LOCUS       NP_082173                686 aa            linear   ROD 01-JUN-2024
DEFINITION  rhophilin-2 [Mus musculus].
ACCESSION   NP_082173
VERSION     NP_082173.3
DBSOURCE    REFSEQ: accession NM_027897.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 686)
  AUTHORS   Liu,Z., Fang,F., Li,J., Zhao,G., Zang,Q., Zhang,F. and Die,J.
  TITLE     [RHPN2 is highly expressed in osteosarcoma cells to promote cell
            proliferation and migration and inhibit apoptosis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (9), 1367-1373 (2022)
   PUBMED   36210710
  REMARK    GeneRIF: [RHPN2 is highly expressed in osteosarcoma cells to
            promote cell proliferation and migration and inhibit apoptosis].
REFERENCE   2  (residues 1 to 686)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   3  (residues 1 to 686)
  AUTHORS   Lal,M.A., Andersson,A.C., Katayama,K., Xiao,Z., Nukui,M.,
            Hultenby,K., Wernerson,A. and Tryggvason,K.
  TITLE     Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is
            essential for glomerular filtration
  JOURNAL   J Am Soc Nephrol 26 (3), 647-662 (2015)
   PUBMED   25071083
REFERENCE   4  (residues 1 to 686)
  AUTHORS   Sewell,W., Sparrow,D.B., Smith,A.J., Gonzalez,D.M., Rappaport,E.F.,
            Dunwoodie,S.L. and Kusumi,K.
  TITLE     Cyclical expression of the Notch/Wnt regulator Nrarp requires
            modulation by Dll3 in somitogenesis
  JOURNAL   Dev Biol 329 (2), 400-409 (2009)
   PUBMED   19268448
REFERENCE   5  (residues 1 to 686)
  AUTHORS   Behrends,J., Clement,S., Pajak,B., Pohl,V., Maenhaut,C.,
            Dumont,J.E. and Schurmans,S.
  TITLE     Normal thyroid structure and function in rhophilin 2-deficient mice
  JOURNAL   Mol Cell Biol 25 (7), 2846-2852 (2005)
   PUBMED   15767687
  REMARK    GeneRIF: Mice lacking rhophilin 2 develop normally, have normal
            life spans, and are fertile; rhophilin 2 does not play an essential
            role in thyroid physiology
REFERENCE   6  (residues 1 to 686)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ080543.1, AK004849.1 and AC154126.2.
            
            On May 1, 2009 this sequence version replaced NP_082173.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050214.1, SRR9219382.205139.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.36 cM"
     Protein         1..686
                     /product="rhophilin-2"
                     /note="GTP-Rho-binding protein 2"
                     /calculated_mol_wt=76826
     Region          27..108
                     /region_name="HR1_Rhophilin-2"
                     /note="Protein kinase C-related kinase homology region 1
                     (HR1) Rho-binding domain of Rhophilin-2; cd11634"
                     /db_xref="CDD:212024"
     Site            order(41,44,47..48,51..52,54..55,58..59,61..62,77..78,81,
                     84..85,88)
                     /site_type="other"
                     /note="putative Rho binding site 1 [polypeptide binding]"
                     /db_xref="CDD:212024"
     Region          46..66
                     /region_name="Interaction with Rho. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BWR8.2)"
     Site            order(49..50,52..53,56..57,59..60,63..64,72..73,75)
                     /site_type="other"
                     /note="putative Rho binding site 2 [polypeptide binding]"
                     /db_xref="CDD:212024"
     Region          112..496
                     /region_name="BRO1_Rhophilin_2"
                     /note="Protein-interacting Bro1-like domain of
                     RhoA-binding protein Rhophilin-2; cd09249"
                     /db_xref="CDD:185772"
     Site            order(227,230,243,246..247,291,294..295,306,309..310,480,
                     482,484,486)
                     /site_type="other"
                     /note="putative ESCRT-III binding site"
                     /db_xref="CDD:185772"
     Region          514..591
                     /region_name="PDZ_rhophilin-like"
                     /note="PDZ domain of rhophilin-1, rhophilin-2, and related
                     domains; cd06712"
                     /db_xref="CDD:467196"
     Site            order(525..531,539,542,571,575,578..579)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467196"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BWR8.2)"
     CDS             1..686
                     /gene="Rhpn2"
                     /gene_synonym="1300002E07Rik; D7Ertd784e"
                     /coded_by="NM_027897.4:107..2167"
                     /db_xref="CCDS:CCDS21148.1"
                     /db_xref="GeneID:52428"
                     /db_xref="MGI:MGI:1289234"
ORIGIN      
        1 mtdtllpaap qplekegddy frkgcnplaq tgrsklqnqr aalnqqilka vrmrtgaenl
       61 lkvatnqkvr eqvrlelsfv nsdlqmlkee leglnisvgv yqgteeafti pliplglket
      121 kevdfsivfk dfilehysed sylyeddiad lmdlrqacrt psrdeagvel lmsyfiqlgf
      181 vesrffpptr hmgllftwyd sftgvpvsqq tlllekasvl fnigalytqi gtrcnrqtqa
      241 glesavdafq raagvlnylk etfthtpsyd mspamlsvlv kmmlaqaqes vfekvclpgi
      301 qneffvlvkv aqeaakvaea yrqlhaamsq epvkenipys wasvayvkay hygalahyfa
      361 atllidhqlk pgadedhqek clsqlydrmp egmtplatlk nagqrvllgk ghlhraigfh
      421 eeslreanlc kklrdiqvlr dvlsaahqrt qlkhtqhred ddllnlidap dvlpkterev
      481 kitfpdfskv tvtdffqklg plsvfsaskr wspprgihft veegdlgftl rgntpvqvhf
      541 ldphcsasla gakegdyivs iqgvdckwlt vsevmkllks fggeevemkv vslldstssm
      601 hnkcatysvg mqktysmicl smddddkadk tkkiskklsf lswgtsknrq ksastlclpe
      661 vglarsqnkk klptpfslln sdssly
//
