LOCUS       NM_139228               3767 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus rhomboid like 3 (Rhbdl3), mRNA.
ACCESSION   NM_139228
VERSION     NM_139228.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3767)
  AUTHORS   Knopf,J.D., Steigleder,S.S., Korn,F., Kuhnle,N., Badenes,M.,
            Tauber,M., Theobald,S.J., Rybniker,J., Adrain,C. and Lemberg,M.K.
  TITLE     RHBDL4-triggered downregulation of COPII adaptor protein TMED7
            suppresses TLR4-mediated inflammatory signaling
  JOURNAL   Nat Commun 15 (1), 1528 (2024)
   PUBMED   38453906
  REMARK    GeneRIF: RHBDL4-triggered downregulation of COPII adaptor protein
            TMED7 suppresses TLR4-mediated inflammatory signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3767)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3767)
  AUTHORS   Smith,K.S., Bihannic,L., Gudenas,B.L., Haldipur,P., Tao,R., Gao,Q.,
            Li,Y., Aldinger,K.A., Iskusnykh,I.Y., Chizhikov,V.V., Scoggins,M.,
            Zhang,S., Edwards,A., Deng,M., Glass,I.A., Overman,L.M.,
            Millman,J., Sjoboen,A.H., Hadley,J., Golser,J., Mankad,K.,
            Sheppard,H., Onar-Thomas,A., Gajjar,A., Robinson,G.W.,
            Hovestadt,V., Orr,B.A., Patay,Z., Millen,K.J. and Northcott,P.A.
  TITLE     Unified rhombic lip origins of group 3 and group 4 medulloblastoma
  JOURNAL   Nature 609 (7929), 1012-1020 (2022)
   PUBMED   36131015
REFERENCE   4  (bases 1 to 3767)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3767)
  AUTHORS   Wu,D., Schieren,I., Qian,Y., Zhang,C., Jessell,T.M. and de
            Nooij,J.C.
  TITLE     A Role for Sensory end Organ-Derived Signals in Regulating Muscle
            Spindle Proprioceptor Phenotype
  JOURNAL   J Neurosci 39 (22), 4252-4267 (2019)
   PUBMED   30926747
REFERENCE   6  (bases 1 to 3767)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3767)
  AUTHORS   Gohlke,J.M., Armant,O., Parham,F.M., Smith,M.V., Zimmer,C.,
            Castro,D.S., Nguyen,L., Parker,J.S., Gradwohl,G., Portier,C.J. and
            Guillemot,F.
  TITLE     Characterization of the proneural gene regulatory network during
            mouse telencephalon development
  JOURNAL   BMC Biol 6, 15 (2008)
   PUBMED   18377642
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3767)
  AUTHORS   Trimarchi,J.M., Stadler,M.B. and Cepko,C.L.
  TITLE     Individual retinal progenitor cells display extensive heterogeneity
            of gene expression
  JOURNAL   PLoS One 3 (2), e1588 (2008)
   PUBMED   18270576
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3767)
  AUTHORS   Petri,A., Ahnfelt-Ronne,J., Frederiksen,K.S., Edwards,D.G.,
            Madsen,D., Serup,P., Fleckner,J. and Heller,R.S.
  TITLE     The effect of neurogenin3 deficiency on pancreatic gene expression
            in embryonic mice
  JOURNAL   J Mol Endocrinol 37 (2), 301-316 (2006)
   PUBMED   17032746
REFERENCE   10 (bases 1 to 3767)
  AUTHORS   Jaszai,J. and Brand,M.
  TITLE     Cloning and expression of Ventrhoid, a novel vertebrate homologue
            of the Drosophila EGF pathway gene rhomboid
  JOURNAL   Mech Dev 113 (1), 73-77 (2002)
   PUBMED   11900977
  REMARK    GeneRIF: Cloning and expression of Ventrhoid
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591426.17, BC054784.1 and AL591146.21.
            
            On Dec 16, 2009 this sequence version replaced NM_139228.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ313479.1, BC056969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AL591426.17        119839-120002
            165-2413            BC054784.1         1-2249
            2414-3767           AL591146.21        22140-23493
FEATURES             Location/Qualifiers
     source          1..3767
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.73 cM"
     gene            1..3767
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /note="rhomboid like 3"
                     /db_xref="GeneID:246104"
                     /db_xref="MGI:MGI:2179276"
     exon            1..360
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1464
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /EC_number="3.4.21.105"
                     /note="rhomboid protease 3; ventrhoid transmembrane
                     protein; rhomboid, veinlet-like 3; rhomboid related gene
                     1; rhomboid, veinlet-like 4"
                     /codon_start=1
                     /product="rhomboid-related protein 3"
                     /protein_id="NP_631974.1"
                     /db_xref="CCDS:CCDS25131.1"
                     /db_xref="GeneID:246104"
                     /db_xref="MGI:MGI:2179276"
                     /translation="MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFE
                     KFDPGSTGYISTGKFRSLLESHSSKLDPHKKEVLLALADSHADGQICYQDFVNLMSNK
                     RSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCC
                     PPPWFMITITLLEVALFLYNGVLLDQFVLQVTHPRYLKNSLVYHPQLRAQAWRYVTYI
                     FMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVG
                     SSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPP
                     CPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVTMYTIFVLFAVFWNIFA
                     YTLLDLKLPPAP"
     exon            361..384
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     exon            385..543
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     exon            544..768
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     exon            769..917
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1030
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1131
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1192
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..3767
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3613
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
     regulatory      3709..3714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /note="hexamer: ATTAAA"
     polyA_site      3736
                     /gene="Rhbdl3"
                     /gene_synonym="Rhbdl4; Rhomr1; Vrho"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggggag cggtagggcc cggctggccc aagggcgccc tgcctcgggc ccgcgacaga
       61 ggccaagaag tttggcggct aggggcccag cgccccgggt cgcgggggcc gcagtgaggg
      121 cggtggggag agcagaacca tgggagcgag cgcggaggcg gcgaggggcg cagctagctc
      181 ctggagcagc acggccgcgg cggcgcaaag ttagcccggc gccccgggac gagcgccgca
      241 gtctgggcca tgggcgagca ccccagcccc ggccccgcag tggccgcctg cgcggaggct
      301 gagcgcatcg aggagctgga gcccgaggcc gaggagcgac tgcccgccgc gccagaagac
      361 cactggaaag tcctgtttga aaagtttgac cctggaagca ccggctacat cagcacagga
      421 aagttccgga gcctcctgga gagccacagc tctaagctgg acccacacaa aaaggaggtg
      481 ctcctggctc tcgcagacag ccatgcagat gggcagatct gctaccagga ctttgtcaac
      541 ctgatgagca acaaacgttc caacagcttc cgccaggcca tccttcaggg aaaccgcagg
      601 ctgagcagca aggccctgct ggaggagaag gggctgagcc tctctcagcg gctcatccgc
      661 cacgtggcct acgagactct gccccgggag attgaccgca agtggtacta tgacagctac
      721 acctgctgcc ctccgccctg gttcatgatc acaatcacgc tgctggaggt tgcccttttc
      781 ctgtacaacg gggtcctact agatcagttt gtgctgcagg tgacgcaccc tcgatacctg
      841 aagaactctc tggtttacca cccgcagctc cgtgcgcagg cttggcgcta tgtgacgtac
      901 atcttcatgc atgcaggggt ggaacagctg ggactcaatg tggcactgca gctgctggta
      961 ggggtacccc tggagatggt gcatggagcc acccgaattg ggcttgtcta cgtggccggt
     1021 gttgtggcag gctccttggc ggtgtctgtg gctgacatga ctgcacctgt tgtgggctct
     1081 tccggagggg tgtatgcgct cgtctctgcc cacctagcca acattgtcat gaactggtca
     1141 ggcatgaagt gccagttcaa gctgctgcgg atggctgtgg ccttgatctg tatgagtatg
     1201 gagttcggaa gggctgtatg gctccgtttc cacccatcgg cttatccccc gtgcccccac
     1261 ccaagctttg tggcacactt gggtggcgtg gccgtgggca tcaccctggg cgtggtggtt
     1321 ctcagaaatt acgagcagag gctgcaggac cagtcgctgt ggtggatctt tgtgaccatg
     1381 tacaccatct tcgtgctgtt tgctgtcttc tggaacatct ttgcctacac actgctggac
     1441 ttgaagctgc cacccgcccc ctaagggacc agaggtccaa ggcagggcgg ggaaacagaa
     1501 gcatcccgag aaagtacctg catctgcttc tcatctccaa ttcagtgaaa gcagggagaa
     1561 ccggagactg ttggagctgg ggggtgcgtg ttgctttgaa aggatggtgg ggagatggat
     1621 gtggctgctg tcatctttct aggctggtct gatgatatgg agtcatgggt aaggtctgag
     1681 gcagggtaag agtggctgtc cctgtggctt gggcttgtcc catgcattcc ctctcactgc
     1741 cacagagtga gcaaatagcc ctcttcccta gtctccacct ggagagacac agagaagttc
     1801 tgaggatagc cacagccagg cttgccacgg cccagaggtg actgtaggct aggccacatt
     1861 ctctttgcag ctcaaggtct ggtgctctgg caatggatgt gatggctttg atccggggga
     1921 gcccagagca agccaggctc cagtcctgtc agtggtgcta tggcattgct cctagggctg
     1981 ggcagggaga tgctataagc tccaggcctt tttcttgccc taggggaggg ccctgtgctg
     2041 aggtaatgac tttcttcatc ccaggttccc ccaagagagt tccaggacgg tttcttcttc
     2101 ctgcctgtag tcacgagtca gcattccaga ccatcgctct gcatccatgc cctatctgga
     2161 ctgtggggtc tcttctttcc tttctactgc cctgacccta ctttgtgcct ctctctttgg
     2221 gtgtggagac agggttttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2281 gcaatgtcag gcaagtcaga agctgcagag ggaagaagtg ggagacaatg tacacaagag
     2341 gatatctaca ggggatttct ggaatgggta gcagcagtgt gctctccagt gctcgctcag
     2401 tggccttgcc tttagcatca tgcaccccct ttcccatctt gccctcccaa acacctgctg
     2461 agcaccactg actggtggaa aaactgtcga gctagaggga agaccaaagc actaccagac
     2521 atttgagaga aaactctcag ctgtattctt ctggttctct tgggggtagc ttttgtgtct
     2581 gtactgccgc ctgtagaagg aagtctttgg gatgaaagaa agcccaggac agtgatactg
     2641 tggccatctc tccatgtgaa ttagtgggac aagaagctgt agtaaaatat attttggtgg
     2701 aaaacgtagc ctctgagaag aattggggaa gcttgggtga gggaatgtcc ccagtgagag
     2761 cagctgaggg ttagatggct ccatctacag ggacttggaa gtactcttac agggaagtga
     2821 gattgggggg cgtggccttg tgctgtccat accccagcag cctgggatgc cacatcaggt
     2881 gtttggcaag gtaactgtag actcagagcc cagtgcctct gctcctctga gacagtctac
     2941 tcaggctggc acgagacgct tctggggacc ctaagtggag gctgtgaggc aggtgacctt
     3001 tatagggact ttcagcccct gggataagga accacaggtc tgagattgga gggaggcagg
     3061 aggatgagaa ctgctcctgg tcctctcacc atcccagcaa tacctcccag ctcatctcca
     3121 ttctcctgag tccctcagcc cttcctctct ccaatgtggc cacccatcag ggctgggagt
     3181 cactcctcat gctggaggct gtaggttggc ctcaaaggct ggggaatccc caaacagcag
     3241 ctatgtagac tagcttgcat ttaaagggga gaagactcat ggaaaccaga caagggaaaa
     3301 cgggctttca aaaaaagagg aatttctctt taatgatacc attcatcact tgattttttt
     3361 ttttttaatt aggagaagct ccctaaccgg gctctttaaa ttctgcattt ccatgtgaac
     3421 cattcttgcc tagagcatta gtggaggcat cgctcaccga acccagatct tcctctagtg
     3481 tccaattcag tttgcagata atgaggttta cccagtgctg tgtgcttccc agggctggct
     3541 gcaaatcgtt gactctcctc tgccttaaaa acagtgcccg tcagtgagct gccctcccag
     3601 gactaagtga aaatcaaaac actagccgcg acgttggttt ctagatattt ttgtattgtg
     3661 tacattctgt atatttttgt tgtaacatat tatttgagca cagattccat taaagatttt
     3721 tttaagctgt tggttattca gggagtgacc tcaagggctg ccatgct
//
