LOCUS       NM_011268               2486 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus regulator of G-protein signaling 9 (Rgs9), transcript
            variant 1, mRNA.
ACCESSION   NM_011268
VERSION     NM_011268.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell (2025) In press
   PUBMED   39938516
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Duvick,L., Southern,W.M., Benzow,K.A., Burch,Z.N., Handler,H.P.,
            Mitchell,J.S., Kuivinen,H., Gadiparthi,U., Yang,P., Soles,A.,
            Sheeler,C.A., Rainwater,O., Serres,S., Lind,E.B., Nichols-Meade,T.,
            You,Y., O'Callaghan,B., Zoghbi,H.Y., Cvetanovic,M., Wheeler,V.C.,
            Ervasti,J.M., Koob,M.D. and Orr,H.T.
  TITLE     Mapping SCA1 regional vulnerabilities reveals neural and skeletal
            muscle contributions to disease
  JOURNAL   JCI Insight 9 (9), e176057 (2024)
   PUBMED   38512434
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Pandey,M., Zhang,J.H., Adikaram,P.R., Kittock,C., Lue,N., Awe,A.,
            Degner,K., Jacob,N., Staples,J., Thomas,R., Kohnen,A.B.,
            Ganesan,S., Kabat,J., Chen,C.K. and Simonds,W.F.
  TITLE     Specific regulation of mechanical nociception by Gbeta5 involves
            GABA-B receptors
  JOURNAL   JCI Insight 8 (13), e134685 (2023)
   PUBMED   37219953
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   5  (bases 1 to 2486)
  AUTHORS   Ramirez-Jarquin,U.N., Sharma,M., Shahani,N., Li,Y., Boregowda,S.
            and Subramaniam,S.
  TITLE     Rhes protein transits from neuron to neuron and facilitates mutant
            huntingtin spreading in the brain
  JOURNAL   Sci Adv 8 (12), eabm3877 (2022)
   PUBMED   35319973
REFERENCE   6  (bases 1 to 2486)
  AUTHORS   Hu,G., Jang,G.F., Cowan,C.W., Wensel,T.G. and Palczewski,K.
  TITLE     Phosphorylation of RGS9-1 by an endogenous protein kinase in rod
            outer segments
  JOURNAL   J Biol Chem 276 (25), 22287-22295 (2001)
   PUBMED   11292825
REFERENCE   7  (bases 1 to 2486)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   8  (bases 1 to 2486)
  AUTHORS   Chen,C.K., Burns,M.E., He,W., Wensel,T.G., Baylor,D.A. and
            Simon,M.I.
  TITLE     Slowed recovery of rod photoresponse in mice lacking the GTPase
            accelerating protein RGS9-1
  JOURNAL   Nature 403 (6769), 557-560 (2000)
   PUBMED   10676965
REFERENCE   9  (bases 1 to 2486)
  AUTHORS   Rahman,Z., Gold,S.J., Potenza,M.N., Cowan,C.W., Ni,Y.G., He,W.,
            Wensel,T.G. and Nestler,E.J.
  TITLE     Cloning and characterization of RGS9-2: a striatal-enriched
            alternatively spliced product of the RGS9 gene
  JOURNAL   J Neurosci 19 (6), 2016-2026 (1999)
   PUBMED   10066255
REFERENCE   10 (bases 1 to 2486)
  AUTHORS   He,W., Cowan,C.W. and Wensel,T.G.
  TITLE     RGS9, a GTPase accelerator for phototransduction
  JOURNAL   Neuron 20 (1), 95-102 (1998)
   PUBMED   9459445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604043.11.
            
            On Apr 28, 2007 this sequence version replaced NM_011268.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF125046.1, BC129899.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AL604043.11        190049-190292       c
            245-341             AL604043.11        173560-173656       c
            342-392             AL604043.11        168681-168731       c
            393-499             AL604043.11        167931-168037       c
            500-551             AL604043.11        167690-167741       c
            552-610             AL604043.11        167372-167430       c
            611-687             AL604043.11        165387-165463       c
            688-769             AL604043.11        161034-161115       c
            770-832             AL604043.11        151947-152009       c
            833-862             AL604043.11        142138-142167       c
            863-924             AL604043.11        141090-141151       c
            925-1038            AL604043.11        140175-140288       c
            1039-1154           AL604043.11        138564-138679       c
            1155-1242           AL604043.11        132961-133048       c
            1243-1381           AL604043.11        131565-131703       c
            1382-1467           AL604043.11        130205-130290       c
            1468-1585           AL604043.11        128011-128128       c
            1586-2064           AL604043.11        119237-119715       c
            2065-2486           AL604043.11        117466-117887       c
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 71.86 cM"
     gene            1..2486
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /note="regulator of G-protein signaling 9"
                     /db_xref="GeneID:19739"
                     /db_xref="MGI:MGI:1338824"
     exon            1..244
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2215
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /note="isoform 1 is encoded by transcript variant 1; ROS
                     GAP"
                     /codon_start=1
                     /product="regulator of G-protein signaling 9 isoform 1"
                     /protein_id="NP_035398.2"
                     /db_xref="CCDS:CCDS25576.1"
                     /db_xref="GeneID:19739"
                     /db_xref="MGI:MGI:1338824"
                     /translation="MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMHNQRVLVT
                     SVPHAMTGGDVLQWITQRLWISNLEAQNLGNFIVKYGYIYPLQDPKNLILKPDSSLYR
                     FQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYDFLNKKINYKWDFVIM
                     QAKEQYRTGKERNKADRYALDCQEKAYWLVHRSPPGMNNVLDYGLDRVTNPNEVKKQT
                     VTAVRKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQ
                     FWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFLKKEFSGENLGFWEACED
                     LKYGDQSKVKEKAEEIYKLFLAPGARRWINIDGKTMDITVKGLRHPHRYVLDAAQTHI
                     YMLMKKDSYARYLKSPIYKEMLAKAIEPQETTKRSSTLPFMRRHLRSSPSPVILRQLE
                     EEEKAREAANTVDITQPGQHLAPSPHLAVYTGTCVPPSPSSPFSPSCRSPRKPFASPS
                     RFIRRPSIAICPSPSRVALEGSSGLEPKGEASWSGANSGPSVTENREPSADHSRPQPR
                     APPKARAALSLGRFLRRGCLASPVFARLSPKCPSVSHGKVQPLGDMGQQLPRLKPKKV
                     ANFFQIKMEMPTDSGTCLMDSDDPRAGESGDQTTEKEVICPWESLAEGKAG"
     exon            245..341
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            342..392
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..499
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..551
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..610
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..687
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..769
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..832
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..862
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..924
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1038
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1154
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1242
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1381
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1467
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1585
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..2064
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2486
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="Rgs9"
                     /gene_synonym="RGS9-1; Rgs9-2"
                     /note="major polyA site"
ORIGIN      
        1 tttgcatgtc ggcgggtgcg agggagagtc gaggggtgga gggcggtatt ctgggccctg
       61 cgcgctccgc tctctgtgcc tcccggtcta cgcccaggct ggggcagacc aggctggctt
      121 gtgaacttgg gggtttcccc tttcgctccc attcgtgttg tggtcgtgaa ttcatccagg
      181 gtccagaatg acgatccgac accaaggcca gcagtacagg ccgaggatgg catttctcca
      241 aaagatcgaa gccctggtga aggacatgca gaacccagag acgggagtca gaatgcataa
      301 ccagagagtc ctggtcacca gtgtccctca cgccatgaca ggaggtgacg tgctgcagtg
      361 gatcacccag cgcctttgga tctctaacct ggaggcacag aacctgggca actttattgt
      421 caagtatggc tacatctatc ctttgcaaga ccccaagaat ctcatcctca agccggacag
      481 cagtctctac cgatttcaga cgccatattt ctggcccacg cagcagtggc cagctgaaga
      541 cacagactac gccatctatc tagcgaagcg gaatatcaag aagaagggga ttttagaaga
      601 atatgaaaag gaaaattatg atttcttgaa caagaagatt aattacaagt gggattttgt
      661 catcatgcag gccaaagagc agtaccggac tggaaaggaa aggaacaaag ccgacaggta
      721 cgcgctggac tgccaggaga aggcgtattg gctggtgcac cgaagtccgc ctggaatgaa
      781 caatgtgtta gactacggcc tggaccgcgt gaccaatcca aacgaagtta agaaacaaac
      841 tgtcactgct gtcagaaaag agatcatgta ttaccaacag gccttaatga ggtccacagt
      901 gaagtcttcg gtgtctcttg gaggaattgt caagtacagc gagcagttct cgtccaatga
      961 cgccatcatg tccggctgcc ttccaagcaa tccttggata acagacgaca cccagttctg
     1021 ggatttaaat gccaaattgg tggagatccc aaccaagatg cgagtggaga gatgggcttt
     1081 caacttcagc gaactgattc gagaccccaa gggtcggcag agcttccagt actttctcaa
     1141 gaaggaattt agtggggaga acctaggatt ctgggaagcc tgtgaggacc tgaagtacgg
     1201 cgatcagtcc aaggtcaagg agaaagcaga ggagatctac aagctgttcc tggccccagg
     1261 tgcgaggcgg tggatcaaca tagacggcaa aaccatggac atcaccgtga aggggctcag
     1321 acacccccac cgctatgtac tggatgcagc gcagacccac atttacatgc tcatgaagaa
     1381 ggattcttac gcacgctatt tgaaatctcc aatctataaa gaaatgctgg ccaaagctat
     1441 cgagccccag gaaaccacca agagaagctc caccctccca tttatgaggc gtcacctacg
     1501 ctccagccca agccctgtca ttctgcggca gctggaagaa gaagagaaag ctcgagaagc
     1561 agccaacacc gtggacatca cccagccagg tcagcacttg gctcccagtc ctcacctggc
     1621 cgtgtataca gggacctgcg tgcctccctc tccctccagt cccttctcac catcctgccg
     1681 ctcccccagg aagccctttg cttccccgag tcgcttcatc cggcggccca gcattgccat
     1741 ctgcccctcg cccagccgag tggctttgga gggttcttcg ggactggagc ccaaggggga
     1801 agccagctgg tctggcgcca actctgggcc ctcagtcact gagaacagag agccctctgc
     1861 agaccactca agaccccagc ccagggcccc tcccaaggcc cgtgcagctc tgtcccttgg
     1921 caggttcctg agacggggct gtttggcatc accagttttt gccaggctct cacccaagtg
     1981 cccctctgtg tcacacggga aggtgcagcc tctgggggac atgggccaac agctgcccag
     2041 gctgaaaccc aagaaagtag ccaacttttt ccagatcaaa atggaaatgc ctacagacag
     2101 tgggacctgc ctgatggact cggatgaccc cagagcagga gagtctggtg accagaccac
     2161 agaaaaagaa gtcatctgcc cctgggagag cctggcggaa gggaaggcgg gctgagcagg
     2221 gccttgggcc gggaagatgg tcctggcaga cgccatcaga cgtggggcac acttgctctc
     2281 aagcccaagt gcccaagtgc attaggataa tattggaaga ctggaaaaag cgaatggggt
     2341 gttgggcagg gatgtgtgct ctggctgact cccaacggcc acctttcccc tttccctgcc
     2401 tttcccttgc ttggccagac aggcatgtgg gccagaagat atcccttgct gccttaaaaa
     2461 caataaaagg gtcacctgga gaaatt
//
