LOCUS       NM_026380               5827 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript
            variant 1, mRNA.
ACCESSION   NM_026380
VERSION     NM_026380.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5827)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5827)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5827)
  AUTHORS   Kobayashi,Y., Takemoto,R., Yamato,S., Okada,T., Iijima,M.,
            Uematsu,Y., Chaki,S. and Saito,Y.
  TITLE     Depression-resistant Phenotype in Mice Overexpressing Regulator of
            G Protein Signaling 8 (RGS8)
  JOURNAL   Neuroscience 383, 160-169 (2018)
   PUBMED   29758252
  REMARK    GeneRIF: these findings suggest that RGS8 participates in
            modulation of depression-like behavior
REFERENCE   4  (bases 1 to 5827)
  AUTHORS   Taylor,V.G., Bommarito,P.A. and Tesmer,J.J.
  TITLE     Structure of the Regulator of G Protein Signaling 8 (RGS8)-Galphaq
            Complex: MOLECULAR BASIS FOR Galpha SELECTIVITY
  JOURNAL   J Biol Chem 291 (10), 5138-5145 (2016)
   PUBMED   26755720
  REMARK    GeneRIF: the crystal structure of RGS8 was determined in complex
            with Galphaq.
REFERENCE   5  (bases 1 to 5827)
  AUTHORS   Dansithong,W., Paul,S., Figueroa,K.P., Rinehart,M.D., Wiest,S.,
            Pflieger,L.T., Scoles,D.R. and Pulst,S.M.
  TITLE     Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic
            mouse model
  JOURNAL   PLoS Genet 11 (4), e1005182 (2015)
   PUBMED   25902068
  REMARK    GeneRIF: ATXN2 interacted selectively with RGS8 mRNA. This
            interaction was impaired when ATXN2 harbored an expanded
            polyglutamine. Mutant ATXN2 also reduced RGS8 expression in an in
            vitro coupled translation
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5827)
  AUTHORS   Kuwata,H., Nakao,K., Harada,T., Matsuda,I. and Aiba,A.
  TITLE     Generation of RGS8 null mutant mice by Cre/loxP system
  JOURNAL   Kobe J Med Sci 53 (6), 275-281 (2008)
   PUBMED   18762722
  REMARK    GeneRIF: RGS8 null mutant mice were viable, fertile and showed
            apparently normal development
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5827)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 5827)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   9  (bases 1 to 5827)
  AUTHORS   De Vries,L. and Gist Farquhar,M.
  TITLE     RGS proteins: more than just GAPs for heterotrimeric G proteins
  JOURNAL   Trends Cell Biol 9 (4), 138-144 (1999)
   PUBMED   10203790
  REMARK    Review article
REFERENCE   10 (bases 1 to 5827)
  AUTHORS   Chen,C.K., Wieland,T. and Simon,M.I.
  TITLE     RGS-r, a retinal specific RGS protein, binds an intermediate
            conformation of transducin and enhances recycling
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12885-12889 (1996)
   PUBMED   8917514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY292997.1 and BC065056.1.
            
            On Jul 26, 2005 this sequence version replaced NM_026380.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065056.1, SRR1660817.290295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BY292997.1         1-67
            68-5827             BC065056.1         1-5760
FEATURES             Location/Qualifiers
     source          1..5827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.41 cM"
     gene            1..5827
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /note="regulator of G-protein signaling 8"
                     /db_xref="GeneID:67792"
                     /db_xref="MGI:MGI:108408"
     exon            1..319
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            320..400
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            401..529
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..1046
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="regulator of G-protein signaling 8 isoform 1"
                     /protein_id="NP_080656.2"
                     /db_xref="CCDS:CCDS15375.1"
                     /db_xref="GeneID:67792"
                     /db_xref="MGI:MGI:108408"
                     /translation="MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKR
                     LSTEEATRWAESFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLV
                     TKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYP
                     RFLRSKMYLDLLSQSQRRLS"
     exon            530..631
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            632..696
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            697..863
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            864..5804
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5544..5549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5565
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /note="major polyA site"
     regulatory      5783..5788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5804
                     /gene="Rgs8"
                     /gene_synonym="6530413N01Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtcctcccc caactgcgtg gctgcgcatc atctgtcaga gtgcccctct cccctccctc
       61 tgcctccccg ctccctcccc tgcgctcgct agctctttcc cttttcatga gatgcaaagt
      121 ccggcgcaga gcagagccct ccagagcagc atggtgcagg agctcttcta ggggcccgag
      181 gtgaggcggc cacgctccac taccctcacc catgtaccag gagagggccg actctgtcac
      241 tcagggtttc accgagccat gcactgctgt tgccggcacc agccacatct ttccagctgc
      301 gctgcccacc gccaggcaga gctccttaac ccggaggagc aagcatctct gaccatctac
      361 ctggcaaaga cctgcaggcc atgaggacca gtcaacgaca gtgagaggac gtgagagggt
      421 aaatccctgc acccagcagt attatttcca accctgccgt ccctgcaaac cagcccaagg
      481 ggtaaccgta agcggatgcc tgtatggctg ccttactgat gccacgcagg aacaaaggca
      541 tgaggactcg actggggtgc ctgtcacaca aatcagactc ctgcagtgac ttcactgcca
      601 tcctccctga caaacccaac cgtgctctca agagactctc cacggaagaa gcaacgaggt
      661 gggcggagtc tttcgatgtg cttctctctc ataagtatgg ggtggcagcc ttccgtgcct
      721 tcttgaagac ggagttcagc gaggagaacc tggagttctg gctggcctgc gaggagttca
      781 agaagaccag gtcaactgca aagctagtca ccaaggccca caggatcttt gaggagtttg
      841 tggatgtgca ggctccacgg gaggtgaata tcgatttcca gacccgagag gccacgagga
      901 agaacatgca agagccatcc ctgacttgtt ttgatcaagc tcagggaaaa gtccacagcc
      961 tcatggagaa agactcctac cctaggttcc tgaggtccaa aatgtactta gatctgctgt
     1021 cccagagcca gaggaggctc agctagacct cggaggggga ctcttggaag tcactggctt
     1081 tcctttcccc ttgctgccaa gaccatattc tgaagtgaaa tgtcatagat gtccaaaggc
     1141 gctggggttt ggggtagaag gctgggggcg gtgacaaggg aatgaagggc ttttccaaag
     1201 tatgaccgag ctgatggagc tgggactcta ttccttctac ccagatttgt gttttggtta
     1261 gaggcagcac cgctgctatc acccttctct gggtgggcca gtaactggcc ctttataatg
     1321 ccttcggtca tctctatcga gaaggcagat tcactgtgcc gggctaattt gtaaataacg
     1381 caaatgcagc tcccgtgacc tacacaccac accctcctca gcaggattcc tggccttcac
     1441 cttgtccttt cctcaaggga ggattagcta gatgcctcag tttctcagtt ctgctgcact
     1501 gttacaaccc agtggcccag cctgagtaac tggacctcac agtgtagaag agaggtcttt
     1561 ttggaattcc atttccctag catcattgac aggtgacctc tgacaaagga tatataatcc
     1621 ctggagttgg ctgtgtcttc catttccacg ggaccaatag ggagtctgag gtcccctttc
     1681 agtctaagga attcattgaa cttccttaca tttgaaattc tagaaagggt cttgggagat
     1741 ttctcccagg acttctgagc agagctgtcc ttttgaaaga taagagtttg tgaatcttct
     1801 tcaattctat taagaacttt cctagaagcc gagtgaccag ggaatgtagc atcagtagtt
     1861 ttgtgcaatg aggctccgta tgacctgtct gttgcctaat gtattccatg tcctcacttt
     1921 cctgtggcat cacatagcac tgatctctta ggatgaaaga tggcttggca aagggaggta
     1981 cattcccata gcatgacagc ttccctagtg cctgttgctt tccctgtctc tccacctcct
     2041 tcttccatga agggcatgta actatgatgg gaagactgag aacctagcct gagactctca
     2101 ttgcagcttg cttcctggac ataccttctt agaatgggtc cacttttggc tgttgagaaa
     2161 tagctccctt cttggtctct agcctttggg actgacctgg gaagatcact gtgaatacca
     2221 ggctgcggaa actctcctgc aatgtttatg cggtaccctg gtggggtgct ggctcctgga
     2281 aacacaccag gatactcttt cttggaggag gcacgaacat cctggagtct ctgaagttac
     2341 ccaggagaaa gctgaccctg ccatctccta cagggacaga aagatgaatc ttcagcacag
     2401 agagcagaag atggaagatg aacctagaag ctgcgacctc tgggtgacct gagaatgtgg
     2461 tgaaggcact gctgtgataa ttcacaacca gtcaactcgg gcccattgaa gagccataaa
     2521 ctttcagctt gggtgaatga aatagtctgt gaccaagctg ccctagaaag caggaggtga
     2581 aaggctgggc tgatactccc ctttgtggag tgctagccct tctaagacat cctagggttt
     2641 gtattctgct cttggagaat tagttccttc cttggttgta gccagacaag gccaagaagg
     2701 ccccatgagt ccgtattagt gccaactgcc cttccaagtg gcacactgtc atctgtgagt
     2761 gggtgttagt gtctgggtgt gaacctcaaa gagagagaac atctacttcc taggcctcac
     2821 actgaaggga cctggggcag tcatttaaaa agaactctga agcttcaaat ggtgatccta
     2881 gtcagagcac atagatttcc ctaccctgac ataaaaatat tcttagctaa agctgccaga
     2941 attaatgtaa tgattaaatt ctctcacagg gtattttaaa cattgtttac atatgaaatg
     3001 tgcatctgct gccaaatgct actgtccaat atgcggtgca tatacactgg acctgcagtg
     3061 atggaatcat cccagatggg tcttctcaac actggcccca tcccaatgca aaacggctcc
     3121 acgcgtgtgg tgtggcaccc tcctttgggg cctagagttc ttgcaagctc ttggtgggat
     3181 gaaggctgta gatgatgatg tcatgcaccc tggtgactcc tttccaaatt gggggggggg
     3241 gtcacggaga gtaggtatga aggaccaagt ttgagtattc tgaattttgt agctagataa
     3301 gtttgtgtgt gtgtcatagt cccatttatg gtactcccat gtgtccacac atacatcttg
     3361 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttgtgtttc gttgtgagtt gtgagtcttg
     3421 ggcagtacac cacagacatg atcttcccat gtgagtagct tttcacatac cctatctccc
     3481 ctgcttcttc tagaaagcac agcgtttcta tccccgatac ctcctcttaa gcactttggt
     3541 catgctagcc caggttttgg tctgtgatga gacagagaaa tgtttacaac atctagagca
     3601 atatccaagc atacctcatc tccgagcttc cacgtctccc agccccctcc cctcatctcc
     3661 tcctctacga gcctcatctg cctcactggg ttgtcatcac agatgccacc atttccattt
     3721 gatgtcttcc tttgctccag tcatgcgagt gtgctgacga ctggctctgg actcaggcca
     3781 gcccaggcag taggacaccg tgctgtgact ttccatccca gagagacctg ttggtcccac
     3841 cggagtgttg acttgctttg ggtctggtgt gtggttggcc gttgctcttg tggactaact
     3901 agatctcagt cactgactac tcgagcgttc tgggttgaag gggggagtga taccctgaag
     3961 tagtatttat tattaagcat gagcatgaag aatagggggt caccttgaaa gcccctcaca
     4021 aacgctaacc cccagcttcc acacccggag gaggtgctga tcctatagac ctaagcaaga
     4081 ggcccataaa gcaacattga acaaaagaaa gaagctcctg gatgtgtaat ggcctgcagg
     4141 cactggacag agatggccca agacagtggg tctcagcctc gctgctcact aggcttacca
     4201 ggggagcatt aagaaacaac atcatcatca tcaacaacaa aaaacttaag tgttcagttt
     4261 ctaccataga gtagctaaat cggagaggct cggagggagc caggtggcag tagtttttaa
     4321 tgtcttgcta gcgattccaa tgtgcagatg tggacaggaa acggcagcct aagcaatgaa
     4381 gaggaacgga actgagtaaa acagggcccg gcagcccacc tggatgccaa aagcacaata
     4441 accaggccgc cctgcccact ctgcagctgg ctctcacggt ggttgcctcc tgcctttcag
     4501 tctgactggc tcctttgagg tcatgtttgg gttcaggcta aatgcgatag ttggtagtag
     4561 gtccgccaag gttggggaca tcaaggcact taatggagaa ctgttttgcc ctgcttcccc
     4621 ggcctctacc acagcgcttc ctccccagcc tgcatcatgg actccatctc cgtttgtctt
     4681 catatactct tgtgtttggc cattgtgtgt caggctgtgc ctctgtaccc aaggtcatgc
     4741 agtagggtga ctagaacata gctagggagt gaaaagtgtc ttggtagtga cagtcgtgat
     4801 gcaacagctt ccaaatttct ctgtggaggg tggcccttcc tggatgaaat ctgggaggct
     4861 acagtgtgac tcagactcct gctgtaagcc ctcatcattt tctttggccc tgtgctggat
     4921 aggcagcaag gaagctgcaa gctggctctg ttttctggtg ctttctccag aacttgctgc
     4981 tctgagaaac caaagctgtg aacaggcgaa tgctctccca ggtgtttgtc atggatgggc
     5041 ccgcaccgcc tggacagtag agaagctttc tctgctggaa ggagaaggca tgagaaccgg
     5101 ggaaaggtgg acaaggtgga gggagcctga ggaggaaggg gcaaggcagg agagactccc
     5161 cagttgcttc tccatttccc agagggaaag ggggaggggg cacattcata ggcaggatgg
     5221 ccttctagca agaaccccag aagtccgtag agcctgcaga ggaactgtgg ttttctaccc
     5281 ttgccttcag tctgtcaagt gtcagctttc ctgaggtcca tccccttcca gttaaaacag
     5341 gagaggtggt accaatactc ctggcgctgg gcgtctgtgc cactgtgtca cttggcatga
     5401 gacaaggagg gagaagcgaa gaggagagat ggctttctgt ccctgtggct tctcaaagac
     5461 tctacaggat gccgtagggg cacaatggga tacgtcagga tgggactccg ggcctcgcca
     5521 ggttttgggt ttggggtcct ctcaataaac tgtttatttc ttgaacttaa cccctctgct
     5581 ccttcccctc tgccaggtta caaggcgagt aggccctaca taggccccaa ccacagtagc
     5641 cttagctggt cactcacgga gcacaacgca gctcatctgc cctataaacc gcttggccga
     5701 cgaatcctca ttgagttctt tcattaccat gtaaagtgaa atacactcac tcacctttac
     5761 tatacacagg ctgtgagaac ataataaaca aaacctgaac aagcaaaaaa aaaaaaaaaa
     5821 aaaaaaa
//
