LOCUS       NM_145383               4463 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus rhodopsin (Rho), mRNA.
ACCESSION   NM_145383
VERSION     NM_145383.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4463)
  AUTHORS   Cho,S.H., Kim,J.H. and Kim,S.
  TITLE     Perturbed cell cycle phase-dependent positioning and nuclear
            migration of retinal progenitors along the apico-basal axis
            underlie global retinal disorganization in the LCA8-like mouse
            model
  JOURNAL   Dev Biol 517, 39-54 (2025)
   PUBMED   39284539
REFERENCE   2  (bases 1 to 4463)
  AUTHORS   Gunes,K., Chang,K., Lennikov,A., Tai,W.L., Chen,J., ElZaridi,F.,
            Cho,K.S., Utheim,T.P. and Dong Feng,C.
  TITLE     Preservation of vision by transpalpebral electrical stimulation in
            mice with inherited retinal degeneration
  JOURNAL   Front Cell Dev Biol 12, 1412909 (2024)
   PUBMED   39206091
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4463)
  AUTHORS   Leinonen,H., Zhang,J., Occelli,L.M., Seemab,U., Choi,E.H., L P
            Marinho,L.F., Querubin,J., Kolesnikov,A.V., Galinska,A.,
            Kordecka,K., Hoang,T., Lewandowski,D., Lee,T.T., Einstein,E.E.,
            Einstein,D.E., Dong,Z., Kiser,P.D., Blackshaw,S., Kefalov,V.J.,
            Tabaka,M., Foik,A., Petersen-Jones,S.M. and Palczewski,K.
  TITLE     A combination treatment based on drug repurposing demonstrates
            mutation-agnostic efficacy in pre-clinical retinopathy models
  JOURNAL   Nat Commun 15 (1), 5943 (2024)
   PUBMED   39009597
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4463)
  AUTHORS   Seidemann,S., Salomon,F., Hoffmann,K.B., Kurth,T., Sbalzarini,I.F.,
            Haase,R. and Ader,M.
  TITLE     Automated quantification of photoreceptor outer segments in
            developing and degenerating retinas on microscopy images across
            scales
  JOURNAL   Front Mol Neurosci 17, 1398447 (2024)
   PUBMED   38854587
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4463)
  AUTHORS   Takita,S., Jahan,S., S Imanishi,S., Harikrishnan,H., LePage,D.,
            Mann,R.J., Conlon,R.A., Miyagi,M. and Imanishi,Y.
  TITLE     Rhodopsin mislocalization drives ciliary dysregulation in a novel
            autosomal dominant retinitis pigmentosa knock-in mouse model
  JOURNAL   FASEB J 38 (8), e23606 (2024)
   PUBMED   38648465
  REMARK    GeneRIF: Rhodopsin mislocalization drives ciliary dysregulation in
            a novel autosomal dominant retinitis pigmentosa knock-in mouse
            model.
REFERENCE   6  (bases 1 to 4463)
  AUTHORS   Olsson,J.E., Gordon,J.W., Pawlyk,B.S., Roof,D., Hayes,A.,
            Molday,R.S., Mukai,S., Cowley,G.S., Berson,E.L. and Dryja,T.P.
  TITLE     Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model
            of autosomal dominant retinitis pigmentosa
  JOURNAL   Neuron 9 (5), 815-830 (1992)
   PUBMED   1418997
REFERENCE   7  (bases 1 to 4463)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   8  (bases 1 to 4463)
  AUTHORS   Danciger,M., Chakraborti,A., Farber,D.B. and Kozak,C.A.
  TITLE     Localization of the gene for a third G protein beta-subunit to
            mouse chromosome 6 near Raf-1
  JOURNAL   Genomics 12 (4), 688-692 (1992)
   PUBMED   1572642
REFERENCE   9  (bases 1 to 4463)
  AUTHORS   Birkenmeier,E.H., Schneider,U. and Thurston,S.J.
  TITLE     Fingerprinting genomes by use of PCR with primers that encode
            protein motifs or contain sequences that regulate gene expression
  JOURNAL   Mamm Genome 3 (10), 537-545 (1992)
   PUBMED   1421760
  REMARK    Erratum:[Mamm Genome 1993;4(2):133]
REFERENCE   10 (bases 1 to 4463)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044333.1, BC013125.1, AK164314.1 and AC142099.3.
            
            On Jun 3, 2018 this sequence version replaced NM_145383.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044333.1, BC013125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK044333.1         2-20
            20-3255             BC013125.1         1-3236
            3256-4459           AK164314.1         477-1680
            4460-4463           AC142099.3         13849-13852         c
FEATURES             Location/Qualifiers
     source          1..4463
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 53.72 cM"
     gene            1..4463
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /note="rhodopsin"
                     /db_xref="GeneID:212541"
                     /db_xref="MGI:MGI:97914"
     exon            1..458
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1144
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /note="L opsin; LWS opsin; opsin 2; red opsin; rod opsin;
                     long wavelength sensitive opsin"
                     /codon_start=1
                     /product="rhodopsin"
                     /protein_id="NP_663358.1"
                     /db_xref="CCDS:CCDS20446.1"
                     /db_xref="GeneID:212541"
                     /db_xref="MGI:MGI:97914"
                     /translation="MNGTEGPNFYVPFSNVTGVVRSPFEQPQYYLAEPWQFSMLAAYM
                     FLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGY
                     FVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVVFT
                     WIMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIV
                     IFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAFYIF
                     THQGSNFGPIFMTLPAFFAKSSSIYNPVIYIMLNKQFRNCMLTTLCCGKNPLGDDDAS
                     ATASKTETSQVAPA"
     exon            459..627
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /inference="alignment:Splign:2.1.0"
     exon            628..793
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1033
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..4463
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1492..1497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /note="hexamer: AATAAA"
     polyA_site      1516
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /note="major polyA site"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /note="hexamer: AATATA"
     polyA_site      1909
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
     regulatory      4441..4446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
                     /note="hexamer: AATAAA"
     polyA_site      4463
                     /gene="Rho"
                     /gene_synonym="Noerg1; Opn2; Ops; RP4"
ORIGIN      
        1 ggagttgcgc tgtgggagcc gtcagtggct gagctcgcca agcagccttg gtctctgtct
       61 acgaagagcc cgtggggcag cctcgagagc cgcagccatg aacggcacag agggccccaa
      121 tttttatgtg cccttctcca acgtcacagg cgtggtgcgg agccccttcg agcagccgca
      181 gtactacctg gcggaaccat ggcagttctc catgctggca gcgtacatgt tcctgctcat
      241 cgtgctgggc ttccccatca acttcctcac gctctacgtc accgtacagc acaagaagct
      301 gcgcacaccc ctcaactaca tcctgctcaa cttggccgtg gctgacctct tcatggtctt
      361 cggaggattc accaccaccc tctacacatc actccatggc tacttcgtct ttgggcccac
      421 aggctgtaat ctcgagggct tctttgccac acttggaggt gaaatcgccc tgtggtccct
      481 ggtggtcctg gccattgagc gctacgtggt ggtctgcaag ccgatgagca acttccgctt
      541 cggggagaat cacgctatca tgggtgtggt cttcacctgg atcatggcgt tggcctgtgc
      601 tgctccccca ctcgttggct ggtccaggta catccctgag ggcatgcaat gttcatgcgg
      661 gattgactac tacacactca agcctgaggt caacaacgaa tcctttgtca tctacatgtt
      721 cgtggtccac ttcaccattc ctatgatcgt catcttcttc tgctatgggc agctggtctt
      781 cacagtcaag gaggcggctg cccagcagca ggagtcagcc accactcaga aggcagagaa
      841 ggaagtcacc cgcatggtta tcatcatggt catcttcttc ctgatctgct ggcttcccta
      901 cgccagtgtg gccttctaca tcttcaccca ccagggctcc aacttcggcc ccatcttcat
      961 gactctgcca gctttctttg ctaagagctc ttccatctat aacccggtca tctacatcat
     1021 gttgaacaag cagttccgga actgtatgct caccacgctg tgctgcggca agaatccact
     1081 gggagatgac gacgcctctg ccaccgcttc caagacggag accagccagg tggctccagc
     1141 ctaagcctgg ccagagactg tggctgaaag taggagtctc ctgtccccac acaccccagc
     1201 cacagccccc accaggagca gcacccgttg ggatgaggtc atgcaggctc cctcagtgtt
     1261 cttttctttg tttttaatga attcatgaaa gcaaaatgag gctccccact caatggggac
     1321 agcttgacaa agggcatcca tccaccaaga ccatcctcaa cctggagtcc ccaattcccg
     1381 gggggccagc gggatctgta cccctccctc agcttgtcta tcaggaacat gacaagtgtc
     1441 ccggcttagg gctaaatgtc taggacagaa tggaacacat agtagctgat taataaatgc
     1501 tagctggatg aagggaggaa tgagtgactg actgagtgga tatatgagtg aagggattaa
     1561 tggaagggaa catggatgtc ctcaggtgcc caacctggca gatccagtca tgtctggctg
     1621 gaatctataa gcagttttac atacctgccc tggttttctc tgcccccacc cccaccccag
     1681 ttggatctcc caaatccagg gccctgatag aatatggctg cttcaaagac agagagatga
     1741 ggggagggag gggggaggga gagagggagg gagggagaca cagagaggga atatgtgtga
     1801 tgcgtgtgta tgtgtgtatg tgtgtgtgta aacactttgt atataaagag tacagctggt
     1861 agttatgtta caagtaacac cgactaatat aattaattaa ccatcctaat ggtctctgct
     1921 tgttagtgac tgcttgggaa ttaggcaggg cccaagcact cagataaggt atttccctca
     1981 gcctcagtag gcttttgcaa atgacccagg ccttcaggcc tgtgcagggc tagagctgga
     2041 ttacagagat aaatgacagt gacagcaacg tgagctgcag cccttaggac tgagaaagca
     2101 tcgagaccag gggtctccgg caaggcctag gtcctccctt cagtatggaa accttgcctc
     2161 atgtctctca gcctccttgg cctgtggaga tccagccctt cctcttggct tctggataca
     2221 tttgctcttc tacaccagca accaagtggc aacagttcca ggccagtatg gagttttaga
     2281 agccatgcca atatgcccac cttcagggag cagctgagtc cttgatgcca cccttgttct
     2341 gaagagttca gaaacacagt gcaagacatg accaggcctc atccttagga tgctcatgga
     2401 tccagttctt agctcccttg ttggatatgc tgttttcctt ggcctttggt cttttcttta
     2461 tcccagaggg ttttggcttt aaggccaaca ggaactatgg ggtaccagaa ttgagcagcc
     2521 tcagtctgca tccctcctct atagaaccac agctgggccc tcagcaggcc caactctgca
     2581 tggggacaga ggcattaaaa gctcagctcc tacacttggt ggcagtggtg gtctgttgct
     2641 ctcaagctct ttcaaaatgg atggaaactg ggacgcttcc ctgacccctg gttatgaaag
     2701 actagactgt gtggggacaa acagtccaga gtcccgggga atgtgataga gcagctccat
     2761 catttttaga aacccaattt gaggcagtat agagagatgg tgacctctat aagcctctgt
     2821 atctgcaaag aggagcttag acctgccctt gaggggatta tatgagattt aagggactta
     2881 tgtggccagc ctacttcctg gcatgctgaa gacattggca cactctggta ttctagacct
     2941 tggctcagag ctgcctttac taggatactg tcacttagca aaagaatggg atggagcctc
     3001 agatgtggag tgacaccatc ttccaagaag gaaagggtgc cagggtctgg gatgaaagcc
     3061 ctttggtgct atgttgggca agggcgagtg ccagcaaggg gttatttgct tgctctctcc
     3121 atcagtgatg aggttccatt tggtcacaag aaattcaccc caattgctga aacagaggct
     3181 gactattggc ttataggcat gaaaccccac tcccctccac ttcaggctgg ctagattaaa
     3241 agctcagacc tgtgacccct tgtgtctctc ttctgtgttg acttcactca caggcctaac
     3301 ctcagaggtg tctgtagcag tcccagggcc agacaccctt ccagaaaggg gctttccttc
     3361 cctttataat cgtggtgaca ggtcagattc ttattgggca gacctaagtt acctgattat
     3421 ccttaagcca atcatcatgt ctaagacaga gattcatttg attggccagg gctgagtcac
     3481 ttgtttacct ctaagtcaat caacaggcct gagatggaga gtcatcttct gattagctag
     3541 acctgggtca cctgatcacc tctaagccaa ccactatgtc tgatataggg ctccctcatt
     3601 tgtaatgtgt tcccacacta caagataaag ttgactccac atagttaagg agcctgtagg
     3661 atgtgttccc caaaagcaaa caggggaaca ggatcaggac cagccctgag gggtggggac
     3721 tgggatgtgc tagacaaggc tccggggtgt catggatgaa ggggattcca tggctgccac
     3781 acctctggtt gtctctcatg ctttatgggc caggagtgcc tgttggaagg ctactttagc
     3841 tgcctggcct tgacctccct cactcctcca tgcccagttc acttgtcctg tggggtgtca
     3901 tctttactcc tgccttctcc tgcccgggaa aaataaccct ttagaaccag aatgctcttg
     3961 tcagcctccc tcgacagtca ctgtgagtgt agacagaaga gctcctgcca tgagctggga
     4021 cctggagtcc ccacagggtc acctgccagg ctccaagcaa gcagcctttg tggaacatac
     4081 aacacactca gccaatcaca ggtcagacag ggctgtcacc ccaataaaga gacacctggg
     4141 ttaccaggta acctgaggtg ccccagagaa acacagtgcc agtcccaggg taagtcccta
     4201 gactacacag gccacagctc tgagctgaaa gtgagagaca ccttagctgg tggaggcttt
     4261 atttctgtat ttgtttccac ccacggtcac tttacctctg agaaacattg agggtgaccc
     4321 cagatatata gggaattaaa taggaacaca agtcaaatat ctactgataa tcataaagaa
     4381 acctaatgtg aagtaagtct ttgatatata tatgcaattt tacaattgat taaagatgaa
     4441 aataaatttg cattctaatg aga
//
