LOCUS       NM_001004193            1202 bp    mRNA    linear   ROD 06-DEC-2023
DEFINITION  Mus musculus reproductive homeobox 8 (Rhox8), mRNA.
ACCESSION   NM_001004193 XM_486664
VERSION     NM_001004193.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1202)
  AUTHORS   Oh Y, Kasu M, Bottoms CJ, Douglas JC, Sekulovski N, Hayashi K and
            MacLean Ii JA.
  TITLE     Rhox8 homeobox gene ablation leads to rete testis abnormality and
            male subfertility in micedagger
  JOURNAL   Biol Reprod 109 (4), 520-532 (2023)
   PUBMED   37471646
REFERENCE   2  (bases 1 to 1202)
  AUTHORS   Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y,
            Zhang Z and Yuan S.
  TITLE     hnRNPU in Sertoli cells cooperates with WT1 and is essential for
            testicular development by modulating transcriptional factors Sox8/9
  JOURNAL   Theranostics 11 (20), 10030-10046 (2021)
   PUBMED   34815802
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1202)
  AUTHORS   Welborn JP, Davis MG, Ebers SD, Stodden GR, Hayashi K, Cheatwood
            JL, Rao MK and MacLean JA 2nd.
  TITLE     Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi
            Approach Results in Impaired Male Fertility in Mice
  JOURNAL   Biol Reprod 93 (1), 8 (2015)
   PUBMED   25972016
  REMARK    GeneRIF: male RHOX8-knockdown animals showed significantly reduced
            spermatogenic output, increased germ cell apoptosis, and
            compromised sperm motility, leading to impaired fertility.
REFERENCE   4  (bases 1 to 1202)
  AUTHORS   Karow M and Berninger B.
  TITLE     In-TOX-icating neurogenesis
  JOURNAL   EMBO J 34 (7), 832-834 (2015)
   PUBMED   25691243
REFERENCE   5  (bases 1 to 1202)
  AUTHORS   Artegiani B, de Jesus Domingues AM, Bragado Alonso S, Brandl E,
            Massalini S, Dahl A and Calegari F.
  TITLE     Tox: a multifunctional transcription factor and novel regulator of
            mammalian corticogenesis
  JOURNAL   EMBO J 34 (7), 896-910 (2015)
   PUBMED   25527292
  REMARK    GeneRIF: Tox is regulated by calcineurin/Nfat signalling.
REFERENCE   6  (bases 1 to 1202)
  AUTHORS   Brown RM, Davis MG, Hayashi K and MacLean JA.
  TITLE     Regulated expression of Rhox8 in the mouse ovary: evidence for the
            role of progesterone and RHOX5 in granulosa cells
  JOURNAL   Biol Reprod 88 (5), 126 (2013)
   PUBMED   23536368
  REMARK    GeneRIF: suggests a model in which Rhox8 transcription is dependent
            upon RHOX5 during early folliculogenesis and upon progesterone
            during the periovulatory window when RHOX5 normally wanes.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1202)
  AUTHORS   Daggag H, Svingen T, Western PS, van den Bergen JA, McClive PJ,
            Harley VR, Koopman P and Sinclair AH.
  TITLE     The rhox homeobox gene family shows sexually dimorphic and dynamic
            expression during mouse embryonic gonad development
  JOURNAL   Biol Reprod 79 (3), 468-474 (2008)
   PUBMED   18562707
REFERENCE   8  (bases 1 to 1202)
  AUTHORS   Aliahmad P and Kaye J.
  TITLE     Development of all CD4 T lineages requires nuclear factor TOX
  JOURNAL   J Exp Med 205 (1), 245-256 (2008)
   PUBMED   18195075
  REMARK    GeneRIF: TOX-dependent transition to the CD4(+)CD8(lo) stage is
            required for continued development of class II major
            histocompatibility complex-specific T cells, regardless of ultimate
            lineage fate
REFERENCE   9  (bases 1 to 1202)
  AUTHORS   Maclean JA 2nd, Chen MA, Wayne CM, Bruce SR, Rao M, Meistrich ML,
            Macleod C and Wilkinson MF.
  TITLE     Rhox: a new homeobox gene cluster
  JOURNAL   Cell 120 (3), 369-382 (2005)
   PUBMED   15707895
REFERENCE   10 (bases 1 to 1202)
  AUTHORS   Kang YL, Li H, Chen WH, Tzeng YS, Lai YL and Hsieh-Li HM.
  TITLE     A novel PEPP homeobox gene, TOX, is highly glutamic acid rich and
            specifically expressed in murine testis and ovary
  JOURNAL   Biol Reprod 70 (3), 828-836 (2004)
   PUBMED   14627546
  REMARK    GeneRIF: Tox transcripts were detected predominately in the testis
            and ovary of mice
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY329370.1 and AL590629.16.
            
            On Dec 14, 2017 this sequence version replaced NM_001004193.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY329370.1, BC139098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1064              AY329370.1         1-1064
            1065-1202           AL590629.16        60116-60253         c
FEATURES             Location/Qualifiers
     source          1..1202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.12 cM"
     gene            1..1202
                     /gene="Rhox8"
                     /gene_synonym="Tox"
                     /note="reproductive homeobox 8"
                     /db_xref="GeneID:434768"
                     /db_xref="MGI:MGI:3579898"
     exon            1..208
                     /gene="Rhox8"
                     /gene_synonym="Tox"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1026
                     /gene="Rhox8"
                     /gene_synonym="Tox"
                     /note="homeoprotein TOX"
                     /codon_start=1
                     /product="reproductive homeobox on X chromosome, 8"
                     /protein_id="NP_001004193.1"
                     /db_xref="CCDS:CCDS30082.1"
                     /db_xref="GeneID:434768"
                     /db_xref="MGI:MGI:3579898"
                     /translation="MLFFLRLNQEVKPRISRSRSTVNSIHAMEPQEVTQSSLLRDDEI
                     KESDDAAAWIVSQEMKEREENAGIQDCPLLGAMAAEGEGENEEEGEEGEEGEEGEEGE
                     EGEEGEEGEEGEEEEEEEEEEEEEEEEEEEEEEEEEEGEEGEEGEEGDEGGEGGEGGE
                     EGEEEGEEEEGGEGEGEEEEEEEEEEEEEEEEEEEEEEEEEAAAAAAARDETTAGSSA
                     PVDDRSHDAGASSNGEDRGQGEELIPGGTKGLEALPSPSGQLPRNRYRFTKFQLQELE
                     RIFERNHYPSAAARRELARWIGVTESRVENWFKSRRAKYRKCLM"
     exon            209..932
                     /gene="Rhox8"
                     /gene_synonym="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            933..978
                     /gene="Rhox8"
                     /gene_synonym="Tox"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1202
                     /gene="Rhox8"
                     /gene_synonym="Tox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactaactag atacattgta aagtgggcca ggccagaaga gaacacttcc aggtcatggg
       61 tcaatgcttt tcttcttaag gcttaaccaa gaggttaagc ccagaatttc cagaagcagg
      121 agcaccgtca acagcatcca tgctatggaa cctcaagaag tcacccagtc gtctcttctg
      181 agagatgatg aaattaaaga aagcgatgac gcagctgcat ggatagtctc acaggagatg
      241 aaggagagag aggagaacgc aggtatacag gactgccctt tgttgggggc catggctgca
      301 gaaggagaag gtgaaaatga agaagaagga gaagaaggag aagaaggaga agaaggagaa
      361 gaaggagaag aaggagaaga aggagaagaa ggagaagaag gagaagaaga agaagaagaa
      421 gaagaagaag aagaagaaga agaagaagaa gaagaagaag aagaagaaga agaagaagaa
      481 ggagaagaag gagaagaagg agaagaagga gacgaaggag gagaaggagg agaaggagga
      541 gaagaaggag aagaagaagg agaagaagaa gaaggaggag aaggagaagg agaagaagaa
      601 gaagaagaag aagaagaaga agaagaagaa gaagaagaag aagaagaaga agaagaagaa
      661 gaagaagcag cagcagccgc cgccgccaga gatgaaacta ctgctggcag ttcagcccca
      721 gtagatgaca gaagccatga tgccggggcc agcagcaatg gcgaggatag gggtcaagga
      781 gaggagctga tccctggggg cacaaagggc cttgaggctc tcccaagtcc atcaggccag
      841 ctaccccgca accgctacag gtttaccaag ttccagctcc aggaactgga gcgcattttc
      901 gaacgcaatc actatcccag tgctgcggcc cgaagggagc tcgcgagatg gataggtgtg
      961 actgaatcca gagtggagaa ctggtttaag agtaggagag ccaaatacag gaaatgcctg
     1021 atgtaagtgc tctggagtgc tctcatggtg ctccctgcag gggcaccttt ccctagagat
     1081 tgtggaggag cgctggagaa ccaactgtgc ccagaagaca gaagcagatg agattttgct
     1141 gccaccaacg cattatttta ccacccccct ctctcatttg caataaagtg aaatctcaat
     1201 at
//
