LOCUS       NM_001185002             919 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus reproductive homeobox 13 (Rhox13), mRNA.
ACCESSION   NM_001185002 XM_356401 XM_976021
VERSION     NM_001185002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 919)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 919)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 919)
  AUTHORS   Busada,J.T., Velte,E.K., Serra,N., Cook,K., Niedenberger,B.A.,
            Willis,W.D., Goulding,E.H., Eddy,E.M. and Geyer,C.B.
  TITLE     Rhox13 is required for a quantitatively normal first wave of
            spermatogenesis in mice
  JOURNAL   Reproduction 152 (5), 379-388 (2016)
   PUBMED   27486269
  REMARK    GeneRIF: RHOX13 is not essential for mouse fertility in a
            controlled laboratory setting, but that it is required for optimal
            development of differentiating germ cells and progression of the
            first wave of spermatogenesis
REFERENCE   4  (bases 1 to 919)
  AUTHORS   Song,H.W., Bettegowda,A., Lake,B.B., Zhao,A.H., Skarbrevik,D.,
            Babajanian,E., Sukhwani,M., Shum,E.Y., Phan,M.H., Plank,T.M.,
            Richardson,M.E., Ramaiah,M., Sridhar,V., de Rooij,D.G., Orwig,K.E.,
            Zhang,K. and Wilkinson,M.F.
  TITLE     The Homeobox Transcription Factor RHOX10 Drives Mouse
            Spermatogonial Stem Cell Establishment
  JOURNAL   Cell Rep 17 (1), 149-164 (2016)
   PUBMED   27681428
REFERENCE   5  (bases 1 to 919)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 919)
  AUTHORS   Song,H.W., Bettegowda,A., Oliver,D., Yan,W., Phan,M.H., de
            Rooij,D.G., Corbett,M.A. and Wilkinson,M.F.
  TITLE     shRNA off-target effects in vivo: impaired endogenous siRNA
            expression and spermatogenic defects
  JOURNAL   PLoS One 10 (3), e0118549 (2015)
   PUBMED   25790000
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 919)
  AUTHORS   Geyer,C.B., Saba,R., Kato,Y., Anderson,A.J., Chappell,V.K., Saga,Y.
            and Eddy,E.M.
  TITLE     Rhox13 is translated in premeiotic germ cells in male and female
            mice and is regulated by NANOS2 in the male
  JOURNAL   Biol Reprod 86 (4), 127 (2012)
   PUBMED   22190708
  REMARK    GeneRIF: results strongly suggest that RHOX13 expression is
            regulated at a posttranscriptional step by direct interaction of
            NANOS2 with Rhox13 mRNA to suppress translation.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 919)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   9  (bases 1 to 919)
  AUTHORS   Geyer,C.B. and Eddy,E.M.
  TITLE     Identification and characterization of Rhox13, a novel X-linked
            mouse homeobox gene
  JOURNAL   Gene 423 (2), 194-200 (2008)
   PUBMED   18675325
  REMARK    GeneRIF: The Rhox13 gene encodes a 25.3 kDa protein expressed in
            the adult testis in germ cells at the basal aspect of the
            seminiferous epithelium.
REFERENCE   10 (bases 1 to 919)
  AUTHORS   Oda,M., Yamagiwa,A., Yamamoto,S., Nakayama,T., Tsumura,A.,
            Sasaki,H., Nakao,K., Li,E. and Okano,M.
  TITLE     DNA methylation regulates long-range gene silencing of an X-linked
            homeobox gene cluster in a lineage-specific manner
  JOURNAL   Genes Dev 20 (24), 3382-3394 (2006)
   PUBMED   17182866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512346.41.
            
            On Jun 30, 2022 this sequence version replaced NM_001185002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.260656.1, AK007253.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-641               AL512346.41        136635-137275
            642-687             AL512346.41        138527-138572
            688-919             AL512346.41        145195-145426
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.38 cM"
     gene            1..919
                     /gene="Rhox13"
                     /gene_synonym="1700123J19Rik"
                     /note="reproductive homeobox 13"
                     /db_xref="GeneID:73614"
                     /db_xref="MGI:MGI:1920864"
     exon            1..641
                     /gene="Rhox13"
                     /gene_synonym="1700123J19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..807
                     /gene="Rhox13"
                     /gene_synonym="1700123J19Rik"
                     /note="novel homeobox domain-containing protein;
                     reproductive homeobox protein 13"
                     /codon_start=1
                     /product="homeobox protein Rhox13"
                     /protein_id="NP_001171931.1"
                     /db_xref="CCDS:CCDS57754.1"
                     /db_xref="GeneID:73614"
                     /db_xref="MGI:MGI:1920864"
                     /translation="MAHGVPFDHNYYIVECKEETNAEAQAGAMAATSTEEAPGAVEVA
                     QAAVASSHDSGGAIGCATVKESESDSESESDSESESDSSDSSDESDDDSSTSDEDTSD
                     PEEAAAPSVAAVAAAAAPPTVPAAAAIQIPGPYRYRPPRRHVRRRRRGPPFHFAQWQV
                     EEMESLFEETQYPDLLTRGELARTLNVPEVKVKVWFTNRRAKQRKIERREMLRNIPPG
                     AEDFIFITDFEEPS"
     exon            642..687
                     /gene="Rhox13"
                     /gene_synonym="1700123J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            688..919
                     /gene="Rhox13"
                     /gene_synonym="1700123J19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      894..899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhox13"
                     /gene_synonym="1700123J19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      914
                     /gene="Rhox13"
                     /gene_synonym="1700123J19Rik"
                     /note="major polyA site"
ORIGIN      
        1 actttcggct ggcttccgtc tggactggac cggtaacaga cgctgggctt cgaggtcttt
       61 ttttcctagg gccccgaagc tgttggtggc ttcggcccgg ttctagtcat ggcccacggg
      121 gtcccttttg accacaatta ctacattgtg gagtgcaagg aggaaacaaa tgctgaagcc
      181 caggcagggg ccatggccgc cacctcaacc gaggaggccc caggggctgt ggaggtggcg
      241 caggcagcag tggcgagcag ccacgacagt ggaggagcca taggctgtgc cactgtcaag
      301 gagagtgaga gcgactcgga gagtgagagc gactcggaga gtgagagcga ctcctccgac
      361 tcctccgacg agagtgatga cgactcgagc accagcgacg aggatacttc agatcctgag
      421 gaggcggcag ctccctcggt ggctgcggtg gctgctgctg ccgctcctcc aactgttcct
      481 gctgccgctg ctattcagat tccggggccg taccgctacc gcccccctcg ccgccatgtt
      541 cgccgtcgtc gccgtggacc gccattccac ttcgcacagt ggcaggtcga ggaaatggaa
      601 agcctgtttg aagagaccca gtacccggat ttgcttacaa ggggagagct tgcaagaact
      661 ttgaatgtgc ctgaggtcaa agtgaaggtg tggtttacca atcggagagc gaagcagagg
      721 aagattgaga gacgtgaaat gctgagaaat attccgcctg gtgctgaaga cttcattttc
      781 ataaccgatt ttgaagagcc ttcttaatgt gccatatttg gtcagtagac aaagggcaaa
      841 ttggcaacct ctgtgcccaa tgccaagctt aactattcag catgcatgtt aacaataaaa
      901 gcatgaattt ccaagttct
//
