LOCUS       NM_030168               9328 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RPTOR independent companion of MTOR, complex 2
            (Rictor), mRNA.
ACCESSION   NM_030168 XM_127914
VERSION     NM_030168.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9328)
  AUTHORS   Rosenlehner,T., Pennavaria,S., Akcabozan,B., Jahani,S.,
            O'Neill,T.J., Krappmann,D., Straub,T., Kranich,J. and Obst,R.
  TITLE     Reciprocal regulation of mTORC1 signaling and ribosomal
            biosynthesis determines cell cycle progression in activated T cells
  JOURNAL   Sci Signal 17 (859), eadi8753 (2024)
   PUBMED   39436996
  REMARK    Erratum:[Sci Signal. 2024 Dec 17;17(867):eadu7437. doi:
            10.1126/scisignal.adu7437.. PMID: 39689184]
REFERENCE   2  (bases 1 to 9328)
  AUTHORS   Li,M., Wang,Y., Wei,X., Cai,W.F., Wu,J., Zhu,M., Wang,Y., Liu,Y.H.,
            Xiong,J., Qu,Q., Chen,Y., Tian,X., Yao,L., Xie,R., Li,X., Chen,S.,
            Huang,X., Zhang,C., Xie,C., Wu,Y., Xu,Z., Zhang,B., Jiang,B.,
            Wang,Z.C., Li,Q., Li,G., Lin,S.Y., Yu,L., Piao,H.L., Deng,X.,
            Han,J., Zhang,C.S. and Lin,S.C.
  TITLE     AMPK targets PDZD8 to trigger carbon source shift from glucose to
            glutamine
  JOURNAL   Cell Res 34 (10), 683-706 (2024)
   PUBMED   38898113
REFERENCE   3  (bases 1 to 9328)
  AUTHORS   Qiu,P., Zhou,K., Wang,Y., Chen,X., Xiao,C., Li,W., Chen,Y.,
            Chang,Y., Liu,J., Zhou,F., Wang,X., Shang,J., Liu,L. and Qiu,Z.
  TITLE     Revitalizing gut barrier integrity: role of miR-192-5p in enhancing
            autophagy via Rictor in enteritis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (3), G317-G332 (2024)
   PUBMED   38954822
  REMARK    GeneRIF: Revitalizing gut barrier integrity: role of miR-192-5p in
            enhancing autophagy via Rictor in enteritis.
REFERENCE   4  (bases 1 to 9328)
  AUTHORS   Long,Q., Yang,J. and Liu,A.
  TITLE     [Platelet-specific Rictor knockout inhibits platelet production and
            activation and reduces thrombosis in mice]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (8), 1605-1611 (2024)
   PUBMED   39276057
  REMARK    GeneRIF: [Platelet-specific Rictor knockout inhibits platelet
            production and activation and reduces thrombosis in mice].
REFERENCE   5  (bases 1 to 9328)
  AUTHORS   Cullen,E.R., Safari,M., Mittelstadt,I. and Weston,M.C.
  TITLE     Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates
            epilepsy downstream of somatic PTEN loss
  JOURNAL   Elife 12, 91323 (2024)
   PUBMED   38446016
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9328)
  AUTHORS   Jacinto,E., Loewith,R., Schmidt,A., Lin,S., Ruegg,M.A., Hall,A. and
            Hall,M.N.
  TITLE     Mammalian TOR complex 2 controls the actin cytoskeleton and is
            rapamycin insensitive
  JOURNAL   Nat Cell Biol 6 (11), 1122-1128 (2004)
   PUBMED   15467718
REFERENCE   7  (bases 1 to 9328)
  AUTHORS   Sarbassov,D.D., Ali,S.M., Kim,D.H., Guertin,D.A., Latek,R.R.,
            Erdjument-Bromage,H., Tempst,P. and Sabatini,D.M.
  TITLE     Rictor, a novel binding partner of mTOR, defines a
            rapamycin-insensitive and raptor-independent pathway that regulates
            the cytoskeleton
  JOURNAL   Curr Biol 14 (14), 1296-1302 (2004)
   PUBMED   15268862
REFERENCE   8  (bases 1 to 9328)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 9328)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 9328)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036149.1, BC120903.1, AK173326.1 and AI854883.1.
            
            On Feb 22, 2008 this sequence version replaced NM_030168.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY540053.1, BC120904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2496              AK036149.1         2-2497
            2497-5365           BC120903.1         2136-5004
            5366-9278           AK173326.1         2871-6783
            9279-9328           AI854883.1         1-50                c
FEATURES             Location/Qualifiers
     source          1..9328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.25 cM"
     gene            1..9328
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /note="RPTOR independent companion of MTOR, complex 2"
                     /db_xref="GeneID:78757"
                     /db_xref="MGI:MGI:1926007"
     exon            1..71
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..5149
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /note="mAVO3; AVO3 homolog; protein pianissimo"
                     /codon_start=1
                     /product="rapamycin-insensitive companion of mTOR"
                     /protein_id="NP_084444.3"
                     /db_xref="CCDS:CCDS37032.1"
                     /db_xref="GeneID:78757"
                     /db_xref="MGI:MGI:1926007"
                     /translation="MAAIGRGRSLKNLRIRGRNDSGEENVPLDLTREPSDNLREILQN
                     VAKLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFNYEDIIICLRLALLNEAKEVRAA
                     GLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASL
                     FPSSVANSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDC
                     QLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLKED
                     REARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDI
                     FRLPLPVVTDEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYL
                     ALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLP
                     TLMNMAASFDIPKEKRLRASAALNCLNRFHEMKKRGPKPYSLHLDHIIQKAIATHHKR
                     DQYLRVQKDIFVLKDTEEALLINLRDSQVLQHKENLDWDWNLIGTILKWPNVNLRNYK
                     DEQLHRFVRRLLYFYKPSSKLYASLDLDLAKSKQLTVVGCQFTEFLLESEEDGQGYLE
                     DLVKDIVQWLNASSGVKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVF
                     QCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLL
                     RANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLG
                     DKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHKEYNSKYVDLIEEQLNEALTTYRK
                     PIDGDNYVRRSNQRLQRPHVYLPVHLYGQLVHHKTGCHLLEVQSIITELCHNVRTPDL
                     DKWEDIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVL
                     GLIAKTKQGCDILKCHSWDSVRHSRKHLWPVVPDDVEQLCNELSSVPSTLSLNSESTS
                     SRHNSESESAPSSMFMLEDDRFGSTSTSTFFLDINEDAEPAFYDRPGPIKDKNSFPFF
                     GSSKLVKNRILNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTLTEPSVDLNHSED
                     FTSSSAQKSLQLEPSFVGNKHLEDAGSTPSIGENDLKFPKSFGTETHRENTSRERLVV
                     EGSASSHIKIRSQSFNTDTTTSGISSMSSSPSRETVAVDPTAMDTDCGSLSTVVSTKT
                     VKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSY
                     TSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSR
                     FMKALSYASLDKEDLLSPINHNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIF
                     QIKDVPYFQSKHVPPPDDRGARMFSHDGAGLSSGAGGLVKNSFHLLRQQMSLTEIMNS
                     VHSDASLFLESTEDTGLQEHTDDNCLYCVCIELLGFQPSNQLSSICSHSDLQDIPYSD
                     WCEQTIHNPLEVVPSKFSGISGCSDGASQEEGSASSTKSTELLLGVKTIPDDTPMCRI
                     LLRKEVLRLVVNLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLQ
                     CRRFIQELFQDVQFLQMHEEAEAVLAIPPIQPIVDESAES"
     exon            72..119
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            120..217
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            218..282
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            283..414
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            415..478
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            479..605
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..775
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            776..843
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            844..911
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            912..994
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1082
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1173
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1240
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1321
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1422
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1588
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1690
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1737
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1873
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2073
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2200
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2365
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2442
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2521
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2631
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2719
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2812
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2919
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3149
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..4155
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4333
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4418
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4419..4652
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4653..4811
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..4935
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5074
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5075..9314
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9289..9294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      9314
                     /gene="Rictor"
                     /gene_synonym="4921505C17Rik; 6030405M08Rik; AVO3;
                     D530039E11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgactg aaacccgtca atatggcggc gatcggccgc ggccgctctc tgaagaacct
       61 ccgaatacga gggcggaatg acagcggcga ggagaacgtc ccgctcgatc tgacccgaga
      121 accttctgat aacttgaggg agattctcca aaatgtggcc aaattgcaag gagtatcaaa
      181 tatgagaaag ctgggccatc tgaataactt cactaagctt ctttgcgata ttggccatag
      241 tgaagaaaaa ctgggcttta attatgaaga catcataatt tgtttgcgct tagctttatt
      301 aaatgaggca aaagaagtaa gagcagccgg gttgcgagcg ctgcgctatc tcatccaaga
      361 ttccagtatt ctccagaagg tgctaaaact gaaagtggac tatttaatag ctaggtgcat
      421 tgacattcag cagagcaacg aggtggagag gacacaagcc cttcgcttag tcagaaagat
      481 gattactgtg aatgcttcct tgtttcctag ttctgtggcc aactcattaa ttgcggttgg
      541 aaatgatggg cttcaggaac gagacagaat ggtccgggct tgcatcgcca tcatctgtga
      601 actagcactt cagaacccag aggtggtagc ccttcgagga ggactaaaca ccatactgaa
      661 aaatgtgatt gattgccaat taagtcgaat aaatgaggct ctcattacta caattttgca
      721 ccttcttaat catccaaaga cccggcagta tgtgcgagct gatgtagaat tagagcgaat
      781 tttagcaccc tatactgatt tccactacag acacagtcca gatacggctg aaggacagct
      841 caaagaagac agagaagcac gatttctagc cagtaagatg ggaatcattg cgacattccg
      901 ctcgtgggca ggtattatta atttatgtaa gcctggaaat tctgggatac agtctctaat
      961 tggagtactt tgcataccga atatggaaat aaggcgaggt ctgctcgaag tgctctatga
     1021 catctttcgt ctccctctgc ccgttgtgac ggatgagttc atagaagccc tgctcagtgt
     1081 agatccagga agattccagg acagttggag gctttccgat ggctttgtgg cagctgaggc
     1141 aaaaactatt cttccccatc gtgctagatc caggccagac ctcatggaca attatttggc
     1201 tctgatactc tctgcattta ttcgtaatgg acttttagag ggcttggtcg aggtgataac
     1261 gaacagtgac gaccacatct cagtgagggc gaccatcctt ttaggagagc tcctgcatat
     1321 ggcaaacacc atcctgcctc actcgcatag ccaccatcta cactgcttgc caaccctcat
     1381 gaacatggct gcgtccttcg atattcccaa ggaaaagagg ctgcgagcca gtgcagccct
     1441 gaactgtttg aaccgcttcc atgagatgaa gaagcgagga cctaagccct acagccttca
     1501 tttagatcac atcattcaga aagcaatcgc aactcaccac aagcgggatc agtatcttcg
     1561 agttcagaaa gatatatttg ttcttaagga tacagaggaa gctcttttaa taaaccttag
     1621 agacagccaa gtccttcagc ataaagagaa tcttgactgg gattggaatc tgattgggac
     1681 catccttaag tggccaaatg taaatctaag aaactataaa gatgagcagt tgcacaggtt
     1741 tgtgcgcaga cttctttact tttacaagcc cagcagcaaa ctgtacgcta gtctggatct
     1801 ggacttggcc aagtccaagc agctcacagt tgttggttgt cagtttacag aatttctgct
     1861 cgagtctgaa gaggatgggc aaggatactt agaagatctc gtgaaagata ttgttcagtg
     1921 gctcaatgct tcatctggag tgaaacctga gagaagcctt cagaataatg gcttactgac
     1981 cacccttagt caacactact tcttatttat cggaacactc tcttgtcatc ctcatggagt
     2041 caaaatgctg gaaaagtgca gtgtctttca gtgtctcctt aatctttgtt ccttgaaaaa
     2101 ccaagatcat ctgataaaac tcactgtttc cagcctagac tatagcagag atggattagc
     2161 cagagtcatt ctttcaaaaa tcctcacggc agccacagat gcttgcagac tgtatgcaac
     2221 aaaacattta agggttttat tgagagctaa cgttgaattc ttcaacaatt ggggaattga
     2281 gttactagta actcagctac atgataaaaa caaaacaatt tcttctgaag cgctggatat
     2341 tcttgatgaa gcttgtgaag acaaggccaa tcttcatgct cttattcaga tgaagccagc
     2401 cttatcccac cttggagaca agggcttgct tctactgctg agatttcttt ccattccgaa
     2461 aggattttct tacctgaatg aaaggggtta tgttgcaaaa cagttggaaa agtggcacaa
     2521 ggaatataat tcaaagtatg ttgacttgat tgaggaacaa cttaatgaag ccctcactac
     2581 atacaggaag cctattgatg gtgataacta cgttcgtcgc agtaatcaaa gactacagcg
     2641 acctcatgtc tacctgcccg tacaccttta tggacaactg gtacaccaca aaacaggctg
     2701 ccatttactg gaagtacaga gtatcatcac agagctctgt cacaatgttc gcactccaga
     2761 cttggacaaa tgggaagaca ttaagaagct gaaagcctct ctttgggcct tgggaaatat
     2821 tggctcatcg aattgggggc ttaatttgct acaggaagaa aatgtgatcc cagatatact
     2881 aaaacttgca aaacagtgtg aggtcctttc catccgaggg acctgtgtat atgttcttgg
     2941 gctcatagct aaaaccaagc aaggctgtga tattttgaaa tgtcacagct gggattctgt
     3001 aaggcacagt cgcaagcatc tatggccagt ggttccagat gatgtggagc agctctgcaa
     3061 tgagctctca tctgtcccaa gcaccctcag cttgaactct gagtcgacca gctctagaca
     3121 taacagtgag agtgagtctg caccatcaag catgttcatg ctggaggacg accgcttcgg
     3181 cagcacctcc accagcacat ttttccttga catcaatgaa gatgctgagc cagcatttta
     3241 tgaccgacct ggacccataa aagataaaaa ttcatttccc ttttttggct ccagcaaact
     3301 tgtaaagaat cgtatcttaa attcacttac tttgcctact aaaaaacacc gcagtagcag
     3361 tgatccaaaa ggaggaaaac tgtcatctga aaataagaca agcaaccggc gaatcagaac
     3421 acttacggag cccagtgttg acttgaatca cagcgaagac ttcacaagct cctcagcaca
     3481 gaaatcatta cagctagagc cttccttcgt tgggaataag caccttgaag acgcgggcag
     3541 cactccaagt attggagaga atgacctcaa attccccaag agttttggta ccgagactca
     3601 cagagaaaac acaagccgag aaaggttggt tgtggaaggc tcagcaagct cccacatcaa
     3661 gatccgcagc cagagcttta acacggacac tacgacgagt ggcatcagct ccatgagctc
     3721 gagcccctcc cgagagacag tcgctgtcga ccccacagct atggacacgg actgtggaag
     3781 tctgagtacc gtggtaagta ctaaaactgt taagacgagc cactatttga caccacagtc
     3841 taaccatctg tctctctcca aatcgaactc agtgtccctg gtgccaccag gttcttctca
     3901 cacccttcct agaagagccc agtcccttaa agcgccctcc attgcaacaa taaaaagtct
     3961 agcagattgc aacttcagct acacaagctc tagagatgcc tttggctatg ctacattgaa
     4021 aaggttacag cagcaaagaa tgcacccgtc cttgtctcac tcggaagctt tggcgtcgcc
     4081 ggcaaaagat gtgcttttta ccgacaccat caccatgaag gccaacagct ttgaatccag
     4141 actgacgcca agcaggttta tgaaagcttt aagttatgcg tcattagata aagaagattt
     4201 actaagtcct attaatcaca ataccctcca gcgctcctcc tcagttaggt ctatggtgtc
     4261 cagtgctaca tatggaggtt ccgatgacta cattggactt gctcttccag tagacatcaa
     4321 tgacatcttc cagataaagg atgttcctta ttttcaatca aagcacgtgc ctccaccaga
     4381 tgaccgaggt gcaagaatgt tttcccatga tggagcaggt ctttcatctg gagccggtgg
     4441 tctcgtaaag aactcttttc acttgctgcg gcagcagatg agtctcacag aaataatgaa
     4501 ctctgtccat tcggacgcct ccctgttctt agagagcaca gaagacactg ggctgcagga
     4561 gcacacggat gacaattgcc tttactgcgt ctgcattgaa ctcctgggct tccagcccag
     4621 taaccagcta agttccatct gcagtcactc cgatcttcaa gatattccgt actccgattg
     4681 gtgcgagcag acgatccaca accccttaga agtggttccc tctaagttct cggggatttc
     4741 tggctgcagc gatggcgcat ctcaggaaga aggctcagcc agcagcacca aaagcactga
     4801 gctgttactg ggtgttaaaa ccattccaga tgacacaccc atgtgccgga tcctgcttcg
     4861 taaggaagtg ctaagattag ttgtcaattt gagtagttca gtttccacca agtgtcacga
     4921 gaccgggctt ctgaccatta aagagaagta tcctcaaaca tttgatgaca tatgccttta
     4981 ttctgaagtt tctcatctgt tgtcacactg cacatttaga cttcagtgtc ggcggttcat
     5041 acaagagtta tttcaggatg tacagttttt acaaatgcat gaagaagcag aggctgtgtt
     5101 ggcaattcca ccaattcagc ctatagttga tgagtctgct gaatcctgac ctcatgctta
     5161 tgacgtttat agctggatac tctatatgta ttcctactgt ggacttcctg aaagccccac
     5221 aggatactga ctggctgaca gtgaggcagg agagccttct gacactggcc agcagttatt
     5281 ggtacagaac agctgggact gctggcattc ctagccaagc caacttctct cccgcgttgg
     5341 gcccttctcg gggttcgtgg ttcattacca tggttttaat tcagttacca tcatatgcaa
     5401 gagccaagca ctgaatatct acataggttt tctatttttt tattttcaaa gcgcaatggc
     5461 agtggaacaa aacaggacat gaagacgcat ccttcacacc gttgttttct gaatgctttt
     5521 taatcaaggg taaatacaaa agatgccttg tttgttaact aatttgtgga aagcaggagt
     5581 cactgactcc gagactgcat cctgttaccc cgtgggctgt aactgctggt atcagaggaa
     5641 cacactcgcc tttccacact tcttaatgtc tgtaacacta cttcagaggt ttataacttc
     5701 acagcagaag gaacacctca gcactcggaa cttggaagtt agtttacgat gctagatgca
     5761 taaggatgct tacttgtcct ctgtcgcttc aggttgttgc aatacgttgt taaaggctat
     5821 ttctactaat taaggttttt cactatggtt gtgatgtagt aaggagtaaa tacttctcgt
     5881 gttcagagca cattgtaccc aacctcctcc actcctctca ccacttacaa gggactgagc
     5941 cagatgagca gtctggacaa agcaaaggaa gcatgaagtg aggctgcagt ctctcaagga
     6001 aaagacagct ttgcctgcag tttacacatt ccatgggaaa aaggaagagc catatgtcct
     6061 attaaaacgt cattgagact cgttattaag attcagaatt gtggtgaaaa gccttaatta
     6121 ctaaatttta aagcagcgat aatttaattt ttgttagtgt tcctgttttg cataaattgc
     6181 agttataggt gagttaaaag tatagtcatt gcctttatca catttgtgaa gttgatgaag
     6241 gcgagacttt gtctgtctaa tttgtttatg tataaagaga cttggaaatc ttcacaggaa
     6301 ttaaacatat atgcaaattt gtacataaag tagcatgaac atcattacta gactgcttac
     6361 gcgtgaaagg gttatcttgg aacaaaccat ccagctgact aggactgact aggacctttg
     6421 caattccttt gtgtaaccca ttttacaatt gcacatcagc tttaacatgt catagacatt
     6481 ggtccatatt ttcccatgtc gtacaccctt ctcataatgg tcttgtttgc aagactgctg
     6541 taaagtaccc tgtgaactag aaaacataac tcacagaaat ttgtctttga acttgctggc
     6601 actgaaagtt ggcactgaga cgaagcattt cctgtccctc ctgactcctc tttgactgca
     6661 cttgagcgag ttgttcttct gtgcactgta tagcaacttc catgataaca aagcagacaa
     6721 gggctctaag ctgctgctca cattacagca cagttcgcat tttcccagaa aattcagtga
     6781 gggtaaaact ttcttttcaa cttcatcact gaacccgtgt tcattaaatg tcagcagtgc
     6841 ttgaaagagc atgcctatca ccttggtctt tggtcttgga caataaaact gcctttccag
     6901 agaaccaaat gtcagagata ctagaccaaa taatggttac aattccaaag gaagtaatgt
     6961 agtcttattc ataaatggga ttaacatttt agacattcat tttaaacact acctcagtta
     7021 acagagtaga aaatctgtgg tttcgtccct tgagagttaa tgataactat tcttgtttgt
     7081 ttttcttcac acaaaactat gcccattctc gcgcccaagt cagccatcat gaacctgagg
     7141 ctgtgcccta gtgtcctaag ccaaggattg tgttttcact ttgactgtta ctttgaaagg
     7201 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgatcata tctgcctata gcacttactt
     7261 tgggaagata tcagagcttt gtgatgatca gtatactggg ggaaattgtc tatgcttaaa
     7321 tttatagtgc tatttggttt aaccatggtt tcaccaacag gtgtaataca tttcttttta
     7381 agtacatgta taaaagtaga cttttatgac gaaaacgaca tgcagtgcca agtgattagc
     7441 ataggtgttt aagactatta aattatagca gaaaaggtta tgaatgatgt caatggtaat
     7501 agcaatcatt gaaaaattgt ctataaatat tagatattac caaaatgtca ataccgtagt
     7561 ttttcaagag tttagaatta atcttagtca tataaatttg tactattgat aattatttaa
     7621 taatttggag gagtttgaac agttaagctg gttgtaaact gtgaatttct aattgtaaat
     7681 tgtcatttct aattgaaatt ttttcaagaa cagatttcag cttcacatac taagtactga
     7741 caaataaaaa agtgagaaat ttagtattta taagaaaata ggctctaaaa tgtcttatgc
     7801 ttttctgttt ctgcttagag tataatggag gaagacagtg tcccctgacc taagtgtttc
     7861 taataaagag taagtgtaga gacatcccac aagacagcag cagtgcaagg ctcttaggaa
     7921 gtgtgtgcac tgttgctgtg gtgatgtatc caagtcacca ggagccgtgt cctcaggagc
     7981 tttcggctct tgtccagagc ttgagacagt tgaagctggg ttccatcact gagaccagat
     8041 gtgcgtaggg gctgctagtg tgtgtgtaaa ctgcccactg ctgtttccat gcactctcag
     8101 ccccttcagc tgatgcccct ggtgccccac tcaaagcaca gaccattaag caataaacaa
     8161 aattgtcatt caaattataa ttgtggttat tctcctgtga taagaggtgc taattttgtg
     8221 tgagaagaac atgtgacctc tttggaaata tagtttggaa gtaaagtttt tccccctctt
     8281 cttgtacttc cattttgtcc caaattcaca gttcatgaaa gaaaagtaaa attgtttagg
     8341 agacttctaa gaagagctgc ttgcaataaa catttcagat tttcccgagt gtgagttggg
     8401 aaggtctcca tttcctccat actgacaaag cctgttgttc caacgtctct tagcttggag
     8461 agtgtctcta cactgagtct cacctcagcc tgccagtgac cctgaggtca ctgctgagga
     8521 agacacagga gtctgcacta gtctttacaa gagccgttgt catttcaggt ccccgggggt
     8581 tcattacagt acatttatac aactcacaag agtgtgggat tccgcccctt tgagtatttt
     8641 tatagttagg tggataactg ccgcagatgc atggattgca cattttgact ctataatact
     8701 tagtatgaaa aattaattta tgccaaaaaa aaaggaaaca tatcttacaa tttccccaac
     8761 taggttgatc tagcacaaga tgcaaagtct tggggcagag cgggagtggt aaaatctttt
     8821 aatgtatgat tgttgaaaaa tgttccatta ctagcctgtc aaaaacccta atgatgcatt
     8881 gtaaaacaaa tgatgtaaat taaattagct ttgaaaagtg gtaagggatt ataaagagga
     8941 tctcagattt aatgctctct gaccacatga cctttttttt ttttttttta gtaatacgct
     9001 gctacatttt tggaggttct ggtgtttgta ggtcactgaa cagacattga aatctgattt
     9061 atattgtata actgtaacat agaaagaaaa agtatttata tattttcctt aagaatattt
     9121 cattgagttg tgtataattt aaataagatt tgtcccaaaa tggttttgct cactttgatt
     9181 tttttgttgt tgttattgtg gttgtattgt ttttgtacaa tgtgtacagt ttatgttaag
     9241 ggcattaaag cctcctgaag cataatctta tcaaagggat tcattgttaa taaaatgtac
     9301 ttaaaattct taaaaaaaaa aaaaaaaa
//
