LOCUS       NM_001355415           12868 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus replication timing regulatory factor 1 (Rif1),
            transcript variant 3, mRNA.
ACCESSION   NM_001355415 XM_006498177
VERSION     NM_001355415.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12868)
  AUTHORS   Kabrani,E., Rahjouei,A., Berruezo-Llacuna,M., Ebeling,S., Saha,T.,
            Altwasser,R., Delgado-Benito,V., Pavri,R. and Di Virgilio,M.
  TITLE     RIF1 integrates DNA repair and transcriptional requirements during
            the establishment of humoral immune responses
  JOURNAL   Nat Commun 16 (1), 777 (2025)
   PUBMED   39824820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12868)
  AUTHORS   Malzl,D., Peycheva,M., Rahjouei,A., Gnan,S., Klein,K.N.,
            Nazarova,M., Schoeberl,U.E., Gilbert,D.M., Buonomo,S.C.B., Di
            Virgilio,M., Neumann,T. and Pavri,R.
  TITLE     RIF1 regulates early replication timing in murine B cells
  JOURNAL   Nat Commun 14 (1), 8049 (2023)
   PUBMED   38081811
  REMARK    GeneRIF: RIF1 regulates early replication timing in murine B cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12868)
  AUTHORS   Liu,C., Yu,P., Ren,Z., Yao,F., Wang,L., Hu,G., Li,P. and Zhao,Q.
  TITLE     Rif1 Regulates Self-Renewal and Impedes Mesendodermal
            Differentiation of Mouse Embryonic Stem Cells
  JOURNAL   Stem Cell Rev Rep 19 (5), 1540-1553 (2023)
   PUBMED   36971904
  REMARK    GeneRIF: Rif1 Regulates Self-Renewal and Impedes Mesendodermal
            Differentiation of Mouse Embryonic Stem Cells.
REFERENCE   4  (bases 1 to 12868)
  AUTHORS   Balasubramanian,S., Andreani,M., Andrade,J.G., Saha,T.,
            Sundaravinayagam,D., Garzon,J., Zhang,W., Popp,O., Hiraga,S.I.,
            Rahjouei,A., Rosen,D.B., Mertins,P., Chait,B.T., Donaldson,A.D. and
            Di Virgilio,M.
  TITLE     Protection of nascent DNA at stalled replication forks is mediated
            by phosphorylation of RIF1 intrinsically disordered region
  JOURNAL   Elife 11, e75047 (2022)
   PUBMED   35416772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12868)
  AUTHORS   Zhang,W., Yao,C., Luo,Y., Li,Q., Zhao,Q., Zhao,Y., Wang,Y.,
            Geng,M., Wang,Q., Xu,M., Sun,S., Wu,D., Gao,Q., Wu,X. and Shuai,L.
  TITLE     Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem
            cells
  JOURNAL   Cell Rep 38 (13), 110570 (2022)
   PUBMED   35354046
  REMARK    GeneRIF: Rif1 and Hmgn3 regulate the conversion of murine
            trophoblast stem cells.
REFERENCE   6  (bases 1 to 12868)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 12868)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 12868)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 12868)
  AUTHORS   Adams,I.R. and McLaren,A.
  TITLE     Identification and characterisation of mRif1: a mouse
            telomere-associated protein highly expressed in germ cells and
            embryo-derived pluripotent stem cells
  JOURNAL   Dev Dyn 229 (4), 733-744 (2004)
   PUBMED   15042697
  REMARK    GeneRIF: This is a mouse ortholog of the yeast Rif1 family of
            telomere-associated proteins identified on the basis of its high
            expression in primordial germ cells and embryo-derived pluripotent
            stem cell lines.
REFERENCE   10 (bases 1 to 12868)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929138.15 and AL844571.8.
            
            On Sep 15, 2017 this sequence version replaced XM_006498177.2.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (b)
            has the same N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY428571.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL929138.15        94406-94435
            31-147              AL929138.15        94706-94822
            148-226             AL929138.15        95816-95894
            227-323             AL929138.15        97650-97746
            324-451             AL929138.15        98550-98677
            452-546             AL929138.15        98762-98856
            547-736             AL929138.15        99900-100089
            737-829             AL844571.8         3811-3903
            830-968             AL844571.8         5250-5388
            969-1120            AL844571.8         7612-7763
            1121-1238           AL844571.8         11233-11350
            1239-1403           AL844571.8         12109-12273
            1404-1514           AL844571.8         12759-12869
            1515-1577           AL844571.8         14627-14689
            1578-1678           AL844571.8         14865-14965
            1679-1765           AL844571.8         16088-16174
            1766-1839           AL844571.8         17174-17247
            1840-2020           AL844571.8         18407-18587
            2021-2128           AL844571.8         20502-20609
            2129-2278           AL844571.8         20942-21091
            2279-2378           AL844571.8         21438-21537
            2379-2643           AL844571.8         26018-26282
            2644-2686           AL844571.8         27131-27173
            2687-2889           AL844571.8         28020-28222
            2890-2989           AL844571.8         29486-29585
            2990-3109           AL844571.8         30223-30342
            3110-3261           AL844571.8         31025-31176
            3262-3345           AL844571.8         31777-31860
            3346-3397           AL844571.8         31936-31987
            3398-6487           AL844571.8         32496-35585
            6488-6634           AL844571.8         38833-38979
            6635-6712           AL844571.8         39253-39330
            6713-6828           AL844571.8         39420-39535
            6829-6982           AL844571.8         41602-41755
            6983-7091           AL844571.8         42845-42953
            7092-12868          AL844571.8         43577-49353
FEATURES             Location/Qualifiers
     source          1..12868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 29.98 cM"
     gene            1..12868
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="replication timing regulatory factor 1"
                     /db_xref="GeneID:51869"
                     /db_xref="MGI:MGI:1098622"
     exon            1..30
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            31..147
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..7303
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="isoform b is encoded by transcript variant 3;
                     mRif1; rap1-interacting factor 1 homolog;
                     telomere-associated protein RIF1; Rap1 interacting factor
                     1 homolog"
                     /codon_start=1
                     /product="telomere-associated protein RIF1 isoform b"
                     /protein_id="NP_001342344.1"
                     /db_xref="GeneID:51869"
                     /db_xref="MGI:MGI:1098622"
                     /translation="MTAPGRSPLEPLLETWEDPSVPPGEQTDAYLTLTSRMTGEEGKE
                     VIAEIEKNLSRLYTVLKAHISSQNSELSSAALQALGFCLYNPRITSGLSEANIQELLL
                     TLNGIIKSSDKNVCTRALWVISKQTFPAELVSKMVSSIIDSLEVILSKGEIHSAVVDF
                     EALNVIIRLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQ
                     QEIALITEHLMTTKLISELQKLFKNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQ
                     LEELGFRSGTPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETL
                     ALTKLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSIPSPQGNSSRGSASPGLSP
                     LTPGHKGASPYGSPRGNLSSNTGGMAAIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIV
                     LSLEPLEHPLISSPSFFSKYAHTLITAVHDSFVSVGKDASDAVVSAIWKELISLVKSV
                     TEAGNRKEKSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPPKVLGSPAYQ
                     VANMDILNGTPALFLIQLIFNNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAFSDS
                     VLTVINQNAKQLVNKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALTL
                     PINHIFSAQTFPTGTMKALLKTWSELYRAFTRCASLVATAEENLCCEELSSKIMCSLE
                     DEVLSDLLFLDRISHIIIVMVDCIDFSPYNKKYQPKIKSPQRSSDWSRKKKEPLGKLA
                     SLFKLIVKVIDTFHTLSLKETFSDTLLAIGNSIISMLSNVFGHISLPSMIREIFATFT
                     RPLALLYENSKLDEAPKVYTSLNNKLEKLLGEIVACLQFSYLGAYDSELLEHLSPLLC
                     VIFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKILLLLPGLENVEMM
                     DESSEPYSESTENSQLNVKISGMERKSSGKRDSILAHTKDKKKKVKLSAKLKLESSSP
                     KIKSGKLLEEEKSTDFVFIPPEGKETKARVLTEHQKEVLKTKRCDIPALYNNLDASQD
                     TLFSAQFSQEESMESLTLTEKPKEDAKIIKEEQMESTIFIHQDAPENCGIDEHSENAS
                     LPNCGGSVAETNPETLITGFDARKEVLISSKILSAESSSSTETSVVSSSSVSNATFSG
                     TPPQPTSRRQTFITLEKFDGSETRPFSPSPLNNISSTVTVRNNQDNTTNTDMPPKARK
                     REVTNSKSDSENLANAGKKSSRRWSKAEQSVTKKSKPSLTSEQEEHSSENNSPDLLSP
                     TEHVSENDDHPSEATLEHKDGDPKPAVENASLEDLTTEEKNVGINMESKESTASVVAR
                     TEQIVNEDSQAAALAPNPKTLRRSSRRRSEAVDSCSDSQERESGQQKKERRKEEEKII
                     SKSPLRIKDDKLPTQKLTDESPIQENLTEKGNTLPERTSGEPSVNAEIDQNRRKPDLE
                     NVSSEGGGGTLDNLDKSSEKPLRGRTRYQTRRASQGLISAVENSESDSSEAKEEVSRK
                     KRSGKWKNRSSDSVDIEEQEEKKAEEEVMKTANQTLDGQAVPDVDVNAAAQVCEKSTN
                     NNRVILQDSAGPADSLQAPPKGEEKSKINKCVDSSFVSLPVPESNLRTRNASKRLLYK
                     QDNDSNVRVSDSSLSPEKFTQVECQHKRSRRVRRSKSCDCCGEKSQSQEKSFIGLKNT
                     ESYAIKSVEKKKTDLQVPETAPETREARDHAETKLAGEEPLVNFHVGLKEENCTTGDS
                     VKSEAELQEASLPPEIVTVKEKTYDTDASEAVSEIQGPCSENHSPAEDPGLSECKDIS
                     QKQLSENGELDISDVGKACKVIAGSSPEGVETMELNVRNDAFVAADSEKSTQMDVSVD
                     VATEEDNKKDECEAVTTEVNVEGVATEDFNSGMDLSDTPIPVSKDVETEHAASGEIEG
                     ESNESDSGSCEEMNKEMGSHKAQMSTEIDSARVKETDILASASKSEEALIGRLDVNTQ
                     SFVSDIEMSSGERTVNCKTETSIELNKLDEAKLSGNEATVGNDTLQEVCFTSEKVEKL
                     PQCLLVQVASELGAESNTTSPEKLELDSFGSVNESPSGMQQARCVWSPLASPSTSILK
                     RGLKRSQEDEISPVNKIRRVSFADPIYQAGLADDIDRRCSVVRSHSSNSSPIIKSVKT
                     SPTSHSKHNTTSAKGFLSPGSQSSKFKSPKKCLITEMAQESMLSPTESVYPALVNCAA
                     SVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASEIKTLPIRSPKVFNVKKAL
                     RVYHEQQMKSRGLEEIPIFDISEKAVNGVESRTVSTDEERFASDLIEPVTLDTPLSKN
                     LVAQISALALQLDSEDLYSYTGSQLFEMHEKLGTMANSIIRNLQSRWRSPAHENS"
     exon            148..226
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            227..323
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            324..451
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            452..546
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            547..736
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            737..829
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            830..968
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1120
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1238
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1403
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1514
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1577
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1678
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1765
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1839
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2020
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2128
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2278
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2378
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2643
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2686
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2889
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..2989
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3109
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3261
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3345
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3397
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..6487
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            6488..6634
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            6635..6712
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            6713..6828
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            6829..6982
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            6983..7091
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     exon            7092..12868
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8126..8131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="hexamer: AATAAA"
     polyA_site      8160
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="major polyA site"
     regulatory      8192..8197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="hexamer: ATTAAA"
     polyA_site      8215
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="major polyA site"
     regulatory      8460..8465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="hexamer: ATTAAA"
     polyA_site      8481
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="major polyA site"
     regulatory      12851..12856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
                     /note="hexamer: AATAAA"
     polyA_site      12868
                     /gene="Rif1"
                     /gene_synonym="5730435J01Rik; 6530403D07Rik; D2Ertd145e"
ORIGIN      
        1 atcttggtcg tggaggagcg ggctgcacgc ggtggcggcc gacatgacgg ccccaggtcg
       61 cagccccctg gagccgcttc tggagacttg ggaagacccc tcggtgcctc cgggagagca
      121 gacggacgcc tacctaactc tgaccagtcg tatgactgga gaagaaggaa aagaagtcat
      181 tgcagaaatc gagaaaaacc tttctcggct gtacacggtt ttaaaggctc acatttccag
      241 tcagaactca gaactgagca gtgctgcttt gcaagccttg ggattttgtt tatataatcc
      301 cagaattacc tcaggattgt cagaggcaaa tattcaagaa ctgcttttaa ccttgaatgg
      361 tatcattaag agttcagaca aaaatgtgtg taccagggca ctgtgggtaa tatccaaaca
      421 gacgtttcct gctgaacttg ttagcaaaat ggtatccagt attattgatt cattggaagt
      481 gatactaagt aaaggagaga tacattctgc tgttgttgat tttgaagcat taaatgttat
      541 tataaggcta attgaacaag ccccagttca aatgggagaa gagtctgtga ggtgggccaa
      601 attggtcata ccattagttg ttcactcagc acaaaaagta catttgcggg gagccactgc
      661 tctagagatg gggatgccat tgctgcttca gaaacaacaa gaaatagcct tgattacaga
      721 gcaccttatg actactaaat taatctcaga actccaaaaa ctatttaaga ataaaaatga
      781 gacttatgtg ttaaaactat ggcctttgtt tgtcaaactt cttggaaaga ccttgcaccg
      841 aagtgggagt ttcatcaact ctttgttaca gctggaagaa ctgggcttcc gtagtggaac
      901 acccatgatt aaaaaaatcg ctttcattgc ttggaaaagc ttaatagata attttgcttt
      961 aaacccagat atactttgta gtgcaaaaag actgaagttg ttaatgcaac ccttgagttc
     1021 catccatgtg agaacagaaa ctttagcatt aacaaaacta gaagtctggt ggtatttact
     1081 gatgagactt ggacctcagc tccctgccaa ttttgaacag gtgtgcgtgc cactgattca
     1141 gagtacaata agtgttgata gtattccttc acctcaaggc aattcatctc gagggtctgc
     1201 ttctccaggc ttaagtccac tgactccggg acataaaggt gcttctcctt atggaagtcc
     1261 ccgtgggaac ctgagttcaa atacaggtgg aatggctgca atcccttcta ttcagctttt
     1321 gggactggaa atgatgcttc attttttgtt gggcccagaa gttttgagtt ttgccaagca
     1381 acacaagatt gtattgagtt tagagccact ggaacacccg ctaatcagca gcccttcttt
     1441 cttctccaag tatgcgcata cacttatcac tgctgttcat gatagctttg tctcagttgg
     1501 aaaggatgcc tcagatgcag tagtcagtgc tatctggaag gagctaatta gcttggtgaa
     1561 gtcagttact gaagcaggaa acagaaaaga aaaatcaggt tctgaagttt tgacccttct
     1621 actaaaatct ttggaaaaca tagtgaagtc agaagtattt cctgtatcaa aaacactggt
     1681 tctcatggaa attacagtta aaggacttcc tccgaaagta ctaggttcac cagcatatca
     1741 ggttgctaat atggatattc ttaatggaac tccagcattg tttttaatcc agttaatttt
     1801 caacaacaat cttttagaat gtggtgtaga agatgagaag ttttttctca atctagaaac
     1861 acttgtaggc tgtgtacttt ctggtccaac atcaccactg gcttttagtg attctgttct
     1921 aactgtgatt aatcagaatg caaagcagtt ggtaaacaag gagcatctct ggagaatgtg
     1981 gagtatgata gtcagtccac tgactgatgt gattcaccag accaatgaag tgaatcaagg
     2041 cgatgcctta gaacataatt ttagtgccat ctatggtgca ttgactttac caataaacca
     2101 tattttttca gctcagacat ttcccacggg taccatgaaa gctttactta aaacttggtc
     2161 agaattgtat agagcattta ctcgctgtgc ttctttggtg gcaacagcag aagagaatct
     2221 gtgctgtgaa gaactttctt ctaaaataat gtgcagtttg gaagatgaag tcctttcaga
     2281 tttgctattc ttggacagga tctctcatat tattattgta atggttgatt gtatcgactt
     2341 ttcaccatat aataagaaat accagccaaa aatcaaatca ccgcagagat cttcagattg
     2401 gtccagaaag aagaaggagc ctctagggaa attggcttct ttatttaagc taattgtgaa
     2461 agtcatcgat actttccaca ctctaagcct caaggaaaca ttctctgata cactgcttgc
     2521 tattggtaac tctatcatta gcatgctttc caatgtattt ggacatattt ccttgccctc
     2581 tatgatccga gaaatatttg caacttttac aagacctctg gctttactgt atgaaaactc
     2641 aaagctggat gaggctccta aagtgtatac tagtctgaac aacaagttag aaaagctatt
     2701 gggagaaatt gttgcatgcc tacagttcag ctatcttgga gcctatgaca gtgaacttct
     2761 tgaacatctt tctccactcc tgtgcgtaat atttcttcac aagaataaac agattcggaa
     2821 acagagtgct ctgttgtgga atgccacatt tgctaaagcg acagctctgg tttatcctga
     2881 ggaattaaaa ccaatattaa gacaagccaa acagaaaatt ttgcttctgc tgcctggttt
     2941 ggaaaatgtt gaaatgatgg atgagtccag tgaaccgtat tcagaatcaa cagagaattc
     3001 acaattaaat gtcaagataa gtggcatgga aagaaaatca agtggaaaaa gagattccat
     3061 tttggcacat acaaaggata aaaaaaaaaa agtgaaactg tcggccaaac tgaaactaga
     3121 atcttcatct ccaaaaataa agagtggtaa gcttttggaa gaggaaaagt ctaccgactt
     3181 tgtcttcatt cctccagaag gaaaagagac aaaggcaagg gttctaactg agcatcagaa
     3241 agaagtactc aaaacaaaac ggtgtgatat tcctgccttg tataataatc tggatgcttc
     3301 acaggacact ttattttctg ctcagtttag tcaagaagaa tcaatggaaa gcctcacttt
     3361 aactgaaaaa ccaaaagaag atgccaagat aattaaggaa gagcaaatgg aaagtactat
     3421 tttcatccat caagatgccc cggagaactg tggaatagat gaacattctg agaatgcttc
     3481 tttaccaaat tgtggtggct ctgttgctga aaccaatcca gaaacattga tcactggttt
     3541 tgatgctaga aaagaagtat taatttcatc aaagatattg tctgctgaaa gttcatctag
     3601 tacagaaact tcggtggtca gcagtagttc agtttctaat gccacttttt ctggaactcc
     3661 tccacagcct acaagtcgga gacaaacctt tattactttg gagaaatttg atggctcaga
     3721 aactagacct tttagtccat cccccttgaa taacatatct tccactgtta cagtgagaaa
     3781 taaccaggat aacacaacta acactgacat gccaccaaaa gcaaggaaaa gagaagtgac
     3841 gaactcaaaa tctgattcag aaaatttagc gaatgcaggt aagaaatcaa gtcggagatg
     3901 gagtaaagct gagcagtcag ttactaaaaa gtctaagcca tcactgacat ctgaacagga
     3961 agagcactca tccgaaaata actctcctga tctgctcagc ccaacagaac atgtgtcaga
     4021 aaatgatgat catccttctg aagctaccct agagcataaa gatggagatc ctaaaccagc
     4081 agtagaaaat gcttcattgg aagacttaac aacagaagag aaaaatgtag gcattaatat
     4141 ggaatctaaa gaaagtacag cctcagttgt agcacgaaca gaacaaatag taaatgaaga
     4201 tagtcaggct gctgcactag ccccaaatcc aaaaacactc cgacggtctt cgaggcggcg
     4261 ttcagaagct gtagattctt gcagtgacag ccaagagaga gagagtggtc agcaaaaaaa
     4321 ggaaagacga aaggaagaag aaaaaataat ctccaagagt ccgttgcgta tcaaagatga
     4381 taagttgccc acgcaaaaac taactgatga gtcacctata caggaaaatt taactgaaaa
     4441 gggaaatact ttacctgaga gaacttcagg ggaacccagt gttaatgctg aaattgacca
     4501 aaatagaaga aaaccagacc ttgagaatgt tagttctgaa ggaggtggtg gtaccctgga
     4561 caatctagac aagtcgtctg agaaaccttt aagaggacgg acacgttatc aaacaagaag
     4621 agcttcgcag ggtttgattt ctgctgttga aaactcagaa tctgacagtt ctgaggcaaa
     4681 ggaagaagtt tctagaaaga aacgatcagg gaaatggaaa aatagaagca gtgacagtgt
     4741 tgacattgaa gaacaagaag aaaaaaaggc tgaagaggaa gttatgaaaa ctgcaaatca
     4801 gacactcgat ggccaggcag ttcctgatgt tgatgtaaat gcagcggctc aggtttgtga
     4861 aaaaagtaca aataacaaca gggtcatcct ccaggattct gctgggcctg cagattcact
     4921 gcaagctcca cccaaaggcg aggagaaaag taagattaac aaatgtgtag acagttcatt
     4981 tgtaagtcta cctgtgccag agtcaaacct caggactagg aatgccagta agagattatt
     5041 atataaacaa gataatgata gtaatgtgag ggtatcagac agctctctgt ctcccgaaaa
     5101 attcacccaa gttgaatgcc aacacaagag aagtaggaga gtcaggagat ctaaaagttg
     5161 tgactgctgt ggcgaaaaat cacagtccca ggaaaagtca tttattgggt taaagaacac
     5221 agaaagttat gctataaaga gtgtggagaa aaaaaagaca gatctacaag tacctgagac
     5281 tgcccctgaa actcgtgaag ctcgtgacca tgctgaaaca aagttggcag gcgaagagcc
     5341 tcttgtgaat tttcatgtgg gtcttaaaga agagaattgt actactggtg attcagttaa
     5401 gtctgaggct gagttgcaag aagcttccct tccacctgaa atagtaactg tgaaagagaa
     5461 gacttacgat acagacgcta gtgaagcagt gtctgaaatc caagggccat gtagtgagaa
     5521 ccacagccct gctgaggacc caggcttaag tgagtgcaaa gacatttcac agaagcagct
     5581 ttcagagaac ggagagcttg acatcagcga tgtagggaag gcatgcaaag tcatagctgg
     5641 gtccagtcca gagggagttg aaactatgga attaaatgta agaaatgatg catttgtagc
     5701 tgctgactct gaaaagagta cccaaatgga tgtttctgta gatgtggcaa cagaggaaga
     5761 taataaaaaa gatgaatgtg aagcagtcac aactgaagtg aatgttgaag gagtagccac
     5821 tgaggacttt aattcaggta tggatctttc tgatactccc atacctgtaa gcaaggatgt
     5881 tgagactgag cacgcagcta gtggggaaat agagggggag agcaatgaat ctgattcagg
     5941 ctcatgtgag gaaatgaaca aagaaatggg aagtcacaaa gcccagatga gcactgaaat
     6001 tgacagtgcc agggtaaagg agacggacat acttgccagt gcctctaaat ctgaagaagc
     6061 gctgattgga agactagacg tcaacaccca gagctttgtt agtgacattg aaatgagttc
     6121 tggagaaaga actgttaatt gcaaaactga gacatccatt gaacttaata aattagatga
     6181 agcaaaatta agtggcaatg aagctacagt gggaaatgat actctgcagg aagtttgctt
     6241 tacttcagag aaagtggaga aattaccaca gtgtctgcta gttcaagtgg cttctgaact
     6301 tggagcagaa agcaatacta cgtctcccga aaagttagag ctggattctt ttggatcagt
     6361 aaatgaaagt cctagtggta tgcagcaggc acgttgtgtc tggtcacctt tggcttctcc
     6421 atccacaagc attttaaaga gaggactaaa aagatcccaa gaagatgaga tctcaccagt
     6481 taacaagatt agacgtgtct cgtttgcaga tccaatatac caagcaggat tggcagatga
     6541 cattgatagg cgttgctctg ttgttagatc tcattcttca aatagctctc ccataataaa
     6601 aagtgttaaa acttcaccta cttcacactc taagcataat accacttcag ccaaaggatt
     6661 tctgtcccca ggatcacaga gctctaaatt taagagccca aagaagtgtt taattacaga
     6721 aatggcccaa gaatccatgc tgtccccaac agaaagtgtt tacccagctt tggtgaactg
     6781 tgcagcatca gttgacatca ttttacctca gattacatca aatatgtggg caagaggtct
     6841 tgggcaactc atcagagcca agaatataaa aaccattggg gatttgagta cgcttacggc
     6901 atctgaaata aaaactctgc ctatccgttc tccaaaggtg tttaatgtaa aaaaggccct
     6961 cagagtatac catgagcaac agatgaaatc tcgtggactt gaagaaattc caatttttga
     7021 tatttctgag aaggcagtaa atggagtgga gagcaggact gtctccacgg atgaagaaag
     7081 gttcgcctca gatttgattg aacctgtgac cctagatacc ccattgtcta aaaatcttgt
     7141 ggcacaaatt agtgctcttg ctcttcaact ggactcagaa gatctctaca gttacactgg
     7201 aagccagcta tttgaaatgc atgaaaaact tggtaccatg gcaaactcta taataagaaa
     7261 tctacagtca cgttggagat caccagccca tgaaaattct tagtatttta agagaaatgt
     7321 aaagtttttt caccatcaga ttttattttt tggcttttag aaatattcac accatttaaa
     7381 gaggacactt tgtaaaattg ataaaataat caaatcctga aaggtaatga attactaggt
     7441 catttttata agttcattag atcttcccta ctgtattttc ttggccagta cacatagttt
     7501 tttaagaagt ttaaatgtta ctgaaacttg aaagcaaaag agatatacat accttttttt
     7561 tttcatgctt taattcatgc atattttggt atagctcatg taaaagattt taattaagat
     7621 agaagaaaag ttttatttac actttattga gttgacagag atgtttatac tctttcaaaa
     7681 tatttatatt tgttgtgcct ggtggaacac ctgtactgag atgcaaaaga atgagaacat
     7741 ttcctgaaga ttacagctgt agaaaatctt tgaaatatca agtttcaact tgtgtgttaa
     7801 aataataatg cttaattcac taagattctg ttcattttgc attgacaaat acttgtgcag
     7861 cagcctttgt gaaaatgtgt tcttatgaag gtatagtgtt caaccttaaa tgcatgactc
     7921 tgtatattat gtatagaaga caatgttttt taatttataa agttcagcct tcattaatcg
     7981 catgggtttt tctgcagctt tttgtgaata ctattgtttt gtgtaataga aacatttgta
     8041 tatatttaat atcaaaatat ccatgtggat agtaaaagta cttcattgga cctactgtgg
     8101 atatttgtag gagtctttat ctacaaataa agcaacagat agttttgtat ttagttaaaa
     8161 catgagttta ttttctcaaa tgtccagaat aattaaaatt attggaacca gcaaatgtta
     8221 cataccactg ccttttttct tatggtttgg aagaggatcc cagccactag aaaatgtgcc
     8281 tccctcatat ttcttcttaa tggagagtta ccctggatat tttcattgca agtgtactat
     8341 aaactgtctg tagagataat tggtttttca catattttga agactaaacg tggaagaaat
     8401 tggaaactgc cattttttta tatgtacgtt tttgttgagt taaaaaatta ggatatataa
     8461 ttaaaccatt tgtaaatttc accaagtagt tagtgcctgc cttcacatat ttgtttcatg
     8521 ggttttgttt gttttgtttt tcgttcttga gatacagtct ctgtacgtag cccaggctag
     8581 ctttacttcc gtgatcctcc tgcctctgct gtcagagatc tggagttgcc gttgtttgcc
     8641 actatgcttg gctatgtctc cccaagggta tattttgctt gttttctgag taaaattagt
     8701 gagtgagctt agtttcaaac ttaacctctg cttagaaaga cactgccatt ttaaaataaa
     8761 taaagccggt gccatttttt agtttaaggt ctcccttttt ccagcagaga cccccccccc
     8821 cgcccttcgt aaataaagtt ggtgtcactt tgcataagca taaatcatta cagatatttt
     8881 ggaaataagt gtgttcacct acaaagaggg ccataaagaa tctgggattg ttgcaccaag
     8941 gacctaggag accgtaacaa acaagaaaaa gcctagtgtt taaaacaatt gataatggtg
     9001 gtttgcattg tcaggccact gtatttaagt actgaggtgt gcgtgaacac ctcagaatat
     9061 agtgaatggg agtgattagc aaggagaatg tggatggatg gatggctcat tgcacaaact
     9121 gcattctttt aactctggtt tactcacttg taggcatagc aaagttctta gggagttcaa
     9181 agttcagcag gaagggtggc aaataaatga tttgcttaaa ttcctgaatt taataacagc
     9241 atatatctga gtgaagccat agctcagtga gatggtgttt taccatcagt ttattgaatc
     9301 tttgttattt ttaaggttga gtcgccttct tttcagtatt cttggctttg cttttttttc
     9361 ttctgtctgt taattcctaa aataacaaag aacattaata tttctgagtt gacaccaaag
     9421 aattgtttta ctattacatg gaaccccttc agttcttttc taatggttac tttttgttgt
     9481 tgttgttttg ttttttcttt cttttttttt tttgtttttt gtttgtttgt ttttgtttgt
     9541 ttgtttgttt tttgtttgtt tgttttttga gatagggttt ctctgtgtat ccctggctct
     9601 cctggaactc actttgtaga ccaggctggc ctggaactca aaaatccgcc tgcctctgcc
     9661 tcccaagtac taggatttta ggcgtgcacc actacgcccg gcttctaatg gttaattttt
     9721 taaaaacgtt gaaatattgg ctttcagctg tgatgcccta ttatatatat ttaagcaata
     9781 aatctagggc tggctagatg gccccgtgga tgcagtgctt tcctcccatc ctggttatgt
     9841 ctttgagtgc cattcttgat acatgcacat ggtggaacga tagtggtcct ttgacctctg
     9901 tatgtacttg gtgcacatgt atatgcacac acaaatatgt aatttaaatt tttaagattt
     9961 ttattttctg tgcatgatta ttttgcatgt atggatatgt accatgtaca agcctggtgc
    10021 ctgtgacagt cagaagaagc cacctaatcc ctagaaacca gagttataga taagcatgag
    10081 ctaccttgta ggttctggga atcaaacttg ggttttctga aagaacagca agtgttgtta
    10141 attgctgagc aatcttaatc cttttttaaa agactctgta aagtgtataa ttttttatgt
    10201 ctttgaatat agttgatttt catgttcaaa ctgagttcat tagtaaagat gccatctgtt
    10261 tcagcaagtt aaactactac tgagtactgc agggtcttaa cgctgcattt caaatagtgg
    10321 tgatggatct aattaatagg gctaatacag tttgtaaata gaatttaaat ctaaagatta
    10381 aaagcatggt tgttgaatga cgttcttgga ctcttagtac aacttaaagg tagccagaaa
    10441 ctcccatatt taagggtcac tagaatgtca ataatttaaa atcttaattg aaggctgagg
    10501 catatgacat ctttgtgctg aggtcaacct ggtctacaga aaagaacctg tttaaaaccc
    10561 aattaatctg gggggaaaat agggtcttag aaacacattt aagttaatgt tctattccgc
    10621 aaataatagc tgaagagttt tatttggtct aagatacaca tattaaaatg ataaagtatt
    10681 gtttctgaag tcagtggaaa tatttaacat gcttccagac ttgactgatt aagagtcagg
    10741 tttcatttga ttatttgtag ttgatttcat aggtagtttg tcaggtccac gggctgtaga
    10801 acaattgtgg gcattgttgt ggtgacattt gactggggca gaagcctgtt tttattacca
    10861 aaactctagc tcaggctggc ctgcaactca gtctcaaacc ctcttgtttc agcctcccaa
    10921 atgttttttc aacatttcat aggtatctta attttgtggt gtctgataac ttagttctgg
    10981 ttatgttttt gttgtccctg gctttatata ttgctctttg gtagtatcca ttaaagtcca
    11041 tgtcctttaa gtttaagatc tgtaattcct tttaacagtg ctcttactag ctatggaact
    11101 tcactgaggt cttagaatag atgatgttat aattttgtca caacatttct tcctgaggat
    11161 aaaaaccttt cttcaatgaa aagaaatgac ctgacctaag atgctaaaaa gaacaacctc
    11221 tgtcatgtag cttttatgct tcagttatag cagagtggat gttgtctttg ttaatttgta
    11281 attgggtaga gaactaactt tttaacatta aacacatatg cttattagtg cacagggaag
    11341 tgatagagtg agggggaatc aggtgggctg aatttgattt tgaggcaatc tcacattacc
    11401 cccagctgtc atcaaactta ggacaaatta ggctggctga cctcttgcag agatctgttt
    11461 gcctccaact tccctatgta ggcattaaca gtgtgtacta ccatatgaca ctcccttagc
    11521 caaaaatttg atgataaaac cttttggtgg aagaacaagc aatcctgtag ttagaaaata
    11581 gtggttggct tggaatgctt ctctgtcatg tataacacta ccttttccca attaatatga
    11641 ttagtttaaa atatatagtc aggtgtgtgg taagcaactt atctaattct agccttgtgg
    11701 ggtagagagc aagagttcaa ggctgggaaa actattttgt acatagttta ataagaaatg
    11761 tctaaagcat tttagttttt atagaataag acttttcaaa aaaactggaa ttgagtatag
    11821 aaaccaaagt atagtaggag aacttagtca ctacagcaca atgcaaacga tgccttacct
    11881 tttgtgtttt tgtgtttgtg tgtttgtttt gcctgtgtgc accatgtgca tgatgtgccc
    11941 acagacgtca gaaaaagggc atatcttctg gaatcttctg gaacttaaca gttccagaag
    12001 gttgtggtgg taggaattga acctgggtcc tctagaaggg cagccagtgc tcttagttac
    12061 tccggcccca ctttctctta ttttaaacca ttgggaagaa ttttttataa gtattttgaa
    12121 gcaaaggaag aaatagttct atattcttag tatccagaat tagttgtatt gtggcagtca
    12181 ggctgtgttt ggctgctttc ctaatttggt gacagttaag taatctgaaa ttagcctacc
    12241 gtcctcaagt atttatttgt ctcttaattt aaaagtttgt cagtcctttt aacaggataa
    12301 ttttattcat gtttggtatg tggtcaattt agttactgct agactggtct gaacgccttt
    12361 cctattagcc ataaaagttt gcctttataa gatagtcatg gttgtgattg ctttactggt
    12421 gttctaatac acatatagta tgaaacaact acttattttt ggtgagttag ttgctttcag
    12481 tccattttaa acactgttct gctaatagcc ttaacaaaat atgaactagt catttgttaa
    12541 tattttgctg cccttggtga aagtttagtt tatactgaaa gtatatttga tgagattctc
    12601 taattttaag ttacaattta acagaaatat ctgttaatta tattaataac actagtacct
    12661 gagaaataag ggcaccattc taaggggttg tattattaac agtcttggga acaagcagct
    12721 tccttagtat gtcgggcaca tgattgttga gaacgtttgc ttcagagtaa aatttctcat
    12781 gtgtaattgg gagttggctg tagtcatttg ccatttgaga ctgattattt ttaaatgtac
    12841 ttttatttaa aataaaagta taacttat
//
