LOCUS       NM_026967               1155 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus Ras homolog enriched in brain like 1 (Rhebl1), mRNA.
ACCESSION   NM_026967 XM_354936
VERSION     NM_026967.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1155)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1155)
  AUTHORS   Shi,H., Chapman,N.M., Wen,J., Guy,C., Long,L., Dhungana,Y.,
            Rankin,S., Pelletier,S., Vogel,P., Wang,H., Peng,J., Guan,K.L. and
            Chi,H.
  TITLE     Amino Acids License Kinase mTORC1 Activity and Treg Cell Function
            via Small G Proteins Rag and Rheb
  JOURNAL   Immunity 51 (6), 1012-1027 (2019)
   PUBMED   31668641
REFERENCE   3  (bases 1 to 1155)
  AUTHORS   Baker,M.D., Ezzati,M., Aloisio,G.M., Tarnawa,E.D., Cuevas,I.,
            Nakada,Y. and Castrillon,D.H.
  TITLE     The small GTPase Rheb is required for spermatogenesis but not
            oogenesis
  JOURNAL   Reproduction 147 (5), 615-625 (2014)
   PUBMED   24713393
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1155)
  AUTHORS   Jiang,W., Yang,W., Yang,W., Zhang,J., Pang,D., Gan,L., Luo,L.,
            Fan,Y., Liu,Y. and Chen,M.
  TITLE     Identification of Tmem10 as a novel late-stage oligodendrocytes
            marker for detecting hypomyelination
  JOURNAL   Int J Biol Sci 10 (1), 33-42 (2013)
   PUBMED   24391449
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1155)
  AUTHORS   Zou,J., Zhou,L., Du,X.X., Ji,Y., Xu,J., Tian,J., Jiang,W., Zou,Y.,
            Yu,S., Gan,L., Luo,M., Yang,Q., Cui,Y., Yang,W., Xia,X., Chen,M.,
            Zhao,X., Shen,Y., Chen,P.Y., Worley,P.F. and Xiao,B.
  TITLE     Rheb1 is required for mTORC1 and myelination in postnatal brain
            development
  JOURNAL   Dev Cell 20 (1), 97-108 (2011)
   PUBMED   21238928
REFERENCE   6  (bases 1 to 1155)
  AUTHORS   Roma,G., Cobellis,G., Claudiani,P., Maione,F., Cruz,P., Tripoli,G.,
            Sardiello,M., Peluso,I. and Stupka,E.
  TITLE     A novel view of the transcriptome revealed from gene trapping in
            mouse embryonic stem cells
  JOURNAL   Genome Res 17 (7), 1051-1060 (2007)
   PUBMED   17540781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161165.5.
            
            On Feb 3, 2022 this sequence version replaced NM_026967.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY327413.1, BC016521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC161165.5         90499-90723         c
            226-297             AC161165.5         89857-89928         c
            298-365             AC161165.5         89126-89193         c
            366-448             AC161165.5         88754-88836         c
            449-505             AC161165.5         88608-88664         c
            506-553             AC161165.5         88357-88404         c
            554-635             AC161165.5         87802-87883         c
            636-1155            AC161165.5         87127-87646         c
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.99 cM"
     gene            1..1155
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /note="Ras homolog enriched in brain like 1"
                     /db_xref="GeneID:69159"
                     /db_xref="MGI:MGI:1916409"
     exon            1..225
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..728
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /note="rheb-like protein 1; ras homolog enriched in
                     brain-like protein 1"
                     /codon_start=1
                     /product="GTPase RhebL1"
                     /protein_id="NP_081243.1"
                     /db_xref="CCDS:CCDS27809.1"
                     /db_xref="GeneID:69159"
                     /db_xref="MGI:MGI:1916409"
                     /translation="MPLVRYRKVAILGYRSVGKTSLAHQFVEGEFLEGYDPTVENTYS
                     KTVTLGKDEFHLHLVDTAGQDEYSILPYSLIIGVHGYVLVYSVNSLRSFQIVKNLYQK
                     LHEGHGKTRLSVLLVGNKADLSPEREVQAVEGKKLAESWGAMFMESSARDNQLTQDVF
                     IKVIQEIARVENSYGRQDRRCYLM"
     exon            226..297
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..365
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..448
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..505
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..553
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..635
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..1155
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1131..1136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /note="hexamer: AATAAA"
     polyA_site      1155
                     /gene="Rhebl1"
                     /gene_synonym="1810036J22Rik; Rheb2"
                     /note="major polyA site"
ORIGIN      
        1 gtgatcacgt gggctgcccc gggcgcgcgg cttgttttgg ttttccttgg cttgccgggc
       61 gtagcttcag cgagctactc ttcttcccag agtccacctc ggcctgcacc tcggctgatc
      121 ttcgggttcc ctcggcccgc actcctacga gccccgcggg gcggcgtcct gtcatgccgc
      181 tggtgcgcta caggaaggtg gccatcctag ggtaccgctc cgtagggaag acatctttgg
      241 cacatcaatt tgtggaaggc gagttcctgg aaggctacga tcctacagtg gagaatactt
      301 acagcaagac agtgactctt ggcaaagatg agtttcacct acatctggtg gacacagcag
      361 ggcaggatga gtacagcatt ctgccctact cgctcatcat cggggtccat ggttacgttc
      421 ttgtatactc ggttaactct ctgcgcagct ttcagatcgt taagaacctg taccaaaagc
      481 tacacgaagg ccacggtaaa acccggctgt cggtgctgct tgtggggaac aaggcagatc
      541 tctctcctga gagagaggtg caggcagttg aagggaagaa gctagcagag tcctggggtg
      601 cgatgtttat ggagtcgtct gctcgggata atcagctaac tcaagatgtc ttcatcaaag
      661 tcatccagga gattgcccgg gtggagaatt cttatggacg acaagaccgc cgatgctatc
      721 ttatgtgaac tcttggcatg gaataactgc cctgtttctg ccgcagacat tgtctaaccc
      781 gcagcagtgg ggcagaccct caggatataa ctgctatggt tgccaactat gtcccctgtc
      841 ctctgggcac acagtatggc actcttattt ttgcacactc atcccaggtt ctggtagcct
      901 ggatgttaat gtttacaaag gggcaagatg tctcagggac cctggcttct aactccttgg
      961 ttttctaaac caatttttac agtctgtaca gtagggatat gagtcttgtg cattgattac
     1021 ccaggaccca ccctcctggg taggttttgg gtgttggttg ggtaagggtg tttggttcct
     1081 tggcagttct gaagtagaac tgtctgctgg ggtaacaatg tatatttcca aataaactga
     1141 gaaatctttt gttga
//
