LOCUS       NP_032313                135 aa            linear   ROD 30-APR-2024
DEFINITION  2-iminobutanoate/2-iminopropanoate deaminase [Mus musculus].
ACCESSION   NP_032313
VERSION     NP_032313.2
DBSOURCE    REFSEQ: accession NM_008287.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 135)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 135)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 135)
  AUTHORS   Sinha,S., Rappu,P., Lange,S.C., Mantsala,P., Zalkin,H. and
            Smith,J.L.
  TITLE     Crystal structure of Bacillus subtilis YabJ, a purine regulatory
            protein and member of the highly conserved YjgF family
  JOURNAL   Proc Natl Acad Sci U S A 96 (23), 13074-13079 (1999)
   PUBMED   10557275
REFERENCE   4  (residues 1 to 135)
  AUTHORS   Samuel,S.J., Tzung,S.P. and Cohen,S.A.
  TITLE     Hrp12, a novel heat-responsive, tissue-specific, phosphorylated
            protein isolated from mouse liver
  JOURNAL   Hepatology 25 (5), 1213-1222 (1997)
   PUBMED   9141440
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU559752.1, BC125592.1 and AW045776.1.
            
            On Jan 13, 2004 this sequence version replaced NP_032313.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI196495.1, BC092375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..135
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.34 cM"
     Protein         1..135
                     /product="2-iminobutanoate/2-iminopropanoate deaminase"
                     /EC_number="3.5.99.10"
                     /note="ribonuclease UK114; heat-responsive protein 12;
                     translation inhibitor L-PSP ribonuclease"
                     /calculated_mol_wt=14124
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P80601; propagated from
                     UniProtKB/Swiss-Prot (P52760.3)"
     Region          6..129
                     /region_name="TIGR00004"
                     /note="reactive intermediate/imine deaminase"
                     /db_xref="CDD:129116"
     Site            order(21..22,25,27,30,32,34..35,75,77..78,80,82,93,96,
                     105..112,122,124,126)
                     /site_type="other"
                     /note="homotrimer interaction site [polypeptide binding]"
                     /db_xref="CDD:100004"
     Site            order(21,89,93,107,122)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:100004"
     CDS             1..135
                     /gene="Rida"
                     /gene_synonym="HR12; HRP12; Hrsp12"
                     /coded_by="NM_008287.3:130..537"
                     /db_xref="CCDS:CCDS27418.1"
                     /db_xref="GeneID:15473"
                     /db_xref="MGI:MGI:1095401"
ORIGIN      
        1 mssiirkvis ttkapaaigp ysqavqvdrt iyisgqvgld pssgqlvpgg vveeakqalk
       61 nlgeilkaag cdfnnvvktt vlladmndfg tvneiyktyf qgslparaay qvaalprgsr
      121 veieaiavqg pfika
//
