LOCUS       NM_001029938            1510 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Rab interacting lysosomal protein (Rilp), mRNA.
ACCESSION   NM_001029938 XM_207763 XM_489700
VERSION     NM_001029938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1510)
  AUTHORS   Ke,J., Pan,J., Lin,H., Huang,S., Zhang,J., Wang,C., Chang,A.C.Y.
            and Gu,J.
  TITLE     Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid
            Toxicity in Diabetic Cardiomyopathy
  JOURNAL   Adv Sci (Weinh) 11 (29), e2401676 (2024)
   PUBMED   38837607
  REMARK    GeneRIF: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates
            Lipid Toxicity in Diabetic Cardiomyopathy.
REFERENCE   2  (bases 1 to 1510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1510)
  AUTHORS   Wu,B., Shang,J., Lin,S., Jiang,N., Xing,B., Peng,R., Xu,X. and
            Lu,H.
  TITLE     A Novel Role for RILP in Regulating Osteoclastogenesis and Bone
            Resorption
  JOURNAL   Lab Invest 103 (5), 100067 (2023)
   PUBMED   36801641
  REMARK    GeneRIF: A Novel Role for RILP in Regulating Osteoclastogenesis and
            Bone Resorption.
REFERENCE   4  (bases 1 to 1510)
  AUTHORS   Sarkar,C., Sadhukhan,T., Bagh,M.B., Appu,A.P., Chandra,G.,
            Mondal,A., Saha,A. and Mukherjee,A.B.
  TITLE     Cln1-mutations suppress Rab7-RILP interaction and impair autophagy
            contributing to neuropathology in a mouse model of infantile
            neuronal ceroid lipofuscinosis
  JOURNAL   J Inherit Metab Dis 43 (5), 1082-1101 (2020)
   PUBMED   32279353
  REMARK    GeneRIF: Cln1-mutations suppress Rab7-RILP interaction and impair
            autophagy contributing to neuropathology in a mouse model of
            infantile neuronal ceroid lipofuscinosis.
REFERENCE   5  (bases 1 to 1510)
  AUTHORS   Zhou,Y., Liu,Z., Zhang,S., Zhuang,R., Liu,H., Liu,X., Qiu,X.,
            Zhang,M., Zheng,Y., Li,L., Hong,W. and Wang,T.
  TITLE     RILP Restricts Insulin Secretion Through Mediating Lysosomal
            Degradation of Proinsulin
  JOURNAL   Diabetes 69 (1), 67-82 (2020)
   PUBMED   31624142
  REMARK    GeneRIF: A new pathway regulating insulin secretion and a novel
            function of RILP in modulating insulin secretion through mediating
            the lysosomal degradation of proinsulin.
REFERENCE   6  (bases 1 to 1510)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 1510)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1510)
  AUTHORS   Matsui,T., Ohbayashi,N. and Fukuda,M.
  TITLE     The Rab interacting lysosomal protein (RILP) homology domain
            functions as a novel effector domain for small GTPase Rab36: Rab36
            regulates retrograde melanosome transport in melanocytes
  JOURNAL   J Biol Chem 287 (34), 28619-28631 (2012)
   PUBMED   22740695
  REMARK    GeneRIF: Rab36 mediates retrograde melanosome transport in
            melanocytes through interaction with RILP.
REFERENCE   9  (bases 1 to 1510)
  AUTHORS   Ohbayashi,N., Maruta,Y., Ishida,M. and Fukuda,M.
  TITLE     Melanoregulin regulates retrograde melanosome transport through
            interaction with the RILP-p150Glued complex in melanocytes
  JOURNAL   J Cell Sci 125 (Pt 6), 1508-1518 (2012)
   PUBMED   22275436
  REMARK    GeneRIF: A new mechanism by which the dynein-dynactin motor complex
            recognizes Mreg on mature melanosomes is revealed through
            interaction with RILP and is involved in the centripetal movement
            of melanosomes.
REFERENCE   10 (bases 1 to 1510)
  AUTHORS   Seto,S., Matsumoto,S., Tsujimura,K. and Koide,Y.
  TITLE     Differential recruitment of CD63 and
            Rab7-interacting-lysosomal-protein to phagosomes containing
            Mycobacterium tuberculosis in macrophages
  JOURNAL   Microbiol Immunol 54 (3), 170-174 (2010)
   PUBMED   20236428
  REMARK    GeneRIF: CD63, but not RILP, is recruited to the phagosomes in
            macrophages expressing the dominant negative form of Rab7.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW012811.1, AK139016.1, AK160517.1 and BC038146.1.
            
            On Jan 25, 2013 this sequence version replaced NM_001029938.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139016.1, BC116750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AW012811.1         1-9
            10-1474             AK139016.1         2-1466
            1475-1484           AK160517.1         1268-1277
            1485-1510           BC038146.1         803-828
FEATURES             Location/Qualifiers
     source          1..1510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..1510
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /note="Rab interacting lysosomal protein"
                     /db_xref="GeneID:280408"
                     /db_xref="MGI:MGI:2144271"
     exon            1..279
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1164
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /codon_start=1
                     /product="rab-interacting lysosomal protein"
                     /protein_id="NP_001025109.1"
                     /db_xref="CCDS:CCDS25049.1"
                     /db_xref="GeneID:280408"
                     /db_xref="MGI:MGI:2144271"
                     /translation="MEPRRAAPRLPSQASSSVGAGSAAELVYHLAGALGTELQGLARR
                     FGPDAAAGLVPLVVRALELLEKAAVGPAPDSLQVSAQQAEVELRRLREENQRLRQELG
                     SGPQEERALLRQLKEVTDRQRDELRAHNRDLQRRSQETEALQEQLQRLLLINSELRHK
                     LAAVQTQLRAAQDRERERQIAQDGSSQLAKEQSLEPDAATSDDPVDTQKQPGNLPEAV
                     QCGFSREELKQILQERNELKANVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVKKQ
                     RRKIKAKMLGTPEEAESSEDEDGSWLLLSNDKEDVPLVPESRIQNFFGLWYRGETEAP
                     EAETSNPASSSLQKGEETPQQPHLQPVNSPPAPNS"
     exon            280..373
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     exon            374..480
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     exon            481..666
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     exon            667..812
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     exon            813..935
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1019
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1489
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1464..1469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /note="hexamer: AATAAA"
     polyA_site      1489
                     /gene="Rilp"
                     /gene_synonym="Gm857"
                     /note="major polyA site"
ORIGIN      
        1 ttttcctgca ccagttaagg gtgtgggtgg cttttgacct taagagagga aaaaatggag
       61 cccaggaggg cagcgcccag gctacccagt caggcctctt cttcagtggg cgcagggtca
      121 gccgccgagc tcgtgtacca tctagcgggg gctctgggca ctgagctaca ggggctggca
      181 cgccgcttcg gacccgacgc ggcggctggg ctggtgccac tagtcgtgcg ggcgctggag
      241 ctcttggaaa aggccgccgt ggggccggct ccggactcgc tgcaggtgtc cgcacagcag
      301 gcagaagtgg agctgcggcg gctgcgcgag gagaaccaac gcctccgcca ggagctaggc
      361 tccgggccgc aggaggagcg cgcgctgctc cgacagctca aggaggtgac agacagacag
      421 cgggatgagc ttcgggcaca caaccgagat ctgcagcgcc gaagccaaga gaccgaagcg
      481 ctgcaggaac agctacagcg cctcctgctg atcaactctg agctgcggca caagctggct
      541 gcagtgcaga cccagttgag ggccgcccag gaccgggaga gggagcgcca gatagctcag
      601 gatggctcca gccagctggc taaagaacag agcttggaac ctgatgcggc aacctcagat
      661 gacccggtgg atactcagaa gcagccaggg aaccttccag aagctgtcca gtgtggattc
      721 agcagggaag agcttaagca aatccttcag gagcggaatg agctcaaagc caacgtgttc
      781 ttgctcaagg aggagttggc gtacttccag cgagagctgc tcacagatca ccgtgttcct
      841 gggcttctgc ttgaagccat gaaggtggca gtcaagaaac agaggaggaa gatcaaggcc
      901 aagatgttag ggacacctga agaagcagag agcagtgagg atgaggatgg ctcgtggctc
      961 ctgctctcca acgacaagga agatgttccc ctagttcctg agtccagaat ccagaatttc
     1021 tttggcttat ggtatcgggg tgaaactgag gcccctgaag ccgagaccag caacccagct
     1081 tccagcagcc tacagaaagg agaagagacc ccacagcaac cccacctgca gcctgtgaac
     1141 agccctccag cccccaactc ctgactagtc ccctgctttc aatgaacatc ttggtctgag
     1201 ggcttcagct atgcaggagg cttaactctg gattccagct aactgtgtgt ggatgtgtga
     1261 cctcaaatga ggatgtggct ccccacttaa acctcgcctg tactagctat ggtggaacgt
     1321 cagcctgtct cccattcttg acatctctgt accacacttt acagacataa agggatctct
     1381 gagctctgct tttccccatt gtgagacaga ggactgcctg cctgcctgcc tgcctcgctg
     1441 gggcttgtgc aggtgaccag tgcaataaat aaccataata cccctaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa
//
