LOCUS       NM_001038624            5303 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus RIC3 acetylcholine receptor chaperone (Ric3),
            transcript variant 1, mRNA.
ACCESSION   NM_001038624
VERSION     NM_001038624.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5303)
  AUTHORS   Ben-David,Y., Kagan,S., Cohen Ben-Ami,H., Rostami,J., Mizrahi,T.,
            Kulkarni,A.R., Thakur,G.A., Vaknin-Dembinsky,A., Healy,L.M.,
            Brenner,T. and Treinin,M.
  TITLE     RIC3, the cholinergic anti-inflammatory pathway, and
            neuroinflammation
  JOURNAL   Int Immunopharmacol 83, 106381 (2020)
   PUBMED   32179243
  REMARK    GeneRIF: RIC3, the cholinergic anti-inflammatory pathway, and
            neuroinflammation.
REFERENCE   2  (bases 1 to 5303)
  AUTHORS   Deshpande,A., Vinayakamoorthy,R.M., Garg,B.K., Thummapudi,J.P.,
            Oza,G., Adhikari,K., Agarwal,A., Dalvi,P., Iyer,S., Thulasi
            Raman,S., Ramesh,V., Rameshbabu,A., Rezvaya,A., Sukumaran,S.,
            Swaminathan,S., Tilak,B., Wang,Z., Tran,P.V. and Loring,R.H.
  TITLE     Why Does Knocking Out NACHO, But Not RIC3, Completely Block
            Expression of alpha7 Nicotinic Receptors in Mouse Brain?
  JOURNAL   Biomolecules 10 (3), 470 (2020)
   PUBMED   32204458
  REMARK    GeneRIF: Why Does Knocking Out NACHO, But Not RIC3, Completely
            Block Expression of alpha7 Nicotinic Receptors in Mouse Brain?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5303)
  AUTHORS   Ben-David,Y., Mizrachi,T., Kagan,S., Krisher,T., Cohen,E.,
            Brenner,T. and Treinin,M.
  TITLE     RIC-3 expression and splicing regulate nAChR functional expression
  JOURNAL   Mol Brain 9 (1), 47 (2016)
   PUBMED   27129882
  REMARK    GeneRIF: Regulation of expression level and splicing of RIC-3 in
            brain and in immune cells following inflammation enables regulation
            of nicotinic acetylcholine receptor functional expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5303)
  AUTHORS   Alexander,J.K., Sagher,D., Krivoshein,A.V., Criado,M., Jefford,G.
            and Green,W.N.
  TITLE     Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking
            through the ER subcompartment of dendrites
  JOURNAL   J Neurosci 30 (30), 10112-10126 (2010)
   PUBMED   20668195
  REMARK    GeneRIF: In neurons, Ric-3 ER retention appears to promote
            transport within the dendritic ER subcompartment, thereby
            restricting 7 trafficking to dendrites and preventing axonal
            transport.
REFERENCE   5  (bases 1 to 5303)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 5303)
  AUTHORS   Wang,Y., Yao,Y., Tang,X.Q. and Wang,Z.Z.
  TITLE     Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly
            of the alpha7 acetylcholine receptor through a cytoplasmic
            coiled-coil domain
  JOURNAL   J Neurosci 29 (40), 12625-12635 (2009)
   PUBMED   19812337
REFERENCE   7  (bases 1 to 5303)
  AUTHORS   Osman,A.A., Schrader,A.D., Hawkes,A.J., Akil,O., Bergeron,A.,
            Lustig,L.R. and Simmons,D.D.
  TITLE     Muscle-like nicotinic receptor accessory molecules in sensory hair
            cells of the inner ear
  JOURNAL   Mol Cell Neurosci 38 (2), 153-169 (2008)
   PUBMED   18420419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY279630.1, BY241896.1 and BC059258.1.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134663.1, SRR1660815.77078.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-381               BY279630.1         3-383
            382-427             BY241896.1         389-434
            428-5303            BC059258.1         170-5045
FEATURES             Location/Qualifiers
     source          1..5303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.21 cM"
     gene            1..5303
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /note="RIC3 acetylcholine receptor chaperone"
                     /db_xref="GeneID:320360"
                     /db_xref="MGI:MGI:2443887"
     exon            1..162
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1142
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; protein RIC-3; resistant to inhibitor of
                     cholinesterase 3; resistance to inhibitors of
                     cholinesterase 3 homolog"
                     /codon_start=1
                     /product="protein RIC-3 isoform a precursor"
                     /protein_id="NP_001033713.1"
                     /db_xref="CCDS:CCDS21733.1"
                     /db_xref="GeneID:320360"
                     /db_xref="MGI:MGI:2443887"
                     /translation="MAYSTVQRVALASGLVLAVSLLLPKAFLSRGKRPEPPPGPEGKL
                     DRFPPMMHHHSAPSDGQTPGARFQRSHLAEAFAKAKGAGGGAGGGGSGRGLMGQIIPI
                     YGFGIFLYILYILFKLSKGKTAEDRNCSTAPPGNAHRKITNFELVQLQEKLKETEEAM
                     EKLINRVGPNGESRAQAVTSDQEKRLLHQLREITRVMKEGKFIDTSPEKEAEEAPYME
                     DWEGYPEETYPIYDLSDGIKRRQETILVDYPDLKEPSAEEIAEQMGEIEEEGSERLSW
                     DHLPTDPGAQKDNSVAPCDPKPESCSCCVHEEEDPAVLAENAGFSADGYSEQEEATKE
                     NLPQDFTNEGLGVSTDNAHVGGMLRKRNPQGFE"
     exon            163..389
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            390..462
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            463..556
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            557..702
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            703..5267
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4058..4063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4077
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
     regulatory      5240..5245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5262
                     /gene="Ric3"
                     /gene_synonym="E130307J04Rik"
ORIGIN      
        1 gttccggttc ggactcctgg gtcctgcggt acgcagccat ggcgtactcc acggtgcaga
       61 gagtggcgct ggcctcgggg ctcgtcctgg ccgtgtcgct gctgctgccc aaggccttct
      121 tgtctcgcgg gaagcgaccg gagccgccgc cgggcccgga aggaaaattg gaccgatttc
      181 cacctatgat gcatcaccac tcggcaccct cagatggtca gacaccaggg gctcgtttcc
      241 agaggtctca ccttgcagag gcctttgcaa aggccaaggg agcaggtgga ggtgctggag
      301 gagggggtag tggaagagga ctgatgggcc agatcattcc aatctatggc tttgggatct
      361 ttttgtacat actgtacatt ttgtttaagc tttcaaaggg gaaaactgca gaggatcgga
      421 actgctccac tgccccacct ggaaacgccc acaggaagat taccaacttt gagcttgttc
      481 aactacaaga aaaactaaaa gagacagaag aagccatgga aaaattaatc aacagagttg
      541 gacctaatgg tgagagcaga gcacaggctg tgacttctga ccaagagaaa cgattactgc
      601 atcagctccg agaaatcacc agggtcatga aagaaggcaa gttcatcgac acatctccag
      661 agaaggaagc tgaggaagcc ccatacatgg aggactggga aggttaccca gaagagactt
      721 atccaatata tgacctttcg gatggtatca agcgtaggca agaaacaatc ctggtggatt
      781 accctgacct aaaagagccc tctgctgaag aaattgctga acaaatggga gagatagaag
      841 aggaaggatc agagcgtttg agctgggatc atttgcccac tgaccctgga gcccagaaag
      901 ataattctgt tgccccgtgt gatcccaaac cagaatcatg ctcctgctgt gttcatgaag
      961 aggaggatcc tgctgtcttg gcagagaatg ctggtttcag tgcagatggc tacagtgagc
     1021 aagaggaagc caccaaggaa aacttgcccc aggactttac aaatgaaggg ctgggagtca
     1081 gcactgataa tgcacacgtg ggtggtatgt tgaggaagcg caacccccag ggttttgagt
     1141 gaaagcagcc tgcttgggaa agtatccatt actctgttcc catggcacct ttcctcagtt
     1201 tcatccatgg ccttgtgccc tctgcatcct ctgtgttcaa taccatagct cttgggccac
     1261 taccatggat acagctaatc cttcccggtg cttgcacacc tgtcactttg taaagtagcc
     1321 agtagtgtga acacgggaca gaatcacctt cctagtcatg cgcttcccta tcagagtgtg
     1381 aacacagcac agaatcacct tcctattcat gagtttccct atcagagaca ctaatccact
     1441 cggtaattgt atttggttgt ttgtgcttgc aggtggtacc acctaggcaa atgtctgacc
     1501 cctcctcata ggagcaacag atgatttacc tgtgaatgat ttattgaatg gatttgttag
     1561 gataggatga ccgtgaaaga gaactgggtt agctgatatt gaggacttaa gttttaagaa
     1621 tgaagatttt agattcccaa atgccttatt ctttgggcct tcagctggtt agtggtccct
     1681 gagaagagca tgctcaattc tgagcctagg ggcccagagc acagcaagat atctgattga
     1741 gctgcagtct ctcctcacag ccttctaaga tgccctgact cctccagagc agcaggccat
     1801 gaactcacgg gcctatttgg agaccatttt gcttgtatat tccctcgatc cctgcttcct
     1861 ttgtctttat tctgttgaac agaactgcca aatctagagg caactctgaa tgtcttctgt
     1921 ggctagaggg atttggaggc attaatctgt gtcccacaga gctgaagttt gaggctgttg
     1981 aagctacagg actgcttaag tatggtggtc cttccatgag gagctcaagt agccaggaaa
     2041 ccctgagaat tctaacaagg gtgtgtcagt tcagttacat gaattgaaag ctgaaaggct
     2101 gtgcatctcc aacaacattc cgagtcatga aatgggagac tcaaaattta aggaattctg
     2161 tgaagctgga tagtctttag agttctattg tgcctggcat gcctatgatg ccagaagata
     2221 gtttggacca ctcaggagcg tactgccctg gctgtcatca ggtctgagac cacactaaga
     2281 cactgtcagc tactagaaag ctttacatgt taacgggact agagaaacac aaacgctgca
     2341 ctgtaccaat ccctgtgtag aatgtttgat tgaaattgtg cagaatgcag ttgaacatgt
     2401 actgaagatg gtcttgacat aactaagtgt aaaaagcaac gcagatactc ttgtttgagc
     2461 agattgtttt ctggatggtt ctggcatcca ccatgagaag ttgatttaag atagccccgt
     2521 atcactggtt ctaatttttg ttcataggat ataattctgt tattagataa gaacttgttt
     2581 ccttctcatt catttgttgg acaacggccc tgtgctaagt actgagtgtc tgtgcatagt
     2641 ccaatgcccc aactaagaag actgaatttg tacgaatttc agtttaatgt gctaatctaa
     2701 cagatgcact atggaccata ggaaggctag agattgtgaa ttcttcagac agatttccct
     2761 gcaattcagg ctgtggaatt ctggattggc tccttaagca tcccaagcct ggttgggcat
     2821 ctataaagtg tgagggtagt aaaaacacag gtcttacagg gctgtaagct gcaaatgagg
     2881 tagtcagtgc acatagggca gcatgcttat gttgttagct catgcaaaac aacatatcat
     2941 gtggtagctg ttttattcat tatagtgtgg accctaaact gtaggagcac agaagaacaa
     3001 gaatgttctt gccaagtacc aaaaaaatct cagagacacc ttgtggaaag ctaaaacatg
     3061 gcaagaggag gaaggacatt tgggcaaaaa aagtaggtta gcaagaacag tgtggttggt
     3121 gtatagatgg gtaatcaggt gaaaagggtt tagcaccaac tctatcattg gggattagct
     3181 atggaaacaa ttcctgccaa aaggaccagt ccttcatggt tcttgccact ctacatgtta
     3241 gtctgcatat aggaatatat ttgtttgtat ataccagaaa ctttgaagaa cctattagta
     3301 atttggaata taggcatttt ttcccagaat tttatctttt agatatgatt tttacaggtt
     3361 gaccaaaatc aaggggcttg gtttcattgt atgatcttca tttctcaata ttaagggttt
     3421 catcaaggcc ttaccattag gtctccagtg acctatgggg caccatagca gtagttggcc
     3481 taagaagcca ctgtacatca cctaggagtg tgcttggtaa gtcaggtggg tgatcagcca
     3541 gaagacccct taacacagct atggaacaag actgtgtgcc tccttatctc aaggcctggg
     3601 cctgggaggt atgctgaaga gtggagatgg actcagcctc tagaaataat ggcttgagag
     3661 aattatgttc tttgtattta gacttaagca ataatggtct tcactcagac actctggaaa
     3721 gaagaaccta aactcacggc ataattaaac gttctcattg tatggaaggt aacaatgcag
     3781 gaggagcatg tagttgaggg cagtccttca gggcagcagg agccagcggg caggctcaca
     3841 gggagctgag gtgaatgatg atacacagca cttggcttgt tttgcccctc ttatcagtct
     3901 gggaccccag ccaaagggat gatactgtcc atagtaagga tgggtcttcc tcctcaacta
     3961 actttcttgt aaacaccttc atagacaagt atgttttcat ggtgattcta agccccttaa
     4021 gttggcaatc aagagcaaac cagaggtaat aggtataaat aaagattttc ctctgcatgt
     4081 gttctacaca attgaggatt ttttcttaaa cttgatgact aaacaaacaa aacctcttcc
     4141 ctttgtcgaa caccctgtat atggtcttca caaatgcaat cactacagga accaggccat
     4201 gttcaggtag ggaatgcttt tgactcacat caaaaacact tagctgagta gataaatgaa
     4261 ccctaattat agacctgctc ttaaattctt tttatttaga caatttgtat ctgcaaagaa
     4321 catttcatat gtcacctatt gggcagtgat caggaaggat actaatcaac tattctgtaa
     4381 tctccttaac cattagcatg tctaaaacac tttgtagtat caaaaaacca ggccattcct
     4441 tcacttcaaa gggtaccact ttccttatgg atggaccagg aatcacgtcc accttacagg
     4501 actgtttctg aaagctgccc agtgtgaagt gtgcaatggt aggtgcttat tagcacatca
     4561 ctgtcttgaa tctcatgctt ctggactacc caacttgata ctctatggcc actctgcatg
     4621 ccaagaatgg tccagagtca ctctgaggag ttcttgtgac tttgtgatga ctccttttag
     4681 aacaactata ggctttcatc atgttggcct caaatccacc acagactgaa aaagggttcc
     4741 cactatgtaa gagtcctgtt taaatagacc cacctccaag caaggcctgc agtcatgtgg
     4801 ctgggccttt cccactcttg agtactacag cccagttctg tccacaaggg ccatgtccac
     4861 caagcatact taagaactgt cagccagttc cttaagtgac cagatgacct gaagtatcct
     4921 ctaacccttt tttccccatg ctatagatgt ggtttcacag gagaaggcag tgctgatctg
     4981 tatgccactc actggttcta aacgtgctct gggccctcag ttgctcttac gcacctgacc
     5041 ctttgaagcg cctagaaagg actgggatgg agaacatttt aggagagaca tgttctcttc
     5101 tctatgaaaa ccaaggacac agccgtcaaa cagttcaagt ttaatgtgtt gatacatgtc
     5161 tgtacttaga caaacactaa attctacaac atacataatg tcattatggg aaaataccaa
     5221 gtttgtcatt gcacatacca ataaataaat acatttgctt cagaataaaa aaaaaaaaaa
     5281 aaaaaaaaaa aaaaaaaaaa aaa
//
