LOCUS       NM_019799               2106 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus Rhesus blood group-associated C glycoprotein (Rhcg),
            mRNA.
ACCESSION   NM_019799
VERSION     NM_019799.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2106)
  AUTHORS   Bourgeois,S., Bounoure,L., Mouro-Chanteloup,I., Colin,Y., Brown,D.
            and Wagner,C.A.
  TITLE     The ammonia transporter RhCG modulates urinary acidification by
            interacting with the vacuolar proton-ATPases in renal intercalated
            cells
  JOURNAL   Kidney Int 93 (2), 390-402 (2018)
   PUBMED   29054531
  REMARK    GeneRIF: RhCG and H+ATPases are located within the same cellular
            protein complex in the kidney and this interaction is required for
            maximal urinary acidification by H+-ATPases, a prerequisite for
            efficient NH3 secretion and urine excretion of NH4+.
REFERENCE   2  (bases 1 to 2106)
  AUTHORS   Caner,T., Abdulnour-Nakhoul,S., Brown,K., Islam,M.T., Hamm,L.L. and
            Nakhoul,N.L.
  TITLE     Mechanisms of ammonia and ammonium transport by rhesus-associated
            glycoproteins
  JOURNAL   Am J Physiol Cell Physiol 309 (11), C747-C758 (2015)
   PUBMED   26354748
  REMARK    GeneRIF: We characterized ammonia and ammonium (NH3/NH4 (+))
            transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg,
            and Rhcg expressed in Xenopus oocytes. We used ion-selective
            microelectrodes and two-electrode voltage clamp to measure changes
            in intracellular pH, surface pH, and whole cell currents induced by
            NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+)).
REFERENCE   3  (bases 1 to 2106)
  AUTHORS   Bounoure,L., Ruffoni,D., Muller,R., Kuhn,G.A., Bourgeois,S.,
            Devuyst,O. and Wagner,C.A.
  TITLE     The role of the renal ammonia transporter Rhcg in metabolic
            responses to dietary protein
  JOURNAL   J Am Soc Nephrol 25 (9), 2040-2052 (2014)
   PUBMED   24652796
  REMARK    GeneRIF: investigated the renal adaptive response of acid excretory
            pathways to high-protein diets containing normal or low amounts of
            acid-producing sulfur amino acids (SAA) and examined how this
            adaption requires the RhCG ammonia transporter
REFERENCE   4  (bases 1 to 2106)
  AUTHORS   Weiner,I.D. and Verlander,J.W.
  TITLE     Ammonia transport in the kidney by Rhesus glycoproteins
  JOURNAL   Am J Physiol Renal Physiol 306 (10), F1107-F1120 (2014)
   PUBMED   24647713
  REMARK    GeneRIF: Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are
            identified as ammonia transporters. They are expressed in specific
            cell populations and membrane domains in distal renal epithelial
            cells, where they facilitate ammonia secretion.
            Review article
REFERENCE   5  (bases 1 to 2106)
  AUTHORS   Lee,H.W., Verlander,J.W., Handlogten,M.E., Han,K.H. and Weiner,I.D.
  TITLE     Effect of collecting duct-specific deletion of both Rh B
            Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response
            to metabolic acidosis
  JOURNAL   Am J Physiol Renal Physiol 306 (4), F389-F400 (2014)
   PUBMED   24338819
  REMARK    GeneRIF: Rhcg is critically important in the renal response to
            metabolic acidosis. in mice with intact Rhcg expression, metabolic
            acidosis does not induce maximal changes in PEPCK, NHE-3, and GS
            expression despite the presence of persistent metabolic acidosis.
REFERENCE   6  (bases 1 to 2106)
  AUTHORS   Zhang,J., Gao,F.L., Zhi,H.Y., Luo,A.P., Ding,F., Wu,M. and Liu,Z.H.
  TITLE     Expression patterns of esophageal cancer deregulated genes in
            C57BL/6J mouse embryogenesis
  JOURNAL   World J Gastroenterol 10 (8), 1088-1092 (2004)
   PUBMED   15069704
REFERENCE   7  (bases 1 to 2106)
  AUTHORS   Weiner,I.D., Miller,R.T. and Verlander,J.W.
  TITLE     Localization of the ammonium transporters, Rh B glycoprotein and Rh
            C glycoprotein, in the mouse liver
  JOURNAL   Gastroenterology 124 (5), 1432-1440 (2003)
   PUBMED   12730882
  REMARK    GeneRIF: RhCG immunoreactivity is present in bile duct epithelial
            cells, where it may contribute to ammonium secretion into bile
            fluid.
REFERENCE   8  (bases 1 to 2106)
  AUTHORS   Quentin,F., Eladari,D., Cheval,L., Lopez,C., Goossens,D., Colin,Y.,
            Cartron,J.P., Paillard,M. and Chambrey,R.
  TITLE     RhBG and RhCG, the putative ammonia transporters, are expressed in
            the same cells in the distal nephron
  JOURNAL   J Am Soc Nephrol 14 (3), 545-554 (2003)
   PUBMED   12595489
  REMARK    GeneRIF: RhBG and RhCG are present in a major site of ammonia
            secretion in the kidney, i.e., the CNT and CD, in agreement with
            their putative role in ammonium transport.
REFERENCE   9  (bases 1 to 2106)
  AUTHORS   Verlander,J.W., Miller,R.T., Frank,A.E., Royaux,I.E., Kim,Y.H. and
            Weiner,I.D.
  TITLE     Localization of the ammonium transporter proteins RhBG and RhCG in
            mouse kidney
  JOURNAL   Am J Physiol Renal Physiol 284 (2), F323-F337 (2003)
   PUBMED   12388412
  REMARK    GeneRIF: Localization of the ammonium transporter proteins RhBG and
            RhCG in mouse kidney.
REFERENCE   10 (bases 1 to 2106)
  AUTHORS   Liu,Z., Chen,Y., Mo,R., Hui,C., Cheng,J.F., Mohandas,N. and
            Huang,C.H.
  TITLE     Characterization of human RhCG and mouse Rhcg as novel nonerythroid
            Rh glycoprotein homologues predominantly expressed in kidney and
            testis
  JOURNAL   J Biol Chem 275 (33), 25641-25651 (2000)
   PUBMED   10852913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076757.1 and AI648871.1.
            
            On May 1, 2009 this sequence version replaced NM_019799.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076757.1, AF193810.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2084              AK076757.1         1-2084
            2085-2106           AI648871.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.09 cM"
     gene            1..2106
                     /gene="Rhcg"
                     /note="Rhesus blood group-associated C glycoprotein"
                     /db_xref="GeneID:56315"
                     /db_xref="MGI:MGI:1888517"
     exon            1..318
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1628
                     /gene="Rhcg"
                     /note="rh family type C glycoprotein; rhesus-associated C
                     glycoprotein; rhesus blood group family type C
                     glycoprotein; Rh type C glycoprotein"
                     /codon_start=1
                     /product="ammonium transporter Rh type C"
                     /protein_id="NP_062773.2"
                     /db_xref="CCDS:CCDS21383.1"
                     /db_xref="GeneID:56315"
                     /db_xref="MGI:MGI:1888517"
                     /translation="MAWNTNLRGRLPITCLILQVTMVVLFGVFVRYDIQADAHWWLEK
                     KRKNISSDVENEFYYRYPSFQDVHAMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQ
                     WALLMQGWFHYFEEGHIVLSVENIIQADFCVASSCVAFGAVLGKVSPMQLLIMTFFQV
                     TLFTVNEFILLNLIEAKDAGGSMTIHTFGAYFGLTVTWILYRKNLDQSKQRQSSVYHS
                     DLFAMIGTLFLWIYWPSFNSASSFHGDAQHRAALNTYLSLAASVLTTVTVSSIVHKKG
                     KLDMVHIQNATLAGGVGVGTAAEMMLTPYGALIVGFFCGIFSTLGFAYLTPFLESRHR
                     IQDTCGIHNLHGIPGIIGGIVGAVTAAYSSPDVYGEPGIVHSFGFGSYKMDWNKRMQG
                     RSQIFGLLLSLAMALVGGIIVGFILKLPFWGQAADENCFEDSIYWEVHEEVNTVYIPE
                     DLAHKHSTSLVPAMPLVLPTTSASIVPPVPPTPPVSLATSAPSAALVH"
     exon            319..505
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            506..656
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            657..804
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            805..971
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1109
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1246
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1371
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1445
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1652
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..2090
                     /gene="Rhcg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2065..2070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhcg"
                     /note="hexamer: AATAAA"
     polyA_site      2090
                     /gene="Rhcg"
                     /note="major polyA site"
ORIGIN      
        1 tagagcccga ggcgcgtggg cggcaccatg gtcagctgtt ccgcgtccgc cccgcccagt
       61 gtcccggtcc tttaagcgtc tccctggtct cggagcccag cgttcagagc aagcggccag
      121 cagtgcggag catggcctgg aacaccaacc ttcgggggcg gctgcccatc acctgcctga
      181 tcctgcaagt gaccatggtg gttctctttg gcgtgttcgt gcgctacgac atccaagccg
      241 atgctcactg gtggttggag aagaagcgca agaacatctc cagcgacgtt gagaacgagt
      301 tttactatcg ctacccgagc ttccaggatg tacacgccat ggtcttcgtg ggcttcggct
      361 tcctcatgac cttcctgcag cgctacggct tcagcgctgt aggcttcaac ttcctgctgg
      421 cagctttcgg catccagtgg gcactgctca tgcagggatg gttccattac tttgaagaag
      481 gccacattgt cctgagcgtc gagaacatca tccaagctga cttctgtgtg gcatcttcct
      541 gtgtggcctt cggggcagtt ctaggcaagg tcagcccgat gcagctgctc attatgacct
      601 tcttccaagt gactctcttt acagtgaatg agttcatcct cctgaacctg atagaggcaa
      661 aggatgcagg gggctctatg accatccaca catttggcgc ctactttggg ctcacagtga
      721 cctggatcct ctaccgaaaa aacctggatc agagcaagca gagacagagc tcagtgtacc
      781 actcggacct tttcgccatg attggcaccc tcttcttgtg gatatactgg cccagtttca
      841 attcagccag ttccttccac ggagatgccc agcaccgagc agccctcaat acctacctct
      901 ccttggcagc gagtgtgcta accacagtga cagtatccag tattgtacac aagaagggca
      961 agttggatat ggtgcacatc cagaatgcca cgcttgcagg tggggtgggt gtgggcacag
     1021 ctgcggagat gatgctcaca ccttacggcg ctctcatcgt ggggttcttc tgcggcattt
     1081 tctccaccct aggatttgca tacctaacgc cattcctgga gtcccgccat cgcatccagg
     1141 acacatgtgg cattcacaac ctgcacggca ttcctggcat cataggcggc attgtgggtg
     1201 ctgtgacagc ggcttactcc tcccctgatg tgtatggaga gccagggata gtccattcct
     1261 tcggcttcgg gagttataag atggactgga acaagagaat gcagggcagg tcccagatat
     1321 ttggcctcct cctgagcctg gccatggccc tggtgggcgg catcattgtg ggattcattt
     1381 tgaaattgcc gttctgggga caagctgcag atgagaactg ttttgaggat tccatctact
     1441 gggaggttca tgaagaggtg aacactgtct acattcccga ggaccttgct cacaaacatt
     1501 ctacttctct ggtacctgca atgcccttgg tacttccaac tacttcagca tccatagttc
     1561 ctccagtccc tccgacacct ccagtatcct tagcaacttc agcaccttca gcagccttgg
     1621 tacactaaac tcccagggca ggtgagaagc aggccccaca gattgccccc aagctctgga
     1681 gagagctggg gctgacatat ctgggaactc agggacaggg cagcggaaag gcccactggc
     1741 ctgactccag cacctctaca cccgcttcat cccagggggc tcaccgggct gagaatggag
     1801 gagattcgga caaagtgagc tccaagccag ggtcagctgc agaaggtctg tccctgcctg
     1861 cggtcatgat gctcatagcc tgtgagaagt agcatgaaga gaagctgagg ccgggggttg
     1921 ggaagggggt gtggaatggg agggcgagct tgcccccacc ccacccggga taccccttct
     1981 tggactcttc aagcctccgc ctgctcccca acaatgtatt tcccatgttc caaggcaccc
     2041 aagatcactc tattttgtgt agtaaataaa tgttgttgat gctctttgta aaaaaaaaaa
     2101 aaaaaa
//
