LOCUS       NM_053075               1521 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus Ras homolog enriched in brain (Rheb), mRNA.
ACCESSION   NM_053075 XM_906651
VERSION     NM_053075.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1521)
  AUTHORS   Zhao,Z., Chen,Q., Xiang,X., Dai,W., Fang,W., Cui,K., Li,B., Liu,Q.,
            Liu,Y., Shen,Y., Li,Y., Xu,W., Mai,K. and Ai,Q.
  TITLE     Tip60-mediated Rheb acetylation links palmitic acid with mTORC1
            activation and insulin resistance
  JOURNAL   J Cell Biol 223 (12) (2024)
   PUBMED   39422647
  REMARK    GeneRIF: Tip60-mediated Rheb acetylation links palmitic acid with
            mTORC1 activation and insulin resistance.
REFERENCE   2  (bases 1 to 1521)
  AUTHORS   Deng,D., Liu,X., Huang,W., Yuan,S., Liu,G., Ai,S., Fu,Y., Xu,H.,
            Zhang,X., Li,S., Xu,S., Bai,X. and Zhang,Y.
  TITLE     Osteoclasts control endochondral ossification via regulating
            acetyl-CoA availability
  JOURNAL   Bone Res 12 (1), 49 (2024)
   PUBMED   39198395
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1521)
  AUTHORS   Zhang,Y., Wen,J., Lai,R., Zhang,J., Li,K., Zhang,Y., Liu,A. and
            Bai,X.
  TITLE     Rheb1 is required for limb growth through regulating chondrogenesis
            in growth plate
  JOURNAL   Cell Tissue Res 395 (3), 261-269 (2024)
   PUBMED   38253890
  REMARK    GeneRIF: Rheb1 is required for limb growth through regulating
            chondrogenesis in growth plate.
REFERENCE   4  (bases 1 to 1521)
  AUTHORS   Nguyen,L.H., Xu,Y., Nair,M. and Bordey,A.
  TITLE     The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have
            convergent and divergent impacts on cortical neuron development and
            function
  JOURNAL   Elife 12, 91010 (2024)
   PUBMED   38411613
  REMARK    GeneRIF: The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1
            have convergent and divergent impacts on cortical neuron
            development and function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1521)
  AUTHORS   Wang,T., Zhao,C., Zhang,J., Li,S., Zhang,Y., Gong,Y., Zhou,Y.,
            Yan,L., Zhang,S., Zhang,Z., Hu,H., Liu,A., Bai,X. and Zou,Z.
  TITLE     Whitening of brown adipose tissue inhibits osteogenic
            differentiation via secretion of S100A8/A9
  JOURNAL   iScience 27 (2), 108857 (2024)
   PUBMED   38303710
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1521)
  AUTHORS   Takahashi,K., Nakagawa,M., Young,S.G. and Yamanaka,S.
  TITLE     Differential membrane localization of ERas and Rheb, two
            Ras-related proteins involved in the phosphatidylinositol
            3-kinase/mTOR pathway
  JOURNAL   J Biol Chem 280 (38), 32768-32774 (2005)
   PUBMED   16046393
  REMARK    GeneRIF: ERas and Rheb are two Ras-related proteins involved in the
            phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at
            the plasma membrane, while Rheb is on endomembranes.
REFERENCE   7  (bases 1 to 1521)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1521)
  AUTHORS   Garami,A., Zwartkruis,F.J., Nobukuni,T., Joaquin,M., Roccio,M.,
            Stocker,H., Kozma,S.C., Hafen,E., Bos,J.L. and Thomas,G.
  TITLE     Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling,
            is inhibited by TSC1 and 2
  JOURNAL   Mol Cell 11 (6), 1457-1466 (2003)
   PUBMED   12820960
REFERENCE   9  (bases 1 to 1521)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1521)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC125270.7 and
            AC137938.12.
            
            On Mar 21, 2007 this sequence version replaced NM_053075.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY197373.1, BC012273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC125270.7         37104-37280         c
            178-249             AC137938.12        132509-132580       c
            250-317             AC137938.12        128547-128614       c
            318-400             AC137938.12        123102-123184       c
            401-457             AC137938.12        122497-122553       c
            458-505             AC137938.12        122354-122401       c
            506-587             AC137938.12        121748-121829       c
            588-1521            AC137938.12        117572-118505       c
FEATURES             Location/Qualifiers
     source          1..1521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.93 cM"
     gene            1..1521
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /note="Ras homolog enriched in brain"
                     /db_xref="GeneID:19744"
                     /db_xref="MGI:MGI:97912"
     exon            1..177
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..680
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /EC_number="3.6.5.2"
                     /note="RAS-homolog enriched in brain"
                     /codon_start=1
                     /product="GTP-binding protein Rheb"
                     /protein_id="NP_444305.2"
                     /db_xref="CCDS:CCDS39032.1"
                     /db_xref="GeneID:19744"
                     /db_xref="MGI:MGI:97912"
                     /translation="MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFT
                     KLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGK
                     LLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVF
                     KRIILEAEKIDGAASQGKSSCSVM"
     exon            178..249
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..317
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..400
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..457
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..505
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..587
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..1521
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1074..1079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /note="hexamer: AATAAA"
     polyA_site      1096
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /note="major polyA site"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
                     /note="hexamer: AGTAAA"
     polyA_site      1521
                     /gene="Rheb"
                     /gene_synonym="Rheb1"
ORIGIN      
        1 ccgcgcccgc cgccgtgctc tgtatgccgc gttctcccgg cgcagccgcc gccgatagtc
       61 tgagccggag gagccgccgc cgccgcggtt aatgtggttg ggtcggggct gagcaggcca
      121 ccaagatgcc tcagtccaag tcccggaaga tcgccatcct gggctaccgg tctgtgggaa
      181 agtcctcatt gacaattcag tttgttgaag gccaatttgt tgattcctac gatccaacca
      241 tagagaacac gttcaccaag ttgatcacgg taaatggtca agagtatcat cttcagcttg
      301 tagacacagc ggggcaggat gaatattcca tttttcctca gacatactcc atagatatta
      361 atggttatat tcttgtgtat tctgttacat caatcaaaag ttttgaagta attaaagtta
      421 tccatggcaa gttgttggat atggtgggga aagtgcagat acctattatg ttggttggaa
      481 ataagaagga cctgcatatg gaaagggtga tcagctatga agaaggaaag gctttggcag
      541 aatcttggaa tgcagctttt ttggaatctt ctgctaaaga aaatcaaact gctgttgatg
      601 tttttaaaag gataattttg gaagcagaaa agattgatgg agcagcttca caaggaaagt
      661 cttcgtgctc ggtgatgtga caattctgct gcagagcctg cggacactgg ggatatattc
      721 cacctgagga agcaaactgc ccgtcatcct tgaagataaa actatgcttc tgttttcttc
      781 tgttaacctg aaagatgtca tttgggtcag gggtcctccc ctttcagatt atgttaacgt
      841 ctgactctgt ccaaatgagt tcacctccat tttcaaattt taaacaatca tattttcaat
      901 ttatatattg tatttcttaa tattatgacc aagaatttta tcggcattaa ttttttcagt
      961 gtagtttgtt gtttaaaata atgtaatcat caaaatgata cacatgttac actactatta
     1021 actaggcttc aatatatcag tgtttatttc attgtgttaa atgtatactt gtaaataaaa
     1081 tagctgcaaa ccttaagcct ttgagctact tggtgtggtt tttaaaccag gaaccatgtt
     1141 aggatggggc atgggcgtgc acatcgtttg tttttgtttt gtttgctttt tcgagacagg
     1201 gtttctctat gtaacagcac tggctgtcct ggaacccact ctgtagacca ggctgtcctc
     1261 gaactcgaga tttgcctgcc tctgcctccc aagtgctggg attaaaggcg tgcaccacca
     1321 ctgcctggct gtacagtgtt ccctggttct attaaccccg gctcttttac ctcacttggc
     1381 cccaacacct ccctcttaca ttttcacatt ctctcctgca tccagttatt gcctcctgtt
     1441 ggcatgttag ttcatctggt ctctatcttc cgtgttaact gcagtggcca tgtcatgcct
     1501 agtaaacagt attttactgc a
//
