LOCUS       NM_019566               1264 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ras homolog family member G (Rhog), mRNA.
ACCESSION   NM_019566
VERSION     NM_019566.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1264)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1264)
  AUTHORS   Boccasavia,V.L., Bovolenta,E.R., Villanueva,A., Borroto,A.,
            Oeste,C.L., van Santen,H.M., Prieto,C., Alonso-Lopez,D.,
            Diaz-Munoz,M.D., Batista,F.D. and Alarcon,B.
  TITLE     Antigen presentation between T cells drives Th17 polarization under
            conditions of limiting antigen
  JOURNAL   Cell Rep 34 (11), 108861 (2021)
   PUBMED   33730591
REFERENCE   3  (bases 1 to 1264)
  AUTHORS   Martinez-Riano,A., Bovolenta,E.R., Mendoza,P., Oeste,C.L.,
            Martin-Bermejo,M.J., Bovolenta,P., Turner,M., Martinez-Martin,N.
            and Alarcon,B.
  TITLE     Antigen phagocytosis by B cells is required for a potent humoral
            response
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   29987136
REFERENCE   4  (bases 1 to 1264)
  AUTHORS   Fujiwara,K., Fujita,Y., Kasai,A., Onaka,Y., Hashimoto,H., Okada,H.
            and Yamashita,T.
  TITLE     Deletion of JMJD2B in neurons leads to defective spine maturation,
            hyperactive behavior and memory deficits in mouse
  JOURNAL   Transl Psychiatry 6 (3), e766 (2016)
   PUBMED   27023172
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1264)
  AUTHORS   Jackson,B.C., Ivanova,I.A. and Dagnino,L.
  TITLE     An ELMO2-RhoG-ILK network modulates microtubule dynamics
  JOURNAL   Mol Biol Cell 26 (14), 2712-2725 (2015)
   PUBMED   25995380
  REMARK    GeneRIF: ELMO2-RhoG-ILK complex has a key role in
            integrin-independent stabilization of the microtubule network in
            differentiated keratinocytes.
REFERENCE   6  (bases 1 to 1264)
  AUTHORS   Vigorito,E., Bell,S., Hebeis,B.J., Reynolds,H., McAdam,S.,
            Emson,P.C., McKenzie,A. and Turner,M.
  TITLE     Immunological function in mice lacking the Rac-related GTPase RhoG
  JOURNAL   Mol Cell Biol 24 (2), 719-729 (2004)
   PUBMED   14701744
  REMARK    GeneRIF: In RhoG deficient mice, the development of B and T
            lymphocytes was unaffected. However, there was an increase in the
            level of serum IgG1 and IgG2b as well as a mild increase of the
            humoral immune response to thymus-dependent antigens.
REFERENCE   7  (bases 1 to 1264)
  AUTHORS   Prieto-Sanchez,R.M. and Bustelo,X.R.
  TITLE     Structural basis for the signaling specificity of RhoG and Rac1
            GTPases
  JOURNAL   J Biol Chem 278 (39), 37916-37925 (2003)
   PUBMED   12805377
  REMARK    GeneRIF: different biological properties of RhoG and Rac1 can be
            traced to specific amino acid variations in their switch I,
            beta2/beta3 hairpin, alpha5 helix, and C-terminal polybasic
            regions.
REFERENCE   8  (bases 1 to 1264)
  AUTHORS   Wennerberg,K., Ellerbroek,S.M., Liu,R.Y., Karnoub,A.E., Burridge,K.
            and Der,C.J.
  TITLE     RhoG signals in parallel with Rac1 and Cdc42
  JOURNAL   J Biol Chem 277 (49), 47810-47817 (2002)
   PUBMED   12376551
  REMARK    GeneRIF: RhoG function is mediated by signals independent of Rac1
            and Cdc42 activation and instead by direct utilization of a subset
            of common effectors
REFERENCE   9  (bases 1 to 1264)
  AUTHORS   Zalcman,G., Closson,V., Camonis,J., Honore,N., Rousseau-Merck,M.F.,
            Tavitian,A. and Olofsson,B.
  TITLE     RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification
            of a non-cytosolic GDI protein interacting with the small
            GTP-binding proteins RhoB and RhoG
  JOURNAL   J Biol Chem 271 (48), 30366-30374 (1996)
   PUBMED   8939998
REFERENCE   10 (bases 1 to 1264)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ942269.1 and AK143623.1.
            
            On May 22, 2007 this sequence version replaced NM_019566.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143623.1, AK169853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BQ942269.1         1-8
            9-1264              AK143623.1         2-1257
FEATURES             Location/Qualifiers
     source          1..1264
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..1264
                     /gene="Rhog"
                     /gene_synonym="2810426G09Rik; Arhg; Sid10750"
                     /note="ras homolog family member G"
                     /db_xref="GeneID:56212"
                     /db_xref="MGI:MGI:1928370"
     exon            1..74
                     /gene="Rhog"
                     /gene_synonym="2810426G09Rik; Arhg; Sid10750"
                     /inference="alignment:Splign:2.1.0"
     exon            75..1264
                     /gene="Rhog"
                     /gene_synonym="2810426G09Rik; Arhg; Sid10750"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..718
                     /gene="Rhog"
                     /gene_synonym="2810426G09Rik; Arhg; Sid10750"
                     /note="aplysia ras-related homolog G (RhoG); ras homolog G
                     (RhoG); sid 10750; ras homolog gene family, member G"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoG"
                     /protein_id="NP_062512.1"
                     /db_xref="CCDS:CCDS21529.1"
                     /db_xref="GeneID:56212"
                     /db_xref="MGI:MGI:1928370"
                     /translation="MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQS
                     AVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVC
                     HHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSAL
                     QQDGVKEVFAEAVRAVLNPTPIKRGRSCILL"
     regulatory      1242..1247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhog"
                     /gene_synonym="2810426G09Rik; Arhg; Sid10750"
                     /note="hexamer: AATAAA"
     polyA_site      1261
                     /gene="Rhog"
                     /gene_synonym="2810426G09Rik; Arhg; Sid10750"
                     /note="major polyA site"
ORIGIN      
        1 cagttctcac ttccttcttg agcccagagc cgccgccgcc gcccccagct cccccgccgc
       61 ggggagggca ccaggtcact acttcagtgg ggtccagaag agagaggagg cactgcctcc
      121 acgacagtaa ctttacagca caatgcagag catcaagtgt gtggtggtgg gcgatggggc
      181 cgtaggcaag acgtgccttc tcatctgcta tacaactaac gccttcccca aggaatacat
      241 ccccactgtg tttgacaatt acagcgccca gagtgcggtt gatgggcgca ccgtgaacct
      301 aaacctgtgg gacactgcgg gccaggagga atatgaccgc ctccgcaccc tttcctaccc
      361 tcagaccaac gtcttcgtca tctgtttctc cattgccagt ccaccctcct atgagaacgt
      421 gaggcacaaa tggcacccag aggtttgtca ccactgccct gacgtgccta tcctcctggt
      481 gggtaccaag aaggacctga gagcccagcc tgatacccta cggcgcctca aggagcaggg
      541 tcaagcgccc atcactccac agcagggcca ggcactggcc aagcagatcc atgctgtgcg
      601 ctacctcgag tgctcagcac tgcaacaaga cggcgtcaag gaggtgtttg cggaggctgt
      661 ccgggcggtg cttaacccaa caccgataaa gcgtgggcgg tcctgcatcc tcttgtgacc
      721 ctggcactca gcttggaggc tatccctttg cccccccacc aattgtgcct tggcgccttg
      781 tctgccccca gctgtgcctt aaggactaat tctggcaccc cttgcctgga aactccctga
      841 atgcctttta ttccttaagg aggtacacag ggaaaggggc tttgggcccc accccactct
      901 gcttgggaat accaagtatt ccatgagttc aactaagcca ggtttaccta agaggccaac
      961 ccggtgctcg cctccattcc ctgctactga ccagttcatc cagctttcca aagttgttgc
     1021 tgcctgttgt gatgcctcct aagacagggg ctctaacctc tctctgcctt agctcttgga
     1081 ctaggctctc caagatgttc tctccctccc ccaaaggaga agccacagaa tcctgagaag
     1141 aaagatgtgc cctaacctgc cccatgtgcc caggacttac gcgcctgctg actgactcag
     1201 gccccgtgct cctgggggcc tttcctaccc ccaccagcat caataaaacc tcctgtctcc
     1261 agtg
//
