LOCUS       NM_010117               2955 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus rhomboid 5 homolog 1 (Rhbdf1), transcript variant 1,
            mRNA.
ACCESSION   NM_010117
VERSION     NM_010117.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2955)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2955)
  AUTHORS   Rabinowitsch,A.I., Maretzky,T., Weskamp,G., Haxaire,C.,
            Tueshaus,J., Lichtenthaler,S.F., Monette,S. and Blobel,C.P.
  TITLE     Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis
            with esophageal cancer mutant mice
  JOURNAL   J Cell Sci 136 (13) (2023)
   PUBMED   37282854
REFERENCE   3  (bases 1 to 2955)
  AUTHORS   Sun,H., Yang,H., Wu,Y., Bian,H., Wang,M., Huang,Y. and Jin,J.
  TITLE     iRhom1 rescues cognitive dysfunction in multiple sclerosis via
            preventing myelin injury
  JOURNAL   Genes Brain Behav 20 (8), e12771 (2021)
   PUBMED   34672089
  REMARK    GeneRIF: iRhom1 rescues cognitive dysfunction in multiple sclerosis
            via preventing myelin injury.
REFERENCE   4  (bases 1 to 2955)
  AUTHORS   Tushaus,J., Muller,S.A., Shrouder,J., Arends,M., Simons,M.,
            Plesnila,N., Blobel,C.P. and Lichtenthaler,S.F.
  TITLE     The pseudoprotease iRhom1 controls ectodomain shedding of membrane
            proteins in the nervous system
  JOURNAL   FASEB J 35 (11), e21962 (2021)
   PUBMED   34613632
  REMARK    GeneRIF: The pseudoprotease iRhom1 controls ectodomain shedding of
            membrane proteins in the nervous system.
REFERENCE   5  (bases 1 to 2955)
  AUTHORS   Fang,R., Haxaire,C., Otero,M., Lessard,S., Weskamp,G.,
            McIlwain,D.R., Mak,T.W., Lichtenthaler,S.F. and Blobel,C.P.
  TITLE     Role of iRhoms 1 and 2 in Endochondral Ossification
  JOURNAL   Int J Mol Sci 21 (22), 8732 (2020)
   PUBMED   33227998
  REMARK    GeneRIF: Role of iRhoms 1 and 2 in Endochondral Ossification.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2955)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 2955)
  AUTHORS   Dragani,T.A., Peissel,B., Zanesi,N., Aloisi,A., Dai,Y., Kato,M.,
            Suzuki,H. and Nakashima,I.
  TITLE     Mapping of melanoma modifier loci in RET transgenic mice
  JOURNAL   Jpn J Cancer Res 91 (11), 1142-1147 (2000)
   PUBMED   11092979
REFERENCE   8  (bases 1 to 2955)
  AUTHORS   Kielman,M.F., Smits,R., Hof,I. and Bernini,L.F.
  TITLE     Characterization and comparison of the human and mouse
            Dist1/alpha-globin complex reveals a tightly packed multiple gene
            cluster containing differentially expressed transcription units
  JOURNAL   Genomics 32 (3), 341-351 (1996)
   PUBMED   8838797
REFERENCE   9  (bases 1 to 2955)
  AUTHORS   Hendrey,J., Lin,D. and Dziadek,M.
  TITLE     Developmental analysis of the Hba(th-J) mouse mutation: effects on
            mouse peri-implantation development and identification of two
            candidate genes
  JOURNAL   Dev Biol 172 (1), 253-263 (1995)
   PUBMED   7589805
REFERENCE   10 (bases 1 to 2955)
  AUTHORS   Kielman,M.F., Smits,R., Devi,T.S., Fodde,R. and Bernini,L.F.
  TITLE     Homology of a 130-kb region enclosing the alpha-globin gene
            cluster, the alpha-locus controlling region, and two non-globin
            genes in human and mouse
  JOURNAL   Mamm Genome 4 (6), 314-323 (1993)
   PUBMED   8318735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY270878.1, BY733688.1, CN664154.1, CD554689.1, AK144437.1 and
            AI842763.1.
            
            On Apr 8, 2009 this sequence version replaced NM_010117.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027346.1, SRR7345562.2303203.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                BY270878.1         8-100
            94-544              BY733688.1         82-532
            545-702             CN664154.1         126-283
            703-1196            CD554689.1         1-494
            1197-2937           AK144437.1         1066-2806
            2938-2955           AI842763.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.83 cM"
     gene            1..2955
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /note="rhomboid 5 homolog 1"
                     /db_xref="GeneID:13650"
                     /db_xref="MGI:MGI:104328"
     exon            1..125
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            126..266
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2720
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rhomboid family member 1; inactive rhomboid protein 1;
                     iRhom1; epidermal growth factor receptor related sequence;
                     epidermal growth factor receptor-related protein; rhomboid
                     family 1"
                     /codon_start=1
                     /product="inactive rhomboid protein 1 isoform 1"
                     /protein_id="NP_034247.2"
                     /db_xref="CCDS:CCDS24519.1"
                     /db_xref="GeneID:13650"
                     /db_xref="MGI:MGI:104328"
                     /translation="MSEARRDSTSSLQRKKPPWLKLDIPAAVPPAAEEPSFLQPLRRQ
                     AFLRSVSMPAETARVPSPHHEPRRLVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQ
                     RKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLA
                     RGRAFRMADDTADGLSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRA
                     AAALVKGRSIRDGTLRRGQRRSFTPASFLEEDMVDFPDELDTSFFAREGVLHEEMSTY
                     PDEVFESPSEAALKDWEKAPDQADLTGGALDRSELERSHLMLPLERGWRKQKEGGPLA
                     PQPKVRLRQEVVSAAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSY
                     VKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRKRGVYE
                     NVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFILAAREREKHSACCVRNDR
                     SGCVQTSKEECSSTLAVWVKWPVHPSAPDLAGNKRQFGSVCHQDPRVCDEPSSEDPHE
                     WPEDITKWPICTKSSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFH
                     EEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTVLR
                     DLEKLAGWHRIAIIYLLSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQ
                     ILARPWRAFFKLLAVVLFLFAFGLLPWIDNFAHISGFVSGLFLSFAFLPYISFGKFDL
                     YRKRCQIIIFQVVFLGLLAGLVVLFYFYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
                     "
     exon            267..397
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            398..611
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            612..821
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            822..944
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1102
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1360
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1472
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1547
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1709
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1810
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1874
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..1969
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2045
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2146
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2300
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2939
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2900..2905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /note="hexamer: AATAAA"
     polyA_site      2939
                     /gene="Rhbdf1"
                     /gene_synonym="C16ORF8; Dist; Dist1; Egfr-rs; mKIAA4242"
                     /note="major polyA site"
ORIGIN      
        1 ggcattccca ggcggacggg tcgggccggc gcgcgggcgg cgcaggcagg gactaggcgc
       61 gggcgccctc ccggcccgca gcggcggcag cagccggtgc agacccttct gaggacccta
      121 cggcggcttg tctcactgcg cccggaacca tgagtgaagc caggagagac agtactagca
      181 gcctgcaacg caagaaaccc ccatggctca agttggacat cccagccgcg gtgcccccgg
      241 cagcagagga gcccagcttc ctgcagcccc tgcggcgaca ggctttcttg cggagtgtga
      301 gtatgccagc tgagacagcc cgggtcccat caccccacca tgagcctcgc cggctggtgc
      361 tgcagcgtca gacatccatc acacagacca tccgcagggg gacagcagac tggtttggag
      421 tgagcaagga cagtgacagc acccagaagt ggcagcgcaa gagcatccgt cactgcagcc
      481 agcggtatgg gaagctaaag ccgcaggtca tccgggagct ggacctgccc agccaggaca
      541 atgtgtccct aaccagcacc gagacaccac ctcccctcta cgtggggcca tgccagctgg
      601 gcatgcagaa gatcatagac cctctggccc gaggccgggc ctttcgcatg gctgatgaca
      661 ctgctgatgg cctgagtgcc ccccacactc ccgtcacacc aggtgcagcc tccctctgct
      721 ctttctccag ctcccgctca ggtttcaacc gactccctcg gcgtcgcaaa cgtgaatcgg
      781 tggccaagat gagcttccgg gccgctgcag cattggtgaa gggtcggtct attagggatg
      841 gcactttacg aaggggacag cgccgaagct ttacccctgc cagctttctt gaggaagaca
      901 tggtggactt ccctgatgag ttggatacat ctttctttgc tcgggaaggt gtcctccacg
      961 aggagatgtc cacgtaccca gatgaggtgt ttgagtcccc atcagaggca gcgctcaagg
     1021 actgggagaa agccccggat caggccgacc tcacgggtgg ggccctggac cgcagtgagc
     1081 ttgagagaag ccacttgatg ttgcccctgg aacgaggctg gagaaagcag aaggaaggcg
     1141 gccctctagc cccgcagccc aaggtgcggc ttcgccagga ggtggtcagt gcggcgggac
     1201 ccaggagggg tcagcgtatc gctgtgccag tgcgcaaact cttcgctcgg gaaaagcggc
     1261 cttatggtct ggggatggtg ggacggctca ccaaccgcac gtaccggaaa cgcatcgaca
     1321 gctatgtcaa gcggcagatc gaggacatgg atgatcacag gcccttcttc acttactggc
     1381 tcacctttgt gcactcactg gtcaccattc tggctgtgtg catctatggc atagcgcccg
     1441 tgggcttctc gcagcatgag acggtggact cggtacttcg gaagcggggt gtctatgaga
     1501 atgtcaaata cgtccagcag gagaacttct ggattggccc cagctcggag gccctcattc
     1561 acttgggtgc caagttctca ccctgcatgc gtcaggaccc acaggtgcac agcttcatcc
     1621 tggctgcccg ggagcgtgaa aagcactcgg cttgctgtgt acgcaatgat cggtctgggt
     1681 gtgtgcagac ttccaaggag gagtgctcgt ccacgttggc ggtgtgggtg aagtggcccg
     1741 ttcatcctag tgccccagac cttgcaggca acaagagaca gtttggttct gtctgccacc
     1801 aggaccccag ggtatgtgac gagccttcct ctgaggatcc ccacgagtgg ccagaagata
     1861 tcaccaagtg gccgatctgc accaaaagca gcgcggggaa ccacactaac caccctcaca
     1921 tggattgtgt cataacaggc cggccttgct gcatcggcac caagggcagg tgtgagatca
     1981 cctcccggga gtactgtgac ttcatgaggg gctacttcca tgaggaggcc acactctgct
     2041 ctcaggtgca ctgcatggac gatgtctgtg gcctcctgcc tttcctcaat cctgaggtgc
     2101 ctgaccagtt ctaccgcctg tggctgtccc tcttcctgca cgctgggatc ctgcactgct
     2161 tggtgtccgt ctgcttccag atgacggtcc tgcgggacct ggagaagctg gcaggctggc
     2221 accgcatagc catcatctac ctgctgagtg gtatcacggg caatctagcc agtgccatct
     2281 tcctgccata ccgggcagag gtaggtccgg ccggctccca gtttggcatc ctggcctgcc
     2341 tctttgtgga gttgttccag agctggcaga tcctggcccg accctggcgt gccttcttca
     2401 agctcctggc cgtggtgctc ttcctctttg cctttgggct gctgccctgg atcgacaact
     2461 tcgcccacat ctcgggcttt gtcagcggcc tcttcctttc ctttgccttc ctgccttaca
     2521 tcagctttgg caagttcgac ctgtaccgca agcgctgcca gatcatcatc ttccaggtcg
     2581 tcttcctggg cctgctggcc ggcctggtgg tcctcttcta cttctacccg gtgcgctgtg
     2641 aatggtgcga gttcctcacc tgcatccctt tcacggacaa gttctgtgaa aagtacgagc
     2701 tggacgctca gctccactga accagccgtg gactccccag gccagcccgg cctcccaggg
     2761 ctgaacagat gggtgcttcc tggacactga cctcttgtgc cttgctcgct ccggttgtac
     2821 gcttacactg ctgggcattt agtacatgag ttcccatgat aacctcctaa ctagtccccg
     2881 acaaccacct catgtggtca ataaatggac tgggagcgtt ttagctgcca ctaactcgaa
     2941 aaaaaaaaaa aaaaa
//
