LOCUS       NM_007484               1082 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus ras homolog family member C (Rhoc), transcript variant
            2, mRNA.
ACCESSION   NM_007484
VERSION     NM_007484.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Raghuram,N., Temel,E.I., Kawamata,T., Kozma,K.J., Loch,A.J.,
            Wang,W., Adams,J.R., Muller,W.J. and Egan,S.E.
  TITLE     Elevated expression of wildtype RhoC promotes ErbB2- and
            Pik3ca-induced mammary tumor formation
  JOURNAL   Breast Cancer Res 26 (1), 86 (2024)
   PUBMED   38807216
  REMARK    GeneRIF: Elevated expression of wildtype RhoC promotes ErbB2- and
            Pik3ca-induced mammary tumor formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Bertol,J.W., Johnston,S., Ahmed,R., Xie,V.K., Hubka,K.M., Cruz,L.,
            Nitschke,L., Stetsiv,M., Goering,J.P., Nistor,P., Lowell,S.,
            Hoskens,H., Claes,P., Weinberg,S.M., Saadi,I., Farach-Carson,M.C.
            and Fakhouri,W.D.
  TITLE     TWIST1 interacts with beta/delta-catenins during neural tube
            development and regulates fate transition in cranial neural crest
            cells
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35781329
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Nakamura,Y., Ueno,M., Niehaus,J.K., Lang,R.A., Zheng,Y. and
            Yoshida,Y.
  TITLE     Modulation of Both Intrinsic and Extrinsic Factors Additively
            Promotes Rewiring of Corticospinal Circuits after Spinal Cord
            Injury
  JOURNAL   J Neurosci 41 (50), 10247-10260 (2021)
   PUBMED   34759029
REFERENCE   4  (bases 1 to 1082)
  AUTHORS   Egami,Y., Kawai,K. and Araki,N.
  TITLE     RhoC regulates the actin remodeling required for phagosome
            formation during FcgammaR-mediated phagocytosis
  JOURNAL   J Cell Sci 130 (24), 4168-4179 (2017)
   PUBMED   29113998
  REMARK    GeneRIF: what was seen for RhoC, mDia1 silencing through RNAi
            inhibited phagosome formation. Additionally, the coexpression of
            mDia1 with constitutively active mutant RhoC-G14V or expression of
            active mutant mDia1-DeltaN3 drastically inhibited the uptake of
            IgG-Es. These data suggest that RhoC modulates phagosome formation
            be modifying actin cytoskeletal remodeling via mDia1
REFERENCE   5  (bases 1 to 1082)
  AUTHORS   Escamilla,C.O., Filonova,I., Walker,A.K., Xuan,Z.X., Holehonnur,R.,
            Espinosa,F., Liu,S., Thyme,S.B., Lopez-Garcia,I.A., Mendoza,D.B.,
            Usui,N., Ellegood,J., Eisch,A.J., Konopka,G., Lerch,J.P.,
            Schier,A.F., Speed,H.E. and Powell,C.M.
  TITLE     Kctd13 deletion reduces synaptic transmission via increased RhoA
  JOURNAL   Nature 551 (7679), 227-231 (2017)
   PUBMED   29088697
REFERENCE   6  (bases 1 to 1082)
  AUTHORS   Reid,T., Furuyashiki,T., Ishizaki,T., Watanabe,G., Watanabe,N.,
            Fujisawa,K., Morii,N., Madaule,P. and Narumiya,S.
  TITLE     Rhotekin, a new putative target for Rho bearing homology to a
            serine/threonine kinase, PKN, and rhophilin in the rho-binding
            domain
  JOURNAL   J Biol Chem 271 (23), 13556-13560 (1996)
   PUBMED   8662891
REFERENCE   7  (bases 1 to 1082)
  AUTHORS   Madaule,P., Furuyashiki,T., Reid,T., Ishizaki,T., Watanabe,G.,
            Morii,N. and Narumiya,S.
  TITLE     A novel partner for the GTP-bound forms of rho and rac
  JOURNAL   FEBS Lett 377 (2), 243-248 (1995)
   PUBMED   8543060
REFERENCE   8  (bases 1 to 1082)
  AUTHORS   Segade,F., Claudio,E., Wrobel,K., Ramos,S. and Lazo,P.S.
  TITLE     Isolation of nine gene sequences induced by silica in murine
            macrophages
  JOURNAL   J Immunol 154 (5), 2384-2392 (1995)
   PUBMED   7868905
REFERENCE   9  (bases 1 to 1082)
  AUTHORS   Hall,A.
  TITLE     Small GTP-binding proteins and the regulation of the actin
            cytoskeleton
  JOURNAL   Annu Rev Cell Biol 10, 31-54 (1994)
   PUBMED   7888179
  REMARK    Review article
REFERENCE   10 (bases 1 to 1082)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY147599.1, AK160650.1 and AI324259.1.
            
            On Nov 16, 2007 this sequence version replaced NM_007484.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011599.1, AK152802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY147599.1         2-7
            7-1051              AK160650.1         2-1046
            1052-1082           AI324259.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.86 cM"
     gene            1..1082
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /note="ras homolog family member C"
                     /db_xref="GeneID:11853"
                     /db_xref="MGI:MGI:106028"
     exon            1..50
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /inference="alignment:Splign:2.1.0"
     exon            51..214
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..640
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /note="aplysia ras-related homolog 9 (RhoC); ras homolog 9
                     (RhoC); ras homolog gene family, member C; SIG-61;
                     silica-induced gene 61 protein"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoC"
                     /protein_id="NP_031510.2"
                     /db_xref="CCDS:CCDS17704.1"
                     /db_xref="GeneID:11853"
                     /db_xref="MGI:MGI:106028"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECS
                     AKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL"
     exon            215..335
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /inference="alignment:Splign:2.1.0"
     exon            336..466
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /inference="alignment:Splign:2.1.0"
     exon            467..1056
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /note="hexamer: AATAAA"
     polyA_site      1056
                     /gene="Rhoc"
                     /gene_synonym="Arh9; Arhc"
                     /note="major polyA site"
ORIGIN      
        1 agtctcagcc tccggcactg gccgcgcagc tggaggcggt ggagcccaag tttcagccat
       61 ggctgcgatc cgaaagaagc tggtgattgt gggtgacggt gcctgtggga agacctgcct
      121 cctcattgtc ttcagcaaag atcagtttcc agaggtctac gtgcctaccg tctttgagaa
      181 ctatatagcc gacatcgaag tggatggcaa gcaggtggag ctggctctgt gggacacagc
      241 tgggcaagaa gactacgatc gcctgcggcc tctctcctac ccggacactg acgtcatcct
      301 catgtgtttc tccattgaca gccctgacag tttggaaaac attcctgaga agtggacccc
      361 agaggtgaag cacttttgtc ccaacgtgcc catcatccta gtggggaata aaaaggacct
      421 gaggcaagat gagcatacca ggagagagct ggccaagatg aaacaggagc cggttcgatc
      481 tgaggaaggc cgggacatgg caaacaggat cagtgccttt ggctacctcg agtgctcggc
      541 caagactaag gaaggggtgc gggaggtatt tgagatggcc actcgggcgg gcctacaggt
      601 ccggaagaat aagcgccgga ggggctgtcc cattctctga cttccccaaa gcttcctcaa
      661 ccctcccacc cttcccttcc caggggtaca gttaccctcc cccacgccat ccttgtagga
      721 ctccatgctg ccagtttctt ttttggttcc tttctgccca ggactgcatg agtttcccag
      781 ccccaagtgg gggctgctag gcccttcctc cctgcctctg ggaaccgggc tggtgccctg
      841 cctttcctga gcagggctcc tcctccagaa gcggtggtcc agggggtggg gctcttagtc
      901 cctctggcct tccccatatt acacaccagc actttatata tttttggctc acaggaggag
      961 tctagggtag ggactggggt ttctgctttg ggtagtagcc ttgttatttg acttaacttg
     1021 gtggggacat gaataaaggt caaaggttgc accgtgaaaa aaaaaaaaaa aaaaaaaaaa
     1081 aa
//
