LOCUS       NM_175092               2143 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ras homolog family member F (in filopodia) (Rhof),
            mRNA.
ACCESSION   NM_175092
VERSION     NM_175092.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Shaverdashvili,K., Padlo,J., Weinblatt,D., Jia,Y., Jiang,W.,
            Rao,D., Laczko,D., Whelan,K.A., Lynch,J.P., Muir,A.B. and Katz,J.P.
  TITLE     KLF4 activates NFkappaB signaling and esophageal epithelial
            inflammation via the Rho-related GTP-binding protein RHOF
  JOURNAL   PLoS One 14 (4), e0215746 (2019)
   PUBMED   30998758
  REMARK    GeneRIF: RHOF is required for NFkappaB activation by KLF4 in
            esophageal keratinocytes and is also important for esophageal
            keratinocyte proliferation and migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Kishimoto,M., Matsuda,T., Yanase,S., Katsumi,A., Suzuki,N.,
            Ikejiri,M., Takagi,A., Ikawa,M., Kojima,T., Kunishima,S., Kiyoi,H.,
            Naoe,T., Matsushita,T. and Maruyama,M.
  TITLE     Rhof promotes murine marginal zone B cell development
  JOURNAL   Nagoya J Med Sci 76 (3-4), 293-305 (2014)
   PUBMED   25741038
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Goggs,R., Savage,J.S., Mellor,H. and Poole,A.W.
  TITLE     The small GTPase Rif is dispensable for platelet filopodia
            generation in mice
  JOURNAL   PLoS One 8 (1), e54663 (2013)
   PUBMED   23359340
  REMARK    GeneRIF: small GTPase Rif does not appear to be critical for
            platelet function in mice. Functional overlap between Rif and other
            small GTPases may be responsible for the non-essential role of Rif
            in platelets
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Goh,W.I., Sudhaharan,T., Lim,K.B., Sem,K.P., Lau,C.L. and Ahmed,S.
  TITLE     Rif-mDia1 interaction is involved in filopodium formation
            independent of Cdc42 and Rac effectors
  JOURNAL   J Biol Chem 286 (15), 13681-13694 (2011)
   PUBMED   21339294
  REMARK    GeneRIF: Rif-mDia1 interaction is involved in filopodium formation
            independent of Cdc42 and Rac effectors.
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Babbin,B.A., Sasaki,M., Gerner-Schmidt,K.W., Nusrat,A. and
            Klapproth,J.M.
  TITLE     The bacterial virulence factor lymphostatin compromises intestinal
            epithelial barrier function by modulating rho GTPases
  JOURNAL   Am J Pathol 174 (4), 1347-1357 (2009)
   PUBMED   19286565
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 2143)
  AUTHORS   Smith,J.B., Wadleigh,D.J., Xia,Y.R., Mar,R.A., Herschman,H.R. and
            Lusis,A.J.
  TITLE     Cloning and genomic localization of the murine LPS-induced CXC
            chemokine (LIX) gene, Scyb5
  JOURNAL   Immunogenetics 54 (8), 599-603 (2002)
   PUBMED   12439624
REFERENCE   9  (bases 1 to 2143)
  AUTHORS   Klingenspor,M., Xu,P., Cohen,R.D., Welch,C. and Reue,K.
  TITLE     Altered gene expression pattern in the fatty liver dystrophy mouse
            reveals impaired insulin-mediated cytoskeleton dynamics
  JOURNAL   J Biol Chem 274 (33), 23078-23084 (1999)
   PUBMED   10438476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK617811.1, DV646753.1 and AC158114.8.
            
            On May 25, 2006 this sequence version replaced NM_175092.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096597.1, AK172212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               CK617811.1         8-615
            609-1266            DV646753.1         31-688
            1267-2143           AC158114.8         116658-117534       c
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.77 cM"
     gene            1..2143
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /note="ras homolog family member F (in filopodia)"
                     /db_xref="GeneID:23912"
                     /db_xref="MGI:MGI:1345629"
     exon            1..395
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..893
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /note="ras homolog gene family, member f (in filopodia);
                     induced in fatty liver dystrophy 1"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoF"
                     /protein_id="NP_780301.1"
                     /db_xref="CCDS:CCDS39263.1"
                     /db_xref="GeneID:23912"
                     /db_xref="MGI:MGI:1345629"
                     /translation="MDAPGAPAPAAAPSSARKELKIVIVGDGGCGKTSLLMVYCQGSF
                     PEHYAPSVFEKYTASVTVGNKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICYDVMN
                     PTSYDNVLIKWFPEVTHFCRGIPTVLIGCKTDLRKDKEQLRKLRAAQLEPITYTQGLN
                     ACEQMRGALYLECSAKFRENVEDVFREAAKVALSALKKAQRQKKHRICLLL"
     exon            396..483
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /inference="alignment:Splign:2.1.0"
     exon            484..593
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /inference="alignment:Splign:2.1.0"
     exon            594..728
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /inference="alignment:Splign:2.1.0"
     exon            729..2143
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2121..2126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /note="hexamer: AATAAA"
     polyA_site      2143
                     /gene="Rhof"
                     /gene_synonym="Arhf; Ifld1; Rif"
                     /note="major polyA site"
ORIGIN      
        1 cactgcgctt gcggttcagc atccatttct tcaggttctt catttcccct gggactgcaa
       61 gacaaatacc cggggtcccc ggaccatagc cgaggagaat taagacaggg tggtgaacct
      121 gggaggctgc ctggcagagg tggcgccagc tgcccgtggg tggagcctcg tagccctgcc
      181 ctgtaacccc gcccctgccc tgtcgctcta ctgggctcta gccagcgcgc agcatccagc
      241 gctgcgggct ccgggctatg gacgccccgg gtgctccggc cccagccgcc gcccccagct
      301 cggcgaggaa ggagctgaag atagtgatcg taggtgacgg cggctgcggc aagacgtccc
      361 tgctaatggt gtactgccaa ggctcatttc ccgagcacta cgccccgtcg gtgtttgaga
      421 agtacacggc tagtgtgaca gtgggtaaca aggaggtgac cctgaacctc tacgacacgg
      481 ctgggcagga agactacgat aggctgcggc ccttgtccta ccagaacaca cacctcgtcc
      541 tcatctgcta cgatgtcatg aaccccacca gttacgacaa cgtcctcatc aagtggttcc
      601 ccgaagtcac acatttctgc cgagggatcc ccacggtgct catcggctgc aagacagacc
      661 tgaggaagga caaggagcag ttgcggaaac tccgggcagc tcagctggag cctattacct
      721 acacacaggg cctgaatgcc tgtgaacaga tgcgaggtgc actctatctg gaatgttctg
      781 ccaagtttcg ggagaatgtg gaagatgtct tcagggaagc cgccaaggtg gccctcagcg
      841 ccctgaagaa agcgcagaga cagaaaaaac acaggatctg cctgctgctg tgaccctggg
      901 gacagagggc ctgactggaa ctattacagc cagggaccca ggcccagtgg gtcttacagt
      961 gtctggcatc tggggactct cagaacattc tggaatggcc cctttgggtt caggctgtag
     1021 tgcactagtg aatgagggtg ccagacccac caatgttcct ctacttcatg actggcactt
     1081 gtcccaggcc acaggagggt ccttgtcaca gctcctctgc ccccagccat gcgtgtctct
     1141 ccctttccaa accaatttat gcctgaaact cagaactggc accggggaat tgtgggtaag
     1201 catgggtaca caacgctgtt cacgagagtc ccaagcccac tgtttctgtc acagtctccc
     1261 tgagctcctg agataggctc ggctacatcc tccagcccct tcctgcttcc cttcaggaac
     1321 ctggggacca cagcctatca ggagaacaca ggcatcaagc cggacgtggg tctggcacca
     1381 gcttctccct tcctaccaca ccgaggactt ctgtctcggg cttggtcaca gcctgagatg
     1441 catgttcaga gtgagaagaa acaatctctc aaaatgtcaa aatatactcg ggccagccag
     1501 gccactcatc tgacccctgc tccaggtctg acctccaact ccccagccga ctactggaaa
     1561 ctcctgatgg ttgggttcat cccaccattg gggacctcag acaaatgggc tctccctaga
     1621 ctatggccca cctgaaaatg ggtcattagt cagtcaagct cctcactggt ccactcagtt
     1681 tctgcttcta ctggatgtgg agctcaggag tagcctacct ctgcctcatt ccagaactga
     1741 catggccacc cctgtccacg ctggacaatt tctcagaact agcctgctga ctatctccaa
     1801 cagccaaagt cttgagtcct ggcactcctc ctggacgtca caactgttca atacctacgt
     1861 ggtataccag gtaggtttag cgcctccaag atgaaggcac agtccgagaa gaaaccatgg
     1921 ccttggctgg cccctgcccc agcaccactt gacttggtcc ccttccccaa atgctccaag
     1981 cccctgctgt cccctgcgga gccaaacaag gacctcttgt tctctcagaa cccaaggcct
     2041 tgtgaacaga tcgtgggata cagcagcagt cagcaaccca cagcctgtgg gccacatgtg
     2101 gccggctgcc tggttttgta aataaagttt tattgaatag cca
//
