LOCUS       NM_145840               6604 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signalling 9 binding protein
            (Rgs9bp), mRNA.
ACCESSION   NM_145840
VERSION     NM_145840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6604)
  AUTHORS   Sarria,I., Orlandi,C., McCall,M.A., Gregg,R.G. and Martemyanov,K.A.
  TITLE     Intermolecular Interaction between Anchoring Subunits Specify
            Subcellular Targeting and Function of RGS Proteins in Retina
            ON-Bipolar Neurons
  JOURNAL   J Neurosci 36 (10), 2915-2925 (2016)
   PUBMED   26961947
REFERENCE   2  (bases 1 to 6604)
  AUTHORS   Chen,C.K., Woodruff,M.L. and Fain,G.L.
  TITLE     Rhodopsin kinase and recoverin modulate phosphodiesterase during
            mouse photoreceptor light adaptation
  JOURNAL   J Gen Physiol 145 (3), 213-224 (2015)
   PUBMED   25667411
REFERENCE   3  (bases 1 to 6604)
  AUTHORS   Pearring,J.N., Lieu,E.C., Winter,J.R., Baker,S.A. and
            Arshavsky,V.Y.
  TITLE     R9AP targeting to rod outer segments is independent of rhodopsin
            and is guided by the SNARE homology domain
  JOURNAL   Mol Biol Cell 25 (17), 2644-2649 (2014)
   PUBMED   25009288
  REMARK    GeneRIF: R9AP is actively targeted in rods by its SNARE homology
            domain.
REFERENCE   4  (bases 1 to 6604)
  AUTHORS   Sundermeier,T.R., Vinberg,F., Mustafi,D., Bai,X., Kefalov,V.J. and
            Palczewski,K.
  TITLE     R9AP overexpression alters phototransduction kinetics in iCre75
            mice
  JOURNAL   Invest Ophthalmol Vis Sci 55 (3), 1339-1347 (2014)
   PUBMED   24526444
  REMARK    GeneRIF: the presence of a second, R9AP-expressing transgene in the
            iCre75 mouse line, leading to altered kinetics of
            phototransduction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6604)
  AUTHORS   Tian,M., Zallocchi,M., Wang,W., Chen,C.K., Palczewski,K.,
            Delimont,D., Cosgrove,D. and Peng,Y.W.
  TITLE     Light-induced translocation of RGS9-1 and Gbeta5L in mouse rod
            photoreceptors
  JOURNAL   PLoS One 8 (3), e58832 (2013)
   PUBMED   23555598
REFERENCE   6  (bases 1 to 6604)
  AUTHORS   Strissel,K.J., Sokolov,M., Trieu,L.H. and Arshavsky,V.Y.
  TITLE     Arrestin translocation is induced at a critical threshold of visual
            signaling and is superstoichiometric to bleached rhodopsin
  JOURNAL   J Neurosci 26 (4), 1146-1153 (2006)
   PUBMED   16436601
REFERENCE   7  (bases 1 to 6604)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 6604)
  AUTHORS   Keresztes,G., Martemyanov,K.A., Krispel,C.M., Mutai,H., Yoo,P.J.,
            Maison,S.F., Burns,M.E., Arshavsky,V.Y. and Heller,S.
  TITLE     Absence of the RGS9.Gbeta5 GTPase-activating complex in
            photoreceptors of the R9AP knockout mouse
  JOURNAL   J Biol Chem 279 (3), 1581-1584 (2004)
   PUBMED   14625292
  REMARK    GeneRIF: photoreceptors R9AP determines the stability of the
            RGS9.Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5
            , and R9AP, are obligate members of the regulatory complex that
            speeds the rate at which transducin hydrolyzes GTP.
REFERENCE   9  (bases 1 to 6604)
  AUTHORS   Keresztes,G., Mutai,H., Hibino,H., Hudspeth,A.J. and Heller,S.
  TITLE     Expression patterns of the RGS9-1 anchoring protein R9AP in the
            chicken and mouse suggest multiple roles in the nervous system
  JOURNAL   Mol Cell Neurosci 24 (3), 687-695 (2003)
   PUBMED   14664818
REFERENCE   10 (bases 1 to 6604)
  AUTHORS   Hu,G. and Wensel,T.G.
  TITLE     R9AP, a membrane anchor for the photoreceptor GTPase accelerating
            protein, RGS9-1
  JOURNAL   Proc Natl Acad Sci U S A 99 (15), 9755-9760 (2002)
   PUBMED   12119397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044285.1, AY229888.1, BC118006.1, AC151531.3 and CO046102.1.
            
            On Jun 2, 2007 this sequence version replaced NM_145840.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY229888.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AK044285.1         2-115
            115-1558            AY229888.1         77-1520
            1559-2164           BC118006.1         1515-2120
            2165-3436           AY229888.1         2127-3398
            3437-5902           AC151531.3         65439-67904
            5903-6604           CO046102.1         15-716
FEATURES             Location/Qualifiers
     source          1..6604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.37 cM"
     gene            1..6604
                     /gene="Rgs9bp"
                     /gene_synonym="R9AP; Rgs9-1bp"
                     /note="regulator of G-protein signalling 9 binding
                     protein"
                     /db_xref="GeneID:243923"
                     /db_xref="MGI:MGI:2384418"
     exon            1..6590
                     /gene="Rgs9bp"
                     /gene_synonym="R9AP; Rgs9-1bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1076
                     /gene="Rgs9bp"
                     /gene_synonym="R9AP; Rgs9-1bp"
                     /note="RGS9 anchor protein; RGS9-1 anchor; RGS9-anchoring
                     protein"
                     /codon_start=1
                     /product="regulator of G-protein signaling 9-binding
                     protein"
                     /protein_id="NP_665839.1"
                     /db_xref="CCDS:CCDS21153.1"
                     /db_xref="GeneID:243923"
                     /db_xref="MGI:MGI:2384418"
                     /translation="MAREECKALLDALNKTTACYHHLVLTVGGSADTQDLREELQKTR
                     QKARELAVATGARLTVALRDRSLATEERAEFERLWVAFSGCLDLLEADMQRALALGAT
                     FPLHAPRRPLVRTGVTGGSSAVAARALSARSLRHEAESDFDVADLPQLEREVLQVGEM
                     IDDMEMKVNVPRWTVQARQAAGAELLSGASAGASSAGGISVEERAGPCDPSKALAATV
                     FSAVLLVAVALALCVAKLS"
     regulatory      6556..6561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs9bp"
                     /gene_synonym="R9AP; Rgs9-1bp"
                     /note="hexamer: AATAAA"
     polyA_site      6574
                     /gene="Rgs9bp"
                     /gene_synonym="R9AP; Rgs9-1bp"
                     /note="major polyA site"
ORIGIN      
        1 gctgcccttg gccggggcta aggcgcgcgg ctcgtcttgg agacttgggg tcgatcaagg
       61 atggggtctt cactctgggc ttctcaggga gccgccgtga aaaagaaagt ggtgcaaaga
      121 cactacgcgt gacccggagc gcgtctgggg gaaatggagg agcggatggg gagaagctaa
      181 ccagactacc ccagccgtgg ggacgccgga ggcgcacctc aagggtccct ggagagctct
      241 gttgagaaca gcggcgagga catgaggagc tttcagtccg ccctgctcaa ggctggcatc
      301 agggctggag gcgacctacg acgttgaagg ttgcaagtag ggtaccgccg gagggcagcg
      361 ccatggccag agaggagtgc aaggcgctgc tggacgcgct caacaagacc acagcgtgct
      421 accatcactt agtgcttact gtgggcggct ccgcggacac tcaggaccta cgcgaagagc
      481 tgcagaagac ccgccagaag gcgcgggagc tggccgtggc caccggcgcc cggttgaccg
      541 tcgcgctccg ggaccggagc ttagctaccg aggagcgcgc ggagtttgag cggctctggg
      601 tggccttttc aggctgcctg gacctgctcg aagccgacat gcagcgcgca ctagcgctgg
      661 gagccacctt cccgctgcac gcgccgcgcc ggccacttgt tcgcactggg gtgacgggcg
      721 gctcctctgc tgtagctgcg cgcgccctga gcgcccgcag cctgcggcac gaagcggaga
      781 gcgacttcga tgtcgccgat ctgccccagt tggagcgcga agtcctccag gtgggcgaga
      841 tgattgacga catggaaatg aaagtcaacg tgccccgctg gactgtacag gcgcgacaag
      901 cggcaggcgc cgaactcctg tccggtgcca gtgccggcgc gtcctcagcc ggtggcattt
      961 cggtagagga gcgcgcgggc ccctgcgacc ccagcaaggc cctggctgcc accgttttca
     1021 gcgccgtgct gttggtggct gtggccctcg ccttatgtgt ggcaaagctg agctgactga
     1081 tatccaacgg tcgtccgctg ccccttttct ttccagggca tgggcttcgg gtttgaaccg
     1141 ttaaggagag aggtagtgag cctgaatgtg tgcatatgaa catgatcctt tcaaagccca
     1201 cctctgcctg ggcaaaacgt gttttgtttt ttaacatgct ggcccaagag gagttaacag
     1261 cacagggcgg ccaggccatt acctctaatg tctgtaggag ctttacctcc tattaataga
     1321 aatcggtcca cagtgacccc aggtccctct gagtttgatg ggttaagacg tatgtcccaa
     1381 gtttggtgcc ctcacgctgg ttggtagcac tcattctgtt ttagacgaga caattttgtt
     1441 aaggtgtggg gttgtatcaa gcatagtggt ggtgggggag ggagacattt tgttccctag
     1501 acaagaaacc agttgcagta agatgcgcgt gggttttgtt accttaatcc tttggggcct
     1561 aggctttggg agtgtgtacg gatagaggct cgtgcaaagt gctttctctg tgatacacta
     1621 ctgcacttgg cagagcctgc ctattagtca ccaggagctg cagctatgag aggtttttgt
     1681 gtcgtgaccc catttagggt cacagccaag aaggttgtgg tgtatcctct gcacacttgc
     1741 ttcaagagaa gaccgctcca tactcatccc cggatggggg agggacagga tggtgctgct
     1801 ttgggaaggg ccacacggct atgtaaacag gcacgttctc cttctcaccg gcttacttta
     1861 tcccagaatt agaccacagt gtttgaccct cctttgaggg agggctgggg aatcctcttt
     1921 gaagctctta atcctatcta tccctggaat ttactcgata gccaatagga acgctagttt
     1981 tctagagagc tgcccaactg tctgacccca tgttacaggg aagggcgatg ctggtatcac
     2041 tagtaaccag gggttgtgag cctggcagct gagttcaaaa tgtaacagct ttaatttgga
     2101 atttaaagag ctttaaacac tcgcatgcgt acacacacac acacacacac acacacacac
     2161 acactatctg aaagaatgta agcacgttag taccaaagtt gggttgcatg tttgtttttg
     2221 tataaaggaa actgggccac aagctcatag atgccaagtg agtcaagctt agagaacttt
     2281 tacattgtat atgtagtctg ctaaatatga atctgcatct gcttttttct aaaaccctgg
     2341 ggaccagcga gatggcttaa gaggtagaag tatgtactgt atcgggacat agtagtgcac
     2401 acttttaatc cttggaggta aaggcaggag gatctctgag ttggagggca gcctggtctg
     2461 cataatatcc gggacagcca gggctacaca gagagaccct gtaacacaca cacacacaca
     2521 cacacacaca cacacacaca cacaccacac gtaggtattg cacttgcaga acatgcaagt
     2581 tctgttcaca gtattcatcc acccactgcc agccagcagt tcgcaactgc ctgtaactcc
     2641 agctctagga gaggtctagc cccctcttct ggacacctca ggtatttgtc cccatggagg
     2701 cacactattc acacatgcac ataaccaaaa cggaaacttt tacatctata ttcctgaata
     2761 gagactgaat tttaagatca tagctcaaac tgccagaacc ctccacataa aaggcagaaa
     2821 tggcccctgc tttccaccgg taaaggatga gatgtgagaa atgctctctg ccttcctgga
     2881 ggggcttggg gaagtggtac tgagaaagca gatgcattta actttcaaat ggttggtggg
     2941 acaaaagcaa agatctgctt ggctagaaat gggatttcct tttaacctct gaaagtgaga
     3001 aagagggggt gttaccgcca ctctttgcac tccttagcca ttctttggat atttaatgag
     3061 ctgggtcatt agatgtccac ctgtgatggt tcttagatga ctgcaattca ttgcaatgtt
     3121 gcaaaaggtt gacttaaact aaacattcct ctagtagacc tgtgaaccca ggaaactcac
     3181 tgagattgaa aatgttaaac atgaggtgaa gtccttggtg ttatgatgct gtctaagaaa
     3241 gctgctatag gacataggca aagtcacctc ttgccttgta aaactggcta tcttctaact
     3301 aatatgtctt cttgtgtttg tgagctagct tgctgataga atcctggttc tattcatact
     3361 tggatgttga ggtaattcat cttctataga catttggtat gatctcatac ttggtataat
     3421 tgacaagaaa aaaaaaccaa aatacatcag ttaggctggg ttctgtgcag gcctgatact
     3481 tcacaatgat acaggaagat cacacgttca aaattaggtt ggtctggagt gtgacttcaa
     3541 ggccatcctg ggcaacttag actctatctc aaaataaaag atgaaaagag gactggggtt
     3601 atagcctaat ggcggggtac ttgcttagcg tgcttgaagg ttcagattca atcattatac
     3661 cccccaaaat gtattaacca atattaagaa ggcagaacct cggggtgtca aggcacctat
     3721 caagggagtg agctatgagt cagcagtgaa ctgctaatga ctacagtagt cataatgcag
     3781 caagaatatg ctcagataat tggttttcta agacagaatc tcactgtgta gtcctagctg
     3841 tcctggaatt cagtttgtag accaagctgc ccttgaactc ctgggacaac tcctagatgc
     3901 tccttcctct gcctcctgaa tgctaggatt aaaggcatat gctaccctgc cttgctttgt
     3961 agcccagact ggcctcaaag tgatgagcct ccgtgccttg gcctcttcag aatacgctac
     4021 tgatgtgggc ccccacagcc atctggatga tttctgtttt tatgtattat aaaagtttaa
     4081 ttgccacaag ggaaaatact tagggtagag ttaaagccag agctttgtga ttcccctatg
     4141 ggttacagga tgctgtgtaa agaatgtatg attctgttaa gcaattttgg ctgaagagat
     4201 gtcgaattta catgaggtcc ctggtaatgt agcattttgc cctgatgtgc actctggtcc
     4261 atttgtaagc tgttctttcc tccttgctat gttgtacggt ggatgctttg taagcctcgg
     4321 ggctcctgtg tataagaagc tgatgaggaa aatattgcag gaagagctta cttctgcatc
     4381 ccttggggtg tgcctctccc ttgagggccc accatctacc ctgcctctct ccaagtacct
     4441 caagtcattt gatatccctg tgcctcgcat cctccactgg tagcactggg gtcttgggag
     4501 cccttgtgga gcccttgtga gcttgaggtg tcgagcagat ggcactgaag tgggacaggc
     4561 ttattttgtt ggatgatttg gtttgggact ttgtactttg ctggttggtt taggtatatc
     4621 ctcatggaat gtaatcctgt agtctagcgg ttattgtcta aacataggct gttcgggggc
     4681 tggggagatg gctcagaggt taagggcaca tgctgttctt ccagaggcca caagttcagt
     4741 tctcagcacc cacactgggt ggctcacaga tgcccataat gccagctcca ggcagatcgg
     4801 gcatctctag cctctgtgga cacctacatt catgtacaca gatacacata cgtacacata
     4861 actgaaaatc acgtatttga aaagtagttt taaaagatta aaagtcaggc tagtgaggtg
     4921 gctcgggcta agggtgctca ctgccaagct tgaccacctg cgttccatcc tgaaatccac
     4981 aaaatggaag gagagaacag gctcccaaaa gttgttctct gacctacaca gagacagaga
     5041 gagagacaga gagacagaga gacagagaga gagagacaga gacagagaga gagagagaca
     5101 gagaggtgca gcccccttgc cccacaaaat aaataaataa tccatgtaaa acaataacaa
     5161 gtatttagtt ttaaaaatca aaactaatgg cgcttagtgc tcataagctt cagtgcacat
     5221 agagtgtaga cactaaaaaa gcaagcgtgg gattggggta cagcttagca gtagtgggct
     5281 tgatctgcac gtcacagctc tggattcaac tggcagcaat gcaaagggaa gacagaggtt
     5341 cacgtgtata tgctgcctgt gtatagtatt taaatagaca aggaactaaa ctgcagactc
     5401 ttaagtctga atctgagtct ttatttattt ttaggggctg gggagatggc tcacaggtta
     5461 ggagtgtgtg ctgctcttac agagaaccag gattcaattc ttagcgccca tatggggccg
     5521 ctcatgcctg actgtaactc cagttacagg ctctctgtcg ccctcctctg gcctccaggg
     5581 acactgcata ccaagccatg caaagtgcac taattcaatc ttgttttcac agccattagg
     5641 ccatcacaag ggattctggg aaactgcaaa gacaagccct tgctatttgc ccaaaagtct
     5701 gggggctata ctagctccct accatggagc agggggtgtt cctaatgtgt aatggtggat
     5761 ctgtcatgga atcaaagctt tcacatctcc gtgttgtatc aacaggttct aaccacaatg
     5821 tttgtaaata agtaaaaagt acagataata tgcagcatta ataacctctc agggaaagga
     5881 cttcaaatgg gccactatcg gcttgtgatt ttaaacaata tgcttaattt tcttcaccaa
     5941 cattggaatg ttggagtgta caccccatcg atagacttac tctccacaga ctcggatgca
     6001 aaaagagccc agagggttcc aaactgtagg tatctgcgtg ctttcctctg cagtacagtt
     6061 gtacgcagcc attaccacag gaagcttggc cgtggacatc acagctcaaa gccgtccttc
     6121 aaatgcagtg tcttctggtt cctgagaact ggcaaaaggc tgatgactgg gacggtagac
     6181 atttctggaa agatactcct gtcatttata tatgtccacc tcattctgtg ggaggttcag
     6241 ggagttttcc ctgcaggact acgagagaga agacacccta gttgtttaga atttgagaat
     6301 tttaagacct taagtttata tgactgatgt aaatattcga aacgacagct cctgttgtca
     6361 gatgacttta aagagtcttt tgaacgttct ggtgccagaa agcagagttg agtgttgctt
     6421 gcgtggctat ggatgtatta ggtgtgtgga agcgttctat aaagaaatac acagaaacga
     6481 aagtacttgt taaggtggtg aggttatgaa ttgtgaattt ttcaatgttt ttatttcatc
     6541 ttatattgct tttacaataa aactttaaat gctattatca tctggaaaaa aaaaaaaaaa
     6601 aaaa
//
