LOCUS       NM_144816               1557 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus rhomboid like 1 (Rhbdl1), mRNA.
ACCESSION   NM_144816
VERSION     NM_144816.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Shan,Y., Hexige,S., Guo,Z., Wan,B., Chen,K., Chen,X., Ma,L.,
            Huang,C., Zhao,S. and Yu,L.
  TITLE     Cloning and characterization of the mouse Arht2 gene which encodes
            a putative atypical GTPase
  JOURNAL   Cytogenet Genome Res 106 (1), 91-97 (2004)
   PUBMED   15218247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC021549.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021549.1, AK140428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.93 cM"
     gene            1..1557
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /note="rhomboid like 1"
                     /db_xref="GeneID:214951"
                     /db_xref="MGI:MGI:2384891"
     exon            1..140
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1223
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /EC_number="3.4.21.105"
                     /note="RRP; rhomboid-like protein 1; rhomboid,
                     veinlet-like 1"
                     /codon_start=1
                     /product="rhomboid-related protein 1"
                     /protein_id="NP_659065.1"
                     /db_xref="CCDS:CCDS28534.1"
                     /db_xref="GeneID:214951"
                     /db_xref="MGI:MGI:2384891"
                     /translation="MDRSSLLQLIQEQQLDPENTGFIGADTFAGLVHSHELPLDPTKL
                     DMLVALAQSNERGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGLLDEPGLSVYK
                     RFVRYVAYEILPCEVDRRWYFYRHRTCPPPVFMASVTLAQIIVFLCYGARLNKWVLQT
                     YHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGVLR
                     ISLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLR
                     MVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERL
                     RDQCGWWVVLLAYGTFLLFAIFWNVFAYDLLGADIPPPP"
     exon            141..302
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     exon            303..527
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     exon            528..676
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     exon            677..789
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     exon            790..890
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     exon            891..951
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1543
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1524..1529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /note="hexamer: AATAAA"
     polyA_site      1543
                     /gene="Rhbdl1"
                     /gene_synonym="Rhbdl"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcaga gcaggcggag cgggccggcc ggggcggagc ggagcggtcc gcagagcagc
       61 ccctcccggc ctcggccgac cccggccctc ggcccggctc tatggacagg agctcgctgc
      121 tgcagctcat tcaggagcag cagctggatc ctgagaacac aggcttcatc ggtgcggaca
      181 ccttcgctgg tctggtacac agccatgagc tgcccctgga ccccaccaag ttggacatgt
      241 tggtggctct ggctcagagc aacgagcggg gccaggtctg ctaccaggag ctggtggacc
      301 tgatcagcag caagcgttcc agcagcttca agagagccat tgctaacgga cagcgggcac
      361 tgccccgaga cggactgcta gatgagccag gcctgagtgt ctacaagcgg tttgtgcgct
      421 atgtggccta cgagatcctg ccctgcgagg tggaccgccg ctggtacttc tacaggcacc
      481 gcacctgccc accccctgtg ttcatggcct cggtcactct tgcccagatc atcgtgttcc
      541 tgtgctacgg ggcacgtctc aacaagtggg tgctccagac ctaccaccct gaatatatga
      601 agagccctct ggtgtatcac ccaggacacc gtgctcgggc atggcgcttc ctcacctaca
      661 tgttcatgca tgtcgggctg gagcagctag ggttcaatgc cctcctgcag ctgatgatcg
      721 gtgtgcccct ggagatggta catggcgtgc ttcgcatcag cctgctctac ctggcgggcg
      781 tgctggcagg ctccctgact gtctctatca cagatatgcg tgcccccgtg gtagggggct
      841 ctggaggggt ctatgccctg tgctcagcac acctggccaa tgttgtcatg aactgggctg
      901 ggatgcggtg tccatacaag ctgctgagga tggtgctggc tctggtgtgc atgagttccg
      961 aagtgggccg ggctgtgtgg ctacgcttct ccccaccact gcctgcctca ggcccacagc
     1021 ccagcttcat ggcacacctg gctggtgcag tggtaggtgt aagcatgggc cttaccatcc
     1081 ttcggagcta tgaggaacgc ctgagggacc agtgcggctg gtgggtggtg ctacttgcct
     1141 atggcacctt cctgcttttc gccatcttct ggaacgtctt tgcctatgac ctgctgggtg
     1201 ccgatatccc ccctccacct tgacctgctc cctagggcca tgtggctaga gccaggcacc
     1261 aggtgggcct gcatgtctgc cctatatgaa tggacctctc ggctgctttt ccccacaggg
     1321 gcaggggggc cctgtgatcc cccaccccca gctgaagcca agtcttactg cagcccttgc
     1381 tgcacccccc ccccccaggc tttccagggg gaggggtgtt actgggccag ggctgggtgg
     1441 aggaccttga gcgtggccct agaggagacc ccttccctcc ccactgaccc caggacttgc
     1501 agtctgagcc tttttggaga atgaataaat attttacaca gcaaaaaaaa aaaaaaa
//
