LOCUS       NM_030259               1278 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus Rab interacting lysosomal protein-like 2 (Rilpl2),
            mRNA.
ACCESSION   NM_030259
VERSION     NM_030259.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Dhekne,H.S., Yanatori,I., Vides,E.G., Sobu,Y., Diez,F., Tonelli,F.
            and Pfeffer,S.R.
  TITLE     LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during
            ciliogenesis blockade
  JOURNAL   Life Sci Alliance 4 (5), e202101050 (2021)
   PUBMED   33727250
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Cao,Q.J., Zhang,N., Zhou,R., Yao,L.L. and Li,X.D.
  TITLE     The cargo adaptor proteins RILPL2 and melanophilin co-regulate
            myosin-5a motor activity
  JOURNAL   J Biol Chem 294 (29), 11333-11341 (2019)
   PUBMED   31175157
  REMARK    GeneRIF: propose that Rab36 stimulates RILPL2 to interact with the
            myosin-5a globular tail domain (GTD); this interaction then induces
            exposure of the melanophilin-binding site in the GTD, enabling
            melanophilin to interact with the GTD and activate myosin-5a motor
            activity
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   Schaub,J.R. and Stearns,T.
  TITLE     The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane
            content
  JOURNAL   Mol Biol Cell 24 (4), 453-464 (2013)
   PUBMED   23264467
  REMARK    GeneRIF: The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary
            membrane content by promoting protein removal from the primary
            cilium.
REFERENCE   9  (bases 1 to 1278)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   10 (bases 1 to 1278)
  AUTHORS   Lise,M.F., Srivastava,D.P., Arstikaitis,P., Lett,R.L., Sheta,R.,
            Viswanathan,V., Penzes,P., O'Connor,T.P. and El-Husseini,A.
  TITLE     Myosin-Va-interacting protein, RILPL2, controls cell shape and
            neuronal morphogenesis via Rac signaling
  JOURNAL   J Cell Sci 122 (Pt 20), 3810-3821 (2009)
   PUBMED   19812310
  REMARK    GeneRIF: These data represent a novel mechanism linking RILPL2, the
            motor protein MyoVa and Rac1 with neuronal structure and function.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC003324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003324.1, AK133760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.6 cM"
     gene            1..1278
                     /gene="Rilpl2"
                     /note="Rab interacting lysosomal protein-like 2"
                     /db_xref="GeneID:80291"
                     /db_xref="MGI:MGI:1933112"
     exon            1..456
                     /gene="Rilpl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..744
                     /gene="Rilpl2"
                     /note="rab-interacting lysosomal-like protein 2"
                     /codon_start=1
                     /product="RILP-like protein 2"
                     /protein_id="NP_084535.1"
                     /db_xref="CCDS:CCDS19676.1"
                     /db_xref="GeneID:80291"
                     /db_xref="MGI:MGI:1933112"
                     /translation="MEDHPVREEEDGEEDEGALAKSPLQLTTDDVYDISYVVGRELMA
                     LGSDPRVTRLQFKIVRVMEMLETLVNEGSLAVEELRMERDNLKQEVEGLRKAGVSGAQ
                     VNLGPDKMVVDLTDPNRPRFTLQELREVLQERNKLKSQLLLVQEELQCYRSGLLPPRE
                     TPGGRREKDAVVAMGNGEKEERTIMKKLFSFRSGKHT"
     exon            457..608
                     /gene="Rilpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..713
                     /gene="Rilpl2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..1260
                     /gene="Rilpl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1185..1190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rilpl2"
                     /note="hexamer: ATTAAA"
     polyA_site      1205
                     /gene="Rilpl2"
                     /note="major polyA site"
     regulatory      1232..1237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rilpl2"
                     /note="hexamer: AATAAA"
     polyA_site      1260
                     /gene="Rilpl2"
ORIGIN      
        1 gttcggtgct acccgctact cggcgcaatt ccccaaggcc gcccagactg cgcacagcgt
       61 ggactcggcc cagtgcaaag tttccctgac ccagagtcag tggacgcata ggtgccacca
      121 gccccggagg tcgccgaagt ccggggtacc atggaggatc accccgtgcg ggaggaggag
      181 gacggcgagg aagacgaggg cgccctggcc aagagccccc tgcagctgac caccgacgac
      241 gtgtacgaca tctcctatgt agtgggccgc gagctgatgg ccctgggcag cgacccccgc
      301 gtcacccggc tgcagttcaa gatagtacgt gtgatggaga tgctggagac gctggtaaac
      361 gagggcagcc tggcggtcga ggaactgagg atggagagag acaacctcaa gcaagaggtg
      421 gaggggctgc ggaaagccgg tgtgtccgga gcccaggtaa acttgggacc ggacaagatg
      481 gtagtggatc tgacagaccc caaccgtccc cgcttcactc tgcaagagct gagggaggtg
      541 ctgcaggagc gaaacaagct caagtcgcag ctgctgctgg tgcaggagga actgcagtgc
      601 tacaggagtg gtctacttcc acccagagaa actccaggag gaagaagaga gaaggatgct
      661 gtggttgcca tgggcaacgg cgagaaggag gagaggacca ttatgaagaa gctgttctct
      721 ttccggtcag ggaagcatac ctagactgaa aaccatcacc aagatggtga ccctcttgac
      781 ttgagaagac aattgccaat atgccttctg gaaccacctt cctgtgtcag gaatgtgcct
      841 tggcttgctc ctgcacagag cagtcagagg aagatgctcc ctcccatggc tcacctgctc
      901 tctggggaca gacctggaca gtcagtaagc tttggccagg ccaaatgagg ccaatactga
      961 gaactggaga aagcaaagga acagagtgtg tggctgcatc ccgcctcctc cacacatgga
     1021 cagaggcctc tggcctgtgg ctcgttcctg cctccgtgat tatctggtcc ttagcacgtg
     1081 gccgggagcg atggaaaagc aggaacatat ggaatcatcg ccttgactga tatttgatga
     1141 atacttgatc tctctcattc aacttttctt tatacaatgt ttgtattaaa gtgaaaagac
     1201 ttttataatg tctattactg tttcttaaaa taataaagat ggtgtatatg caggtgggaa
     1261 aaaaaaaaaa aaaaaaaa
//
