LOCUS       NM_007485               3355 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ras homolog family member D (Rhod), transcript variant
            1, mRNA.
ACCESSION   NM_007485
VERSION     NM_007485.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3355)
  AUTHORS   Le,D., Lim,S., Min,K.W., Park,J.W., Kim,Y., Ha,T., Moon,K.H.,
            Wagner,K.U. and Kim,J.W.
  TITLE     Tsg101 Is Necessary for the Establishment and Maintenance of Mouse
            Retinal Pigment Epithelial Cell Polarity
  JOURNAL   Mol Cells 44 (3), 168-178 (2021)
   PUBMED   33795534
REFERENCE   2  (bases 1 to 3355)
  AUTHORS   Choi,J.H., Jo,H.S., Lim,S., Kim,H.T., Lee,K.W., Moon,K.H., Ha,T.,
            Kwak,S.S., Kim,Y., Lee,E.J., Joe,C.O. and Kim,J.W.
  TITLE     mTORC1 accelerates retinal development via the immunoproteasome
  JOURNAL   Nat Commun 9 (1), 2502 (2018)
   PUBMED   29950673
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3355)
  AUTHORS   Blom,M., Reis,K., Nehru,V., Blom,H., Gad,A.K.B. and Aspenstrom,P.
  TITLE     RhoD is a Golgi component with a role in anterograde protein
            transport from the ER to the plasma membrane
  JOURNAL   Exp Cell Res 333 (2), 208-219 (2015)
   PUBMED   25746724
REFERENCE   4  (bases 1 to 3355)
  AUTHORS   Aspenstrom,P.
  TITLE     Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics
            and membrane trafficking
  JOURNAL   Biol Chem 395 (5), 477-484 (2014)
   PUBMED   24622787
  REMARK    Review article
REFERENCE   5  (bases 1 to 3355)
  AUTHORS   Gad,A.K. and Aspenstrom,P.
  TITLE     Rif proteins take to the RhoD: Rho GTPases at the crossroads of
            actin dynamics and membrane trafficking
  JOURNAL   Cell Signal 22 (2), 183-189 (2010)
   PUBMED   19818399
  REMARK    Review article
REFERENCE   6  (bases 1 to 3355)
  AUTHORS   Sandilands,E., Brunton,V.G. and Frame,M.C.
  TITLE     The membrane targeting and spatial activation of Src, Yes and Fyn
            is influenced by palmitoylation and distinct RhoB/RhoD endosome
            requirements
  JOURNAL   J Cell Sci 120 (Pt 15), 2555-2564 (2007)
   PUBMED   17623777
REFERENCE   7  (bases 1 to 3355)
  AUTHORS   Tsubakimoto,K., Matsumoto,K., Abe,H., Ishii,J., Amano,M.,
            Kaibuchi,K. and Endo,T.
  TITLE     Small GTPase RhoD suppresses cell migration and cytokinesis
  JOURNAL   Oncogene 18 (15), 2431-2440 (1999)
   PUBMED   10229194
REFERENCE   8  (bases 1 to 3355)
  AUTHORS   Matsumoto,K., Asano,T. and Endo,T.
  TITLE     Novel small GTPase M-Ras participates in reorganization of actin
            cytoskeleton
  JOURNAL   Oncogene 15 (20), 2409-2417 (1997)
   PUBMED   9395237
REFERENCE   9  (bases 1 to 3355)
  AUTHORS   Murphy,C., Saffrich,R., Grummt,M., Gournier,H., Rybin,V.,
            Rubino,M., Auvinen,P., Lutcke,A., Parton,R.G. and Zerial,M.
  TITLE     Endosome dynamics regulated by a Rho protein
  JOURNAL   Nature 384 (6608), 427-432 (1996)
   PUBMED   8945468
REFERENCE   10 (bases 1 to 3355)
  AUTHORS   Chavrier,P., Simons,K. and Zerial,M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124347.4, AK008880.1 and BX516716.1.
            
            On Aug 12, 2016 this sequence version replaced NM_007485.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008880.1, BC047989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC124347.4         91546-91564
            20-1355             AK008880.1         2-1337
            1356-2895           AC124347.4         105531-107070
            2896-3355           BX516716.1         2-461
FEATURES             Location/Qualifiers
     source          1..3355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.07 cM"
     gene            1..3355
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /note="ras homolog family member D"
                     /db_xref="GeneID:11854"
                     /db_xref="MGI:MGI:108446"
     exon            1..224
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..725
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rho-related GTP-binding protein RhoD; aplysia ras-related
                     homolog D; ras homolog gene family, member D; ras homolog
                     D (RhoD)"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoD isoform 1"
                     /protein_id="NP_031511.1"
                     /db_xref="CCDS:CCDS29427.1"
                     /db_xref="GeneID:11854"
                     /db_xref="MGI:MGI:108446"
                     /translation="MNASQVAGEEAPQSGHSVKVVLVGDGGCGKTSLMMVFAKGAFPE
                     SYSPTVFERYNATLQMKGKPVHLQIWDTAGQDDYDRLRPLFYPDANVLLLCFDVTNPN
                     SFDNVSNRWYPEVTHFCKGVPIIVVGCKIDLRKDKVLVNNLRKKRLEPVTYHRGHDMA
                     RSVGAVAYLECSARLHDNVEAVFQEAAEVALSSRRHNFWRRITQNCCLAT"
     exon            225..312
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /inference="alignment:Splign:2.1.0"
     exon            313..422
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /inference="alignment:Splign:2.1.0"
     exon            423..557
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /inference="alignment:Splign:2.1.0"
     exon            558..3342
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1128..1133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /note="hexamer: ACTAAA"
     polyA_site      1147
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /note="major polyA site"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
                     /note="hexamer: AATAAA"
     polyA_site      1366
                     /gene="Rhod"
                     /gene_synonym="Arhd; Rho; RhoHP1; RhoM"
ORIGIN      
        1 attcctgtcc cgccgggcca gccccgcgcc cgccgcagcc agcccgccgc gtaccgcctg
       61 ctgctccgcg caccgccgtc cgccagccag ggatgaacgc gtcccaggtt gcgggagaag
      121 aggcgccgca gagcgggcac tcggtcaagg tggtcctggt gggcgacggg ggctgcggga
      181 agacgtcact gatgatggtc ttcgccaaag gggccttccc agagagctac agtcccacag
      241 tgtttgagcg ctataatgcc actctgcaga tgaagggtaa acctgtgcac ctccaaatct
      301 gggacacagc cgggcaagat gactatgacc gcctccggcc cttgttctat cctgatgcca
      361 atgtcttgct cctctgcttc gatgtgacca atccaaacag ctttgacaac gtctccaacc
      421 ggtggtaccc agaggtgaca catttctgca agggagtgcc catcattgtt gtgggctgca
      481 agatagacct gcgtaaggac aaggtgctgg tgaacaacct gcggaagaaa agactggagc
      541 ccgtgaccta ccacaggggc cacgatatgg caaggtctgt gggagcggtg gcctatcttg
      601 agtgttcagc tcggctccat gacaacgtgg aagccgtctt ccaggaagca gcagaagtgg
      661 ctctcagcag tcgcagacat aacttttggc ggcggattac tcagaattgt tgcttggcca
      721 cctgactggc ttggaaccca ccttgccttc cggtttactc cgctgcagaa agacccagaa
      781 gcagaacttg tactctgttg actgggatgg acctaatccc taggctgagc tggtagaacc
      841 acacatccat ccacagatgg gctccaatga ggcctggccc ctggaccgag gaatcctgga
      901 ttgaggaaga gggttcccag acccttagct ctggaaccat tatagactcc tgtgcccaat
      961 cctggacctg cgtcctgagc ggggtctgtg cggtctgttt ggcgccacct tgtggctatt
     1021 ctattgagtt atatctacag gacctagggt tcccaagacc atcttgcccg ggctaatacc
     1081 ctgccccgtc cgtgatcatc ctatttatcc cattgctaag tgtaacaact aaaatggcag
     1141 cacttgctat tagtgtcctg actcttcctt caaagcatct ttacatacta ctaggtagga
     1201 aagagcccat ccacctagac cctagggtgg aactgctagg accaaacctg actttatcac
     1261 tttaagacct tgaggaagtt ctaggcctca gcctttcatc tgtaaaatgg ccaatcagaa
     1321 attacatcaa gcatgaataa aagtcatgag gactaacaca ttcaaagagc ttagcaagtg
     1381 ccttgcatga aaggtacaca ctctcatttg tctaccatgt tagtagactt ctccagaaac
     1441 agcacagtgt caggcacaca cacacggaga tagtgcagta atgctttcca ggtgccacca
     1501 cataaaccaa acaacctaaa ctcaattccc agaacccata taaaaagcaa gatgcgaggt
     1561 tggtgaggtg gctcagcaga caggggttct tgccacgacg gcttgagttc cttgggaccc
     1621 atatggtagg agaaaactga ctcccacatt tgacctctga cttccatgta taccttggta
     1681 taaacccacc caacacatac acagtagaac tgaagtgtaa cttcactttt ttttaagcta
     1741 gaggctagtg atcaaaagca ttagtgcact atctccgtga gtcctcacac gtgtgtgtgt
     1801 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc gtgtgcgcgt gccactggct tgtcttctaa
     1861 acgatctagg tttggttccc agcacacata ggatagcgca cagtcacctg tagtttctgt
     1921 tctgtgggac tcaatgccct cttctggcct ccataggcac caggcacaaa aaaaaaaacc
     1981 caaaaacaaa accaggcaaa catacacacc ataaaatcaa gccagtgttg gtggtgcaca
     2041 cctttaatcc cagtacttag gaggcagagg caggcagatt tctgagttcg aggccagctc
     2101 agtctacaga gtgaattcca ggacagccag ggatagagaa accctgtctc aaaaaaaaaa
     2161 aaaaaaaaaa aaaaaaaggt gtcagagaca agaaactctt ctaatctctt ggaagctcaa
     2221 aagccttgat acacacaccc cacatatgga aactacagaa acaagagaga cctgcctcaa
     2281 caaggtgaaa aaaactgatt cctgaaagtt gtcttctgac ctctacatgt gcaatgtggg
     2341 gtacacacac acacacacac acacacacac acacacacac acggtttcat taaggaacct
     2401 gctcatatgc tcatacccgt gtggttgtgg ggtctggcag gctgatactt gtaatgcaaa
     2461 tgagttggtg ttgacatcca gcatttgaat ttgcagggct gtgggctgga aactcagggt
     2521 ttttggactg ctaaacttga ggcagaattc ttcaggaaga caagaggccc acacatactg
     2581 agtgccacct gctttattca aagactatca atttaaaatt cttttctcac atgtttattt
     2641 gtgagggctg tgggacatgc catgacacac atgtagaagt tagtggaaaa tcctcaagag
     2701 tcagttttct cctttcacta tgtgagtccc agagatcaaa ctcaggctgt caggcttggt
     2761 ggcaagtgtc ttcatctact gaaggcactg gcctccaaag tctaacaatt taaacataat
     2821 cacatctatt ttttttaata gaaatgaatt ttgcttttat ttttttaatt taaaattttt
     2881 gtttttgttt gaaacagggt ttctttgtgt agccctggct gctctgaaat tcactctata
     2941 gcttacctgg cttttaattt taattatttt tatgtgtatg agtgttttgc ctgcgtgcat
     3001 gtctgtgtac catgtgcatg aagactgtca gatcccctga gactgaagtt acagacggtt
     3061 gtgagctgcc gtgtgagtgt tgggaatgaa cccaggtcct ctggaaaagc agccagtgct
     3121 cttaatcact gagccaactt tctacactac acctgttttg ttttgttttg ttttgtttta
     3181 ttctgtatat gctttttatc aagttaattg ttaacattgt gtgtatgtgg gcgcatgttg
     3241 ccatgacaaa gctgtggaag ttgggggtca attttgtgga atcagttttc tcctactttt
     3301 atgtgcattt tagagaccaa actcggatca tcagacttgt aaaaaaaaaa aaaaa
//
