LOCUS       NM_028493               5048 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Rho-related BTB domain containing 3 (Rhobtb3),
            transcript variant 1, mRNA.
ACCESSION   NM_028493
VERSION     NM_028493.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5048)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5048)
  AUTHORS   Sun,Y., Liu,Y., Chen,H. and Tan,Y.
  TITLE     Circular RNA circRHOBTB3 inhibits ovarian cancer progression
            through PI3K/AKT signaling pathway
  JOURNAL   Panminerva Med 66 (1), 36-46 (2024)
   PUBMED   32720791
  REMARK    GeneRIF: Circular RNA circRHOBTB3 inhibits ovarian cancer
            progression through PI3K/AKT signaling pathway.
REFERENCE   3  (bases 1 to 5048)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5048)
  AUTHORS   Berger,M., Lutz,D.R.J., Lutz,J., Khalil,J.S., Aburima,A.,
            Naseem,K.M. and Rivero,F.
  TITLE     Alterations in Platelet Alpha-Granule Secretion and Adhesion on
            Collagen under Flow in Mice Lacking the Atypical Rho GTPase RhoBTB3
  JOURNAL   Cells 8 (2), 149 (2019)
   PUBMED   30754723
  REMARK    GeneRIF: genetic deletion of Rhobtb3 leads to subtle alterations in
            alpha-granule secretion and adhesion to collagen without
            significant effects on hemostasis in vivo.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5048)
  AUTHORS   Zhang,C.S., Liu,Q., Li,M., Lin,S.Y., Peng,Y., Wu,D., Li,T.Y.,
            Fu,Q., Jia,W., Wang,X., Ma,T., Zong,Y., Cui,J., Pu,C., Lian,G.,
            Guo,H., Ye,Z. and Lin,S.C.
  TITLE     RHOBTB3 promotes proteasomal degradation of HIFalpha through
            facilitating hydroxylation and suppresses the Warburg effect
  JOURNAL   Cell Res 25 (9), 1025-1042 (2015)
   PUBMED   26215701
REFERENCE   6  (bases 1 to 5048)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 5048)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 5048)
  AUTHORS   Ramos,S., Khademi,F., Somesh,B.P. and Rivero,F.
  TITLE     Genomic organization and expression profile of the small GTPases of
            the RhoBTB family in human and mouse
  JOURNAL   Gene 298 (2), 147-157 (2002)
   PUBMED   12426103
REFERENCE   9  (bases 1 to 5048)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   10 (bases 1 to 5048)
  AUTHORS   Noonan,D.M., Fulle,A., Valente,P., Cai,S., Horigan,E., Sasaki,M.,
            Yamada,Y. and Hassell,J.R.
  TITLE     The complete sequence of perlecan, a basement membrane heparan
            sulfate proteoglycan, reveals extensive similarity with laminin A
            chain, low density lipoprotein-receptor, and the neural cell
            adhesion molecule
  JOURNAL   J Biol Chem 266 (34), 22939-22947 (1991)
   PUBMED   1744087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122242.2 and AC158356.2.
            
            On Mar 24, 2023 this sequence version replaced NM_028493.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050836.1, AK129234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-405               AC122242.2         178368-178772
            406-631             AC122242.2         178871-179096
            632-818             AC122242.2         182665-182851
            819-973             AC158356.2         202384-202538       c
            974-1085            AC158356.2         198034-198145       c
            1086-1451           AC158356.2         195321-195686       c
            1452-1564           AC158356.2         186869-186981       c
            1565-1685           AC158356.2         177597-177717       c
            1686-1859           AC158356.2         163488-163661       c
            1860-2026           AC158356.2         162064-162230       c
            2027-2123           AC158356.2         160862-160958       c
            2124-5048           AC158356.2         154228-157152       c
FEATURES             Location/Qualifiers
     source          1..5048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.95 cM"
     gene            1..5048
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /note="Rho-related BTB domain containing 3"
                     /db_xref="GeneID:73296"
                     /db_xref="MGI:MGI:1920546"
     exon            1..405
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..2239
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rho-related BTB domain-containing protein 3"
                     /codon_start=1
                     /product="rho-related BTB domain-containing protein 3
                     isoform 1"
                     /protein_id="NP_082769.1"
                     /db_xref="CCDS:CCDS26652.1"
                     /db_xref="GeneID:73296"
                     /db_xref="MGI:MGI:1920546"
                     /translation="MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLL
                     NAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNV
                     NDKFSFHEVKDNYIPVIKRASNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVTTTE
                     GIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMTSSFHG
                     IRPPQLEQPEKMPVLKAEASHYHSDLNNLLLCCQCVDVVFYHPEVTGVVEAHKIVLCS
                     VSHVFMLLFNVKSPADIQDSSIIRTTQDLFAINRDAVLPGASQEAPSNPPLPVIVKDA
                     LFCSCLSDILRFIYSGAFQWEELEEDVRRKLKDSGDVSDIIEKVKCILKTPGKINCLR
                     NCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGATVPAHRAILVARCEVMAAMFN
                     GNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQH
                     ICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQK
                     PEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM"
     exon            406..631
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            632..818
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            819..973
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1085
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1451
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1564
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1685
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1859
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..2026
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2123
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..5048
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5024..5029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /note="hexamer: AATAAA"
     polyA_site      5048
                     /gene="Rhobtb3"
                     /gene_synonym="1700040C17Rik; 2610033K01Rik;
                     4930503C18Rik; mKIAA0878"
                     /note="major polyA site"
ORIGIN      
        1 cttccgagtt gaggaaactt gctgcaggcg gattggcggc gagctgctcc cgggctccgg
       61 cgtcgtcccc gcgcccaccg ctcctttgtg tcccgcggcc tcggccagca gccagctccc
      121 ccgcgcgccg gactctcggg gcgacacgtg cgggcctccg gccccgccga gcggaggcgg
      181 agcccgggcg gaggcgcggc ggccaggagc ggcgaccagg gaccgcagcg ctgccagcgc
      241 ccggccggcc gctcactccc ggcccgctcc tctgcgtcgg tagcgccgcg tcgtaggagc
      301 gggagggccg cggccgggga tgagctgact gcagtgagag cgtcgcccgg gcccccgcca
      361 ggccgcccgc tgccatctcc gcgccgccct gccagccgcg atcatgtcca tccacatcgt
      421 ggcgttgggg aacgagggcg acacgttcca ccaggacaac cggccgtcgg ggctcatccg
      481 cacatacctg ggaagaagcc cgctggtgtc gggggacgag agtagcttgt tgctgaacgc
      541 ggccagcacg gtcgcgcgcc cggtgttcac tgagtaccag gccagtgcgt tcgggaacgt
      601 caagctggtg gtgcacgact gtcccgtctg ggacattttt gacagtgatt ggtacacctc
      661 ccgaaaccta attgggggtg ccgacatcat tgtgatcaaa tacaatgtaa atgacaagtt
      721 ttcattccat gaagtaaagg ataactatat tccagtgatt aaaagagcat caaactcagt
      781 tccggtaatc attgcggctg ttggtacgag acaaaatgaa gaattacctt gtacatgccc
      841 cctgtgtact tcagaccgag ggagctgtgt taccaccaca gaagggatcc aacttgccaa
      901 agaactggga gctacctatc tggaactcca cagccttgat gatttctaca ttggaaagta
      961 ctttggagga gtgctggagt attttatgat tcaagcctta aatcagaaga caagtgaaaa
     1021 aatgaagaaa aggaaaatga ccagctcctt ccatgggatt cgacctcctc agcttgaaca
     1081 gccagaaaag atgcctgtct tgaaagctga ggcatcacac tatcactccg acttgaataa
     1141 cttgctgctc tgctgccagt gtgtggatgt ggttttttac cacccagaag tgacgggcgt
     1201 cgtggaagcc cacaagatcg ttctctgctc tgtaagccat gttttcatgc tgcttttcaa
     1261 tgtgaaaagc ccggccgaca ttcaggattc cagtatcatc cgaaccaccc aggatctctt
     1321 tgccataaac agagatgctg tgcttccagg tgctagccag gaagccccca gcaacccacc
     1381 attgcctgtt attgttaagg acgccctctt ctgctcctgt ttatcagaca ttctgcgctt
     1441 catttattca ggtgcttttc agtgggaaga gctggaagaa gatgtcagga ggaagttgaa
     1501 agattccggg gatgtttctg atataatcga gaaagttaaa tgtattttaa aaacaccagg
     1561 aaagattaat tgcctgagga actgcaagac ctaccaagcc aggaagcctc tgtggtttta
     1621 taatacgtct ctcaagtttt tccttaataa accgatgctt gccgatgttg tctttgaaat
     1681 acaaggagca actgtgccag cccacagggc catcttggtg gcacgatgtg aagtgatggc
     1741 tgccatgttt aatggtaatt atatggaagc caagagtgta ctgattccag tttatggcgt
     1801 ttccaaagag acattcttgt catttttaga atacttatac acagactctt gttgcccagc
     1861 tggcattttt caggccatgt gtctcctgat ctgtgctgag atgtaccagg tctctagact
     1921 gcagcacatc tgtgagctgt tcatcatcac acagctgcag agcatgccca gcagggagct
     1981 ggcctccatg aacctcgaca ttgtagacct gctcaaaaag gccaagtttc accactcaga
     2041 ctgcctttcc acctggctgc ttcatttcat cgccactaac tacctcatat tcagccaaaa
     2101 gcctgaattt caagaccttt cagtggaaga acgaagtttt gttgaaaagc acagatggcc
     2161 atcaaacatg tacttgaagc agctggcaga atacaggaag tatatccact cccggaaatg
     2221 tcgctgttta gtcatgtgac ctgagcgttt gcatacatac actttttttt attatgaaga
     2281 atgggtactt ctggattcca ggaaaaattc ttataactaa aatcaatatg ttttaaaagt
     2341 caccatatag cttcttacta gttatctttt aaagactgtg gtggtcttaa aagggaacaa
     2401 aagctactac agactaaatt tatgtttcac ctagaatata aaactgttag acattgggtt
     2461 ctcctttacg ttgccctatt gctttaataa catcaagatc tctcctagtt aagaggtgtt
     2521 taattaaaaa aaaaaagcat ctaggataaa tataaaaatt tcatcatgtc tgagtggttg
     2581 ctctgctaaa ataaggggca tttaaaagcc aaatgtaacc atgggattca gaagagcact
     2641 aaccagtgca gcatagaaat aggaatagcg taggaataga aatttgccca agactttgat
     2701 agtcatctgg tttcagttca gcaagggtac ttgaatcaat atggtagccc catctggacc
     2761 atccacccac atctgcttgt caatctggct gcaaacctaa gcaggcaggt agtctatgga
     2821 cttccaaact tagaagggtc tgatattagg tttagtgctc tgctagtgca gttgttgaat
     2881 tcttaagaat gtttgatgaa ggcatatttt cactttgtac tggctcacca aaattgctga
     2941 gatggtgttt tcttttccgt ttggttttgg gttttttttt ggtttttttt tttggttttg
     3001 gttttgtttt aagatggggt ttctctgtgt aacattccta gctgtcctgg aacttgcttt
     3061 atagtccagg ctggcctcac atccacagag acatgctagg attaagggtg tgtgccacta
     3121 tgcctggctt aagtcttttt ctcactcaaa ccttctctct gtagaagcag aaaagttgct
     3181 gatagccagg aaagagagct ttcggccagg ggagcagagt ggagactccc atctttgggg
     3241 aagcatatat gctcaagcgc ctctacaaag acattccctg gcagtaagaa atgctgaaat
     3301 gctttttgtt ggttttgaaa cactccccca gttctagctg taccccagaa aaacaaatac
     3361 tttcttgatc aatatgtaaa gccaggaagt tggtaagagt gactgagtag cctgactata
     3421 atacacagtt atagtgataa tcacaggaaa agatgccttc taaagacttg ggcataaaag
     3481 cttaaatatt ctttctttta aatgtctgtt aagaatatga tgccaatggc ttgaattgag
     3541 ttcttttcaa gaactgatag actatttggt atgaagtagc aaagctacct aggaaggtta
     3601 aaaaattatg tacatcaaag atatcctaga tgtagagacg atggtgtctg ggataaaagg
     3661 cagagttagt ttctctcata gcatatattg gcagaaatgg ttctgcaaga tgctcaaagg
     3721 catggaagaa acatattact atttattgtt aatatcatgg tcatctgaag ttaagtactg
     3781 ggatatattt ttctaatttc tagtgatctt agtatgcata tttttttcta acctttcaaa
     3841 agtttgattc aaccgtctta ccttgtagtg ttaagattcc atacagagag ccctgttatg
     3901 cataccagta ctacaaaata aaggggaaag aattcttgta gatagaatcc caagagagct
     3961 catttaattg tgctgtgaca atgaagatta ctggaatgaa tttttgtctt ttgtatttta
     4021 atcacttgag tgaatcaact attagcaaat tccatttggt ggcttagcat tggaaagaac
     4081 agataaagta gctgatgcct agaagatcct ctgctttttc cgatccagtg gtagcctttg
     4141 atactccaaa gtaattatgt tcaccctctg tactaatgac atttacaatt ctaaaatttt
     4201 atgaaattga aatgaaaact aagagttgta aaacaaagta ttttcttggg aatattactt
     4261 taacattcag atggatcata actaattcga ctagggtgtt tttcctgagt aggagttaag
     4321 tttggaactg gtggtcttga atgttaaaca tggagtgtga ctgggacagc catgagtcag
     4381 aatataaatg aatgcttaaa catttgaata cagattcctc cggattgttg aattcactca
     4441 actagaagta ataggcgatt ttaaatcttt ataaatgatc ttgggtaaat tactggtgat
     4501 tgtgagggtt gtttcccaat caaaggttat ttctagatgg ctatatgctt tgttgcaatt
     4561 tctgcttcca cctattttcc aagcatttta cttaagaagg atactgtgta gttgaactaa
     4621 ggctctttcc aggccgggct tgcatcctgt tgtgtattct ttgtatgctg ctgactatat
     4681 ccctattctg ctgtagggga ctagatttct aatagagaac attggcatgg tagctgaagc
     4741 ccactcctgt gcaagccata ctggaacttc atattgagaa tagaagacgt agaaatcaga
     4801 tggatttcca aagtggccaa acttttcaac tgtaatttta taaatgatac tacactgata
     4861 tagccaatta gatttaaaat gtcttcaaaa attactttat tttatttaaa gcatctgttt
     4921 aatgcaactt ttaatcagat tttgcaaagg gtatgtatgt attttaatat agtctgacct
     4981 gaatttatat gtttttagct ttagtattta accttttata acaaataaac cattttttaa
     5041 aaaaacaa
//
