LOCUS       NM_001378900            4922 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RIMS binding protein 2 (Rimbp2), transcript variant 3,
            mRNA.
ACCESSION   NM_001378900 XM_030254431
VERSION     NM_001378900.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4922)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4922)
  AUTHORS   Miyano,R., Sakamoto,H., Hirose,K. and Sakaba,T.
  TITLE     RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter
            release at hippocampal mossy fiber terminals
  JOURNAL   Elife 12, 90799 (2024)
   PUBMED   38329474
  REMARK    GeneRIF: RIM-BP2 regulates Ca[2+] channel abundance and
            neurotransmitter release at hippocampal mossy fiber terminals.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4922)
  AUTHORS   Banerjee,A., Imig,C., Balakrishnan,K., Kershberg,L., Lipstein,N.,
            Uronen,R.L., Wang,J., Cai,X., Benseler,F., Rhee,J.S., Cooper,B.H.,
            Liu,C., Wojcik,S.M., Brose,N. and Kaeser,P.S.
  TITLE     Molecular and functional architecture of striatal dopamine release
            sites
  JOURNAL   Neuron 110 (2), 248-265 (2022)
   PUBMED   34767769
REFERENCE   4  (bases 1 to 4922)
  AUTHORS   Butola,T., Alvanos,T., Hintze,A., Koppensteiner,P., Kleindienst,D.,
            Shigemoto,R., Wichmann,C. and Moser,T.
  TITLE     RIM-Binding Protein 2 Organizes Ca2+ Channel Topography and
            Regulates Release Probability and Vesicle Replenishment at a Fast
            Central Synapse
  JOURNAL   J Neurosci 41 (37), 7742-7767 (2021)
   PUBMED   34353898
  REMARK    GeneRIF: RIM-Binding Protein 2 Organizes Ca(2+) Channel Topography
            and Regulates Release Probability and Vesicle Replenishment at a
            Fast Central Synapse.
REFERENCE   5  (bases 1 to 4922)
  AUTHORS   Mencacci,N.E., Brockmann,M.M., Dai,J., Pajusalu,S., Atasu,B.,
            Campos,J., Pino,G., Gonzalez-Latapi,P., Patzke,C., Schwake,M.,
            Tucci,A., Pittman,A., Simon-Sanchez,J., Carvill,G.L., Balint,B.,
            Wiethoff,S., Warner,T.T., Papandreou,A., Soo,A., Rein,R.,
            Kadastik-Eerme,L., Puusepp,S., Reinson,K., Tomberg,T., Hanagasi,H.,
            Gasser,T., Bhatia,K.P., Kurian,M.A., Lohmann,E., Ounap,K.,
            Rosenmund,C., Sudhof,T.C., Wood,N.W., Krainc,D. and Acuna,C.
  TITLE     Biallelic variants in TSPOAP1, encoding the active-zone protein
            RIMBP1, cause autosomal recessive dystonia
  JOURNAL   J Clin Invest 131 (7) (2021)
   PUBMED   33539324
REFERENCE   6  (bases 1 to 4922)
  AUTHORS   Acuna,C., Liu,X. and Sudhof,T.C.
  TITLE     How to Make an Active Zone: Unexpected Universal Functional
            Redundancy between RIMs and RIM-BPs
  JOURNAL   Neuron 91 (4), 792-807 (2016)
   PUBMED   27537484
REFERENCE   7  (bases 1 to 4922)
  AUTHORS   Acuna,C., Liu,X., Gonzalez,A. and Sudhof,T.C.
  TITLE     RIM-BPs Mediate Tight Coupling of Action Potentials to
            Ca(2+)-Triggered Neurotransmitter Release
  JOURNAL   Neuron 87 (6), 1234-1247 (2015)
   PUBMED   26402606
REFERENCE   8  (bases 1 to 4922)
  AUTHORS   Mittelstaedt,T. and Schoch,S.
  TITLE     Structure and evolution of RIM-BP genes: identification of a novel
            family member
  JOURNAL   Gene 403 (1-2), 70-79 (2007)
   PUBMED   17855024
  REMARK    GeneRIF: Rimbp2 is identified in mouse.
REFERENCE   9  (bases 1 to 4922)
  AUTHORS   Schoch,S., Mittelstaedt,T., Kaeser,P.S., Padgett,D., Feldmann,N.,
            Chevaleyre,V., Castillo,P.E., Hammer,R.E., Han,W., Schmitz,F.,
            Lin,W. and Sudhof,T.C.
  TITLE     Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered
            neurotransmitter release
  JOURNAL   EMBO J 25 (24), 5852-5863 (2006)
   PUBMED   17124501
REFERENCE   10 (bases 1 to 4922)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110566.17, AC116715.22 and AC111089.27.
            
            On Mar 13, 2020 this sequence version replaced XM_030254431.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.16653.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC110566.17        36755-36848         c
            95-182              AC116715.22        87588-87675
            183-297             AC116715.22        95482-95596
            298-402             AC116715.22        113412-113516
            403-453             AC116715.22        119647-119697
            454-658             AC116715.22        126698-126902
            659-795             AC111089.27        209537-209673       c
            796-872             AC111089.27        208495-208571       c
            873-982             AC111089.27        206628-206737       c
            983-1795            AC111089.27        202741-203553       c
            1796-1947           AC111089.27        195317-195468       c
            1948-2403           AC111089.27        193869-194324       c
            2404-2550           AC111089.27        192362-192508       c
            2551-2709           AC111089.27        190501-190659       c
            2710-2827           AC111089.27        185969-186086       c
            2828-3012           AC111089.27        179879-180063       c
            3013-3181           AC111089.27        179047-179215       c
            3182-3285           AC111089.27        177410-177513       c
            3286-3357           AC111089.27        175939-176010       c
            3358-3492           AC111089.27        167050-167184       c
            3493-4922           AC111089.27        163501-164930       c
FEATURES             Location/Qualifiers
     source          1..4922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 67.91 cM"
     gene            1..4922
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /note="RIMS binding protein 2"
                     /db_xref="GeneID:231760"
                     /db_xref="MGI:MGI:2443235"
     exon            1..94
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            95..182
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            183..297
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            298..402
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..3681
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="RIMS-binding protein 2 isoform 3"
                     /protein_id="NP_001365829.1"
                     /db_xref="GeneID:231760"
                     /db_xref="MGI:MGI:2443235"
                     /translation="MREAAERRQQLELEHEQALAFLNAKQQEIQLLQQAQVEAKKEHE
                     GAVQLLESKVRELEEKCRVQSEQFNLLSRDLEKFRQHTGSIDLLGSSSVALLDVPLAP
                     GKPFPQYMNGLATSIHKGHEGPTGHYSVIGDYIPLSGDKLESPCVKPSFLLRSSSPRC
                     RFESEMDNDRNSNNSKQSSSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYG
                     DMDEDGFYEGELLDGQRGLVPSNFVDFIQDNESRLAGTLGSEQDQNFLNHSGISLERD
                     SILHLHSPTQVDSGITDNGGGTLDVNIDDIGEDTVPYPRKITLIKQLAKSVIVGWEPP
                     AVPPGWGTVSSYNVLVDKETRMSLALGRRTKALIEKLNTAACTYRISVQCVTSRGNSD
                     ELQCTLLVGKDVVVAPSQLRVDNITQISAQLSWLPTNSNYSHIIFLNEEELDIVKAAR
                     YKYQFFNLRPNMAYKVKVLAQPHQMPWQLPLEQREKKEACVEFSTLPAGPPAPPQDVT
                     VHAGATAASVQVSWKPPALTPTGLSNGANVTGYGVYAKGQRVAEVIAPTADGTAVELI
                     RLRSLEAKAVSVRTLSVQGESMDSALAAIPPDLLVPPAPHPRTAPPPKPLASDMDTKD
                     QHLGPHVKVDESWEQSRSPGPAHGHMLEPPDMHSAGPGRRSPSPSRILPQPQGAPVST
                     TVAKAMAREAAQRVAESNRLEKRSLFLEQSSAGQYTNSDEEDGYASPEVKRRGTSVDD
                     FLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGTS
                     HNALKILGNSTLMGRADRMEHVSRRYSHSGGGSHRHRPAMAPSIDEYTGRDHLSPDFY
                     DESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGF
                     YRGETCARLGLIPCNMVSEIHADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRGHSV
                     PTRRMVALYDYDPRESSPNVDVEAELPFCTGDIITVFGEIDEDGFYYGELNGQKGLVP
                     SNFLEEVPDDVEVHLSDAPPHYSHDPPMRSKAKRVPPEGSGTARRAPSPTAHLHSGSP
                     TSSMGSGSPGRGREMSSKKKKGLLSRGKKLLQRLAAVK"
     exon            403..453
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            454..658
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            659..795
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            796..872
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            873..982
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1795
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1947
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2403
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2550
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2709
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2827
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..3012
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3181
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3285
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3357
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3492
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..4922
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4897..4902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /note="hexamer: AATAAA"
     polyA_site      4922
                     /gene="Rimbp2"
                     /gene_synonym="A930033C01Rik; mKIAA0318"
                     /note="major polyA site"
ORIGIN      
        1 agtttgtaat ctgacacagt gcactgcagt ggctgtctct gtctctctct tggagccttg
       61 gagcccggga ggctgggcac cgagaacatc caaggatgat gaactaaagg ccgctgtgca
      121 gagagagcat cacctgaagc ccctggaaag gccttccctt gagggcccgg cagcatgacc
      181 aggtgaaggc tgaacatgcc tggctctccg tggtgacctg agaggagagt tcgattcact
      241 gtgcgggaga aacgccagct ccaagccaaa ctggagaact tggaacaggt cctgaagcat
      301 atgcgagagg ctgctgagcg gcggcaacag ctggagttgg agcatgagca agccctggcc
      361 ttcctcaatg ccaagcagca ggagatccag ctactgcagc aggctcaggt tgaagctaag
      421 aaagagcatg aaggtgctgt gcagctgtta gagtccaagg tccgagagct ggaagagaaa
      481 tgccgtgtgc agagtgagca gtttaacttg ttgtcccggg acctggaaaa gttccggcaa
      541 cacactggga gtattgacct gctgggcagc agctcagtgg ccctgctgga tgttcccttg
      601 gcccctggca agcctttccc tcagtacatg aatggactag ccacctccat ccacaaaggt
      661 cacgagggcc ccactggaca ctactctgtg attggtgact atattccgct gtctggggac
      721 aagctggagt ctccgtgtgt gaagccctcc ttcctcttgc gatccagcag cccaagatgc
      781 agatttgagt ccgagatgga caatgaccgg aactctaaca actccaagca aagcagctcg
      841 gggaaggtgc acctgtgtgt ggcccgctac agttacaacc ccttcgatgg gcccaatgag
      901 aacccagaag ctgagctgcc tctcacggcg ggaaagtacc tctatgtcta tggggacatg
      961 gatgaagatg ggttctatga aggagagctt ctggatgggc aaaggggctt ggtgccctcc
     1021 aactttgtgg attttatcca ggacaatgag tcgcggctgg ctggtactct ggggagtgag
     1081 caggaccaga actttctcaa ccactctggc atcagtctgg agcgcgacag catccttcac
     1141 cttcactccc caactcaagt ggactcgggg atcaccgaca atggtggggg gaccctggac
     1201 gtgaacatcg acgacatcgg agaagacacc gtgccttacc ctaggaaaat cacccttatc
     1261 aaacagcttg ccaaaagtgt catcgtgggc tgggagcccc ctgctgtgcc tcccggctgg
     1321 ggcaccgtga gcagttataa tgtgctggtg gacaaagaga cacgcatgag ccttgccctg
     1381 ggtaggagaa ctaaggcgct gatcgagaaa cttaacacag ctgcctgcac ctaccgcatc
     1441 tccgtgcagt gcgtcacgag ccggggaaac tcagacgagc tgcagtgcac tctgctggtg
     1501 ggcaaggatg tggtggtggc accgtcccag ctgcgtgtgg acaacatcac acagatctct
     1561 gcccagctct cgtggctgcc gaccaacagt aactacagcc atatcatctt cctcaacgaa
     1621 gaagaactgg acatcgtgaa ggcagccagg tacaagtacc aattcttcaa cctcaggcct
     1681 aatatggcct acaaggtgaa ggtcttggcc cagccacacc agatgccctg gcagctgccg
     1741 ctggagcaga gagaaaagaa ggaggcctgt gtggagttct ccacgctgcc tgcaggacct
     1801 ccagccccac cacaagatgt cactgtccac gctggggcca cagccgcctc tgttcaggtc
     1861 tcctggaagc cccctgcact gactcccact gggttgtcca atggagcaaa tgtcacagga
     1921 tacggcgtgt acgccaaagg gcagagggtg gctgaggtca tcgcccccac ggcagatggc
     1981 acggcagtgg agctgatccg gctgcgaagc ctagaggcca aggccgtgag tgtgcgtacc
     2041 ctgtctgtac agggagagtc catggattct gccctcgctg ccatcccccc tgacctcctg
     2101 gtgcctccag ccccccaccc gaggactgct cccccaccaa agccattagc aagtgacatg
     2161 gataccaaag accaacacct ggggccccac gtcaaagtgg atgagtcctg ggagcagagc
     2221 cggtcaccgg gccctgcaca tggccacatg ttggaaccac ctgacatgca cagcgctggc
     2281 ccaggcagaa ggtcaccctc gcccagccgg atccttcctc agccacaagg agcccccgtg
     2341 tctaccactg tcgccaaggc catggcccgt gaagctgcac agagggtggc tgagagcaac
     2401 aggttagaga aaaggagcct ctttctagag caaagcagtg cggggcaata taccaactcg
     2461 gacgaggagg acggctacgc ctcccccgag gtcaagagga gaggcacctc agtggatgac
     2521 ttcctcaaag ggtcagagct gggcaagcag ccccactgtt gccatggaga tgagtaccac
     2581 acagagagca gccgggggtc agacctgtcg gacatcatgg aggaggatga ggaggagcta
     2641 tactcagaga tgcagctgga ggatgggggc cgccgtcggc ccagcggtac ctctcacaac
     2701 gccctcaaga ttttaggaaa ctccacgttg atgggacgag cagaccggat ggaacacgtg
     2761 agccgaaggt attcacacag tggcggaggg tctcataggc accgcccagc gatggctcca
     2821 tccattgatg aatacaccgg gcgagaccat ctttctccag acttctatga tgagtccgaa
     2881 actgaccctg gtgctgagga gctcccagcc cgtatctttg tggctctgtt tgactatgac
     2941 ccactgacca tgtccccaaa cccagacgct gctgaagagg agcttccctt caaagaagga
     3001 cagatcatca aggtatatgg agacaaagac gcagatggct tctaccgtgg ggagacctgt
     3061 gccaggctcg gcctcattcc ctgtaacatg gtctctgaga tccatgcgga tgatgaggag
     3121 atgatggatc agctgctgag gcaaggcttc ctccctctga acacgcctgt ggagaaaata
     3181 gagagaagta gaagaagcgg ccggggtcac tctgtaccca cacgaagaat ggtggctctc
     3241 tacgactatg atcctaggga aagctctcct aacgtggatg ttgaggctga acttccattt
     3301 tgcacaggag acattattac tgtttttggt gaaatcgatg aagatggatt ttattatgga
     3361 gagctgaatg ggcaaaaagg cctcgtgcct tccaatttcc tggaagaagt gcctgatgat
     3421 gtggaggtcc acctttctga tgctccgccc cactactccc acgacccgcc catgcgctcc
     3481 aaggccaaaa gggttcctcc cgagggttca gggacagcaa ggagagctcc atcccccaca
     3541 gcccatctcc attcggggtc acctacgtca tctatgggtt ctggtagtcc tgggagaggc
     3601 agggaaatgt cctcgaaaaa gaaaaaaggg ctgctctcca gaggcaagaa attgctgcaa
     3661 aggctggccg cagtgaagtg acccctgagc ctccggacac ttccaaatcc atgtcactgg
     3721 ctttaattcc aaacgaggac tcccaaaacc caaccttgac ccccaccccc caccccagca
     3781 gtagagagct acactcttac actaccattc acatgatacc actggagaga tcagggaagg
     3841 ggctgcaccg tggtcccctc cccctccgct cccaaggttc tgtccaaggt ctggggtggg
     3901 gaggtgggtg gggggcagct ggctgagcag cagaaggggc agggggaggg ctctctgcag
     3961 ccacctcccc tccacctgca gttccagcct gcacgcatta gagtgtagcc ctgacaggct
     4021 ttctgacctc tccccctctc cccccccccc cacctctcaa gacgtttgcc tcattacaca
     4081 ttattgtcat tttcacgcgg ctcttgagat tcctagttta actcgccttg atgttctggc
     4141 cttataactg cacagtggtt tgtactgtcg aataaaaaac accgtgtata cttcgcatgt
     4201 gttgtgcatt cctggtcttc atcctcactt gacacagtgg cttcacctca cagtggccca
     4261 ggccctacac tttcagatgc ctgtcttggg tctttcaacg caagccagca acacacagga
     4321 catgtttact tagcccacca cacgagagac aggggaaagg agcgggagca actgggcagc
     4381 atgcatgtcc tctagccagc cagggagctg accaatcttt gcctttagtg tcctatcctg
     4441 tggcttttag ctttctgttc ctttcattat ttgttgaaat gccttgcccc gagacaccat
     4501 ccacagcaca catagcaaag ccaccacacg cttcattagc cagaccagaa ggagcctaaa
     4561 ttgaaatctc tcagacaccc cacacccatc tttatcatta gcctcgaaca gcaaacctcc
     4621 ccagacgctg gctgatggga tggccacaac tttgtaattc ctgtccactg taaactgttt
     4681 ttacttcttt atacatactt ttcagactgc ctttcttttg taatttctgg aaggtttgta
     4741 aatgaatggc aaagctttcc ctgtgcgtct tcagaaacta tattgtacat tgtaatataa
     4801 ttgtatgtgg tagattgatt aaaaggtcgt tcctcggtgt gtgaagtact gtgcgggtgt
     4861 gtgcatgtgt acagctaggg tgacatattt tctagaaata aactttgtta ttttgtacaa
     4921 ca
//
