LOCUS       NM_146002               4171 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus rhomboid domain containing 2 (Rhbdd2), transcript
            variant 1, mRNA.
ACCESSION   NM_146002
VERSION     NM_146002.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4171)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   2  (bases 1 to 4171)
  AUTHORS   Ahmedli,N.B., Gribanova,Y., Njoku,C.C., Naidu,A., Young,A.,
            Mendoza,E., Yamashita,C.K., Ozgul,R.K., Johnson,J.E., Fox,D.A. and
            Farber,D.B.
  TITLE     Dynamics of the rhomboid-like protein RHBDD2 expression in mouse
            retina and involvement of its human ortholog in retinitis
            pigmentosa
  JOURNAL   J Biol Chem 288 (14), 9742-9754 (2013)
   PUBMED   23386608
  REMARK    GeneRIF: RHBDD2 protein plays important roles in the development
            and normal function of the retina
REFERENCE   3  (bases 1 to 4171)
  AUTHORS   Cattaruzza,M., Lattrich,C. and Hecker,M.
  TITLE     Focal adhesion protein zyxin is a mechanosensitive modulator of
            gene expression in vascular smooth muscle cells
  JOURNAL   Hypertension 43 (4), 726-730 (2004)
   PUBMED   14967842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140006.1, AK041845.1 and AC083948.3.
            
            On Jan 13, 2006 this sequence version replaced NM_146002.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.143734.1, BC028957.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               AK140006.1         38-646
            610-1472            AK041845.1         556-1418
            1473-4171           AC083948.3         28716-31414
FEATURES             Location/Qualifiers
     source          1..4171
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.31 cM"
     gene            1..4171
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="rhomboid domain containing 2"
                     /db_xref="GeneID:215160"
                     /db_xref="MGI:MGI:1915612"
     exon            1..265
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1173
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rhomboid domain-containing protein 2; rhomboid-like
                     protein 7; upregulated during skeletal muscle growth 1;
                     rhomboid, veinlet-like 7"
                     /codon_start=1
                     /product="rhomboid domain-containing protein 2 isoform 1"
                     /protein_id="NP_666114.1"
                     /db_xref="CCDS:CCDS19743.1"
                     /db_xref="GeneID:215160"
                     /db_xref="MGI:MGI:1915612"
                     /translation="MAAPGPASRFWCSCPEVPSATFFTALLSLLVSGPRLFLLQPPLA
                     PSGLSLRSEALRNWQVYRLVTYIFVYENPVSLLCGAIIIWRFAGNFERTVGTVRHCFF
                     TLIFTVFSAIIYLSFESVSSLSKLGEVEDARGFTPVAFAMLGVTSVRSRMRRALVFGV
                     VVPSVLVPWLLLCASWLIPQTSFLSNVSGLLIGLSYGLTYCYSLDLSERVALKLDQKF
                     PFSLMRRIPLFKYISGSSAERRAAQSRRLNPAPGSYPTQSCHPHLTPSYPVTQMQHAS
                     GQKLASWPPGHMPSLPPYQPASGLCYVQNHFGPNPNASSVYPASAGTSQGVQPPSPIS
                     CPGTVYSGALGTPGATGSKESSKVAMP"
     exon            266..673
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..824
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..4171
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="hexamer: TATAAA"
     polyA_site      1943
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="major polyA site"
     regulatory      2295..2300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="hexamer: AATAAA"
     polyA_site      2322
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="major polyA site"
     regulatory      4079..4084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="hexamer: AATAAA"
     polyA_site      4100
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
     regulatory      4148..4153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
                     /note="hexamer: AATAAA"
     polyA_site      4171
                     /gene="Rhbdd2"
                     /gene_synonym="0610011L13Rik; Rhbdl7; Usmg1"
ORIGIN      
        1 gttgccaggg gagaccgccg caaggaggcg gaaattgagg agggaggcgg ggagtaccga
       61 ggccgcacgc tggaagggct cgcggccatg gcggccccgg gccccgcgag tcgcttctgg
      121 tgctcgtgtc ccgaggtgcc ctccgccaca ttcttcaccg ccctgctctc gctgctggtg
      181 tcgggccccc gcctgttcct gctgcagccg cctctggcgc cctcggggct gtctctgcgc
      241 tccgaggccc tgcgcaactg gcaagtttac aggctggtga cctacatctt cgtctatgag
      301 aacccagtct ccctgctctg tggcgccatc atcatctggc gctttgctgg caacttcgag
      361 aggaccgtgg gcaccgtccg ccattgcttc ttcaccttga tctttacggt cttctccgcc
      421 atcatctacc tgtcatttga gtctgtgtcc tcactgtcta agctggggga ggtggaggat
      481 gccagagggt tcaccccagt agctttcgcc atgctgggag tcacctcggt ccgctctcgc
      541 atgaggcggg ccctggtgtt cggtgtggtg gtgccttccg tccttgtgcc gtggttgctg
      601 ctgtgtgcct cctggctcat ccctcagacc tccttcctca gtaacgtctc tggccttttg
      661 attggcctgt cctatggcct cacctactgc tactccctcg acctctctga gcgagtagcc
      721 ctgaagcttg atcagaagtt ccccttcagc ctcatgagga ggattccctt gttcaagtac
      781 atctcaggtt cttctgccga aagaagagca gcccagagcc gtaggctgaa ccctgcacct
      841 ggctcctacc ccacacagag ttgccaccct catctgactc caagttatcc tgtcacccag
      901 atgcagcatg ccagtggcca gaaactggcc tcctggcctc ctggccacat gcccagccta
      961 cctccatacc agcctgcgtc cggcctgtgc tatgtgcaga accactttgg tcctaacccc
     1021 aatgcctcca gtgtgtaccc agcttctgca gggacctccc agggggtaca gcctccctcc
     1081 cctatcagct gtcctggcac tgtgtattca ggggccctgg gtaccccagg ggctacaggc
     1141 tccaaggagt cttccaaggt agccatgccc taaccagtct gcagaggcgg cttccacctt
     1201 gttggacaga ggaaggttct gagaatgtag gaattattta ttgaagccag ggcatgccgg
     1261 cctgtcattc cagctgcttg ggggttaagg ccaataggta aaaggtcaag gtctgtctgg
     1321 gctccagagt acgtccaagg caagcctagg atatgtatta acaaaaccct gtctcagaat
     1381 gaataacaat gactggggct ctgtggtaga atgcttactt agcataatta aggccctgag
     1441 tcctcagctc cacaaaacaa aaaagaatta ctaattagat acctctgtgt gccagctctg
     1501 aagagtactt tgataaatgt ccctgtatct gtgttgtttc acctcaaggc agctctagaa
     1561 agtagaaact ggatggtaag acaggcctgt aatctcagct atgatcaagg tcagccccag
     1621 ctacagagcg ggttttaggc tagccccccg ggcaggtata tcatggggtc ttgaggctcc
     1681 tgggcttctt ggttcctaat ccagtgtcaa gaaggtgcgg ttatcggctg ccagggactc
     1741 ttgccgtcct acccatcctg ccctgctcag tgcccatggg tccttacttg tgtctggtgt
     1801 gactgtacca ggtagtcctt gtaacatcgt cttccccgca gccatggctg atgggacttc
     1861 tgcctgactg gtgacctgca gcagcaggct ggtgatccgc cctgtgagtc acctctgtat
     1921 aaaaaccagc ctccaacctg ccagtggtgt gtggcatact gtgttcagtc ccgggcaagc
     1981 gtgacaccaa aaagctgtga ggagccagaa tcacatccag tctgtgctca gtggtctgca
     2041 gtgaggacct gatggggtgg gtggggacag cgaagtcaag agttgataaa cccagagatg
     2101 ggtacagcaa gtgaatgaga gactgtctca taaaagaatt ttctttttag taaaaataag
     2161 ctgagcatgg tggcacatgc ctttaatctt atcatgtagg aggcagagac aatggatctg
     2221 agtttgaagc cagcctggtc tatgtactga gttccaggat atccaaggct acaaagtgat
     2281 accctgtctc taaaaataaa gccaggtatg gaaatagtaa aagaattttc tttttagtaa
     2341 aaataagctg agcatggtgg cacatgcctt taatcccatc acttgggagg cagggcactt
     2401 aggtagatct ctaaagtcag cctggaccag ttccaggggt ggggatggga ggtggcttag
     2461 tgatgagtac ctgctaagca tgcaagtggc cctgggtttc atctctagta cttaaaagca
     2521 aagccatggc atcacaaggt attttagata cggtgtatgg ccttcatgtc caggagctct
     2581 atgggatgct ctgggctgcc tctgagggcc tgtattaggg ttctctagag tcacagaatt
     2641 tatagatagt ctctatatag taaaggaatt tattgatgac ttacagtcgg cagcccaatt
     2701 cccaacaatg gttcagtagt agctgtgaat ggaagtccaa gcatctagca gttactcagt
     2761 ctcacacagc aagcaggcga aggagcaaga atgagactcc cttcttccaa tgtccttata
     2821 tggtctctag cagaaggtgt agcccaggtt aaaggtgtgt gccaccacac ctttaattcc
     2881 agatgacctt gaactcgaga tctccctgtc ttaatctgga atccatagcc actatgcttc
     2941 aagatctcca taccaagatc cagatcagaa acttctatct cccagcctcc aggatagggt
     3001 cactggtaag ccttccaatt ctggattgta gttcattcca aatatagtca agttgacaac
     3061 caggaatagc cactacaggg ccctaagtat tccaatacag gtgattcctg accccaagcc
     3121 cactcctcca gagagggtag tctgaagatg ggcacagcca aatggtcttt gaaacccact
     3181 ggcaagcaag ccagtatgac atgagtaaga ttggcactgc attagagact tgagtcgata
     3241 gccaaggaaa caggtgcatc taggcctcag taaggacacg gctggaaact ggtgggaccc
     3301 ggagctttgg actgcagcca cgcctggcat ttcagtggca cttcctgaat acagccagat
     3361 gtgggctctt aggcaaggtc cttccactct gtagataggc ttgtgtgttc ttggtttctt
     3421 cctacatagg gtggctcact ggctagagct gtgaatgcca aacacccagg tttcctggcg
     3481 actgggctgt gagaattgtc aggtcctcct gtgtgaccta gttgctgcct ttactgatgg
     3541 gctccaagga tgcagaggaa ttgctaacag acaatgcaga gctggattcc agcttcctac
     3601 tgccccacac tgatggactg cccctagatc tccattccct gggcctttgt gtgatctgga
     3661 accagtgcac aggcagcctg aagctacact agagtggaac catctgtttc tcagcgcctg
     3721 ctttccttgc cttcagaagc agcctttgcc tagtaggttt cgctgcagat caacctccct
     3781 agggctctga ggtgatacct cagtggatgg aatctttccc ctcttctagg cccagaaaat
     3841 gaccttccct ggagagagga gtttgcagat tggactgagc tatgattttg tctctgtgga
     3901 gataacctcc agacacatgt gtttcacaag acacctgggc gatcccagcc ttccctcgtt
     3961 tgccaaatca tgtgtcccat gtctgcaagt catgactgag tctgtgcctg tccccaggct
     4021 ggggtcagag acatgccatg aaatatgtac tggggacacg ggtacaggtg tgccacgcaa
     4081 taaatatttg tcaaagtcta gatggccctg ccctggctgc tcagaatagt gagggagtgg
     4141 ataaataaat aaaggtgctg ggagctggga a
//
