LOCUS       NM_172689               4943 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RNA sensor RIG-I (Rigi), mRNA.
ACCESSION   NM_172689 XM_985407
VERSION     NM_172689.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4943)
  AUTHORS   Yermalovich,A.V., Mohsenin,Z., Cowdin,M., Giotti,B., Gupta,A.,
            Feng,A., Golomb,L., Wheeler,D.B., Xu,K., Tsankov,A., Cleaver,O. and
            Meyerson,M.
  TITLE     An essential role for Cmtr2 in mammalian embryonic development
  JOURNAL   Dev Biol 516, 47-58 (2024)
   PUBMED   39094818
REFERENCE   2  (bases 1 to 4943)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4943)
  AUTHORS   Huang,X., Zhou,X., Zhang,F., Wang,X., Duan,X. and Liu,K.
  TITLE     DDX58 variant triggers IFN-beta-induced autophagy in trabecular
            meshwork and influences intraocular pressure
  JOURNAL   FASEB J 38 (10), e23651 (2024)
   PUBMED   38752537
  REMARK    GeneRIF: DDX58 variant triggers IFN-beta-induced autophagy in
            trabecular meshwork and influences intraocular pressure.
REFERENCE   4  (bases 1 to 4943)
  AUTHORS   Mendez-Gomez,H.R., DeVries,A., Castillo,P., von Roemeling,C.,
            Qdaisat,S., Stover,B.D., Xie,C., Weidert,F., Zhao,C., Moor,R.,
            Liu,R., Soni,D., Ogando-Rivas,E., Chardon-Robles,J., McGuiness,J.,
            Zhang,D., Chung,M.C., Marconi,C., Michel,S., Barpujari,A.,
            Jobin,G.W., Thomas,N., Ma,X., Campaneria,Y., Grippin,A.,
            Karachi,A., Li,D., Sahay,B., Elliott,L., Foster,T.P., Coleman,K.E.,
            Milner,R.J., Sawyer,W.G., Ligon,J.A., Simon,E., Cleaver,B.,
            Wynne,K., Hodik,M., Molinaro,A.M., Guan,J., Kellish,P., Doty,A.,
            Lee,J.H., Massini,T., Kresak,J.L., Huang,J., Hwang,E.I., Kline,C.,
            Carrera-Justiz,S., Rahman,M., Gatica,S., Mueller,S., Prados,M.,
            Ghiaseddin,A.P., Silver,N.L., Mitchell,D.A. and Sayour,E.J.
  TITLE     RNA aggregates harness the danger response for potent cancer
            immunotherapy
  JOURNAL   Cell 187 (10), 2521-2535 (2024)
   PUBMED   38697107
REFERENCE   5  (bases 1 to 4943)
  AUTHORS   Jiao,H., James,S.J., Png,C.W., Cui,C., Li,H., Li,L., Chia,W.N.,
            Min,N., Li,W., Claser,C., Renia,L., Wang,H., Chen,M.I., Chu,J.J.H.,
            Tan,K.S.W., Deng,Y. and Zhang,Y.
  TITLE     DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response
  JOURNAL   Cell Death Differ 31 (3), 280-291 (2024)
   PUBMED   38383887
  REMARK    GeneRIF: DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN
            response.
REFERENCE   6  (bases 1 to 4943)
  AUTHORS   Ishii,K.J., Coban,C., Kato,H., Takahashi,K., Torii,Y.,
            Takeshita,F., Ludwig,H., Sutter,G., Suzuki,K., Hemmi,H., Sato,S.,
            Yamamoto,M., Uematsu,S., Kawai,T., Takeuchi,O. and Akira,S.
  TITLE     A Toll-like receptor-independent antiviral response induced by
            double-stranded B-form DNA
  JOURNAL   Nat Immunol 7 (1), 40-48 (2006)
   PUBMED   16286919
  REMARK    Erratum:[Nat Immunol. 2006 Apr;7(4):427]
REFERENCE   7  (bases 1 to 4943)
  AUTHORS   Denaxa,M., Kyriakopoulou,K., Theodorakis,K., Trichas,G., Vidaki,M.,
            Takeda,Y., Watanabe,K. and Karagogeos,D.
  TITLE     The adhesion molecule TAG-1 is required for proper migration of the
            superficial migratory stream in the medulla but not of cortical
            interneurons
  JOURNAL   Dev Biol 288 (1), 87-99 (2005)
   PUBMED   16225856
REFERENCE   8  (bases 1 to 4943)
  AUTHORS   Rothenfusser,S., Goutagny,N., DiPerna,G., Gong,M., Monks,B.G.,
            Schoenemeyer,A., Yamamoto,M., Akira,S. and Fitzgerald,K.A.
  TITLE     The RNA helicase Lgp2 inhibits TLR-independent sensing of viral
            replication by retinoic acid-inducible gene-I
  JOURNAL   J Immunol 175 (8), 5260-5268 (2005)
   PUBMED   16210631
  REMARK    GeneRIF: Lgp2 acts as a negative feedback regulator of antiviral
            signaling by sequestering double-stranded RNA from retinoic
            acid-inducible gene-I (RIG-I).
REFERENCE   9  (bases 1 to 4943)
  AUTHORS   Yoneyama,M., Kikuchi,M., Matsumoto,K., Imaizumi,T., Miyagishi,M.,
            Taira,K., Foy,E., Loo,Y.M., Gale,M. Jr., Akira,S., Yonehara,S.,
            Kato,A. and Fujita,T.
  TITLE     Shared and unique functions of the DExD/H-box helicases RIG-I,
            MDA5, and LGP2 in antiviral innate immunity
  JOURNAL   J Immunol 175 (5), 2851-2858 (2005)
   PUBMED   16116171
  REMARK    GeneRIF: Shared and unique functions of the DExD/H-box helicases
            RIG-I, MDA5, and LGP2 in antiviral innate immunity.
REFERENCE   10 (bases 1 to 4943)
  AUTHORS   Kato,H., Sato,S., Yoneyama,M., Yamamoto,M., Uematsu,S., Matsui,K.,
            Tsujimura,T., Takeda,K., Fujita,T., Takeuchi,O. and Akira,S.
  TITLE     Cell type-specific involvement of RIG-I in antiviral response
  JOURNAL   Immunity 23 (1), 19-28 (2005)
   PUBMED   16039576
  REMARK    GeneRIF: RIG-I is essential for induction of type I interferons
            (IFNs) after infection with RNA viruses in fibroblasts and
            conventional dendritic cells (DCs).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087261.1, BC127163.1 and AK049305.1.
            
            On Jul 26, 2007 this sequence version replaced NM_172689.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128929.1, AY553221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-700               AK087261.1         2-701
            701-2930            BC127163.1         567-2796
            2931-4943           AK049305.1         1522-3534
FEATURES             Location/Qualifiers
     source          1..4943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.24 cM"
     gene            1..4943
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /note="RNA sensor RIG-I"
                     /db_xref="GeneID:230073"
                     /db_xref="MGI:MGI:2442858"
     exon            1..235
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2910
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /EC_number="3.6.4.13"
                     /note="probable ATP-dependent RNA helicase DDX58; DEAD/H
                     box helicase 58; DEAD/H box polypeptide RIG-I; retinoic
                     acid-inducible gene-I; RIG-1; retinoic acid-inducible gene
                     1 protein; retinoic acid-inducible gene I protein;
                     RIG-I-like receptor 1; DEAD box protein 58; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 58"
                     /codon_start=1
                     /product="antiviral innate immune response receptor RIG-I"
                     /protein_id="NP_766277.3"
                     /db_xref="CCDS:CCDS18043.1"
                     /db_xref="GeneID:230073"
                     /db_xref="MGI:MGI:2442858"
                     /translation="MTAEQRQNLQAFRDYIKKILDPTYILSYMSSWLEDEEVQYIQAE
                     KNNKGPMEAASLFLQYLLKLQSEGWFQAFLDALYHAGYCGLCEAIESWDFQKIEKLEE
                     HRLLLRRLEPEFKATVDPNDILSELSECLINQECEEIRQIRDTKGRMAGAEKMAECLI
                     RSDKENWPKVLQLALEKDNSKFSELWIVDKGFKRAESKADEDDGAEASSIQIFIQEEP
                     ECQNLSQNPGPPSEASSNNLHSPLKPRNYQLELALPAKKGKNTIICAPTGCGKTFVSL
                     LICEHHLKKFPCGQKGKVVFFANQIPVYEQQATVFSRYFERLGYNIASISGATSDSVS
                     VQHIIEDNDIIILTPQILVNNLNNGAIPSLSVFTLMIFDECHNTSKNHPYNQIMFRYL
                     DHKLGESRDPLPQVVGLTASVGVGDAKTAEEAMQHICKLCAALDASVIATVRDNVAEL
                     EQVVYKPQKISRKVASRTSNTFKCIISQLMKETEKLAKDVSEELGKLFQIQNREFGTQ
                     KYEQWIVGVHKACSVFQMADKEEESRVCKALFLYTSHLRKYNDALIISEDAQMTDALN
                     YLKAFFHDVREAAFDETERELTRRFEEKLEELEKVSRDPSNENPKLRDLYLVLQEEYH
                     LKPETKTILFVKTRALVDALKKWIEENPALSFLKPGILTGRGRTNRATGMTLPAQKCV
                     LEAFRASGDNNILIATSVADEGIDIAECNLVILYEYVGNVIKMIQTRGRGRARDSKCF
                     LLTSSADVIEKEKANMIKEKIMNESILRLQTWDEMKFGKTVHRIQVNEKLLRDSQHKP
                     QPVPDKENKKLLCGKCKNFACYTADIRVVETSHYTVLGDAFKERFVCKPHPKPKIYDN
                     FEKKAKIFCAKQNCSHDWGIFVRYKTFEIPVIKIESFVVEDIVSGVQNRHSKWKDFHF
                     ERIQFDPAEMSV"
     exon            236..370
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..552
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..700
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..823
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..931
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1085
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1344
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1507
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1612
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1770
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1906
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2055
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2146
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2317
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2469
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2613
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..4943
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3845..3850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /note="hexamer: AATAAA"
     polyA_site      3871
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /note="major polyA site"
ORIGIN      
        1 agtttcgatt tcctatggcc agccggctag gcagcttttt catcgggact ccttggaaag
       61 tccccacttc gttcatctct ggcggatttg cgggagccag ggcgctcatc gatcgcctgg
      121 agccacagaa tgacagcgga gcagcggcag aatctgcaag cattcagaga ctatatcaag
      181 aagattctgg accccaccta catcctcagc tacatgagtt cctggctcga ggatgaggag
      241 gtgcagtaca ttcaggctga gaagaacaac aagggcccaa tggaagctgc ctcactcttc
      301 ctccagtacc tgttgaagct gcagtcagag ggctggttcc aggccttttt ggatgccctg
      361 taccatgcag gttactgtgg actttgtgaa gccatcgaaa gttgggactt tcaaaaaatt
      421 gaaaagttag aggaacacag attactttta agacgtttag aaccagaatt taaggccaca
      481 gttgatccaa atgatatcct ttctgaacta tccgaatgtt tgattaatca ggaatgtgaa
      541 gaaatcagac agatccgaga cactaaaggg agaatggcag gtgcggagaa gatggccgaa
      601 tgtcttatca gatccgacaa ggaaaactgg ccaaaggtct tgcaacttgc tttggagaaa
      661 gacaacagca agtttagtga attgtggatt gttgataaag gtttcaaaag ggctgaaagc
      721 aaggctgatg aggatgatgg agcggaggcg tccagcatcc agattttcat tcaggaagag
      781 ccagagtgtc agaatctcag tcagaatccc gggcctcctt cagaagcgtc ttctaataat
      841 ttacacagcc cattgaaacc aagaaattac caactggagc ttgccctgcc tgccaagaaa
      901 gggaaaaata caataatatg tgcccctact ggttgtggaa aaacctttgt gtcgcttctt
      961 atatgtgaac accatcttaa aaaattccca tgtggacaaa aagggaaagt ggtcttcttc
     1021 gctaaccaaa ttcctgtcta tgagcagcag gcaactgtgt tctcacgata ttttgaaaga
     1081 cttgggtaca acattgcgag catttctggg gcaacatctg atagcgtctc agtgcagcac
     1141 atcattgaag acaatgatat catcatcctg acaccccaga ttcttgtgaa caatctcaac
     1201 aacggagcca tcccctcgtt gtctgtcttc actctgatga tatttgatga gtgtcataac
     1261 actagcaaaa accacccata caatcagatc atgttcagat acctagacca caaacttgga
     1321 gagtcacggg acccactgcc tcaggtcgtt gggctgactg cctccgtcgg cgttggagat
     1381 gctaagaccg cggaggaagc catgcaacat atctgtaaac tctgtgccgc cctggatgcc
     1441 tccgtgattg ccacagtcag agacaacgtt gcagaactgg aacaggtcgt ttataagccc
     1501 cagaaaattt ccaggaaagt ggcatcccgg acttcgaaca cgtttaaatg catcatctct
     1561 cagctgatga aggagacaga gaagctagcc aaggatgtct ccgaggaact tggaaagctt
     1621 tttcaaattc aaaacagaga attcggcacc cagaaatatg aacagtggat tgtcggcgtc
     1681 cacaaagcgt gctcagtgtt tcagatggca gacaaagagg aggagagccg ggtctgcaaa
     1741 gcgctcttcc tgtacacatc acatttgcgg aaatacaacg atgcactcat catcagtgag
     1801 gatgcacaga tgacagacgc tctaaattac ctcaaagcct tcttccacga tgtccgagaa
     1861 gcagcattcg atgagaccga gcgagagctt actcggaggt ttgaagaaaa actagaggaa
     1921 ttagaaaaag tttccaggga tcccagcaat gagaatccta aactaagaga cctctacttg
     1981 gtcttacaag aagagtacca cttaaagcca gagaccaaga ccattctctt cgtgaagacc
     2041 agagcactcg tggatgctct gaagaaatgg attgaagaaa atcctgcact aagctttcta
     2101 aagcctggca tactgactgg gcgtggcaga acaaaccggg caacaggaat gacgctcccg
     2161 gcacagaagt gtgtgctgga ggcattcaga gccagcggag ataacaatat tctgattgct
     2221 acctcggtcg ctgatgaagg cattgacatt gctgagtgca atctcgtcat tctctatgag
     2281 tacgtgggca acgtcatcaa gatgatccaa accagaggcc gaggaagagc acgagatagc
     2341 aagtgcttcc tcctgaccag cagcgctgac gtgattgaaa aagaaaaggc gaacatgatc
     2401 aaggaaaaaa taatgaatga atccatctta agactgcaga catgggatga aatgaaattt
     2461 ggaaagacgg ttcaccgcat acaggtgaat gaaaaactcc tcagagacag tcagcacaaa
     2521 ccacaacctg ttcctgacaa agaaaacaag aaactgctgt gtggaaagtg caagaatttt
     2581 gcgtgctaca cagctgacat tcgagtggtt gagacgtccc actacactgt ccttggagac
     2641 gcttttaagg agcgctttgt gtgtaagcca caccctaaac caaagatcta tgacaatttt
     2701 gagaagaaag caaagatatt ctgcgccaaa cagaactgta gccacgactg gggaattttt
     2761 gtgagataca agacgttcga gattccagtc ataaaaattg aaagtttcgt cgtggaagat
     2821 attgtgagcg gagttcagaa ccggcactca aagtggaagg actttcattt tgaaaggata
     2881 cagttcgatc ctgcagaaat gtccgtatga cctcaggctt ctccgtctcg tgccgcaggg
     2941 agccgtgcct taagcatgga gttgatgagc caatgctttc ttacccaagc ttgcacaatc
     3001 ctttcttaca caagcctgca ctgtgttgaa tgccagataa cctgactggt tggtttcaag
     3061 ctggtgctgt ccacacaaag cacacacgcc tgaactgcgg cgccgaatag tttcttcacc
     3121 aataactcat agcgtagccc ttggccatgg tggggagggg ttaaacttgt cccttttaca
     3181 cttttcagaa ctgcccgaca gggaacgtgc agccactcgg tacaccgaga cgcatgatgg
     3241 ctggcgtgct ggaagggttc ccgttctctg tctgctcgat ctgctgtaag ctgcctttgc
     3301 ccttaatgac agtgccctta agaacagtga cttagttctt tttcaggcca ccagactgac
     3361 tgccagatcc cttctgtccc ttctgtccct tgcactgatt cctttccgga tttgaccctg
     3421 ccaccctgtc accctctgca gagtctcctg gtttctgtct cttccttggt ttctttgctg
     3481 actcaaattt ggtagttgca aggttcagta tgcacacata tatatttaaa atgacatata
     3541 atttaaaatg taaaagacta tagttgacag ctatgcttac tgagatggta tttctgttct
     3601 gttcattact atacatctta cccttgctct catctgttct tttaacttgg gccatttccc
     3661 gtctttgaat agacatctca aaccctgtct gtatgtctgt ctgtttccca cctgtttgag
     3721 acagggtctc tctgtagacc agaaactcca tatgtagact atgctggcct tgaactcaca
     3781 gatccccctg cctctcaagt gttgaaatta aaatctttca ccatgcctgg ctctagctat
     3841 tttcaataaa ggctcatgtt taaagtttga actacttcca attcattccc tgacgtggct
     3901 tgttgttgtt gtttactttt ggagacactg ttcctctctg tagccctggc tgtgtagacc
     3961 aggctgccct tggtcacaga gatctgccag cttctgcctc cggagcactg agattgaagg
     4021 cctgcatcac catgcctggc ttgccctttc ttcttaaaca ttatatattc aaatggcatt
     4081 tccgtgtttc ttctcaaggt gtgccagtgc ttcagagagc ttagtttggg gttcttcaga
     4141 tcaagagaca agtgtctgag cgctgttact gccaacagag caaagtactc ttcagttcag
     4201 ggaaggaaca gtgctggttt tgtaggcagt acagtggttt taacaccttc ctagaactta
     4261 cttgtaattc atcagttgta gaccatcaat ggcctaaacc aaactgcaga gatcatctga
     4321 ccacataact ccccttccag gacatttaca tttgaagact atcccaagcc cacccagagc
     4381 acagtgggtt acccaaactc cccaggtcaa ccctggaggt caacagtatg acatgggata
     4441 gcacaccact tctcacagat gcctagagaa attacccagc aacataactc tttggggaaa
     4501 aaacacctat agggattagg cttttaattg atagaatagg tagaaaaaaa gatatgtagt
     4561 agttcttgat agtggttact ggtaaaattc ttagtgcaat aaaatgaatt tgccgagagc
     4621 tgactttctt ttttttcttg tttttttgag acagggtttc tctgtatagc tttggctgtc
     4681 ctggaatgca ctctgtagtc caggctggcc ttcgaactca gaaatccgcc ttcctctgcc
     4741 tcccaagtgt tgggattaaa ggcgtgcgcc accacgcctg gctgagagct gactttcatt
     4801 tatgtctttt agtctatgtt gcctttcttt gctgctacag tttaagaact ctacagcttg
     4861 tataagatac ctactggaaa ttatttgaga aaaaaaactt gtaaacatta caataattta
     4921 attaattaaa aatttatgta ttt
//
