LOCUS       NM_145491               4159 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Mus musculus ras homolog family member Q (Rhoq), mRNA.
ACCESSION   NM_145491
VERSION     NM_145491.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4159)
  AUTHORS   Koinuma,S., Negishi,R., Nomura,R., Sato,K., Kojima,T.,
            Segi-Nishida,E., Goitsuka,R., Iwakura,Y., Wada,N., Koriyama,Y.,
            Kiryu-Seo,S., Kiyama,H. and Nakamura,T.
  TITLE     TC10, a Rho family GTPase, is required for efficient axon
            regeneration in a neuron-autonomous manner
  JOURNAL   J Neurochem 157 (4), 1196-1206 (2021)
   PUBMED   33156548
  REMARK    GeneRIF: TC10, a Rho family GTPase, is required for efficient axon
            regeneration in a neuron-autonomous manner.
REFERENCE   2  (bases 1 to 4159)
  AUTHORS   Jausoro,I. and Marzolo,M.P.
  TITLE     Reelin activates the small GTPase TC10 and VAMP7 to promote neurite
            outgrowth and regeneration of dorsal root ganglia (DRG) neurons
  JOURNAL   J Neurosci Res 99 (1), 392-406 (2021)
   PUBMED   32652719
  REMARK    GeneRIF: Reelin activates the small GTPase TC10 and VAMP7 to
            promote neurite outgrowth and regeneration of dorsal root ganglia
            (DRG) neurons.
REFERENCE   3  (bases 1 to 4159)
  AUTHORS   Lopez Tobon,A., Suresh,M., Jin,J., Vitriolo,A., Pietralla,T.,
            Tedford,K., Bossenz,M., Mahnken,K., Kiefer,F., Testa,G.,
            Fischer,K.D. and Puschel,A.W.
  TITLE     The guanine nucleotide exchange factor Arhgef7/betaPix promotes
            axon formation upstream of TC10
  JOURNAL   Sci Rep 8 (1), 8811 (2018)
   PUBMED   29891904
  REMARK    GeneRIF: The authors show that Arhgef7 interacts with the GTPase
            TC10 that is closely related to Cdc42. Expression of active TC10
            can restore the ability to extend axons in Arhgef7-deficient
            neurons
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4159)
  AUTHORS   Burbage,M., Keppler,S.J., Montaner,B., Mattila,P.K. and
            Batista,F.D.
  TITLE     The Small Rho GTPase TC10 Modulates B Cell Immune Responses
  JOURNAL   J Immunol 199 (5), 1682-1695 (2017)
   PUBMED   28747344
  REMARK    GeneRIF: this study defines TC10 as an immunomodulatory molecule
            playing a role in physiological B cell responses
REFERENCE   5  (bases 1 to 4159)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 4159)
  AUTHORS   Gual,P., Shigematsu,S., Kanzaki,M., Gremeaux,T., Gonzalez,T.,
            Pessin,J.E., Le Marchand-Brustel,Y. and Tanti,J.F.
  TITLE     A Crk-II/TC10 signaling pathway is required for osmotic
            shock-stimulated glucose transport
  JOURNAL   J Biol Chem 277 (46), 43980-43986 (2002)
   PUBMED   12215429
  REMARK    GeneRIF: activation of TC10 and remodeling of cortical actin, which
            could occur through the TC10 signaling, are required for osmotic
            shock-mediated Glut 4 translocation and glucose u
REFERENCE   7  (bases 1 to 4159)
  AUTHORS   Chiang,S.H., Hou,J.C., Hwang,J., Pessin,J.E. and Saltiel,A.R.
  TITLE     Cloning and functional characterization of related TC10 isoforms, a
            subfamily of Rho proteins involved in insulin-stimulated glucose
            transport
  JOURNAL   J Biol Chem 277 (15), 13067-13073 (2002)
   PUBMED   11821390
REFERENCE   8  (bases 1 to 4159)
  AUTHORS   Neudauer,C.L., Joberty,G. and Macara,I.G.
  TITLE     PIST: a novel PDZ/coiled-coil domain binding partner for the
            rho-family GTPase TC10
  JOURNAL   Biochem Biophys Res Commun 280 (2), 541-547 (2001)
   PUBMED   11162552
REFERENCE   9  (bases 1 to 4159)
  AUTHORS   Vignal,E., De Toledo,M., Comunale,F., Ladopoulou,A.,
            Gauthier-Rouviere,C., Blangy,A. and Fort,P.
  TITLE     Characterization of TCL, a new GTPase of the rho family related to
            TC10 andCcdc42
  JOURNAL   J Biol Chem 275 (46), 36457-36464 (2000)
   PUBMED   10967094
REFERENCE   10 (bases 1 to 4159)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC056363.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by NM_145491.3.
            
            On Aug 28, 2003 this sequence version replaced NM_145491.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056363.1, AB060650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 56.9 cM"
     gene            1..4159
                     /gene="Rhoq"
                     /gene_synonym="Arhq; Tc10; TC10A"
                     /note="ras homolog family member Q"
                     /db_xref="GeneID:104215"
                     /db_xref="MGI:MGI:1931553"
     exon            1..637
                     /gene="Rhoq"
                     /gene_synonym="Arhq; Tc10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..1113
                     /gene="Rhoq"
                     /gene_synonym="Arhq; Tc10; TC10A"
                     /note="small GTPase Tc10; ras-related GTP-binding protein
                     TC10; ras-like protein TC10; ras homolog gene family,
                     member Q"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoQ"
                     /protein_id="NP_663466.2"
                     /db_xref="CCDS:CCDS29010.1"
                     /db_xref="GeneID:104215"
                     /db_xref="MGI:MGI:1931553"
                     /translation="MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFD
                     HYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEE
                     WVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPVCVEQGQKLAKEIGACCY
                     VECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT"
     exon            638..696
                     /gene="Rhoq"
                     /gene_synonym="Arhq; Tc10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     exon            697..861
                     /gene="Rhoq"
                     /gene_synonym="Arhq; Tc10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     exon            862..957
                     /gene="Rhoq"
                     /gene_synonym="Arhq; Tc10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     exon            958..4122
                     /gene="Rhoq"
                     /gene_synonym="Arhq; Tc10; TC10A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcacggcgg gcgcgggcgc ggggcgcgcc gcactccgga gccgcccgga ccgccctccc
       61 ccacccccct tcaccggccc aggagggcgg gggccggagc ggcgcggggc gggcagagcc
      121 gcctggcccc tcccctccgc cgccctcccc aaagttgccg actcccctgg ggccggacgg
      181 tcttatgatc cggcggatcc tcctggggag gccgggccgg ggagcgggtt cgggcgccga
      241 gcggcggggc cagcaggcgg gcgcggcgag ccgggccagg gcggggagcg gggcagagat
      301 cgaagcggcg gcggctgcgc cccgggcccg ccgcaccttc tcctccggtc aggggaaccg
      361 ctgcatgggg ccgggagggc ggccctgctg cgccgagcgg cggcgacggc ggacccccca
      421 agcgggctgg ggctgagccc ggggccaggg cgggggctcc ggggggacca tgccccgagg
      481 ccggccggcc gcagcatggc tcacgggccc ggcgcgctga tgctgaagtg cgtggtggtc
      541 ggcgacgggg cggtgggcaa gacgtgcctg ctcatgagct atgccaacga cgccttcccc
      601 gaggagtacg tgcccactgt cttcgaccac tacgcagtca gcgtcaccgt ggggggcaag
      661 cagtacctct tgggactcta tgacacagct ggacaggaag actatgatcg tctgaggcct
      721 ttatcttacc ccatgactga cgtcttcctc atatgcttct ccgtggtaaa tccagcctcg
      781 tttcaaaatg taaaggaaga gtgggtacca gagctaaagg aatatgcgcc aaacgtcccc
      841 ttcttgttaa taggaactca gattgatctc cgagatgacc ccaaaacttt agcaagactg
      901 aatgacatga aagaaaaacc tgtctgtgtg gaacaaggac agaaactagc aaaagagata
      961 ggtgcatgct gctatgtgga gtgttcagct ttaacccaga agggtttgaa gactgtgttt
     1021 gatgaggcta tcatagccat tttaactcca aagaaacaca cagtaaaaaa aagaatagga
     1081 tcaagatgta taaactgttg tttgattacg tgagaaacat ctttagtggc caaggaaact
     1141 gtccatttct cccagaaagc atttgaaatg ctacagcgct atcctgacct cttacagtga
     1201 agcagtttaa cttgaggagg gagggaacct gtcctcagca ttctacagag ttcattgaga
     1261 atgtttcaga aaggtctaag cggcagcgaa cagcatctga agccacaatc tactataaat
     1321 actttatttc aactagaagg tacaatctct caggggtttc atagttaaaa agctacaatc
     1381 acatcatgtt gaaatgacat ttagaaaaca acagtgctgt aaatggactg cccggcttgg
     1441 accatgtaac ttctgcacag cccttatgga atctgcacag agaaataact tctctccttt
     1501 ctcctcttaa ttgttcttgt atgtaagctg ctttctattc cagtagatcc agagtggcga
     1561 gataaccagg ccagccacgt agccaaaggt cgctccgagt gtacaggaga tgggccacac
     1621 ctgaggaaag aattgagatc taaaccaacc gatgctttat tatacttgag cacaaatgaa
     1681 gtgtaacaca aacctttcta tagtgaagct tagtgtgctt tcttaaagaa tgccaagttg
     1741 aatagatcat aactgctttg atcatgaaca ctaaaaatgt acacatttta gttaatgtgc
     1801 attaaacagt aacaaggctt ctggcaactg tagattttag tttgatgtta tccaaattgc
     1861 atgaaataca tgctaaagta acgtttaaaa attgggtcat agtttgccat aatcctgaac
     1921 tcagtttagc tctctgaatt agttggccat tttctaattc ccacattggc tgtatacatc
     1981 aaatgaagta agtgtatagg ctgaccgatt ctcagaaact ctcagtcgtg tcagagggaa
     2041 gacctggaat ctaagcgcgt cctgtgggat ttgtggatat ctgcttccat agtaaaactg
     2101 atgtccgctt ggagctgcag ctagcacatc cacagcagaa ggcacaaccc acagcttacg
     2161 cacacaccta gtgagaggcg agcagagcac tgctgccttc ccaagaccct tcctccagcc
     2221 acgctacatt tcactaagcc agagataata atggtgactt ttctttgtaa tgccacagac
     2281 agggtatgtg tggaacgtct tggaaacaaa ctttcatgct cctttgtaaa gcttatttgg
     2341 tgtaccgcag ccatttctaa cccttctccg gggaataggc catcaaagtg tactgcaggc
     2401 aaaccatctt actaactggc tggaacctca tttggctttc ttcttcggtc tgctatggat
     2461 ctgccttatt ctaaatgcca tgcaacagac agtagtgtag acaaagctcc catgggaacc
     2521 acctcctgca gtggagggaa gcagattcta acccaggcat tcttaccagc cttctttagg
     2581 ttcaaatttg cagttgctta aactacgact tgtctttagc aagcttctgt tatcttccat
     2641 ggtttgtgct taagctttgt gtattgcaca gattgggtaa tggaacacta aacatttata
     2701 cttgaaaatg acagccttaa atgttcatac cagtcacaaa tctagatgta ctgtcttgca
     2761 tgtgagcttt gtaggagttt ttaaaatata agcaccacac tccccacttg gtagtggaca
     2821 gtctactgga caagagtgtt ctcctggaag tgggcacagt atgtcttcag gcagtggtgg
     2881 ttcacattaa gtatatcatg gccttatgta tgctcaaatg ggacttctgt aattttccca
     2941 tttagttttg gtctgttttt agatagaatt ggaagaaact gtatagttaa catgagctaa
     3001 gttgtcaaac ctatgatctg aaggaaccaa gacagtaaag tattattcgt ttccaagttg
     3061 cctgtggaga tttgatggct tgttcttttc ttcaaatcca catctgtgaa acccttgaca
     3121 cttggtgttg gcaatgagtt taagtcaagg actttcctgc tccaagagaa acggattcag
     3181 aatctgaacg tgcactggtg tcacctcagt ctcctcatgt ttgatcacgg ggacaacctc
     3241 ttgtcccagt cattcatgag ctctgagcac tctcctccga ctgacagcag tcatggctgg
     3301 cctccacctt ctccagatgg taagaccttg tacatagacc acgtgaactc tcgcagacgg
     3361 ctgcatcacc cgaacctgag gtgccttagg tgctctattt acctggatgg ggctcggagt
     3421 ttcccattgc ttgttaagag ctctttgtgt ttgttattta gtatttcttt ttgcaaaacc
     3481 ttctctgcca ctttaaccag aaaaccaaag atttgttttc tattcatgag cagattatag
     3541 agacactgcc ttattttcag acgcatatag cttcattaat ggcttaggtt gcagaagaaa
     3601 ttcagactag tctctgaaat aactctttca aactagtgaa atatctggga aagaaaatac
     3661 ttttcaaaaa tattttatta acatgaactg tgttagtgag cacactgctt caaataaggt
     3721 catgtgtgaa agaacattca gaaagttata attggttagt gtttgcatag aaaatttgtt
     3781 ctaaagccct ttaaaatttt tagggaaatc ttgaaatctt acagcactta ctttgctaat
     3841 gtatgccctt atctgtcctt acaggtacac gtagcttcct cgtggtgatt tatcatatta
     3901 catacgtaga gcttgagttc atgctatttg ttataaatta tcttagttac tttagacact
     3961 gcttccgttt gatttttaat tattggtttt aaataccaaa ttaaatgctg gtttgttggt
     4021 tgttgttttt aaatgattgt tccttcaaca gcatcccctc ctgacggatg gggtcataat
     4081 aaaatgagat gcgtagttta ctgttttatg taaagcactg gaaaaaaaaa aaaaaaaaaa
     4141 aaaaaaaaaa aaaaaaaaa
//
