamosa,P., Kapanda,C.N., Lambert,D.M.,
            Muccioli,G.G., Poupaert,J.H., Opperdoes,F. and Van Schaftingen,E.
  TITLE     Molecular identification of N-acetylaspartylglutamate synthase and
            beta-citrylglutamate synthase
  JOURNAL   J Biol Chem 285 (39), 29826-29833 (2010)
   PUBMED   20657015
  REMARK    GeneRIF: Molecular identification of N-acetylaspartylglutamate
            synthase and beta-citrylglutamate synthase.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU611721.1, AK047164.1 and BC057371.1.
            
            On Jul 14, 2009 this sequence version replaced NM_177572.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057371.1, AK163360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BU611721.1         31-36
            7-1244              AK047164.1         2-1239
            1245-2836           BC057371.1         1226-2817
            2837-2837           AK047164.1         2832-2832
            2838-4093           BC057371.1         2818-4073
FEATURES             Location/Qualifiers
     source          1..4093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 55.4 cM"
     gene            1..4093
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /note="ribosomal modification protein rimK-like family
                     member A"
                     /db_xref="GeneID:194237"
                     /db_xref="MGI:MGI:3040686"
     exon            1..302
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1282
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /EC_number="6.3.2.41"
                     /EC_number="6.3.2.42"
                     /note="ribosomal protein S6 modification-like protein A;
                     N-acetylaspartyl-glutamate synthetase A; NAAG synthetase
                     A; N-acetylaspartylglutamylglutamate synthase A"
                     /codon_start=1
                     /product="N-acetylaspartylglutamate synthase A"
                     /protein_id="NP_808240.2"
                     /db_xref="CCDS:CCDS18583.1"
                     /db_xref="GeneID:194237"
                     /db_xref="MGI:MGI:3040686"
                     /translation="MCAQVWLLTDRLIREDYPQVQILRALRQRCSEQDVGFRAVFLDQ
                     IAVTVVGGHLGLQLSQKPLTTFPDVVVVRVSTPSVQSDSEITILRHLEKLGCRLVNRP
                     QSILNCINKFWTFQELAGHGVPMPDTFSYGGHEDFSKMIDEAEPLGYPVVVKSTRGHR
                     GKAVFLARDKHHLSDICHLVRHDVPYLFQKYVKESHGKDIRVVVVGGQVIGSMLRCST
                     DGRMQSNCFLGGVGVKCPLTEQGKQLAIQVSNILGMDFCGIDLLIMDDGSFTVCEANA
                     NVGFLAFDQACNLDVGAIIADYAMSLLPNRQTGKMAILPGLASPREKNEPNGCVSAQG
                     VAESVYAITNGSTSSESEPELGEARDSSVKTMGAPPAHVAQAWLQH"
     exon            303..533
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /inference="alignment:Splign:2.1.0"
     exon            534..620
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /inference="alignment:Splign:2.1.0"
     exon            621..824
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /inference="alignment:Splign:2.1.0"
     exon            825..4067
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4039..4044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /note="hexamer: AATATA"
     polyA_site      4067
                     /gene="Rimkla"
                     /gene_synonym="B930030J24; NAAGS; NAAGS-II; Rimk"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtcggcg cgaggcgatc cggagcattc gccggccggg tctgcagagg cggctggcgc
       61 acggcgcaag caaagccgcg gtgctcgcct gggacgcgcc agggggtcgc gcgggcgagc
      121 ggccgcagct tcggtcgcca tgtgcgcgca ggtctggctg ctgaccgacc ggctcatccg
      181 cgaggactac ccgcaggtgc agatcctgcg cgcgctccgc cagcgctgct cggagcagga
      241 cgtgggtttc cgggcggtgt tcctggacca gatcgccgtc accgtcgtcg gcggccacct
      301 aggcctgcag ctgagccaga aacccctgac caccttcccc gacgtggtgg ttgttcgagt
      361 atccacaccc tctgtccagt cggatagtga gatcaccatc ctgaggcacc tggagaagct
      421 gggctgccgc ttggtcaacc gtcctcaaag catcttaaac tgcatcaaca agttttggac
      481 attccaagag ctggctggac atggggtccc catgccagac accttctcct atggtgggca
      541 cgaagacttc tctaaaatga tcgatgaagc tgagcccctg ggctacccag tggtggtgaa
      601 gagcacacgg gggcaccggg ggaaagctgt ttttctggcc agagacaagc atcacctctc
      661 tgacatctgc cacctagtcc gccatgatgt gccctacctg ttccagaagt atgtgaaaga
      721 gtcgcacggg aaggacatcc gggtggtggt ggtgggtggc caggtgattg gctccatgct
      781 gcgctgctcc acagacggcc gcatgcaaag caactgcttt ctaggtggtg tgggtgtcaa
      841 gtgcccactg accgagcaag gcaagcagct ggctatccag gtgtccaaca tcctgggcat
      901 ggatttctgt ggcatcgacc ttcttatcat ggatgacggc tccttcacgg tgtgtgaggc
      961 caacgccaat gtcggcttcc tggccttcga ccaggcatgc aacttagatg tgggggcaat
     1021 cattgcagac tatgctatgt ccctgctgcc aaacaggcag actgggaaga tggccatcct
     1081 cccgggactg gcaagtccca gggagaagaa cgagccaaat ggttgcgttt cagctcaggg
     1141 agttgcagag agtgtctatg ccatcaccaa tgggtctacc tctagtgaga gtgagcctga
     1201 actgggagag gcccgggatt cctcagtaaa aacaatgggg gccccgcctg cgcatgttgc
     1261 ccaagcctgg ttacagcatt aacaggattg cgtcacgatt ccagtgaatt cctgctttct
     1321 tggcagcatt taaaccaaat gctactgctt ccctgagtag tgttcagtga attagatctg
     1381 gactaacatg atttcatttg cacaggaact agaaaacccc atccaggcac tcagcatcct
     1441 ttctgataac agtctgaaca aaccgcctag ctttgtgggt tttgtaaaga ctcataaaaa
     1501 aagcactcat ggagaacaac ttcccgaatg atcgatttga gaccaacgtc tattgcgagc
     1561 atgtggatgg aagggtgggg ctttaaggca ctgagtccat gttgctgtgc ctggtcctta
     1621 gcagcagcga acatgaactt ggctcctgga aacaccgttc tctcatgcag gagatggagg
     1681 cagaggtgtg tgcaggcagg cgagatgctc ctctctgctt cccccggtca ccgtcttacc
     1741 acatttctcc gacattcagc ttctcactga agcgctctgt agaaggtgag gtggaacatc
     1801 ctttgacctc gccggttggc atgtgtcctg cttcgtaaca ggggatttct acagatggct
     1861 ttgtctctca gaattcacac ccttgcttta cctattgtca gctctagcag cttcatgcac
     1921 ctttgctgcc tttggcctca gctggaaatg catctgatga gctatggcca cactctttgt
     1981 ttcttgtgcc ctagaatgca acaccataga ctttccttct caatggactc tgcccacttg
     2041 tcatctggaa gccagtggga ttttaccaca gaaagctact gggcgatgac tgttcttccc
     2101 tctgcttctt ctggacatgc tcctgttatc cagactccag gaacctggtc ttacccattt
     2161 ttccaaatcg gagagacttg ggtatttgtg gaggggtgag tgggctattg tagacatgat
     2221 atcaagtgct ttcctttata actctttaag cagtagatga gatctttccc ctggaagaaa
     2281 tggtagaggc ggagttttgt ttctgcatat agaaggtcta actcaaaaca agcaatggcc
     2341 aaatccaccc cgagttacct cattatactc actaggaaga ccatcctcct cagctatttt
     2401 atggcaggtg ccaagaacgc tgaggcttcc tctttgggat tacttcaata gccatcaatt
     2461 ccgagaggca agaggcctca taactttatc aacgggcctt gtttagtttc ttaccacccc
     2521 cctacataca tacacacaca cacaactcct gctacctgcc aaggcagtgc caagttccac
     2581 cacccattgt atttaccaga cacaatgctc tttggctatt aataattata gacctgtcat
     2641 aaaggacaaa gatttgccca tcctgaagaa gcatctaagt tcacaatttc caaggaagat
     2701 tctagaaatg tgagttgggc cagctacact ggagtaagca tacgctttcc ttaaggtatc
     2761 tactttgaag gcaccactac ccaataggca cataattcct gcactctact gtaagtataa
     2821 aatgtatata aaccaaatga taattttttc ccacaacaca catttaaata gaaattggcc
     2881 tttaaaatta gttaaaacaa gatttcacca actgacagtc atacacctga aaatgttggt
     2941 cccatgtgac agaagtcata cctcactgct atagttccta tgcagtctca cccctgggtg
     3001 catgccacta aactgtaatc tgagtgtgtg tctataccat tgaaaaatga cagttcaccc
     3061 tcatagacta agactggtat cttctcctta gcactcaggg gtggctttaa aggaaggcta
     3121 gttatattct gttcctgctg gaagaggtca gatgggagcc aggcattggc ccctgagaag
     3181 ctgatagata tcagaacact gatagatgcc cagtgtttag cccaagcctc ttctcattga
     3241 tcgaagtcca tctaggccct acctgagcag agcggctcgg agtgtttcca gattcctttg
     3301 ccaaagaggc ccatttccca gctggcagag atgtctgcca acggtgttat tgcccagaac
     3361 tgcctgccta gaggcagaga aagctgactc tcatctggat cctagcccca ctctgggatt
     3421 tccataccac agctggccat ggtcacatcc ttgagtctca gctctgtggc cccgccatac
     3481 ttgccacagc tgcctacact tgttggaaag aacaaaggga tgcagagcgg gagtctggcc
     3541 ctggctctcc caacacagct gggcacctga gctctgtgtc tccatcttcc cattctgtag
     3601 acagggaaaa tggcctattt catttacctc atggtgcact ctgaggctga agtgagttac
     3661 aaagcacagc tgtctgtctg ggaagaggta acagacacct cccagtgtag tgtgtttttc
     3721 attgctcctg agagagttga aaaaggaaga ggctatgtat tcttggcctt agcaagctca
     3781 atagtagtat gggccccaag atacagagcg cacttacagg ccttccttct agacacaggt
     3841 acttcacaac atgaagcgag taaggcatcc aaggaacctt ctagaggccc tgcataacct
     3901 gaaaccctga ctcgtgtacg ccaacaccaa gtcttcctct gtaatataga ttcagggggt
     3961 gtgtgtggtc tttccactgt cttgtagcaa catcttgaaa ctggtcaaaa cttgaatgtc
     4021 aatagctgag tcactcagaa tatacatgat tctgcacttg ggaaaaaaaa aaaaaaaaaa
     4081 aaaaaaaaaa aaa
//
