LOCUS       NM_001167680            3613 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus rhomboid 5 homolog 2 (Rhbdf2), transcript variant 2,
            mRNA.
ACCESSION   NM_001167680
VERSION     NM_001167680.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3613)
  AUTHORS   Kim,J., Kim,J.H., Kim,Y., Lee,J., Lee,H.J., Koh,S.J., Im,J.P. and
            Kim,J.S.
  TITLE     iRhom2 deficiency reduces sepsis-induced mortality associated with
            the attenuation of lung macrophages in mice
  JOURNAL   Histochem Cell Biol 162 (5), 415-428 (2024)
   PUBMED   39134731
  REMARK    GeneRIF: iRhom2 deficiency reduces sepsis-induced mortality
            associated with the attenuation of lung macrophages in mice.
REFERENCE   2  (bases 1 to 3613)
  AUTHORS   Azzopardi,S.A., Lu,H.Y., Monette,S., Rabinowitsch,A.I.,
            Salmon,J.E., Matsunami,H. and Blobel,C.P.
  TITLE     Role of iRhom2 in Olfaction: Implications for Odorant Receptor
            Regulation and Activity-Dependent Adaptation
  JOURNAL   Int J Mol Sci 25 (11), 6079 (2024)
   PUBMED   38892263
  REMARK    GeneRIF: Role of iRhom2 in Olfaction: Implications for Odorant
            Receptor Regulation and Activity-Dependent Adaptation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3613)
  AUTHORS   Calligaris,M., Spano,D.P., Bonelli,S., Muller,S.A., Carcione,C.,
            D'apolito,D., Amico,G., Miele,M., Di Bella,M., Zito,G., Nuti,E.,
            Rossello,A., Blobel,C.P., Lichtenthaler,S.F. and Scilabra,S.D.
  TITLE     iRhom2 regulates ectodomain shedding and surface expression of the
            major histocompatibility complex (MHC) class I
  JOURNAL   Cell Mol Life Sci 81 (1), 163 (2024)
   PUBMED   38570362
  REMARK    GeneRIF: iRhom2 regulates ectodomain shedding and surface
            expression of the major histocompatibility complex (MHC) class I.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3613)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3613)
  AUTHORS   Dulloo,I., Tellier,M., Levet,C., Chikh,A., Zhang,B., Blaydon,D.C.,
            Webb,C.M., Kelsell,D.P. and Freeman,M.
  TITLE     Cleavage of the pseudoprotease iRhom2 by the signal peptidase
            complex reveals an ER-to-nucleus signaling pathway
  JOURNAL   Mol Cell 84 (2), 277-292 (2024)
   PUBMED   38183983
  REMARK    GeneRIF: Cleavage of the pseudoprotease iRhom2 by the signal
            peptidase complex reveals an ER-to-nucleus signaling pathway.
REFERENCE   6  (bases 1 to 3613)
  AUTHORS   Zettl,M., Adrain,C., Strisovsky,K., Lastun,V. and Freeman,M.
  TITLE     Rhomboid family pseudoproteases use the ER quality control
            machinery to regulate intercellular signaling
  JOURNAL   Cell 145 (1), 79-91 (2011)
   PUBMED   21439629
REFERENCE   7  (bases 1 to 3613)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   8  (bases 1 to 3613)
  AUTHORS   Shi,Y.Z., Wang,D.P., Hu,L.D., Zhao,G.P., Wang,Y.Z., Kong,X.Y. and
            Li,S.R.
  TITLE     A high-resolution genetic and physical map of a mouse coat
            abnormality locus (Uncv)
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35 (5),
            397-402 (2003)
   PUBMED   12766798
REFERENCE   9  (bases 1 to 3613)
  AUTHORS   Johnson,K.R., Lane,P.W., Cook,S.A., Harris,B.S., Ward-Bailey,P.F.,
            Bronson,R.T., Lyons,B.L., Shultz,L.D. and Davisson,M.T.
  TITLE     Curly bare (cub), a new mouse mutation on chromosome 11 causing
            skin and hair abnormalities, and a modifier gene (mcub) on
            chromosome 5
  JOURNAL   Genomics 81 (1), 6-14 (2003)
   PUBMED   12573256
REFERENCE   10 (bases 1 to 3613)
  AUTHORS   Li,S.R., Wang,D.P., Yu,X.L., Ge,B.S., Wang,C.E., Lu,Y.F., Li,J.Q.,
            Wu,N., Li,R.F., Zhu,S.E., Zhang,Z.C. and Chen,Y.F.
  TITLE     Uncv (uncovered): a new mutation causing hairloss on mouse
            chromosome 11
  JOURNAL   Genet Res 73 (3), 233-238 (1999)
   PUBMED   10425919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL607039.25.
            
            On Mar 20, 2020 this sequence version replaced NM_001167680.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            as compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052182.1, AK154639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL607039.25        51751-51793         c
            44-219              AL607039.25        37877-38052         c
            220-419             AL607039.25        34801-35000         c
            420-544             AL607039.25        33681-33805         c
            545-740             AL607039.25        32816-33011         c
            741-944             AL607039.25        32534-32737         c
            945-1073            AL607039.25        31951-32079         c
            1074-1192           AL607039.25        31505-31623         c
            1193-1393           AL607039.25        31226-31426         c
            1394-1505           AL607039.25        29762-29873         c
            1506-1580           AL607039.25        29462-29536         c
            1581-1742           AL607039.25        29167-29328         c
            1743-1849           AL607039.25        28858-28964         c
            1850-1913           AL607039.25        28659-28722         c
            1914-2008           AL607039.25        28468-28562         c
            2009-2084           AL607039.25        28183-28258         c
            2085-2185           AL607039.25        27971-28071         c
            2186-2339           AL607039.25        27634-27787         c
            2340-3613           AL607039.25        25738-27011         c
FEATURES             Location/Qualifiers
     source          1..3613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11"
     gene            1..3613
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /note="rhomboid 5 homolog 2"
                     /db_xref="GeneID:217344"
                     /db_xref="MGI:MGI:2442473"
     exon            1..43
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            44..219
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            220..419
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2759
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /note="isoform 1 is encoded by transcript variant 2;
                     rhomboid family member 2; inactive rhomboid protein 2;
                     rhomboid-like protein 6; rhomboid-related protein;
                     rhomboid veinlet-like protein 6; iRhom2; rhomboid,
                     veinlet-like 6; uncovered"
                     /codon_start=1
                     /product="inactive rhomboid protein 2 isoform 1"
                     /protein_id="NP_001161152.1"
                     /db_xref="CCDS:CCDS25672.1"
                     /db_xref="GeneID:217344"
                     /db_xref="MGI:MGI:2442473"
                     /translation="MASADKNGSNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDS
                     MLPERRKNPAYLKSVSLQEPRGRWQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGDW
                     EGKRQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPL
                     ARGRAFRHPDEVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLPRRKRISVAHMSFQAA
                     AALLKGRSVLDATGQRCRHVKRSFAYPSFLEEDAVDGADTFDSSFFSKEEMSSMPDDV
                     FESPPLSASYFRGVPHSASPVSPDGVHIPLKEYSGGRALGPGTQRGKRIASKVKHFAF
                     DRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVI
                     CTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIR
                     KDQQIEQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTGPSDKS
                     DLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNHTGLLHIDCKI
                     KGRPCCIGTKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQ
                     FYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIF
                     LPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWID
                     NIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYP
                     INWPWIEYLTCFPFTSRFCEKYELDQVLH"
     exon            420..544
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            545..740
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            741..944
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1073
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1192
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1393
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1505
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1580
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1742
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1849
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1913
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2008
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2084
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2185
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2339
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..3613
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3590..3595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /note="hexamer: ATTAAA"
     polyA_site      3613
                     /gene="Rhbdf2"
                     /gene_synonym="4732465I17Rik; cub; Rhbdl6; Uncv"
                     /note="major polyA site"
ORIGIN      
        1 actctgctct cagccgcttc ccgggacgtg gggcctccga gaggttggcc tgcttgggcg
       61 gctgccctgc ctgacccaca gccatctgtc agtccatctg tccgccttga ccccaggaga
      121 cccagagatc gaggaaagga tcggagcatg gtgtagacac cctcagccag cccagggagc
      181 ccggccccgc acatctgagg gaaggaagtg gctggccagg tcctgcggcc cctctggatg
      241 cccgtgctgg cctctcctct agcatcgtgc ccaccatggc ctcagctgac aagaatggca
      301 gcaacctccc atctgtgtct ggtagccgcc tgcagagccg gaagccaccc aacctctcca
      361 tcaccatccc gccaccagag agccaggccc ccggcgagca ggatagcatg cttcctgaga
      421 ggcgcaagaa cccagcctac ctgaagagtg tcagcctaca ggagccccgg ggacgatggc
      481 aggagggcgc agagaagcgc cccggcttcc gccgccaggc ctccctgtcc cagagcatcc
      541 gcaagagcac agcccagtgg tttggggtca gcggcgactg ggagggcaag cgacaaaact
      601 ggcatcgtcg cagcctgcac cactgcagcg tgcactatgg ccgcctcaag gcctcgtgcc
      661 agagagaact ggagctgccc agccaggagg tgccatcctt ccagggcact gagtctccaa
      721 aaccgtgcaa gatgcccaag attgtggatc cactggctcg gggtagggcc ttccgccatc
      781 cagatgaggt ggaccggcct cacgctgccc acccacctct gactccaggg gtcctgtctc
      841 tcacatcctt caccagtgtc cgctctggct actcccatct gccccgccgc aagaggatat
      901 ctgttgccca tatgagcttt caggcagccg ccgccctcct caaggggcgt tccgtgctag
      961 atgcgactgg gcagcggtgc cggcatgtca aacgcagctt cgcttacccc agcttcctgg
     1021 aggaggatgc tgtcgatgga gctgacacct tcgactcctc cttttttagt aaggaagaaa
     1081 tgagctccat gcctgacgat gtctttgagt cccccccact ctctgccagc tacttccgag
     1141 gtgtcccaca ctctgcctcc ccggtctccc cggatggagt gcacatcccg ctaaaagaat
     1201 acagcggtgg ccgagccctg ggtcccggga cccagcgtgg caaacgcatt gcctccaaag
     1261 taaagcactt tgcatttgac cggaagaaga ggcactacgg cctgggcgtc gtgggtaact
     1321 ggctcaaccg aagctatcga cgcagcatca gcagcaccgt gcagcggcag ctggagagct
     1381 tcgatagcca ccggccctac ttcacctact ggctgacgtt cgttcacatc atcatcacct
     1441 tgctggtgat ctgcacctat ggcatcgcac ctgtgggctt tgcccagcac gttaccaccc
     1501 agctggtgct gaagaacaga ggcgtgtatg agagcgtgaa gtacatccag caggagaact
     1561 tctggattgg ccccagctcg attgacctca ttcacctggg agcaaagttc tcgccctgca
     1621 tccggaagga ccagcaaatt gagcagctgg tacggaggga gcgcgacatt gagcgcacct
     1681 ctggctgctg tgtccagaat gaccgctcgg gctgcatcca gaccctgaag aaggactgct
     1741 cggagacttt agccacgttc gtaaagtggc agaatgatac tgggccctca gacaagtctg
     1801 acctgagcca gaagcagcca tcggcggttg tgtgccacca agaccccagg acctgtgaag
     1861 agcctgcctc cagtggggcc cacatctggc ctgatgacat taccaagtgg ccgatctgca
     1921 cagagcaggc tcagagcaac cacacgggct tgttgcacat agactgtaag atcaaaggcc
     1981 gcccctgctg catcggcacc aagggcagct gcgagatcac cactcgggag tactgtgagt
     2041 tcatgcatgg ctatttccat gaagacgcga cgctgtgttc ccaggtgcac tgtttagaca
     2101 aggtgtgtgg gctcctgcct ttcctcaacc ctgaggtccc tgaccagttc taccggatct
     2161 ggctgtcttt attcctgcat gctggcatag tgcactgcct tgtgtctgtg gtcttccaaa
     2221 tgaccatcct gagggaccta gagaagctgg ccggctggca ccgcatctcc atcatcttca
     2281 tccttagtgg cattacaggc aacctggcca gcgccatctt cctcccctac cgggcagagg
     2341 tgggcccagc cgggtcgcag ttcggcctcc tcgcctgcct cttcgtggag ctgttccaga
     2401 gctggcagct gttggagcgg ccgtggaagg ccttcttcaa cctgtcggcc attgtgcttt
     2461 tcctcttcat ctgtggcctc ctgccctgga tagacaacat cgcccacatc ttcgggttcc
     2521 tcagcggcat gcttctggcc ttcgccttcc tgccttacat taccttcggc accagcgaca
     2581 agtaccgcaa gcgagccctc atcctcgtgt cgctgctggt ctttgctggg ctctttgctt
     2641 ccctggtgct gtggctgtac atctacccca tcaactggcc ctggatcgag tacctcacct
     2701 gctttccctt caccagccgc ttctgtgaga agtacgagct agaccaggtg ctacactaac
     2761 tgcagagatt gtgtgtctgc cctgggccgt gtgtctatga accggtgggg ccctgagccc
     2821 agcagctcgg tccacactca aggctgactc cagatgagac gggcggtaaa ggcaggctcc
     2881 ccagggagat gactcctcct ttctcaggtc tgaatgttcc tgacccaagt ctgggggaca
     2941 tccaggacac ttgcttctct gaggctcagg tcccaggccc tgcctgcctc tctggctcta
     3001 taaagatgat aacttttctt gggcctctgg cctctgcggg tgctgtctcc ccactgacac
     3061 tgtgactgtg acctcgccag acacacagct gctctctcag ttgtccccag ggttgaggtc
     3121 cttaccatgc tgctatgacc ccgttttcct gtttctcctc tcctccctgt ccttcctgtg
     3181 tttgtccgtg gactcgtgag cctgctcctg aggctcctgg acatagagca ttgtggggaa
     3241 ggctctggct gttgtctatg ggggatgaca agcaaggaga gatggctata cagggatgct
     3301 aggggctttt gttaagcaaa gaagccagct ctcctaagcc catcagctgc cctagctcca
     3361 gcatgtgtct ggctgcacag gttggctctg atcccaggat gcccctgcca cctgccctca
     3421 ctcctgcgtg gccgtgggcc gagccgcctt gaggactagc tcccagagga ggcctgaggc
     3481 ccagactggt gggttttttg gttttgtttt gttttttttt ttccaattta tattatggtc
     3541 ctaattttgt aaagtaacgc taactttgta cggatgatgt ctcaagttta ttaaatgaca
     3601 ttctttatta aaa
//
