LOCUS       NM_029777               3533 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus rhomboid domain containing 1 (Rhbdd1), transcript
            variant 1, mRNA.
ACCESSION   NM_029777 NM_146111
VERSION     NM_029777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3533)
  AUTHORS   Knopf,J.D., Steigleder,S.S., Korn,F., Kuhnle,N., Badenes,M.,
            Tauber,M., Theobald,S.J., Rybniker,J., Adrain,C. and Lemberg,M.K.
  TITLE     RHBDL4-triggered downregulation of COPII adaptor protein TMED7
            suppresses TLR4-mediated inflammatory signaling
  JOURNAL   Nat Commun 15 (1), 1528 (2024)
   PUBMED   38453906
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3533)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3533)
  AUTHORS   Wang,Z., Zhang,X., Liu,Y., Shi,X., Li,L., Jia,Y., Wu,F., Cui,H. and
            Li,L.
  TITLE     MiR-5195-3p functions as a tumor suppressor by targeting RHBDD1 in
            ovarian cancer
  JOURNAL   Histol Histopathol 38 (12), 1403-1413 (2023)
   PUBMED   36825753
  REMARK    GeneRIF: MiR-5195-3p functions as a tumor suppressor by targeting
            RHBDD1 in ovarian cancer.
REFERENCE   4  (bases 1 to 3533)
  AUTHORS   Lastun,V.L., Levet,C. and Freeman,M.
  TITLE     The mammalian rhomboid protein RHBDL4 protects against endoplasmic
            reticulum stress by regulating the morphology and distribution of
            ER sheets
  JOURNAL   J Biol Chem 298 (6), 101935 (2022)
   PUBMED   35436469
REFERENCE   5  (bases 1 to 3533)
  AUTHORS   Fleig,L., Bergbold,N., Sahasrabudhe,P., Geiger,B., Kaltak,L. and
            Lemberg,M.K.
  TITLE     Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD
            of membrane proteins
  JOURNAL   Mol Cell 47 (4), 558-569 (2012)
   PUBMED   22795130
REFERENCE   6  (bases 1 to 3533)
  AUTHORS   Wan,C., Fu,J., Wang,Y., Miao,S., Song,W. and Wang,L.
  TITLE     Exosome-related multi-pass transmembrane protein TSAP6 is a target
            of rhomboid protease RHBDD1-induced proteolysis
  JOURNAL   PLoS One 7 (5), e37452 (2012)
   PUBMED   22624035
REFERENCE   7  (bases 1 to 3533)
  AUTHORS   Wang,Y., Song,W., Li,S., Guan,X., Miao,S., Zong,S., Koide,S.S. and
            Wang,L.
  TITLE     GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic
            capacity in mouse seminiferous tubules
  JOURNAL   BMC Cell Biol 10, 25 (2009)
   PUBMED   19358743
  REMARK    GeneRIF: Findings suggest that mRHBDD1 may be associated with
            mammalian spermatogenesis.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3533)
  AUTHORS   Wang,Y., Guan,X., Fok,K.L., Li,S., Zhang,X., Miao,S., Zong,S.,
            Koide,S.S., Chan,H.C. and Wang,L.
  TITLE     A novel member of the Rhomboid family, RHBDD1, regulates
            BIK-mediated apoptosis
  JOURNAL   Cell Mol Life Sci 65 (23), 3822-3829 (2008)
   PUBMED   18953687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY324588.1, AK142277.1 and CF616726.1.
            
            [WARNING] On Jul 24, 2024 this sequence was replaced by
            NM_029777.4.
            
            On Mar 15, 2008 this sequence version replaced NM_029777.2.
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142277.1, SRR1660817.60117.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY324588.1         1-12
            13-3500             AK142277.1         2-3489
            3501-3533           CF616726.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..3533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 42.08 cM"
     gene            1..3533
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /note="rhomboid domain containing 1"
                     /db_xref="GeneID:76867"
                     /db_xref="MGI:MGI:1924117"
     exon            1..70
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            71..582
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1097
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /EC_number="3.4.21.105"
                     /note="rhomboid domain-containing protein 1; rhomboid-like
                     protein 4"
                     /codon_start=1
                     /product="rhomboid-related protein 4"
                     /protein_id="NP_084053.3"
                     /db_xref="CCDS:CCDS15097.1"
                     /db_xref="GeneID:76867"
                     /db_xref="MGI:MGI:1924117"
                     /translation="MQRRTRGINTGLLLLLSQVFQIGINNIPPVTLATLAVNVWFFLN
                     PWKPLYHSCISVEKCYQQKDWQRLLLSPLHHGDDWHLYFNMVSMLWKGVKLERRLGSR
                     WFAYVIATFSLLTGVVYLLLQFTVAELLNQPDFKRNCAVGFSGVLFALKVLSNHYCPG
                     GFVNILGFPVPNRFACWAELVAIHFCTPGTSFAGHLAGILVGLMYTQGPLKKIMDTCA
                     GIFISHAGPSGQQNHFNNAGPSGYQNHYADGRPVTYDATYRNYDVYTAGLSEEEQLER
                     ALRASIWDRGNTRNGPMPYGFRLPPEEMRRQRLHRFDGQ"
     exon            583..715
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            716..804
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            805..861
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1005
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..3509
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3485..3490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /note="hexamer: AATAAA"
     polyA_site      3509
                     /gene="Rhbdd1"
                     /gene_synonym="4930418P06Rik; mRHBDD1; RRP4"
                     /note="major polyA site"
ORIGIN      
        1 gattcggcgt ccagacgtag tgacgcacga gcgcgggagt acgtgaggac gcaagcgggt
       61 cttagagaga gtgcagttct ccgtgtacct ccctgggttc ctaatcctct agcacagatc
      121 cttatccacg ctcctgatat cctgcagtca tgcagaggag aacgagaggg atcaacaccg
      181 gcctcctcct gctcctctct caagtgttcc aaattgggat caacaacatt ccgcctgtta
      241 ccctcgcaac cttggctgtc aacgtctggt tcttcctgaa tccttggaag cccctgtacc
      301 attcctgcat cagcgtggaa aagtgttacc agcagaaaga ctggcagcgt ttactgctct
      361 ctcccctgca ccacggagat gactggcatt tgtatttcaa catggtgtcc atgctctgga
      421 aaggtgtgaa gctggagaga aggctgggaa gccgatggtt tgcctacgtg atcgccacct
      481 tctccctgct tacgggggtg gtgtatttgc tcttgcagtt tactgttgcc gaactcttga
      541 atcagcctga cttcaaaagg aactgtgctg tgggcttctc aggagttttg tttgccttga
      601 aagttcttag caaccattac tgccccggag gctttgtcaa cattttgggc tttcctgtcc
      661 ctaatagatt tgcttgttgg gcagagctgg tggccattca cttctgcacc ccagggactt
      721 cctttgctgg gcacctggcc ggcattctgg ttggactgat gtacacgcag gggcctctga
      781 agaaaatcat ggacacgtgt gcaggcattt ttatctccca cgctgggcct tcaggacagc
      841 agaaccactt taacaatgca ggcccctccg gatatcagaa tcactatgca gatggcagac
      901 cagtgaccta tgatgcaact tacaggaact atgatgtcta cacagcgggc ctgagcgagg
      961 aggagcagct ggaacgagca ttaagagcca gcatctggga ccgaggaaat accagaaatg
     1021 gtccaatgcc atatgggttc cggctcccac cagaagaaat gaggagacag cgtcttcaca
     1081 gatttgatgg ccagtgatat ggcaccatgc aggggaagtc cagctgtgcg attggagccc
     1141 gttcacttaa ctccccaagc ccctaattgg ttttaaacaa aagaagagca cagggttact
     1201 gttgcaggtc actcttgtct gccatgaaca agtactccat ggcccctgtg tgcccagatg
     1261 cacaagccca gctgacatgt cccaggaagc ccacagcctt cccagagtgg cctgtctagc
     1321 cccgtgatcg ctcctaaacc aaaggtcacc tcttcagatg ggaccaattt ccacttttct
     1381 ccttccctcc agactcagtg gcttatccac actgcggtaa agcctgggcc cttaatagga
     1441 agtgggttct ttatctcacc aggtgagtgg atcagccctc actctgcctg gcatgccagg
     1501 ttcttggctt agcaggaggg gcagtgctac ccctggtcct cccaccatgt ttccatggtg
     1561 atgcgggaag aggatgtggc taccttccca gggcgttccg ttctctttca cgcaggctcc
     1621 tccgggtgct caggctacca agtctgcctg atgttcacat ctcctgcctt attccacatg
     1681 tagaatgtct aacaggaggg gaataagaaa gatctaaggt aggaaaagaa cccaactcac
     1741 tcattagata tcatgtggca ccagcaattt gggttcagag ccaccccctc caggagtggg
     1801 cgacttaact gctccacaga gcggcaacag gtgccacaca cacacagagc aaagccaacg
     1861 tgttgactgg ggttctcaca gggaatcccc cttgcagcaa gtattttttt ttccttcatg
     1921 aaagtgcctt ctcattggct actctggctg tagttggtca taaacaagtg tgtgaaaaat
     1981 gccccaggga agtgctgtgt ccgagtcact taaggcattt ctgtttcttg tgttctgaga
     2041 ataaaaaggc aaagacagga tgttgccacc tcctcagagt cagggaggat ttagatcaaa
     2101 gggagttagg agcaacaaat ggtgttcctc cgactcttat gcaccctccc tgcatagttt
     2161 ccaatgagaa tgggtgtaga caggctttcc tatgcacaac gcacacacct aggatggaat
     2221 actaagtggc gatacccatc agctctgggg gacaggcaca taggacctga ctttctttgt
     2281 ttacagtttt atattctatt tttttaaagc gtgtgtgcaa gtgtctgctg ctttcagaag
     2341 attactttat acaatgaatc aagaaacatg tagtcagtaa aacaaaccct aagctaagta
     2401 ctctttgtcc attaagaaaa atcatagact gggcatggtg gcacacattt ctaatcccag
     2461 cactcaggat tcagaggaag gaggatctat gagttcaaag ccagcctggt ctacatatgg
     2521 agttctaagc cagccagaac acacacacac ccttatacac caaaaccctg tctcaaaaaa
     2581 gagggaggaa gagtgggggg gggagaagga agatgatgaa ggaaggaaag aaatcacagt
     2641 atttaaataa aggtacaact gctcattttt aaaaggcact ggtgcccaag gccaacattt
     2701 caaggctatt aacatctcag tttctgctgt atgcatttga cacatctggt gcatgccatc
     2761 tgtgtagctc catgcccact tgttaatatg gacccacctg gaatgtctgt aacccgtgca
     2821 tatgaatgga ctaagcaaat ccatggagtc taagcattca gacaatggtg cctgagcacc
     2881 ttagtttaat ttgtaattgg tggaaagcca cacctagttg atattataaa ttatgcccat
     2941 gagcctggta cctccaaaca catttaaatt ataatggtca aggtaaatta tccctggctc
     3001 tcaggctgca catttgcctt ccataccaca atgagaaaca accttttctc tacttgacac
     3061 cttttgataa cacctgggaa ttctacccta acactcttat gtcactattc ttatttgtgc
     3121 atacctgcac caagtcatgt ctgtggttct gagtgaccct agaccacggc ctgttactga
     3181 ccttcaacct tcccagtctc cctccctcca cactcaaaag gctcagtaac tgttattttc
     3241 ccaccaaagt tattattcac ttgttattag aattctgcta gcttgtacat gtagctttaa
     3301 tgtagtaaca gtacctggtt gctttgtttg acttgatggt caaagacact gaaaatccca
     3361 attttggatg gtgtagttat aaaatgcact ttttctttat ttatggagtg ggatgtcacc
     3421 aaatgtttat tacagatgtg ggaaaagtca ttttagggat aagtgaaaac cacatgtctt
     3481 ccagaataaa gatggtctgg aaatgataaa aaaaaaaaaa aaaaaaaaaa aaa
//
