LOCUS       NM_016802               2191 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus ras homolog family member A (Rhoa), transcript variant
            1, mRNA.
ACCESSION   NM_016802
VERSION     NM_016802.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2191)
  AUTHORS   Ye,J., Wang,J., Zhao,J., Xia,M., Wang,H., Sun,L. and Zhang,W.B.
  TITLE     RhoA/ROCK-TAZ Axis regulates bone formation within calvarial
            trans-sutural distraction osteogenesis
  JOURNAL   Cell Signal 121, 111300 (2024)
   PUBMED   39004327
  REMARK    GeneRIF: RhoA/ROCK-TAZ Axis regulates bone formation within
            calvarial trans-sutural distraction osteogenesis.
REFERENCE   2  (bases 1 to 2191)
  AUTHORS   Piao,J., Su,Z., He,J., Zhu,T., Fan,F., Wang,X., Yang,Z., Zhan,H.
            and Luo,D.
  TITLE     SphK1 deficiency ameliorates the development of atherosclerosis by
            inhibiting the S1P/S1PR3/Rhoa/ROCK pathway
  JOURNAL   Cell Signal 121, 111252 (2024)
   PUBMED   38852936
  REMARK    GeneRIF: SphK1 deficiency ameliorates the development of
            atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
REFERENCE   3  (bases 1 to 2191)
  AUTHORS   Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
            Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
            Theveneau,E. and Migeotte,I.
  TITLE     Non-apical mitoses contribute to cell delamination during mouse
            gastrulation
  JOURNAL   Nat Commun 15 (1), 7364 (2024)
   PUBMED   39198421
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2191)
  AUTHORS   Lawrence,A.R., Canzi,A., Bridlance,C., Olivie,N., Lansonneur,C.,
            Catale,C., Pizzamiglio,L., Kloeckner,B., Silvin,A., Munro,D.A.D.,
            Fortoul,A., Boido,D., Zehani,F., Cartonnet,H., Viguier,S.,
            Oller,G., Squarzoni,P., Candat,A., Helft,J., Allet,C., Watrin,F.,
            Manent,J.B., Paoletti,P., Thieffry,D., Cantini,L., Pridans,C.,
            Priller,J., Gelot,A., Giacobini,P., Ciobanu,L., Ginhoux,F.,
            Thion,M.S., Lokmane,L. and Garel,S.
  TITLE     Microglia maintain structural integrity during fetal brain
            morphogenesis
  JOURNAL   Cell 187 (4), 962-980 (2024)
   PUBMED   38309258
REFERENCE   5  (bases 1 to 2191)
  AUTHORS   Schaefer,A., Hodge,R.G., Zhang,H., Hobbs,G.A., Dilly,J.,
            Huynh,M.V., Goodwin,C.M., Zhang,F., Diehl,J.N., Pierobon,M.,
            Baldelli,E., Javaid,S., Guthrie,K., Rashid,N.U., Petricoin,E.F.,
            Cox,A.D., Hahn,W.C., Aguirre,A.J., Bass,A.J. and Der,C.J.
  TITLE     RHOAL57V drives the development of diffuse gastric cancer through
            IGF1R-PAK1-YAP1 signaling
  JOURNAL   Sci Signal 16 (816), eadg5289 (2023)
   PUBMED   38113333
  REMARK    GeneRIF: RHOA[L57V] drives the development of diffuse gastric
            cancer through IGF1R-PAK1-YAP1 signaling.
REFERENCE   6  (bases 1 to 2191)
  AUTHORS   Watanabe,N., Madaule,P., Reid,T., Ishizaki,T., Watanabe,G.,
            Kakizuka,A., Saito,Y., Nakao,K., Jockusch,B.M. and Narumiya,S.
  TITLE     p140mDia, a mammalian homolog of Drosophila diaphanous, is a target
            protein for Rho small GTPase and is a ligand for profilin
  JOURNAL   EMBO J 16 (11), 3044-3056 (1997)
   PUBMED   9214622
REFERENCE   7  (bases 1 to 2191)
  AUTHORS   Reid,T., Furuyashiki,T., Ishizaki,T., Watanabe,G., Watanabe,N.,
            Fujisawa,K., Morii,N., Madaule,P. and Narumiya,S.
  TITLE     Rhotekin, a new putative target for Rho bearing homology to a
            serine/threonine kinase, PKN, and rhophilin in the rho-binding
            domain
  JOURNAL   J Biol Chem 271 (23), 13556-13560 (1996)
   PUBMED   8662891
REFERENCE   8  (bases 1 to 2191)
  AUTHORS   Madaule,P., Furuyashiki,T., Reid,T., Ishizaki,T., Watanabe,G.,
            Morii,N. and Narumiya,S.
  TITLE     A novel partner for the GTP-bound forms of rho and rac
  JOURNAL   FEBS Lett 377 (2), 243-248 (1995)
   PUBMED   8543060
REFERENCE   9  (bases 1 to 2191)
  AUTHORS   Hall,A.
  TITLE     Small GTP-binding proteins and the regulation of the actin
            cytoskeleton
  JOURNAL   Annu Rev Cell Biol 10, 31-54 (1994)
   PUBMED   7888179
  REMARK    Review article
REFERENCE   10 (bases 1 to 2191)
  AUTHORS   Ridley,A.J. and Hall,A.
  TITLE     The small GTP-binding protein rho regulates the assembly of focal
            adhesions and actin stress fibers in response to growth factors
  JOURNAL   Cell 70 (3), 389-399 (1992)
   PUBMED   1643657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161260.2, BC068115.1,
            CX239124.1, CX217831.1, BP772032.1 and BE990465.1.
            
            On Sep 16, 2015 this sequence version replaced NM_016802.4.
            
            Summary: This gene encodes a member of the Rho family of small
            GTPases, which cycle between inactive GDP-bound and active
            GTP-bound states and function as molecular switches in signal
            transduction cascades. Rho proteins promote reorganization of the
            actin cytoskeleton and regulate cell shape, attachment, and
            motility. Overexpression of this gene is associated with tumor cell
            proliferation and metastasis. Multiple alternatively spliced
            variants have been identified. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068115.1, AK172051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC161260.2         163813-163857       c
            46-1163             BC068115.1         1-1118
            1164-1767           CX239124.1         28-631
            1768-1768           BC068115.1         1722-1722
            1769-2060           CX217831.1         458-749
            2061-2166           BC068115.1         2014-2119
            2167-2171           BP772032.1         59-63               c
            2172-2191           BE990465.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..2191
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.2 cM"
     gene            1..2191
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /note="ras homolog family member A"
                     /db_xref="GeneID:11848"
                     /db_xref="MGI:MGI:1096342"
     exon            1..394
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..469
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..627
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..748
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..879
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..2175
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2147..2152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="Rhoa"
                     /gene_synonym="Arha; Arha1; Arha2"
                     /note="major polyA site"
ORIGIN      
        1 tgaggataaa atagcaactc gctcttttat agccccggtg ttcccgtcat gctccacgcg
       61 tctgccatga ttggttaagc gtctagctct cagggcgtgg atgcgttctt gagcaatcgt
      121 ggctgaactg agagtgtgcg cgcgtgcgcg gggccgcgac tggcgccagc tcgagcccgc
      181 agggcgctcg gggccgcgca cgtcgctccc cgccctcccg ccaccgcccg ccctcgttcg
      241 ctcgcgctcc ccgcccgccg cccgcggtcc tccgtcggtt ctctccatag cccgccgtct
      301 cccacggagc tgcccgtcct tggctcggag ctcgcggact cgcggacaag cgtcctcagc
      361 gcgaagaggc cggactcgga gtcctcgcct tgagccttgc atctgagaag ttccaggtac
      421 tttgtacaac tgcatcccag aacctgtgtg ttttcagcac ctttataagt gatggctgcc
      481 atcaggaaga aactggtgat tgttggtgat ggagcttgtg gtaagacatg cttgctcata
      541 gtcttcagca aggaccagtt cccagaggtc tatgtgccca cggtgtttga aaactatgtg
      601 gcggatatcg aggtggatgg gaagcaggta gagttggctt tatgggacac agctggacag
      661 gaagattatg accgcctgcg gcctctctct tatccagaca ccgatgttat attgatgtgt
      721 ttttccattg acagccctga tagtttagaa aacatcccag aaaaatggac tccagaagtc
      781 aagcatttct gtccaaatgt gcccatcatc ctggttggga acaagaagga ccttcggaat
      841 gacgagcaca cgagacggga gttggccaaa atgaagcagg agccggtaaa acctgaagaa
      901 ggcagagata tggcaaacag gattggcgct tttgggtaca tggagtgttc agcaaagacc
      961 aaagatggag tgagagaggt ttttgagatg gccacgagag ctgctctgca agctagacgt
     1021 gggaagaaaa agtctgggtg cctcatcttg tgaagccttg tgaacgcagc ctcatgcggt
     1081 taatttgaag tgctgtttat taatcttagt gtatgattac tggccttttc atttatctat
     1141 aatttaccta agattacaaa tcagaagtca tcttgctacc agtatttaga agccaaccac
     1201 gattattaat aatgtccaac ctgtctgacc agccagggtc cttctgacac tgctctaaca
     1261 gccctctctg cactccacct gacaccaggc gctaattcaa agaatttctt aacttcttgc
     1321 ttctttctag aaagagaaac agttggtaac ttttgtgaat taggctgtaa ctactttata
     1381 actaacatgt cctgcctact ttctgtcaac tgcaagaact ctggtgagtc actacttcag
     1441 agctttcctt gttaacagac tccattgcca gagctctggg gtgggtattc agttttttga
     1501 aatcttgctc agccagaaag gcccaagtcc acgcagctgt tgcagagtta cagttctgtg
     1561 gtctcatgtt agttacctta tagttactgt gtaattagtg ccacttaatg tatgttacca
     1621 aaaaataaat atatctaccc cagactagat gtagtatttt ttgtataatt ggatttccta
     1681 atactgatat ttgtcattcc cacagaaagt gtattgcttc ttttcttttt ctttctttct
     1741 ttcttttttt cttttttttt ttttttttta agaaagtgta tttggaaata aagtcagatg
     1801 gaagaattca tttttaaaat tcccattttg tcactttctc tgataaaata tggccatatc
     1861 ccttattcag ccctatatat cattctagta cccctttcca gactggacta agtaggaatt
     1921 tggtttcccg cctgaggcag ttatactttg gaggtggcat agcctttctc acctggactg
     1981 cagggtctgg ctctaagtca cagtgctcct ttctccacac tgtatccaag ttgcctccca
     2041 gaggagccac cagttcttat gggtggcagt gggtgggggt gggggggtct cttctctcca
     2101 gctgactaaa catttttctg taccagttaa tttttccaac taatagaata aaggcagttt
     2161 tctaaatttc ctgtaaaaaa aaaaaaaaaa a
//
