LOCUS       NM_177370               1995 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus rhomboid domain containing 3 (Rhbdd3), transcript
            variant 2, mRNA.
ACCESSION   NM_177370 XM_988396
VERSION     NM_177370.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1995)
  AUTHORS   Liu,J., Han,C., Xie,B., Wu,Y., Liu,S., Chen,K., Xia,M., Zhang,Y.,
            Song,L., Li,Z., Zhang,T., Ma,F., Wang,Q., Wang,J., Deng,K.,
            Zhuang,Y., Wu,X., Yu,Y., Xu,T. and Cao,X.
  TITLE     Rhbdd3 controls autoimmunity by suppressing the production of IL-6
            by dendritic cells via K27-linked ubiquitination of the regulator
            NEMO
  JOURNAL   Nat Immunol 15 (7), 612-622 (2014)
   PUBMED   24859449
  REMARK    GeneRIF: report that Rhbdd3, a member of the rhomboid family of
            proteases, suppressed the activation of dendritic cells and
            production of interleukin 6 (IL-6) triggered by Toll-like receptors
REFERENCE   2  (bases 1 to 1995)
  AUTHORS   Liu,J., Liu,S., Xia,M., Xu,S., Wang,C., Bao,Y., Jiang,M., Wu,Y.,
            Xu,T. and Cao,X.
  TITLE     Rhomboid domain-containing protein 3 is a negative regulator of
            TLR3-triggered natural killer cell activation
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7814-7819 (2013)
   PUBMED   23610400
  REMARK    GeneRIF: Rhbdd3 is a feedback inhibitor of TLR3-triggered NK cell
            activation
REFERENCE   3  (bases 1 to 1995)
  AUTHORS   Bahar,A., Simpson,D.J., Cutty,S.J., Bicknell,J.E., Hoban,P.R.,
            Holley,S., Mourtada-Maarabouni,M., Williams,G.T., Clayton,R.N. and
            Farrell,W.E.
  TITLE     Isolation and characterization of a novel pituitary tumor apoptosis
            gene
  JOURNAL   Mol Endocrinol 18 (7), 1827-1839 (2004)
   PUBMED   15105437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645845.14, BB841991.1, AK077457.1 and BY641428.1.
            
            On Mar 13, 2014 this sequence version replaced NM_177370.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, and 3 encode the same isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077457.1, SRR7345562.3099356.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL645845.14        31779-31849
            72-165              BB841991.1         74-167
            166-1986            AK077457.1         2-1822
            1987-1995           BY641428.1         404-412
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.26 cM"
     gene            1..1995
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /note="rhomboid domain containing 3"
                     /db_xref="GeneID:279766"
                     /db_xref="MGI:MGI:2444684"
     exon            1..294
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     exon            295..445
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     exon            446..636
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     exon            637..673
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     exon            674..862
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     CDS             715..1872
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /note="isoform a is encoded by transcript variant 2;
                     pituitary-derived proapoptotic; rhomboid domain-containing
                     protein 3"
                     /codon_start=1
                     /product="rhomboid domain-containing protein 3 isoform a"
                     /protein_id="NP_796344.1"
                     /db_xref="CCDS:CCDS24397.1"
                     /db_xref="GeneID:279766"
                     /db_xref="MGI:MGI:2444684"
                     /translation="MHAWEAPGSLSRALPLASSVLMLLLSCLWLLGAGPSLRLAPELL
                     MEPWQVHRLLTHALGHTALPGLLLSLLLLPTLGWWQECHLGTVRFLHNSTVLALATGL
                     LAVLLAGLGVSGAAGGCGYMPVHLAMLAGQSHHPGWPQRTLPPWLLPWLLLALTLLLS
                     SEPPFLQLLCGLLTGLAYAAGAFQWLELSEQRLQVLQEGVLCKSLARCWPLRLFPTPG
                     SLGELPVTYPAGVRPATPRPPYLASSDSWPHSDGSAQLPPRLGPGQLTWKNSERGLDW
                     AGSSFASATTMWAALDEQMLQEGIQASLLDVSVQGSQSSLWLPKPSVSSLRLQQLQHM
                     GFPTEQAAVALAATGRVEGAVSLLVEGLVDTEALVTEGRSSPAHCTGTGAS"
     exon            863..1246
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1409
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1694
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1995
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1965..1970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /note="hexamer: AATAAA"
     polyA_site      1988
                     /gene="Rhbdd3"
                     /gene_synonym="Ptag"
                     /note="major polyA site"
ORIGIN      
        1 gtgagcgagg gttacccacg aacccgagag ctccttggcg cgaggcgcgg tggctcggaa
       61 tggttacgcc cgctggctct agggaccgtc tctgaagagt ctgccctgga gggagacgga
      121 ggctggcggg agggctgggg gaagggatcc cggccggcct gaaacaactg ctgactaatc
      181 ggcgggcggg atcacgcgcc tctgtgtgcg tgcagcgggt ttcgggcacc gagggctcgg
      241 cctggaaccg gcggccggac ttaccgggcg ggcccccctg ctcggttttc taggaaaacc
      301 cagaacccac gaaattgagt tctttcctta aagttacaaa gctgaatgcg acccagaccc
      361 cgggcctccc ctctctgtac accgcccgga agcttcgcca cactgtcctt gccttcccac
      421 tctgtcctcc tggcttccct gcaaggagtg ttacggcttg cctatgatgt atgaggccct
      481 agtttccatt cctatcgcca agaaagagaa gagactggtc cagaggactc gaggcccagt
      541 tccctatgtc catggacctg tcccctagtg cccagggatg gaatggttgt aagaaggtgc
      601 aagaggaagc ttcattttag gtgaccctgc ctccagcact gggaagcaaa tccaggtgcc
      661 tgtgcatggc tagcctacag cctcaggacc acctttgact accatcaacc aaatatgcat
      721 gcctgggagg cccctggctc actgtcccgg gccctgcccc ttgcttcctc agtcctgatg
      781 ctgctgctga gctgtctgtg gttattgggg gctggcccca gcctcagatt ggctccagag
      841 ctgctaatgg aaccctggca ggtgcacagg ctgctgaccc atgctctggg ccacactgca
      901 ctgccaggcc tgctcctgag cctgctgctt ctgcccactc tgggctggtg gcaggagtgc
      961 catctgggca ctgtgcgctt cctgcacaac tccactgtgc ttgccctggc tactgggctg
     1021 ctggctgtgc tgctggcggg ccttggggtg tccggtgcgg ctggaggctg tggctatatg
     1081 cctgtccatc tagctatgct ggctggacag agtcaccacc ctggatggcc tcagaggaca
     1141 ctgccaccat ggctgctacc atggctgctg ctggccctga ccctgctgct cagctctgag
     1201 ccacccttcc tgcagctcct ttgtggcctt ctcactggcc tagcctatgc tgctggggcc
     1261 ttccagtggc tggagctctc agagcagaga ctgcaggtgt tacaggaagg tgtcctttgc
     1321 aagtctctgg cccgatgctg gccgctgagg ctctttccca ccccgggcag tctgggtgag
     1381 ctgcctgtca cttatcctgc tggagtgagg cctgccaccc ctagacctcc ttacctggct
     1441 tcctcagact cctggcctca cagtgatggc tctgctcagc tcccaccacg cctggggcct
     1501 ggacagctga catggaagaa ctcggagagg ggcttggact gggctgggtc tagctttgct
     1561 tcagcaacga cgatgtgggc agccctagac gagcagatgc tacaggaagg gatccaggcc
     1621 tcccttcttg atgtgtcagt tcagggttcc cagagctctc tgtggttgcc aaagccctct
     1681 gtgtcttctc taaggctgca gcagctacag cacatgggat tccccactga gcaggctgca
     1741 gtggccttgg cagctacagg gcgtgtagag ggggcagtgt cactgctggt ggaagggcta
     1801 gtggacactg aggccctagt gactgaggga aggagtagcc ctgcccactg cacaggcact
     1861 ggggcctcat agtcctttcc ttgtctgctg agggcttggt gcggtcttga ctgcatccct
     1921 ggggtaggac taggccccaa catgtttccc tggtactttg taagaataaa agctgatttg
     1981 tttttcaacc tggtc
//
