LOCUS       NM_153514               5231 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Rho-related BTB domain containing 2 (Rhobtb2), mRNA.
ACCESSION   NM_153514 NM_145225
VERSION     NM_153514.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5231)
  AUTHORS   Lutz,J., Grimm-Gunter,E.M., Joshi,P. and Rivero,F.
  TITLE     Expression analysis of mouse Rhobtb3 using a LacZ reporter and
            preliminary characterization of a knockout strain
  JOURNAL   Histochem Cell Biol 142 (5), 511-528 (2014)
   PUBMED   24923387
REFERENCE   2  (bases 1 to 5231)
  AUTHORS   Schenkova,K., Lutz,J., Kopp,M., Ramos,S. and Rivero,F.
  TITLE     MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of
            RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a
            predominantly nuclear dimeric protein
  JOURNAL   J Mol Biol 422 (5), 659-673 (2012)
   PUBMED   22709582
REFERENCE   3  (bases 1 to 5231)
  AUTHORS   St-Pierre,B., Jiang,Z., Egan,S.E. and Zacksenhaus,E.
  TITLE     High expression during neurogenesis but not mammogenesis of a
            murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor
            suppressor
  JOURNAL   Gene Expr Patterns 5 (2), 245-251 (2004)
   PUBMED   15567721
  REMARK    GeneRIF: There is no connection between elevated expression of
            mDbc2/Rhobtb2 and a specific stage of mammary gland development,
            but this gene plays a critical role in the development of the
            nervous system.
REFERENCE   4  (bases 1 to 5231)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   5  (bases 1 to 5231)
  AUTHORS   Hamaguchi,M., Meth,J.L., von Klitzing,C., Wei,W., Esposito,D.,
            Rodgers,L., Walsh,T., Welcsh,P., King,M.C. and Wigler,M.H.
  TITLE     DBC2, a candidate for a tumor suppressor gene involved in breast
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13647-13652 (2002)
   PUBMED   12370419
REFERENCE   6  (bases 1 to 5231)
  AUTHORS   Ramos,S., Khademi,F., Somesh,B.P. and Rivero,F.
  TITLE     Genomic organization and expression profile of the small GTPases of
            the RhoBTB family in human and mouse
  JOURNAL   Gene 298 (2), 147-157 (2002)
   PUBMED   12426103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162936.3.
            
            On Mar 27, 2008 this sequence version replaced NM_153514.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081100.1, AK038196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               AC162936.3         211743-212251       c
            510-711             AC162936.3         207324-207525       c
            712-815             AC162936.3         206384-206487       c
            816-1001            AC162936.3         204845-205030       c
            1002-2020           AC162936.3         202980-203998       c
            2021-2139           AC162936.3         202606-202724       c
            2140-2290           AC162936.3         200610-200760       c
            2291-2379           AC162936.3         195338-195426       c
            2380-2485           AC162936.3         194564-194669       c
            2486-5231           AC162936.3         191696-194441       c
FEATURES             Location/Qualifiers
     source          1..5231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.1 cM"
     gene            1..5231
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /note="Rho-related BTB domain containing 2"
                     /db_xref="GeneID:246710"
                     /db_xref="MGI:MGI:2180557"
     exon            1..509
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            510..711
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..2706
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /note="deleted in breast cancer 2 gene protein homolog"
                     /codon_start=1
                     /product="rho-related BTB domain-containing protein 2"
                     /protein_id="NP_705734.4"
                     /db_xref="CCDS:CCDS27244.1"
                     /db_xref="GeneID:246710"
                     /db_xref="MGI:MGI:2180557"
                     /translation="MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQ
                     LLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDV
                     VVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVGCQLDLRYADLEAVNRARRPLA
                     RPIKPNEILPPEKGREVAKELGIPYYETSVVAQFGIKDVFDNAIRAALISRRHLQFWK
                     SHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEECPAHLLEDPLCADVILVLQERV
                     RIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSGSGGPRPEDHRSHPEQHHHHHHHHH
                     GRDFLLRAASFDVCESVDEAGGSGPAGLRASTSDGILRGNGTGYLPGRGRVLSSWSRA
                     FVSIQEEMAEDPLTFKSRLMVVVKMDNSIQPGPFRAVLKYLYTGELGENERDLMHIAH
                     IAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRRTNRVKECLAKGTFSDVTFILDD
                     GTISAHKPLLISSCDWMAAMFGGPFVESSTREVVFPYTSKSCMRAVLEYLYTGMFTSS
                     PDLDDMKLIVLANRLCLPHLVALTEQYTVTGLMEATQMMVDIDGDVLVFLELAQFHCA
                     YQLADWCLHHICTNYNNVCRKFPRDMKAMSPENQEYFEKHRWPPVWYLKEEDHYQRAR
                     KEREKEDYLHLRRQPKRRWLFWNSPSSPSSSAAGSASPSSSSSAVV"
     exon            712..815
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1001
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..2020
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2139
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2290
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2379
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2485
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..5231
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4317..4322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /note="hexamer: ATTAAA"
     polyA_site      4339
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
     regulatory      5208..5213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /note="hexamer: AATACA"
     polyA_site      5231
                     /gene="Rhobtb2"
                     /gene_synonym="Dbc2; E130206H14Rik; mKIAA0717"
                     /note="major polyA site"
ORIGIN      
        1 ctttgctttt tttgtgaatg aaaaaaggag gtcgtgagcg gtctcgggga ctgcggcgct
       61 cggcgtctta aggctgcgcg cgtgcggcgg cctcacccgg cgcctcgctc tctagcgcgc
      121 cgcccgcaac ctccgcagcg cagccgggcg gcggcgcggc ccagcggccg gaggtcggag
      181 cggcggcgcg caacccggct ccgcgagcct ccatgacatt gggcgcccgg gtcgcgcgga
      241 gatgctgatc cggaagaggc agtggctgca gtgcagcgcc ccaggctgct cacgtgccgc
      301 ggtccgacca gggctcctgt gccagagttt cttctgatcg tacctgaacc gggaccccag
      361 gagtctgggt ctccagcaca gagcagcagc gtcggcggcg ccccaacttg cacgcgcaga
      421 gtgaccccag acatctcact aaaatgagcg tgcttagcag gaagagatgt gttccctaca
      481 ctagaaatta ccccgtcaca tgtagtggtg tcccaattaa tggattctga catggattat
      541 gaaaggccaa acgtagagac catcaagtgc gtggtggtgg gggacaacgc cgtgggcaag
      601 actaggctca tctgtgcccg ggcctgcaat gccaccctca cccagtacca gttgcttgcc
      661 acccatgtgc ccacagtgtg ggccattgac cagtatcgtg tgtgccagga ggtgctagaa
      721 cgctcccgag atgtggtaga tgacgtcagc gtctccctgc gcctctggga caccttcgga
      781 gaccaccaca aagaccggcg ttttgcttat ggaagatccg acgtggtggt tttgtgtttc
      841 tccatcgcca accccaattc cctccaccat gtcaagacca tgtggtaccc agaaatcaag
      901 catttctgcc ccagagctcc tgtcattctg gtgggctgcc agctggacct gcgctatgct
      961 gacctggaag ccgttaacag ggccaggaga cctctggcta ggcccatcaa gcccaatgaa
     1021 atcctccccc cagagaaggg tcgggaagtc gccaaagagc tggggatccc ttactacgag
     1081 accagtgtgg tggcccagtt tggtatcaag gacgtctttg acaatgccat tcgggctgcg
     1141 ctcatctccc gccgccacct gcagttctgg aaatcacatc tgcgcaatgt gcagcggcct
     1201 ctactgcaag cacccttcct cccccccaag ccaccgcccc ccatcatcgt ggtgcccgat
     1261 cccccctcca gcagcgagga gtgccccgcc cacctcctgg aagacccgct ctgtgcggat
     1321 gtcatcctgg tgctgcagga gcgcgtgcgc atctttgccc acaaaatcta cctctccacc
     1381 tcctcctcca aattctatga cttattcctc atggacctga gtgaggggga gctggggggc
     1441 ccctcagggt caggggggcc ccgcccagag gaccaccgga gccaccctga acaacaccac
     1501 catcatcacc atcaccacca tgggcgggac ttcctgcttc gggcagccag ctttgacgta
     1561 tgtgagagtg tggatgaggc cggcggctct ggtccggctg gcctaagggc ttcaaccagt
     1621 gacgggatct tacggggtaa tggaacaggg tacctgccag gcagaggacg tgtgctgtct
     1681 tcctggagcc gagcttttgt gagtatccag gaagagatgg cagaggatcc tctgaccttc
     1741 aaatcccggc tgatggtggt ggtgaagatg gataactcca ttcagccggg gcccttccgg
     1801 gctgttctca agtacctgta cacaggggag ctaggtgaga atgagcggga cctcatgcac
     1861 attgctcaca ttgccgagct gctagaggtc tttgatctac gaatgatggt ggccaacatt
     1921 ctcaacaacg aagccttcat gaatcaggag atcaccaagg ccttccatgt acgccggacc
     1981 aaccgggtta aggagtgttt ggcaaagggc accttttcag atgtgacctt catcctggat
     2041 gatgggacca tcagcgccca taagcccctg ctgatttcca gctgtgactg gatggctgcc
     2101 atgtttgggg ggccatttgt ggagagttct accagggagg tggtgtttcc atacacaagc
     2161 aagagctgca tgagagctgt gttggagtac ctctatacag gcatgttcac ctccagccca
     2221 gacctggatg atatgaagct cattgtcttg gctaaccgcc tctgcctgcc gcacttggtt
     2281 gccctcacag agcagtacac agtgactgga ctgatggagg cgacccagat gatggtggac
     2341 atcgatgggg atgtccttgt attcttggaa ttggcacagt tccactgcgc gtaccagttg
     2401 gccgactggt gtcttcacca tatctgcacc aactacaaca acgtgtgccg caagttcccc
     2461 agagacatga aggctatgtc tccagaaaac caggagtact ttgagaaaca ccggtggccg
     2521 ccagtctggt acctgaaaga agaggaccac tatcagcgtg cgcggaagga gcgagagaaa
     2581 gaggactatt tacacctgcg gaggcagccc aagcggcggt ggctgttttg gaacagtccc
     2641 tcatcaccgt cctcctcagc agcgggctca gcatccccct cctcctcctc ctcggctgtg
     2701 gtctgagatg ctgccaccgt cttctgatcc cgctgctgtt gtcctcatta gcccttgtcc
     2761 ttctgctctt ctgtatcatc ccctctaccc gacaggtgac gagggaattc acctaaccag
     2821 aatcctaagg gcagagccgt tctcaccagc caatgtggcc caggctaaga ggagccagcc
     2881 ctgcagatca gaacagggtc cacctacaat tccaggcagg gcaggaaaac atctgcccca
     2941 aggtggggag caggagagag ctcagagctc ggatattttc tctctggact tgacaataga
     3001 gccagtggag gaaagcttcc cctgtactcg ggcttgtctg tattggtgtc tgctttggtc
     3061 agaggcagct tcctctccag gagctggtct tttttttttt cccatccaca gacttttgag
     3121 ggttgcaagt atttcgtgag cattgtccct cgggcttatt gaaatccttg agaagttaag
     3181 gtagaaaaga agtcttcaga gcccacatca agtctcctag gccgtgaggt gtggctgctg
     3241 gcggggagaa gaataaactg cagcctgcca gcatcctgta aggactgact gcaggcagtg
     3301 tagacttagt ggtgggtagc agcggtgact ccgtgttcag gtttgtaggc agcactttag
     3361 tacaatgtgg gttctctact tcacccttcc cgcacacatt acatctgaca tggatgaagg
     3421 aggaggaaga ggaggaggaa gggtgggttc tgtgctcagc agttttatgc tcctctgggg
     3481 tttctccccc tgcctctggg cagcactgcc ttttatgaga tgggagcaaa aacagcctaa
     3541 caggagaaac ccaaactcaa aagcaccacc aagaccatgt tatccttcat ctccccaaaa
     3601 gaatgaagtt ctaaaaagag agaccctgta gggtgtacat cttcataagg ctgaatggag
     3661 gcctctatta ttatgtggct atgaagggtc agtagtacca accactccaa tgcctttcag
     3721 gggaggacct gtaccctccg tttctgagga tgccactccc caaggcctgc tgggtctagg
     3781 ctactgggtt tcggggaaag tgtgggcttc ggggctcaaa tggctttgta ccttttccac
     3841 cttgatgcag gatacttttc tcttccaaag gtgactctac gggatgtgcg tggggcaatg
     3901 tgcttcctgg ggcgggggga ggctttcagc aggaattaaa tgtcaaaaaa gggagcactg
     3961 gagaacaggc tacacatagc caacctggta ctggctgggg ataaggggaa ggagaaaaca
     4021 ggggtagctg agcaggaagg aaatgatgcg agtctaaaga ggaattgggg agactggagg
     4081 attgacaaca gtggctggaa gcccccgtgg gattgacact gggtctcagt tgacccttcc
     4141 catttcctaa ttacgatcca catatcacca cctttaccct ctctctagac ttacgaggtg
     4201 aagtcccatg agggagtagg tcatgaaagt tctggggtcc ccttccctga gaaaatgctt
     4261 taggtaagga aatactggct gagtccccag gacctagcta ggttgcttaa gctggaatta
     4321 aagcaacccc agaaacaaat gcaacctaca attgtgtggt accgggacct cgagttctga
     4381 tctggtcttg tcagaaggaa caagtagtag caggtctcac agtgctgatt ttctgtagtc
     4441 tgagcctgga accgccaagc ctgctgctgc ctagtagtta aaagccctcc agagttgctg
     4501 gctggggaag tgtgttgtgt gctgccctct actagctggt gtgccctgct gctgaattct
     4561 aaatggcttc tagtgtggag aagcctgcac tcatggaaaa ggcaggcagc ttctcacacc
     4621 ttccttggac gatacagggg tatctctctc gggaactgta aatgataggt agatgtctgt
     4681 cctaatgagc aaggggaatt gggtctccca agtgatttac agggctgagc cgcctggcat
     4741 cactggtaat gaggatggac aggctagtag gagaaagatc tgtggaggtg gaggaagacc
     4801 aaggagaaca ccatgcccca cccaggccag ttcacccctc agggacccac ccctaccccc
     4861 acagctgtca gagctggtgt gcagcaggtg gacccctgtg gccttgtata cccacagtgg
     4921 ggggtggggc tgtgagtgag ccaggagagg gaggtgctgc ttgcagtccc ttagtacatg
     4981 ggtgctctgg attccaggga gacaaaagca ggagaaactc cagtgtggga caagtctggc
     5041 ataacacccc caggggtggg gcagtgtccc aagaacatgc tcctctggac tatgtcacat
     5101 gtcactcagt gttgtcttag aggatggggg taaaaacaca aacccacaac ccctctccac
     5161 acaccttttt atataaggtt tcatatttaa tttggtcatg aattcataat acatgagtat
     5221 tttgtatcta a
//
