LOCUS       NM_007483               2366 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus ras homolog family member B (Rhob), mRNA.
ACCESSION   NM_007483
VERSION     NM_007483.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Englert,M., Aurbach,K., Becker,I.C., Gerber,A., Heib,T.,
            Wackerbarth,L.M., Kusch,C., Mott,K., Araujo,G.H.M., Baig,A.A.,
            Dutting,S., Knaus,U.G., Stigloher,C., Schulze,H., Nieswandt,B.,
            Pleines,I. and Nagy,Z.
  TITLE     Impaired microtubule dynamics contribute to microthrombocytopenia
            in RhoB-deficient mice
  JOURNAL   Blood Adv 6 (17), 5184-5197 (2022)
   PUBMED   35819450
  REMARK    GeneRIF: Impaired microtubule dynamics contribute to
            microthrombocytopenia in RhoB-deficient mice.
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Zhang,D., Wang,Y., Zeng,S., Zhang,M., Zhang,X., Wang,Y., Zhang,Z.,
            Wang,X. and Hu,X.
  TITLE     Integrated Analysis of Prognostic Genes Associated With
            Ischemia-Reperfusion Injury in Renal Transplantation
  JOURNAL   Front Immunol 12, 747020 (2021)
   PUBMED   34557203
  REMARK    GeneRIF: Integrated Analysis of Prognostic Genes Associated With
            Ischemia-Reperfusion Injury in Renal Transplantation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Miao,C., Yu,M., Pei,G., Ma,Z., Zhang,L., Yang,J., Lv,J.,
            Zhang,Z.S., Keller,E.T., Yao,Z. and Wang,Q.
  TITLE     An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance
            of uropathogenic Escherichia coli
  JOURNAL   Nat Commun 12 (1), 2587 (2021)
   PUBMED   33972537
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Lv,T., Kong,L., Jiang,L., Wu,H., Wen,T., Shi,Y. and Yang,J.
  TITLE     Dicer1 facilitates liver regeneration in a manner dependent on the
            inhibitory effect of miR-21 on Pten and Rhob expression
  JOURNAL   Life Sci 232, 116656 (2019)
   PUBMED   31306658
  REMARK    GeneRIF: identified the promotion effect of Dicer1 on liver
            regeneration by increasing miR-21 expression, which inhibits the
            expression of two negative cell proliferation regulators, Pten and
            Rhob
REFERENCE   6  (bases 1 to 2366)
  AUTHORS   Reid,T., Furuyashiki,T., Ishizaki,T., Watanabe,G., Watanabe,N.,
            Fujisawa,K., Morii,N., Madaule,P. and Narumiya,S.
  TITLE     Rhotekin, a new putative target for Rho bearing homology to a
            serine/threonine kinase, PKN, and rhophilin in the rho-binding
            domain
  JOURNAL   J Biol Chem 271 (23), 13556-13560 (1996)
   PUBMED   8662891
REFERENCE   7  (bases 1 to 2366)
  AUTHORS   Madaule,P., Furuyashiki,T., Reid,T., Ishizaki,T., Watanabe,G.,
            Morii,N. and Narumiya,S.
  TITLE     A novel partner for the GTP-bound forms of rho and rac
  JOURNAL   FEBS Lett 377 (2), 243-248 (1995)
   PUBMED   8543060
REFERENCE   8  (bases 1 to 2366)
  AUTHORS   Fritz,G., Kaina,B. and Aktories,K.
  TITLE     The ras-related small GTP-binding protein RhoB is immediate-early
            inducible by DNA damaging treatments
  JOURNAL   J Biol Chem 270 (42), 25172-25177 (1995)
   PUBMED   7559652
REFERENCE   9  (bases 1 to 2366)
  AUTHORS   Hall,A.
  TITLE     Small GTP-binding proteins and the regulation of the actin
            cytoskeleton
  JOURNAL   Annu Rev Cell Biol 10, 31-54 (1994)
   PUBMED   7888179
  REMARK    Review article
REFERENCE   10 (bases 1 to 2366)
  AUTHORS   Adamson,P., Marshall,C.J., Hall,A. and Tilbrook,P.A.
  TITLE     Post-translational modifications of p21rho proteins
  JOURNAL   J Biol Chem 267 (28), 20033-20038 (1992)
   PUBMED   1400319
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164518.1 and BC023334.1.
            
            On Mar 28, 2018 this sequence version replaced NM_007483.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1941              AK164518.1         2-1942
            1942-2342           AK164518.1         1944-2344
            2343-2366           BC023334.1         2075-2098
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.88 cM"
     gene            1..2366
                     /gene="Rhob"
                     /gene_synonym="Arh6; Arhb"
                     /note="ras homolog family member B"
                     /db_xref="GeneID:11852"
                     /db_xref="MGI:MGI:107949"
     exon            1..2349
                     /gene="Rhob"
                     /gene_synonym="Arh6; Arhb"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..968
                     /gene="Rhob"
                     /gene_synonym="Arh6; Arhb"
                     /note="ras homolog gene family, member AB; aplysia
                     ras-related homolog B; ras homolog B; ras homolog gene
                     family, member B"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoB"
                     /protein_id="NP_031509.1"
                     /db_xref="CCDS:CCDS25799.1"
                     /db_xref="GeneID:11852"
                     /db_xref="MGI:MGI:107949"
                     /translation="MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPE
                     VKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECS
                     AKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhob"
                     /gene_synonym="Arh6; Arhb"
                     /note="hexamer: ATTAAA"
     polyA_site      2343
                     /gene="Rhob"
                     /gene_synonym="Arh6; Arhb"
                     /note="major polyA site"
ORIGIN      
        1 atctgccacc gcagttcggt tgtcgtcgtc tgcgcccctg taccctaggt ctagagtgaa
       61 cccgccccgg gaaagaagct aggccgggtc cgcagcatca gccatcactt cgcacaaagc
      121 agcgcagctc cgggaccgcc gaggaccaca gcggcgcggc agcggcgcgg cgacactcag
      181 tgcaccgtat gcccctgcgc ccctgccgag gcaaccggag cgccccgaga gaccgcgccg
      241 ccgcggggtc caggtgcagt tagcgagcct agcccgcagc gcgcagtcgc gggagagcgg
      301 ggagcggcaa gcaacaggga gcgggacggc ggcgaggcgc tcgcgggccc ctcctgctgc
      361 ccgcgcccgg cgagctcatg gcggccatcc gcaagaagct ggtggtggtg ggcgacggcg
      421 cgtgcggcaa gacgtgcctg ctgatcgtgt tcagtaaaga cgaattcccc gaggtgtacg
      481 tgcccaccgt gttcgagaac tatgtggcgg acatcgaggt ggacggcaag caggtggagc
      541 tggcgctgtg ggacacggca ggccaggagg actacgatcg tttacggccg ctctcctatc
      601 cggacaccga cgtcatcctt atgtgcttct cggtggacag cccggactct ctcgagaaca
      661 tccccgagaa gtgggtgccc gaggtaaagc acttctgccc caatgtgccc atcatcctgg
      721 tggccaacaa aaaagacctg cgcagcgacg agcatgtccg cacggagctg gcccgcatga
      781 agcaggagcc agtgcgcacg gatgacggcc gcgccatggc ggtgcgcatc caagcctatg
      841 actacctcga gtgctcggcc aagaccaagg agggcgtgcg cgaggttttt gagacggcca
      901 cgcgcgccgc gctgcagaag cgctacggat cccagaatgg ctgcatcaac tgctgcaagg
      961 tgctatgagg gacgcgtcct gcctcacgcc cttgccagcg tggctccccc tccttggccc
     1021 ggtcgcccac gaaccgggag aaagggagac ccatgccccc aaggacacca ccagactgcc
     1081 tgacatctgc tggtggctct ggctggtcac gctgagaatt agcgtgggca ccgagctccc
     1141 ccttcccagt gtctgtgtgt gtccagctgt gtggcacagg cctgggcacc ctgctgagtg
     1201 ccaaggggtt cctgagcatc cttttctaaa gagccaggcc tcaaagtgtg gttgtgtgtg
     1261 tgtacgactc cctacacccc acccgactcc tgccccaccc ccgcctctgg tttccccagg
     1321 ggcacgcaga gtggttgcgc ccccagcagg tttgcttgta accagcaagc cactactgtt
     1381 gctccatgtc tgtaacatag acccctggaa tggcgggagg ggagggctgg ggggaggatg
     1441 gggctgttac ataaatacag attttatttt cggaggcaga atggtattgt ttagtggtgt
     1501 gtggggcgac cagggcccag agcagctcct ttcccaggct gggtcaggcg cccacccatc
     1561 caagcatgaa ctggacttgg ccatctttcc acaccctggg gaagacattt gcaactgact
     1621 tggggtcgag aggaagcagc tcagacagtg tctcctgggc caacccccag cgaacctccg
     1681 gcagaggatc cagggtgtgc agtggggtca cttttgccat aagcgaactt tgtgcctgtc
     1741 ctacaaatga acattgttca gctcaagaga ctattgttac tgaatttatt taaacgctga
     1801 agctttttgt tgttgatgaa agagttcttt gcacaattgt cccattgttt gacacccagt
     1861 gtacttgtca tttgcataag acagcattct gaccacactt gtatgctgta acctcatcta
     1921 cttctgatgg tttttttaaa actatgatga ctctaagatt acaaaaacaa ctaacttttg
     1981 ctttgttttc ttgaaaaaaa aatgtcaaca gtgtgaattt tttctttaaa tttgtgtagc
     2041 atacgcagtt ttggtaaagg aaggcaacag gtattggggt ctatttaaac cccccctccc
     2101 acaagacaag tctcttctgt gtgaaatttt ctgtacgttc catgtgcaga gaaaagcctc
     2161 ccccctctcc cccccgccag cccagtggta cttctaaatt gtcttgtttt gtttttgttt
     2221 tatttttttt aaataaactg acagatgaca aatggtgaac ttatgatgtt tacataagag
     2281 ttctataagc tgtgtataca gatttttatg taaaatatta aaagactatg atcatgacat
     2341 ttataaacaa aaaaaaaaaa aaaaaa
//
