LOCUS       NM_023275               2358 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ras homolog family member J (Rhoj), mRNA.
ACCESSION   NM_023275
VERSION     NM_023275.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Bou Malhab,L.J., Nair,V.A., Qaisar,R., Pintus,G. and
            Abdel-Rahman,W.M.
  TITLE     Towards Understanding the Development of Breast Cancer: The Role of
            RhoJ in the Obesity Microenvironment
  JOURNAL   Cells 13 (2), 174 (2024)
   PUBMED   38247865
  REMARK    GeneRIF: Towards Understanding the Development of Breast Cancer:
            The Role of RhoJ in the Obesity Microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Sawada,M., Hamaguchi,A., Mano,N., Yoshida,Y., Uemura,A. and
            Sawamoto,K.
  TITLE     PlexinD1 signaling controls domain-specific dendritic development
            in newborn neurons in the postnatal olfactory bulb
  JOURNAL   Front Neurosci 17, 1143130 (2023)
   PUBMED   37534039
  REMARK    Erratum:[Front Neurosci. 2023 Nov 28;17:1338853. doi:
            10.3389/fnins.2023.1338853.. PMID: 38089975]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Debaugnies,M., Rodriguez-Acebes,S., Blondeau,J., Parent,M.A.,
            Zocco,M., Song,Y., de Maertelaer,V., Moers,V., Latil,M., Dubois,C.,
            Coulonval,K., Impens,F., Van Haver,D., Dufour,S., Uemura,A.,
            Sotiropoulou,P.A., Mendez,J. and Blanpain,C.
  TITLE     RHOJ controls EMT-associated resistance to chemotherapy
  JOURNAL   Nature 616 (7955), 168-175 (2023)
   PUBMED   36949199
  REMARK    GeneRIF: RHOJ controls EMT-associated resistance to chemotherapy.
REFERENCE   5  (bases 1 to 2358)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   6  (bases 1 to 2358)
  AUTHORS   Chiang,S.H., Hwang,J., Legendre,M., Zhang,M., Kimura,A. and
            Saltiel,A.R.
  TITLE     TCGAP, a multidomain Rho GTPase-activating protein involved in
            insulin-stimulated glucose transport
  JOURNAL   EMBO J 22 (11), 2679-2691 (2003)
   PUBMED   12773384
REFERENCE   7  (bases 1 to 2358)
  AUTHORS   Nishizuka,M., Arimoto,E., Tsuchiya,T., Nishihara,T. and Imagawa,M.
  TITLE     Crucial role of TCL/TC10beta L, a subfamily of Rho GTPase, in
            adipocyte differentiation
  JOURNAL   J Biol Chem 278 (17), 15279-15284 (2003)
   PUBMED   12578843
  REMARK    GeneRIF: TCL/TC10betaL has a crucial role in the early stage of
            adipocyte differentiation, is probably linked to the PPARgamma
            pathway, and up-regulates epression of genes associated with
            adipogenesis.
REFERENCE   8  (bases 1 to 2358)
  AUTHORS   Abe,T., Kato,M., Miki,H., Takenawa,T. and Endo,T.
  TITLE     Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated
            long process formation and neurite outgrowth
  JOURNAL   J Cell Sci 116 (Pt 1), 155-168 (2003)
   PUBMED   12456725
REFERENCE   9  (bases 1 to 2358)
  AUTHORS   Chiang,S.H., Hou,J.C., Hwang,J., Pessin,J.E. and Saltiel,A.R.
  TITLE     Cloning and functional characterization of related TC10 isoforms, a
            subfamily of Rho proteins involved in insulin-stimulated glucose
            transport
  JOURNAL   J Biol Chem 277 (15), 13067-13073 (2002)
   PUBMED   11821390
  REMARK    GeneRIF: cloning and functional characterization of related
            isoforms
REFERENCE   10 (bases 1 to 2358)
  AUTHORS   Vignal,E., De Toledo,M., Comunale,F., Ladopoulou,A.,
            Gauthier-Rouviere,C., Blangy,A. and Fort,P.
  TITLE     Characterization of TCL, a new GTPase of the rho family related to
            TC10 andCcdc42
  JOURNAL   J Biol Chem 275 (46), 36457-36464 (2000)
   PUBMED   10967094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY004626.1 and AK003482.1.
            
            On Jul 19, 2005 this sequence version replaced NM_023275.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159385.1, AK157518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               BY004626.1         1-113
            114-1938            AK003482.1         2-1826
            1939-2358           AK003482.1         1828-2247
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 32.63 cM"
     gene            1..2358
                     /gene="Rhoj"
                     /gene_synonym="1110005O19Rik; Arhj; TC10L; TCL"
                     /note="ras homolog family member J"
                     /db_xref="GeneID:80837"
                     /db_xref="MGI:MGI:1931551"
     exon            1..689
                     /gene="Rhoj"
                     /gene_synonym="1110005O19Rik; Arhj; TC10L; TCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..1156
                     /gene="Rhoj"
                     /gene_synonym="1110005O19Rik; Arhj; TC10L; TCL"
                     /note="TC10-like Rho GTPase; tc10-like GTP-binding protein
                     TCL; ras homolog gene family, member J"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoJ"
                     /protein_id="NP_075764.1"
                     /db_xref="CCDS:CCDS25981.1"
                     /db_xref="GeneID:80837"
                     /db_xref="MGI:MGI:1931551"
                     /translation="MSCRERTDSSCGCNGHEENRILKCVVVGDGAVGKTCLLMSYAND
                     AFPEEYVPTVFDHYAVTVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSV
                     VNPASYHNVQEEWVPELKDCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHG
                     VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKKKKKGCLGCHGCCAII"
     exon            690..748
                     /gene="Rhoj"
                     /gene_synonym="1110005O19Rik; Arhj; TC10L; TCL"
                     /inference="alignment:Splign:2.1.0"
     exon            749..913
                     /gene="Rhoj"
                     /gene_synonym="1110005O19Rik; Arhj; TC10L; TCL"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1009
                     /gene="Rhoj"
                     /gene_synonym="1110005O19Rik; Arhj; TC10L; TCL"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..2358
                     /gene="Rhoj"
                     /gene_synonym="1110005O19Rik; Arhj; TC10L; TCL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatcctaata tggaatgcag caggaaaccc acgatttcct gacactcggc aagctggagg
       61 aagcgagggg ggggaaactc cgtttaaaag cccttctctc ctccatatta gttgtgtggt
      121 ggaaaaccgg gcaggagtta tccaaatccc accgtgtcat tagccaggct ggggatgggg
      181 agggtagagt gagattctca cgggctgctg atatttctag actgccagga agtcccggga
      241 agtctatgga catgagagtt tcttaactcc agctctaccc ccaactccac ttctccgttg
      301 ggattgggag aaagggacag acccttttca tccctcctcc caagagtgcc ttccttctcc
      361 agcatggtga gctgcggggc tcgagtgtgt ctgggctgtg cctgggagag cccggccagc
      421 cagagtcagg ccgcctgagc tccagcctgg ggccggtgcc accgctccat gcactgcaga
      481 agccccagca gctgctgcgg gagccgccaa catgagctgc agagagagga ccgacagcag
      541 ctgcggctgc aatggacatg aggagaacag gatcctgaag tgcgtggtgg tcggggacgg
      601 cgcggtgggg aagacctgct tgctgatgag ctacgccaac gacgccttcc cagaggaata
      661 cgtgcccact gtgtttgacc actacgcagt taccgtgacg gtgggaggca agcagcactt
      721 gcttggacta tacgacactg caggacagga ggattacaac cagctgcggc cactctctta
      781 ccccaacaca gatgtgtttc tcatctgctt ctctgtcgta aacccagcct cttaccacaa
      841 cgttcaggag gagtgggtcc cggaactgaa ggactgcatg cctcatgtgc cttatgtgct
      901 catcggaacc cagattgatc tccgagatga ccccaaaacc ttggcgcgtc tgctgtacat
      961 gaaggagaag cccctcacct atgagcacgg cgtgaagctg gcgaaagcga ttggagcgca
     1021 gtgctacttg gaatgttctg ccctgaccca gaagggtctc aaagcagttt ttgatgaagc
     1081 catcctcacc attttccacc ccaagaaaaa aaagaaaggc tgcttagggt gtcacggctg
     1141 ctgtgcaatt atctgaagtt gcctgacacc catctccccg ccatgcaagg gcatggaggg
     1201 cagccagtct ctgtgaccca actctagcca aaaaggaggg cgtgaccaga aaggaattcc
     1261 tgcatcccaa cgcctgtccc agtgccctgc cagcttccca gctcagcatc ctgtaagcca
     1321 ctgccacagt cctaagccag ccagaccatg aacactgtgt atggagaatg cagagtcaca
     1381 ttcagaccat atgctggtga ggtgttggaa gccgagtgac aatccatctg gtatttcata
     1441 tcttctctcc cacggttatg gaccaacaga gagtcatgac gggaaaacca agcactctgt
     1501 cctgcactgg tggccttagt tcatgtcttc accaaacttg ggaatacaac accaacattt
     1561 tttttttctg aatcagttcg ttcttttacc caagcacctt aacgctcatt tctattgcag
     1621 tttcccaatg tccaatcact tgagccttac aaatccacat caaaataatt gaaagacaag
     1681 ctggattgtg ttcacaccaa ctgacggtgg atctctgcca atgttcttag agccatcatg
     1741 tacctctgaa tgcctaatta caaaaaaaaa cttttctaaa cttacagacc tataatgttt
     1801 ttaaactttt taaaagaaaa catcctgtga gttacagctc ccaagtttgg ccaaagatca
     1861 tcccacaaat ggttcagaag atagggggac tgctcttgca aaaccctact gttattcaaa
     1921 ccaaaaaaaa aaaaaaaatg gccctgagca ggaaccgctc ccagagagga atcctgcacc
     1981 tgacaggacc attgcaaaca gccagggact ctccgtgtct taattagagg ctgtgatggg
     2041 cccgggttag ccttctttgc ttacaaatgc cctggaatta cccagggaag ctgatttatc
     2101 tttttttttt ttaactttat aacatcagta aatcatatct tagcaagaag aaattatttc
     2161 actttttcta gattgaagct ccctctttgg gggaaaaaaa tctcaatctt tctagtcttt
     2221 tctgctctta gaagaaccac agaagaaaat tgtatggtat gggtcgtctt aagtccttca
     2281 tgacacccct tcagtctttg ggggctttgg ttgtttgtct gttgtttaga atttctgaaa
     2341 tatatttttg cttcttct
//
