LOCUS       NM_001081105            4945 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ras homolog family member H (Rhoh), transcript variant
            1, mRNA.
ACCESSION   NM_001081105 XM_132051
VERSION     NM_001081105.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4945)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4945)
  AUTHORS   Peng,S., Stojkov,D., Gao,J., Oberson,K., Latzin,P., Casaulta,C.,
            Yousefi,S. and Simon,H.U.
  TITLE     Nascent RHOH acts as a molecular brake on actomyosin-mediated
            effector functions of inflammatory neutrophils
  JOURNAL   PLoS Biol 20 (9), e3001794 (2022)
   PUBMED   36108062
  REMARK    GeneRIF: Nascent RHOH acts as a molecular brake on
            actomyosin-mediated effector functions of inflammatory neutrophils.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4945)
  AUTHORS   Horiguchi,H., Xu,H., Duvert,B., Ciuculescu,F., Yao,Q., Sinha,A.,
            McGuinness,M., Harris,C., Brendel,C., Troeger,A., Chiarle,R. and
            Williams,D.A.
  TITLE     Deletion of murine Rhoh leads to de-repression of Bcl-6 via
            decreased KAISO levels and accelerates a malignancy phenotype in a
            murine model of lymphoma
  JOURNAL   Small GTPases 13 (1), 267-281 (2022)
   PUBMED   34983288
  REMARK    GeneRIF: Deletion of murine Rhoh leads to de-repression of Bcl-6
            via decreased KAISO levels and accelerates a malignancy phenotype
            in a murine model of lymphoma.
REFERENCE   4  (bases 1 to 4945)
  AUTHORS   Tamehiro,N., Nishida,K., Sugita,Y., Hayakawa,K., Oda,H., Nitta,T.,
            Nakano,M., Nishioka,A., Yanobu-Takanashi,R., Goto,M., Okamura,T.,
            Adachi,R., Kondo,K., Morita,A. and Suzuki,H.
  TITLE     Ras homolog gene family H (RhoH) deficiency induces psoriasis-like
            chronic dermatitis by promoting TH17 cell polarization
  JOURNAL   J Allergy Clin Immunol 143 (5), 1878-1891 (2019)
   PUBMED   30339851
  REMARK    GeneRIF: RhoH deficiency in mice induced TH17 polarization during
            effector T-cell differentiation, thereby inducing psoriasis-like
            chronic dermatitis
REFERENCE   5  (bases 1 to 4945)
  AUTHORS   Muro,R., Nitta,T., Nakano,K., Okamura,T., Takayanagi,H. and
            Suzuki,H.
  TITLE     gammadeltaTCR recruits the Syk/PI3K axis to drive proinflammatory
            differentiation program
  JOURNAL   J Clin Invest 128 (1), 415-426 (2018)
   PUBMED   29202478
REFERENCE   6  (bases 1 to 4945)
  AUTHORS   Fredenburgh,L.E., Liang,O.D., Macias,A.A., Polte,T.R., Liu,X.,
            Riascos,D.F., Chung,S.W., Schissel,S.L., Ingber,D.E.,
            Mitsialis,S.A., Kourembanas,S. and Perrella,M.A.
  TITLE     Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary
            hypertension and enhances contractility of vascular smooth muscle
            cells
  JOURNAL   Circulation 117 (16), 2114-2122 (2008)
   PUBMED   18391113
REFERENCE   7  (bases 1 to 4945)
  AUTHORS   Chae,H.D., Lee,K.E., Williams,D.A. and Gu,Y.
  TITLE     Cross-talk between RhoH and Rac1 in regulation of actin
            cytoskeleton and chemotaxis of hematopoietic progenitor cells
  JOURNAL   Blood 111 (5), 2597-2605 (2008)
   PUBMED   18089848
  REMARK    GeneRIF: An antagonistic role of RhoH in regulation of cortical
            F-actin assembly and chemotaxis via suppressing Rac1 membrane
            targeting and activation in primary hematopoietic progenitor cells,
            is identified.
REFERENCE   8  (bases 1 to 4945)
  AUTHORS   Dorn,T., Kuhn,U., Bungartz,G., Stiller,S., Bauer,M., Ellwart,J.,
            Peters,T., Scharffetter-Kochanek,K., Semmrich,M., Laschinger,M.,
            Holzmann,B., Klinkert,W.E., Straten,P.T., Kollgaard,T., Sixt,M. and
            Brakebusch,C.
  TITLE     RhoH is important for positive thymocyte selection and T-cell
            receptor signaling
  JOURNAL   Blood 109 (6), 2346-2355 (2007)
   PUBMED   17119112
  REMARK    GeneRIF: RhoH is important for pre-T-cell receptor and T-cell
            receptor signaling
REFERENCE   9  (bases 1 to 4945)
  AUTHORS   Gu,Y., Chae,H.D., Siefring,J.E., Jasti,A.C., Hildeman,D.A. and
            Williams,D.A.
  TITLE     RhoH GTPase recruits and activates Zap70 required for T cell
            receptor signaling and thymocyte development
  JOURNAL   Nat Immunol 7 (11), 1182-1190 (2006)
   PUBMED   17028588
  REMARK    GeneRIF: RhoH is a critical regulator of thymocyte development and
            TCR signaling by mediating recruitment and activation of Zap70.
REFERENCE   10 (bases 1 to 4945)
  AUTHORS   Gu,Y., Jasti,A.C., Jansen,M. and Siefring,J.E.
  TITLE     RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation,
            survival, migration, and engraftment of hematopoietic progenitor
            cells
  JOURNAL   Blood 105 (4), 1467-1475 (2005)
   PUBMED   15494435
  REMARK    GeneRIF: RhoH serves as a negative regulator of both growth and
            actin-based function of hematopoietic progenitor cells possibly via
            suppression of Rac-mediated signaling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156029.2.
            
            On May 18, 2018 this sequence version replaced NM_001081105.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK017885.1, AK169618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC156029.2         66247-66544         c
            299-417             AC156029.2         38457-38575         c
            418-4945            AC156029.2         33428-37955         c
FEATURES             Location/Qualifiers
     source          1..4945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.8 cM"
     gene            1..4945
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /note="ras homolog family member H"
                     /db_xref="GeneID:74734"
                     /db_xref="MGI:MGI:1921984"
     exon            1..298
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /inference="alignment:Splign:2.1.0"
     exon            299..417
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /inference="alignment:Splign:2.1.0"
     exon            418..4945
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..1209
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /note="ras homolog gene family, member H"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoH"
                     /protein_id="NP_001074574.1"
                     /db_xref="CCDS:CCDS39100.1"
                     /db_xref="GeneID:74734"
                     /db_xref="MGI:MGI:1921984"
                     /translation="MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVD
                     VFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWISEI
                     RSNLPCTPVLVVATQTDQREVGPHRASCINAIEGKRLAQDVRAKGYLECSALSNRGVQ
                     QVFECAVRTAVNQARRRNRRKLFSINECKIF"
     polyA_site      1688
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /note="major polyA site"
     regulatory      1735..1740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /note="hexamer: CATAAA"
     polyA_site      1757
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
     regulatory      2295..2300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /note="hexamer: AATAAA"
     polyA_site      2320
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
     regulatory      4925..4930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
                     /note="hexamer: AATAAA"
     polyA_site      4945
                     /gene="Rhoh"
                     /gene_synonym="5830400A04Rik; Arhh"
ORIGIN      
        1 acttcggcac aggaacttgc taatcgcttt tgtcactttc ggagtgttcc tctgcctcgg
       61 tcacctccga cactgaggcc caccaccttg ggctggactc tgccagtccg gtgttgcagc
      121 ttttccaaca gtgactcatt gggagccttg gggaagagag agagagagag aggtagacct
      181 caggagggac tctcagcagt aatagatttg agctacgtta gcttttacat ggcgtggaga
      241 gctacttaga cttccggagt cagtcatttt ggtgatgaga cttggcattc taccccagtt
      301 cccaaagtgg ctgagatcta tgagaacctg aggccacgca cgcccagctg cctttgccag
      361 gctgcctgcc cgcttcttgg ccagtcaaga gctgttcacg agtcattcgc acaccagttg
      421 gcacccaagc ttcagaggtt tcccaagcgg tcactgtttc tcacctgggc agactggaga
      481 ggtacgatct gtaactggtg tctgaggttc tgagcacata agccctggtt gccgtttcct
      541 tactctatgg aactgctaca gtagcccatt gagcccttga gggttctttc ccttgggagc
      601 ctggactctt cagtaggact tcagacaagg aagatgctga gctcaatcaa gtgcgtgctg
      661 gtaggggaca gtgctgtggg gaaaacctca ctgttggtgc gcttcacctc tgagaccttc
      721 ccggaggcct acaaacccac ggtgtacgag aatacgggtg tagacgtctt catggatggc
      781 atccagatca gcctgggtct ctgggacact gccggcaacg acgccttcag aagtatccgg
      841 cccctgtcct accagcaggc agacgtggta ctgatgtgct actctgtggc caaccataac
      901 tcgttcctga acttgaagaa caaatggatt agtgagatca ggagcaacct accctgtacc
      961 ccggtgctgg ttgtggccac acagacggac cagagagagg tgggacctca cagggcttcc
     1021 tgcatcaatg ccatagaagg gaagagactt gcccaggatg tgagagccaa gggctacctg
     1081 gagtgctcag ccctcagcaa ccggggagta cagcaggtat ttgaatgtgc tgtccgaaca
     1141 gctgtcaacc aggccaggag gcgaaacaga aggaagctgt tctccatcaa tgaatgcaag
     1201 atcttctaaa ccccaaggtc ctgtgcccaa cattcatgaa tgtatgaatg tacctcagag
     1261 actcatagga gaggggaaag ggcaagccaa gaggactgat gctctgtctt gaaacatctg
     1321 aacaagcttt ctgcatgggg ttatgaggga gtctgccgct gctgcttcca ctaactctac
     1381 tctgcagaag aactctgtgc ccagcacaac cagagagatt ccttgggaag ccatatgagt
     1441 agtccatctt caatgagaga ctaaaacaac catcctaatt tagacaatga agtgcatttc
     1501 ccaactatgc catatttaaa tccacatctt atttaaataa taaccaaata tcgagctctt
     1561 gttttcatgc tttggaagtc ttttctttga aaaggcaaac tgctgtatga ggagaaaata
     1621 accttgtggg gttcaaccat atgtctgtgg cgttattgtt actcctgaat ttaatttggt
     1681 tggaactact ttgtgtgctg tgtttttttc tagctcatca gactttccaa tgaccataaa
     1741 ctgatctctg taattcatct tccatttccc tgttattcag agttgtgtat aaaatacagc
     1801 tctggcccag aaggtatttt aacactgcca aatgactttc tctgtaatta caaaagaaaa
     1861 tttcttcttt acgatattac ctgtcactca gagaactcca gttgcacacc aagtgttcct
     1921 ttctcactca ttaagacaga gatggaaaga aaaaaaaatc tttcatctcg agagtcacat
     1981 ggatgctgtt gagggacccc ttctccttgc ctgtgtcatc tgacatgtac ttcctgattg
     2041 gttacaggtc tcgggaaaag agggcaggca agtgttgtta taaataatag ttaattggct
     2101 ggcacaaccc catcatttat taattttaag actgaatcaa agcaattaga aaggcgccta
     2161 tatagcatgc ctgtgtatat gtataaggga aaaggcagtg tttatgactt ttactgtttc
     2221 atgaatagat acgcacttgt gaaaaaaatt acagatctca ggttcagaga atgagtaagt
     2281 ctccctactc agataataaa gagtcgttgg gaaatactaa ctcaataggg aggtgtgcat
     2341 atatgcaatc ctccttcctg attgtatgaa agtgatagtg tcgatcacct tttctttttt
     2401 tttctttttt tttagttttt cgagacaggg cttctgtata gccctgactg tcctggaact
     2461 cactttgtaa accaggctgg cctcgagctc agaaatccac ctgcccctgc ctcccgagtg
     2521 ctgggattaa aggcgtgtgc caccacgccc agcttcgatc accttttcta caccctgatg
     2581 tatcatttgt agttccaatc tgataactgg gaacacttgt agcgcctttc ttggagccca
     2641 gcactgtaga ggggttgtat ggctgtcatc atgaagagtg aggagcctgc aggagcaacc
     2701 ctactgtgga ttatactgac ataagcaagt cagcttgtca cacggattct ctggctgact
     2761 ctctgtggat acagtctgtt aaacatatcc taggacgcct cccccaccct ccatgctgtt
     2821 ttctcctctg tctgtctctc tcccaagctc agtcacaagc ctggaacctg ggtcttggtc
     2881 tgggtagaag aagcacttgc catttcccag ggctaatagg tgtgctgtca gctaatctct
     2941 cagccttctg gttctgcggc tggaccacct ccgtcccttg ccttgagagc tcatgtcttc
     3001 tgttcacggc actgggcatc ctgaaggttg gaatgagcag acagaggagg agacagggac
     3061 tatgtcttcc aggtccctca tgtccctctg attctctcct cattctccaa cacacaaagg
     3121 attttgtgtt tatttttctt ttggagtgtg tgtatacact cttattgctg taaattgaaa
     3181 cttttttttt tctcctcaca ttgttgccca ggatgacctc agacttgcaa tggtgctcct
     3241 gtctcagcct ctccggtgct gtgacgatag gtgtgagcta ctaggcctac gaaaggtctt
     3301 tcataacaaa cccggcttca agtttaatct gtggaatagt ttaaaacaca ctgaagaaat
     3361 taatttctac acactcagtt ctacacactc agtaggctgt cccttaatgc ttttctttct
     3421 attgaaggga ggtagggttg gggagcatct aaccgtggga aggccccagg gaggaagagg
     3481 aagtttcatg ctggagacag gaggggaggc catcgaggct gctgatagac ctgagtgagg
     3541 tttgcctgtt gacaggagcc ggtggtaaag ctcctttaag gaaggaagcc tcacactgga
     3601 gggcagaaat tcaagtgtga agcctccttc atgtgcacct ggtggaaact gagccaggca
     3661 gggcctttct tctctgtgtc cctgaggcta tgctgcctca tagttcactc cgtgtcctca
     3721 gggcccagcg cagggaagaa accatagcta gatgaagttg tgtgagagga aggaagagat
     3781 tgatcttcac gggtctgtag gtttagcttt gcacacatcc atgaaggtgt aggagacttc
     3841 cccttcaata ggtggtgctt tttgtatgct tcaccttcaa gtgtcccaag tagcaaaatt
     3901 acagatgctc atgtttccat aagaaagtgg atttaagtgg ttaagttcat ttgttctggc
     3961 ctaagcagaa tcccagaggc tgggaagtct gggatcaggt gtcagcacag tcaagctcag
     4021 tggaaggacc tcttcatctg attggtggct tcttgctatg tcctcatgtg tgtggtggga
     4081 gtttgatcta ttctcataag agccttcgtg ccatctgtga aggtcccgcc tttctgacca
     4141 cgttatctct taatcctatc acagttgatc aggcctcaga ggagcagttt gagggggaag
     4201 ggacccacat tccctcacgc cagtgctttt ctgtcttact ttattcagcc tagctaaata
     4261 gggcaacaga ataggttggc cccatacaat gggttaggtg acaagatgac aaaaaaagca
     4321 tcccgatggt gcaagtatgt cgagcacttc agatagctgg gcactgtgtt aagctcttgt
     4381 gtggtatgta agtggctcac acgagcaact tggccctcaa catgttaatg ggacaagccc
     4441 gagccataca gtgggtgagt atcagaactc ctaagtctgg agcaggtctg tgtggctcca
     4501 aagctctact caaaaccatc atggcccact tcctccctga gcagttacct gcatggcttt
     4561 gccacatctg atatcccata gctgcaggcc tctcccccta ctagtcaaag ggcttgtatt
     4621 taaaagatgg tggtgatgat gatgatggtg gtggtgatgg tggtgatgat gattttggct
     4681 tgttcatttg ttactgttgt tgctgttttg agaaaggatc ttgctatgac cttaaactca
     4741 tggtgctctt tctgtcttat attatccagt gctggcgtta taggcacaca tcaccacaca
     4801 caacttaaaa ggttattttt atttattgtt ttgcatttta ctggttatca aaatcaaggc
     4861 ctcttgaata ccaggcaagt gccccaccct gagctatgcc cccagcccca aaagattgtt
     4921 tttaaataaa atattctaag tctaa
//
