LOCUS       NM_001417895            2239 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus Rab interacting lysosomal protein-like 1 (Rilpl1),
            transcript variant 1, mRNA.
ACCESSION   NM_001417895 XM_036165582
VERSION     NM_001417895.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2239)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2239)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 2239)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2239)
  AUTHORS   Schaub,J.R. and Stearns,T.
  TITLE     The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane
            content
  JOURNAL   Mol Biol Cell 24 (4), 453-464 (2013)
   PUBMED   23264467
  REMARK    GeneRIF: The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary
            membrane content by promoting protein removal from the primary
            cilium.
REFERENCE   5  (bases 1 to 2239)
  AUTHORS   Ohbayashi,N., Maruta,Y., Ishida,M. and Fukuda,M.
  TITLE     Melanoregulin regulates retrograde melanosome transport through
            interaction with the RILP-p150Glued complex in melanocytes
  JOURNAL   J Cell Sci 125 (Pt 6), 1508-1518 (2012)
   PUBMED   22275436
REFERENCE   6  (bases 1 to 2239)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   7  (bases 1 to 2239)
  AUTHORS   Sen,N., Hara,M.R., Ahmad,A.S., Cascio,M.B., Kamiya,A., Ehmsen,J.T.,
            Agrawal,N., Hester,L., Dore,S., Snyder,S.H. and Sawa,A.
  TITLE     GOSPEL: a neuroprotective protein that binds to GAPDH upon
            S-nitrosylation
  JOURNAL   Neuron 63 (1), 81-91 (2009)
   PUBMED   19607794
  REMARK    GeneRIF: In intact mice, virally delivered GOSPEL selectively
            diminishes NMDA neurotoxicity. Thus, GOSPEL may physiologically
            regulate the viability of neurons and other cells.
            Erratum:[Neuron. 2009 Sep 10;63(5):709. Aggrawal, Nishant
            [corrected to Agrawal, Nishant]]
REFERENCE   8  (bases 1 to 2239)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   9  (bases 1 to 2239)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127313.3.
            
            On Mar 13, 2023 this sequence version replaced XM_036165582.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.5035883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               AC127313.3         106859-107541       c
            684-834             AC127313.3         97435-97585         c
            835-953             AC127313.3         91702-91820         c
            954-1178            AC127313.3         90703-90927         c
            1179-1357           AC127313.3         79739-79917         c
            1358-1450           AC127313.3         78024-78116         c
            1451-1474           AC127313.3         72083-72106         c
            1475-2239           AC127313.3         69264-70028         c
FEATURES             Location/Qualifiers
     source          1..2239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.62 cM"
     gene            1..2239
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /note="Rab interacting lysosomal protein-like 1"
                     /db_xref="GeneID:75695"
                     /db_xref="MGI:MGI:1922945"
     exon            1..683
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1619
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RILP-like protein 1; rab-interacting lysosomal-like
                     protein 1"
                     /codon_start=1
                     /product="RILP-like protein 1 isoform 1"
                     /protein_id="NP_001404824.1"
                     /db_xref="GeneID:75695"
                     /db_xref="MGI:MGI:1922945"
                     /translation="MEEPLGSPPAALSALEKNVAELTVMDVYDIASLVGHEFERVIDQ
                     HGCESIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRVERMDRIEKERKHQ
                     KELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLNHKDVGFSEEEFQKQEGMSERER
                     QVMKRLKEVVDKQRDELRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQ
                     GKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEEAEIQPQPDGE
                     ESISDAEKAALDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEIEEE
                     NRIPQPPPITHPRTSPQPESGIKRLKEGPLSDGFSFFSRDKKRLANTQRPTHIHESFG
                     QWAITQRDDGYTEQGQEALQHL"
     exon            684..834
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     exon            835..953
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1178
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1357
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1450
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1474
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..2239
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2239
                     /gene="Rilpl1"
                     /gene_synonym="2900002H16Rik; 6330559I19Rik; GOSPEL"
                     /note="major polyA site"
ORIGIN      
        1 ggggctgcgc accgagaccc ccggggacag agactcgctc cccctcctct ccaaacccac
       61 gtcgcctcgc agcgttccca cggggaggag ccggccaacc ggagtcactc ggcgtcacca
      121 aagtttgatt ctcctctccg ggaggagtct ccgggccgcg gtccctccgg gcaccgggcg
      181 ccaccgcctc ccaggccggg acccgcgtct ccatcgcacc cagttggagc atcaagtccg
      241 gagacgctgc gggcctgcgc acgcgccgcc gccctcgccc tcctccccgc ggtgctccag
      301 gccccccgca ctcccccccc cccaagttca cgagttactg gagtggacgg acggctggga
      361 gcccgcgcag ggccatggag gagccgctag ggtcaccgcc cgccgccctg tcggctctgg
      421 agaagaacgt ggcggagctg accgtcatgg atgtgtacga tatcgcgtcg ctcgtgggcc
      481 acgagttcga gagggtcatc gaccaacacg gctgcgagtc catcgcacgc ctcatgccca
      541 aggtcgtgag ggtcctggag atcctcgagg tgctggttag ccggcaccac gtcgctcccg
      601 agctagacga gctgcgcctg gaactggacc ggttgcgcgt agagaggatg gaccgcattg
      661 aaaaggagcg caagcatcaa aaggagctgg agctggtgga ggacgtgtgg cggggtgaag
      721 cacaggacct cctgtcccag attgcccagc tgcaggagga gaataagcag ctgatgacca
      781 acctcaacca caaggacgtg ggcttctccg aggaggagtt ccagaagcag gaaggcatgt
      841 cagagcgtga gcggcaggtg atgaagaggc tgaaggaggt ggtggacaag cagagggatg
      901 agctccgagc caaagacagg gagctgggcc tgaagaatga ggacgtcgag gctttgcagc
      961 agcagcagac gaggctaatg aagatcaacc atgaccttcg gcaccgggtc accgtggttg
     1021 aggcccaggg gaaagccctg attgagcaga aggtggagct cgaagcagac ctgcagacca
     1081 aggagcagga gatgggcagc ctgcgggctg aactcggaaa gcttcgcgag aggctgcagg
     1141 gcgagcacag ccagaatggg gaggaggagg aggctgagat ccagccgcag ccagatggag
     1201 aggaatcgat ttcagatgca gagaaggccg ccctggacct caaggacccc aaccgcccga
     1261 ggttcacgct ccaggagctg cgggacgtcc tgcacgagag gaacgagctc aagtccaagg
     1321 tgtttctgct gcaagaggaa ctggcctact ataagagtga agaaatagaa gaagagaatc
     1381 gaatacccca gcctccgccc attacacacc cgaggacgtc cccccagcct gaatcgggga
     1441 tcaagcgact taaagaaggt cctttgagtg acgggtttag ctttttctcc cgggacaaga
     1501 agcgcctggc caacacgcag agacccacac acatccacga gtcctttggc cagtgggcaa
     1561 ttacccagcg agatgacggg tacacagagc aaggacagga agccctgcag cacctgtgac
     1621 tgtacctctg cctggactgc ctgccaccag ctctaggtgg cggccgcctc aacatcagtt
     1681 cctcaaacga actgtctgct ttgaggactg atgacgaaaa actgatgcca aatttgaaag
     1741 aagtgtttta tttatctgca gggctaccca gtttatactc aatgcctcga aacccttagg
     1801 acctctattt aataagatga ggatatgaaa ccagaccaca ttaatttcag ttaacaggct
     1861 ttctaagctg aacacttcgc cactatcata gctgtttgac tcctaggttt tgtttgtttt
     1921 cttacggcct ttgtcggtga ggagcagagg aagggagttt tatatcatga agttgccctg
     1981 gaggtagcag gctatacata acaggaagcg tgaatcggac aggtggagcc tcggatcata
     2041 ggatggacta cccagtttgg ctgggacaca acagaaaatc atgcagttct agccactcgc
     2101 tagaaacaac cacaggactg tcacactttg ttctgataaa gctagaggcc caagaagcct
     2161 gtccgagatg gtgtgccttg gaatctgctg tgagctacgc agtactaacc aaacaatgtt
     2221 gtttaggatg agacatcaa
//
